公开(公告)号：US08957228B2

公开(公告)日：2015-02-17

申请号：US13995519

申请日：2011-10-28

申请人： Haruhiko Fuwa ,  Makoto Sasaki ,  Hiroshi Kubo ,  Takaya Suzuki

发明人： Haruhiko Fuwa ,  Makoto Sasaki ,  Hiroshi Kubo ,  Takaya Suzuki

IPC分类号： C07D321/00 ,  C07D493/16 ,  C07D493/18

CPC分类号： C07D493/16 ,  C07D493/18

摘要： The present invention relates to a macrolide compound expected to have a cell growth-inhibiting activity and a novel anticancer drug utilizing the compound. Specifically, the invention relates to a compound represented by Formula (I) or (II) or a pharmaceutically acceptable salt thereof and relates to a cell growth inhibitor and an anticancer drug each containing the compound or the salt as an active ingredient.

摘要翻译： 本发明涉及预期具有细胞生长抑制活性的大环内酯类化合物和利用该化合物的新型抗癌药物。 具体地说，本发明涉及由式（I）或（II）表示的化合物或其药学上可接受的盐，涉及各自含有化合物或盐作为有效成分的细胞生长抑制剂和抗癌药。

公开(公告)号：US20130281714A1

公开(公告)日：2013-10-24

申请号：US13995519

申请日：2011-10-28

申请人： Haruhiko Fuwa ,  Makoto Sasaki ,  Hiroshi Kubo ,  Takaya Suzuki

发明人： Haruhiko Fuwa ,  Makoto Sasaki ,  Hiroshi Kubo ,  Takaya Suzuki

IPC分类号： C07D493/16

CPC分类号： C07D493/16 ,  C07D493/18

摘要： The present invention relates to a macrolide compound expected to have a cell growth-inhibiting activity and a novel anticancer drug utilizing the compound. Specifically, the invention relates to a compound represented by Formula (I) or (II) or a pharmaceutically acceptable salt thereof and relates to a cell growth inhibitor and an anticancer drug each containing the compound or the salt as an active ingredient.

摘要翻译： 本发明涉及预期具有细胞生长抑制活性的大环内酯类化合物和利用该化合物的新型抗癌药物。 具体地说，本发明涉及由式（I）或（II）表示的化合物或其药学上可接受的盐，涉及各自含有化合物或盐作为有效成分的细胞生长抑制剂和抗癌药。

公开(公告)号：US20080026075A1

公开(公告)日：2008-01-31

申请号：US11661688

申请日：2005-08-26

申请人： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Tohru Tanaka ,  Takaya Suzuki ,  Masahiro Ishizuka

发明人： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Tohru Tanaka ,  Takaya Suzuki ,  Masahiro Ishizuka

IPC分类号： A61K33/34 ,  A61K31/195 ,  A61K33/26 ,  A61K33/28 ,  A61P37/00 ,  A61K33/30 ,  A61K33/32

CPC分类号： A61K31/197 ,  A23K20/142 ,  A23K20/24 ,  A23K20/30 ,  A23L33/16 ,  A23L33/175 ,  A61K33/26 ,  A61K33/34 ,  A61K45/06 ,  A61K2300/00

摘要： Health function-improving agents, such as an immunological function-improving agent, an antioxidation function-improving agent, a exercise function-improving agent and a liver function-improving agent, comprising, as an effective ingredient, a δ-amino acid, a derivative thereof or a salt thereof

摘要翻译： 健康功能改善剂，诸如免疫功能改善剂，抗氧化功能改善剂，运动功能改善剂和肝功能改善剂，其包含作为有效成分的δ-氨基酸， 衍生物或其盐

公开(公告)号：US5736753A

公开(公告)日：1998-04-07

申请号：US521548

申请日：1995-08-30

申请人： Toshiyuki Ohno ,  Yohsuke Inoue ,  Daisuke Kawase ,  Yuzo Kozono ,  Takaya Suzuki ,  Tsutomu Yatsuo

