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    Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance
    11.
    发明授权
    Method and apparatus for quantitative hyperspectral fluorescence and reflectance imaging for surgical guidance 有权

    公开(公告)号：US12061328B2

    公开(公告)日：2024-08-13

    申请号：US18144767

    申请日：2023-05-08

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

    IPC: G02B21/06 ,  A61B1/06 ,  G02B21/36

    CPC classification number: G02B21/06 ,  A61B1/063 ,  G02B21/36

    Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE
    14.
    发明申请
    METHOD AND APPARATUS FOR QUANTITATIVE HYPERSPECTRAL FLUORESCENCE AND REFLECTANCE IMAGING FOR SURGICAL GUIDANCE 审中-公开

    公开(公告)号：US20190384048A1

    公开(公告)日：2019-12-19

    申请号：US16443760

    申请日：2019-06-17

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Pablo A. Valdes ,  David W. Roberts ,  Keith D. Paulsen ,  Frederic Leblond

    IPC: G02B21/06 ,  G02B21/36 ,  A61B1/06

    Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.

    Apparatus for measuring in-vivo mechanical properties of biological tissues
    15.
    发明授权
    Apparatus for measuring in-vivo mechanical properties of biological tissues 有权

    公开(公告)号：US09655545B2

    公开(公告)日：2017-05-23

    申请号：US14345029

    申请日：2012-09-17

    Applicant: The Trustees of Dartmouth College

    Inventor： Songbai Ji ,  David W. Roberts ,  Keith D. Paulsen

    IPC: A61B5/107 ,  A61B5/00 ,  G02B21/00 ,  G02B21/36 ,  A61B90/20 ,  G06T7/33 ,  A61B19/00 ,  G06T7/00 ,  A61B90/00

    CPC classification number: A61B5/1079 ,  A61B5/0053 ,  A61B5/0077 ,  A61B90/20 ,  A61B2090/364 ,  A61B2090/371 ,  G02B21/0012 ,  G02B21/367 ,  G06T7/344 ,  G06T2200/04 ,  G06T2207/10012 ,  G06T2207/10056 ,  G06T2207/30016

    Abstract: An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan. An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan.

    Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores
    16.
    发明申请
    Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores 审中-公开
    使用多个荧光团差异的医学成像方法和装置

    公开(公告)号：US20150374308A1

    公开(公告)日：2015-12-31

    申请号：US14767836

    申请日：2014-02-13

    Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE

    Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

    IPC: A61B5/00 ,  A61K49/00

    Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

    Abstract translation: 产生受试者组织中靶向荧光团浓度的校正荧光数据的方法包括向受试者施用第一和第二荧光造影剂，靶向目的组织的第一造影剂，第二剂未被靶向。 用第一刺激波长的光照射组织，并以适当的发射波长获取第一数据; 在第二刺激波长照射组织，并且以与第二试剂相关联的第二发射波长获取第二数据，第一和第二发射波长不同。 通过从第一数据中减去第二数据来产生差分数据。 系统提供多个波长的刺激和捕获，具有图像存储和减法代码，以执行该方法。 校正的数据可以形成荧光图像，或用于产生荧光断层图像。

    Apparatus For Meausring In-Vivo Mechanical Properties of Biological Tissues
    17.
    发明申请
    Apparatus For Meausring In-Vivo Mechanical Properties of Biological Tissues 有权

    公开(公告)号：US20140371600A1

    公开(公告)日：2014-12-18

    申请号：US14345029

    申请日：2012-09-17

    Applicant: The Trustees of Dartmouth College

    Inventor： Songbai Ji ,  David W. Roberts ,  Keith D. Paulsen

    IPC: A61B5/107 ,  G06T7/00 ,  G02B21/36 ,  G02B21/00 ,  A61B5/00 ,  A61B19/00

    CPC classification number: A61B5/1079 ,  A61B5/0053 ,  A61B5/0077 ,  A61B90/20 ,  A61B2090/364 ,  A61B2090/371 ,  G02B21/0012 ,  G02B21/367 ,  G06T7/344 ,  G06T2200/04 ,  G06T2207/10012 ,  G06T2207/10056 ,  G06T2207/30016

    Abstract: An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan. An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired images obtained from the digital cameras form stereo pairs, and a digital image processing system adapted to determine surface topography of tissue from the stereo pairs of images and a resulting surface displacement map as a result from indentation. The apparatus has an one indenter; and mechanical modeling routines stored in memory of the image processing system, the mechanical modeling routines capable of constructing computer models of mechanical properties of tissue, and fitting parameters of the computer model to observed surface displacement maps generated by coregistering surface topography of tissue with and without the indenter positioned on the tissue. In an embodiment, fitted parameters of the computer model are displayed and used to adjust a surgical plan.

    Method and apparatus for medical imaging using differencing of multiple fluorophores
    19.
    发明授权
    Method and apparatus for medical imaging using differencing of multiple fluorophores 有权

    公开(公告)号：US12285277B2

    公开(公告)日：2025-04-29

    申请号：US18614944

    申请日：2024-03-25

    Applicant: The Trustees of Dartmouth College

    Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

    IPC: A61B5/00 ,  A61K49/00

    Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

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