公开(公告)号：US20110195040A1

公开(公告)日：2011-08-11

申请号：US12979883

申请日：2010-12-28

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： A61K31/00

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

摘要： Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

摘要翻译： 提供的交联聚合物组合物包括含有共价结合到含有多个亲电子基团的第二合成聚合物的多个亲核基团的第一合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化为含有两个或多个亲电基团，例如琥珀酰亚胺基。 组合物还可包括其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 防止手术粘连的形成; 并涂覆合成植入物的表面。

公开(公告)号：US06969400B2

公开(公告)日：2005-11-29

申请号：US10766146

申请日：2004-01-27

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： A61K47/34 ,  A61L24/00 ,  A61L24/04 ,  A61L24/08 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/00 ,  A61L31/04 ,  A61L31/16 ,  A61L33/00 ,  C08B37/00 ,  C08G65/329 ,  C08G81/00 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  C08L77/04 ,  C08L101/00 ,  A61F2/00 ,  A61F2/06 ,  A61F2/12 ,  A61F2/24 ,  A61F2/76 ,  A61M5/00 ,  A61M25/00

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

摘要： Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

摘要翻译： 提供的交联聚合物组合物包括含有共价结合到含有多个亲电子基团的第二合成聚合物的多个亲核基团的第一合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化为含有两个或多个亲电基团，例如琥珀酰亚胺基。 组合物还可包括其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 防止手术粘连的形成; 并涂覆合成植入物的表面。

公开(公告)号：US07151135B2

公开(公告)日：2006-12-19

申请号：US11078254

申请日：2005-03-10

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： C08G63/48 ,  C08G63/91 ,  C08G69/48 ,  C08G77/00 ,  C08L89/00 ,  C08F283/00 ,  A61K47/48

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

摘要： Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

摘要翻译： 提供的交联聚合物组合物包括含有共价结合到含有多个亲电子基团的第二合成聚合物的多个亲核基团的第一合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化为含有两个或多个亲电基团，例如琥珀酰亚胺基。 组合物还可包括其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 以防止手术粘连的形成; 并涂覆合成植入物的表面。

公开(公告)号：US06534591B2

公开(公告)日：2003-03-18

申请号：US09932536

申请日：2001-08-17

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： C08F28300

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

摘要： Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

公开(公告)号：US5475052A

公开(公告)日：1995-12-12

申请号：US236769

申请日：1994-05-02

申请人： Woonza M. Rhee ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Richard A. Berg

IPC分类号： A61K47/42 ,  A61F2/00 ,  A61F2/06 ,  A61K38/00 ,  A61K47/48 ,  A61L15/22 ,  A61L24/10 ,  A61L26/00 ,  A61L27/00 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/44 ,  A61L27/54 ,  A61L29/04 ,  A61L29/06 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/12 ,  C07K1/113 ,  C07K14/495 ,  C07K14/52 ,  C07K14/575 ,  C07K14/78 ,  C07K17/08 ,  C08B37/08 ,  C08G81/00 ,  C08H1/00 ,  C08H1/02 ,  C08H1/06 ,  C08L89/06 ,  C09J189/06 ,  G02B1/04 ,  C08G63/48 ,  C08G63/91

CPC分类号： A61K47/48215 ,  A61K47/4823 ,  A61L15/225 ,  A61L24/102 ,  A61L26/0033 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/44 ,  A61L27/54 ,  A61L29/043 ,  A61L29/045 ,  A61L29/06 ,  A61L29/16 ,  A61L31/041 ,  A61L31/044 ,  A61L31/10 ,  A61L31/125 ,  C07K14/495 ,  C07K14/78 ,  C08B37/0069 ,  C08B37/0072 ,  C08H1/06 ,  C08L89/06 ,  C09J189/06 ,  G02B1/043 ,  A61F2/07 ,  A61F2002/072 ,  A61F2310/00365 ,  A61K38/00 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/426 ,  A61L2300/602 ,  A61L2300/62 ,  A61L2430/16

摘要： The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer matrix. The synthetic hydrophilic polymer may be mono- or multifunctionally activated, but is preferably difunctionally activated, resulting in the formation of a crosslinked collagen matrix. The second step comprises modifying the collagen-synthetic polymer matrix according to one or more of the following methods: further crosslinking the matrix using a multifunctionally activated synthetic polymer, conjugating the matrix using a monofunctionally activated synthetic polymer, coupling biologically active molecules or glycosaminoglycans to the matrix, crosslinking the matrix using conventional chemical crosslinking agents, or modifying the collagen in the matrix by means of various chemical reactions. An optional third step may include further modification of the collagen-synthetic polymer matrix by covalently binding, for example, biologically active molecules or glycosaminoglycans to the matrix by means of available active groups on the synthetic hydrophilic polymers. Collagen-synthetic polymer matrices prepared according to the methods of the present invention have very low immunogenicity and can therefore be used to prepare biocompatible implants for use in a variety of medical applications.