发明人： Toshiyuki Ohno ,  Yohsuke Inoue ,  Daisuke Kawase ,  Yuzo Kozono ,  Takaya Suzuki ,  Tsutomu Yatsuo

IPC分类号： H01L21/04 ,  H01L29/24 ,  H01L29/78 ,  H01L29/808 ,  H01L31/0312 ,  H01L29/74 ,  H01L29/861

CPC分类号： H01L29/7802 ,  H01L29/1608 ,  H01L29/66068 ,  H01L29/7801 ,  H01L29/7813 ,  H01L29/8083

摘要： To provide a field-effect transistor having a large power conversion capacity and its fabrication method by decreasing the leakage current between the source and the drain of a semiconductor device made of hexagonal-system silicon carbide when the gate voltage of the semiconductor device is turned off and also decreasing the electrical resistance of the semiconductor device when the gate voltage of the semiconductor device is turned on. The main current path of the field-effect transistor is formed so that the current flowing between the source and the drain of, for example, a field-effect transistor flows in the direction parallel with the {0001} plane and a channel forming plane is parallel with the {1120} plane. �Selected Drawing!FIG. 1

摘要翻译： 为了提供具有大的功率转换能力的场效应晶体管及其制造方法，当半导体器件的栅极电压被关断时，通过减小由六方晶系碳化硅制成的半导体器件的源极和漏极之间的漏电流 并且当半导体器件的栅极电压导通时也降低半导体器件的电阻。 形成场效应晶体管的主电流路径，使得在例如场效应晶体管的源极和漏极之间流动的电流沿与{0001}平面平行的方向流动，沟道形成面为 与{1120}平面平行。 [所选图]

公开(公告)号：US5404740A

公开(公告)日：1995-04-11

申请号：US79114

申请日：1993-06-17

申请人： Shoji Okada ,  Atsumu Nakamura ,  Hideo Kunioku ,  Kenji Shibuya ,  Satoshi Kubota ,  Koichi Inamura ,  Haruotsu Ikeda ,  Takaya Suzuki ,  Kyouhei Murata

发明人： Shoji Okada ,  Atsumu Nakamura ,  Hideo Kunioku ,  Kenji Shibuya ,  Satoshi Kubota ,  Koichi Inamura ,  Haruotsu Ikeda ,  Takaya Suzuki ,  Kyouhei Murata

IPC分类号： B21B1/16 ,  B21B39/14 ,  B21B39/16 ,  B21B1/18

CPC分类号： B21B39/165

摘要： A high-rigid type guiding device for guiding a steel material to be rolled comprises guide rollers toughened by satisfying the condition in which rigidity (K) at contact portions with the steel material is defined by:K=Fmax/Smaxwherein, Fmax represents the maximum load exerted on the guide rollers (Fmax=m.times.FT, 1.0.ltoreq.m.ltoreq.2.0), and Smax represents the maximum allowable value within a range in which increment S of a roller gap defined between the contact portions is determined (Smax=n.times..delta.1, 0.2.ltoreq.n.ltoreq.0.8). Consequently, the efficiency of rolling and the productivity of the rolled steel products can be improved, and the yielding efficiency and quality of the products can be heightened.

摘要翻译： 用于引导待轧制的钢材的高刚性型引导装置包括通过满足通过满足与钢材接触部分的刚性（K）由K = Fmax / Smax定义的条件而增韧的导辊，其中Fmax表示 施加在导向辊上的最大载荷（Fmax = mxFT，1.0

公开(公告)号：US4954855A

公开(公告)日：1990-09-04

申请号：US113360

申请日：1987-10-28

申请人： Akio Mimura ,  Yoshikazu Hosokawa ,  Takaya Suzuki ,  Takashi Aoyama ,  Nobutake Konishi ,  Yutaka Misawa ,  Kenji Miyata

发明人： Akio Mimura ,  Yoshikazu Hosokawa ,  Takaya Suzuki ,  Takashi Aoyama ,  Nobutake Konishi ,  Yutaka Misawa ,  Kenji Miyata

IPC分类号： H01L21/336 ,  H01L29/45 ,  H01L29/49 ,  H01L29/786

CPC分类号： H01L29/66757 ,  H01L29/456 ,  H01L29/458 ,  H01L29/4908 ,  H01L29/7866 ,  H01L29/78675

摘要： A thin film transistor formed on an insulating sulstrate is disclosed in which metal silicide layers are formed in a thin film made of a monocrystalline, polycrystalline, or amorphous semiconductor material, to be used as source and drain regions, and further a gate electrode includes a metal silicide layer.

摘要翻译： 公开了一种形成在绝缘硅片上的薄膜晶体管，其中金属硅化物层形成在由单晶，多晶或非晶半导体材料制成的薄膜中，用作源极和漏极区域，并且还包括一个栅电极 金属硅化物层。

公开(公告)号：US4173674A

公开(公告)日：1979-11-06

申请号：US888981

申请日：1978-03-22

申请人： Akio Mimura ,  Takaya Suzuki ,  Seturo Yagiyu

发明人： Akio Mimura ,  Takaya Suzuki ,  Seturo Yagiyu

IPC分类号： H01L21/762 ,  B32B7/00 ,  B32B9/04 ,  H01L21/304 ,  H01L21/316

CPC分类号： H01L21/76297 ,  Y10T428/265

摘要： A dielectric insulator separated substrate comprises a plurality of monocrystalline semiconductor island regions in which circuit elements are to be formed and a support region for supporting the island regions while a dielectric film formed on the supporting region electrically separates the island regions from each other. The supporting region comprises crystalline semiconductor layers and at least one oxygen diffusion preventive film laminated alternately.The extreme outer polycrystalline semiconductor layer of the supporting region is polished to such a thickness as to prevent the substrate from being curved greatly by the wedge action due to the oxygen diffusion. Since the extreme outer polycrystalline semiconductor layer thus polished has a flat surface, the handling of the substrate is easy. The substrate devoid of any curveness deformation assures a highly accurate formation of the circuit elements in the island regions.

摘要翻译： 介质绝缘体分离衬底包括要形成电路元件的多个单晶半导体岛区域和用于支撑岛区的支撑区域，同时形成在支撑区域上的电介质膜将岛区彼此电分离。 支撑区域包括结晶半导体层和交替层压的至少一个氧扩散防止膜。 支撑区域的极外部多晶半导体层被抛光到这样的厚度，以防止由于氧扩散而产生的楔形作用使衬底大大弯曲。 由于这样抛光的极外部多晶半导体层具有平坦的表面，所以基板的处理容易。 没有任何弯曲变形的基板确保岛状区域中的电路元件的高精度地形成。

公开(公告)号：US20120211371A1

公开(公告)日：2012-08-23

申请号：US13503585

申请日：2011-06-07

申请人： Hiroki Nishijima ,  Shinji Ikeda ,  Keiichiro Aoki ,  Yoshinobu Yoshihara ,  Yasufumi Nakanishi ,  Takaya Suzuki

发明人： Hiroki Nishijima ,  Shinji Ikeda ,  Keiichiro Aoki ,  Yoshinobu Yoshihara ,  Yasufumi Nakanishi ,  Takaya Suzuki

IPC分类号： G01N27/406

CPC分类号： G01N15/0656 ,  F01N9/002 ,  F01N2410/00 ,  F01N2560/05 ,  F01N2560/20 ,  F02D41/1466

摘要： A porous structure including a pair of electrodes disposed in a flow direction of exhaust gas and a solid electrolyte interposed between the electrodes is arranged in an exhaust passage of an internal combustion engine, and the amount of a particulate matter in exhaust gas is specified based on a potential difference generated between the electrodes.

摘要翻译： 在内燃机的排气通道中设置有包括在废气流动方向上设置的一对电极和介于电极之间的固体电解质的多孔结构，并且基于 在电极之间产生的电位差。

公开(公告)号：US20120094304A1

公开(公告)日：2012-04-19

申请号：US13264694

申请日：2010-04-09

申请人： Hiroshi Kubo ,  Naoya Fujino ,  Takaya Suzuki ,  Mutsuo Yamaya

发明人： Hiroshi Kubo ,  Naoya Fujino ,  Takaya Suzuki ,  Mutsuo Yamaya

IPC分类号： C12N5/071 ,  G01N21/64 ,  C12Q1/02

CPC分类号： A61K35/42 ,  A61K35/12 ,  C12N5/0689 ,  C12N2502/13 ,  G01N2500/10

摘要： Provided are: a method of preparing cells that simultaneously express a type II alveolar epithelial cell marker and a stem cell marker, including a process of isolating and extracting constituent cells from human lung tissue, and a process of separating and culturing lung tissue stem cells from the obtained isolated cells; human lung tissue stem cells that are obtained from the method of preparation and are able to differentiate into alveolar epithelial cells; a method of inducing differentiation into human lung epithelial cells, consisting of culturing the human lung tissue stem cells; human alveolar epithelial cells prepared through the method of inducing differentiation; and a method of screening that uses the human lung tissue stem cells or human alveolar epithelial cells.

摘要翻译： 提供：一种制备同时表达II型肺泡上皮细胞标志物和干细胞标记物的细胞的方法，包括从人肺组织分离和提取组成细胞的方法，以及从肺组织干细胞分离和培养肺组织干细胞的方法 获得的分离细胞; 人肺组织干细胞，其从制备方法获得并且能够分化成肺泡上皮细胞; 诱导分化为人肺上皮细胞的方法，其包括培养人肺组织干细胞; 通过诱导分化的方法制备人肺泡上皮细胞; 以及使用人肺组织干细胞或人肺泡上皮细胞的筛选方法。

公开(公告)号：US20100003186A1

公开(公告)日：2010-01-07

申请号：US12166479

申请日：2008-07-02

申请人： HIDEKAZU YOSHIKAWA ,  Taro Oyama ,  Takaya Suzuki ,  Harumitsu Enomoto

发明人： HIDEKAZU YOSHIKAWA ,  Taro Oyama ,  Takaya Suzuki ,  Harumitsu Enomoto

IPC分类号： D01F9/12

CPC分类号： D01F9/12 ,  D01F9/22

摘要： According to the present invention, there is disclosed a carbon fiber having a strand tensile strength of 6,100 MPa or more, a strand tensile modulus of 340 GPa or more and a density of 1.76 g/cm3 or more and possessing, on the surface, striations oriented in a direction parallel to the fiber axis, wherein the distance between striations in a 2×2 μm area of the carbon fiber surface when observed by a scanning probe microscope is 0.1 to 0.3 μm, the root mean square surface roughness Rms (5 μm) in a 5×5 μm area of the carbon fiber surface when observed by a scanning probe microscope is 20 to 40 nm, and the root mean square surface roughness Rms (0.5 μm) when measured in a 0.5×0.5 μm area is 2 to 12 nm.

摘要翻译： 根据本发明，公开了一种具有6,100MPa以上的线股抗拉强度，340GPa以上的线拉伸模量和1.76g / cm 3以上的密度的碳纤维，并且在表面上具有条纹 在平行于纤维轴的方向上定向，其中当通过扫描探针显微镜观察时，碳纤维表面的2x2mum面积中的条纹之间的距离为0.1至0.3μm，根均方根表面粗糙度Rms（5mum） 当通过扫描探针显微镜观察时，碳纤维表面的5×5μm面积为20〜40nm，在0.5×0.5μm面积中测定时的均方根表面粗糙度Rms（0.5μm）为2〜12nm。