摘要翻译： 本发明公开了使用多步反应制备的胶原合成聚合物基质。 反应的第一步通常包括使胶原与功能活化的合成亲水聚合物反应以形成胶原合成聚合物基质。 合成亲水性聚合物可以是单功能或多功能活化的，但优选是双官能的活化的，导致形成交联的胶原基质。 第二步包括根据一种或多种以下方法修饰胶原合成聚合物基质：使用多功能活化的合成聚合物进一步交联基质，使用单官能活化的合成聚合物共轭基质，将生物活性分子或糖胺聚糖偶联至 基质，使用常规化学交联剂交联基质，或通过各种化学反应改性基质中的胶原。 任选的第三步骤可以包括通过在合成的亲水聚合物上通过可用的活性基团将例如生物活性分子或糖胺聚糖共价结合到基质上来进一步修饰胶原合成聚合物基质。 根据本发明方法制备的胶原合成聚合物基质具有非常低的免疫原性，因此可用于制备用于各种医学应用的生物相容性植入物。

公开(公告)号：US06911496B2

公开(公告)日：2005-06-28

申请号：US10766726

申请日：2004-01-27

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： A61K47/34 ,  A61L24/00 ,  A61L24/04 ,  A61L24/08 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/00 ,  A61L31/04 ,  A61L31/16 ,  A61L33/00 ,  C08B37/00 ,  C08G65/329 ,  C08G81/00 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  C08L77/04 ,  C08L101/00 ,  C08F283/00 ,  C08G63/48 ,  C08G63/91 ,  C08L77/00

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

摘要： Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

摘要翻译： 提供的交联聚合物组合物包括含有共价结合到含有多个亲电子基团的第二合成聚合物的多个亲核基团的第一合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化为含有两个或多个亲电基团，例如琥珀酰亚胺基。 组合物还可包括其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 防止手术粘连的形成; 并涂覆合成植入物的表面。

公开(公告)号：US06323278B2

公开(公告)日：2001-11-27

申请号：US09733739

申请日：2000-12-08

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： C08F28300

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

摘要： Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

摘要翻译： 交联聚合物组合物包含含有多个亲核基团的第一合成聚合物，其共价键合到含有多个亲电子基团的第二合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化以含有两个或更多个亲电基团，例如琥珀酰亚胺基。 组合物还可以包含其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 防止手术粘连的形成; 并涂覆合成植入物的表面。

公开(公告)号：US5874500A

公开(公告)日：1999-02-23

申请号：US769806

申请日：1996-12-18

申请人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Frank A. DeLustro ,  Richard A. Berg

IPC分类号： A61K47/34 ,  A61L24/00 ,  A61L24/04 ,  A61L24/08 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/00 ,  A61L31/04 ,  A61L31/16 ,  A61L33/00 ,  C08B37/00 ,  C08G65/329 ,  C08G81/00 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  C08L77/04 ,  C08L101/00 ,  C08F283/00 ,  C08G63/91 ,  C08G69/48

CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  Y10S623/90 ,  Y10S623/901

摘要： Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (--NH.sub.2) or thiol (--SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

公开(公告)号：US5800541A

公开(公告)日：1998-09-01

申请号：US780470

申请日：1997-01-08

申请人： Woonza M. Rhee ,  Richard A. Berg

发明人： Woonza M. Rhee ,  Richard A. Berg

IPC分类号： A61F2/00 ,  A61F2/06 ,  A61L24/10 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/44 ,  A61L27/54 ,  A61L31/04 ,  A61L31/10 ,  A61L31/12 ,  A61L31/16 ,  C08H1/06 ,  C08L89/06 ,  C09J189/06 ,  A61F2/02 ,  C08G63/48

CPC分类号： C08L89/06 ,  A61L24/102 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/44 ,  A61L27/54 ,  A61L31/041 ,  A61L31/044 ,  A61L31/10 ,  A61L31/125 ,  A61L31/16 ,  C08H1/06 ,  C09J189/06 ,  A61F2/07 ,  A61F2002/072 ,  A61F2310/00365 ,  A61L2300/236 ,  A61L2300/414 ,  A61L2430/16

摘要： The present invention discloses collagen-synthetic polymer matrices which are prepared using a multiple step reaction. The first step of the reaction generally involves reacting collagen with a functionally activated synthetic hydrophilic polymer to form a collagen-synthetic polymer matrix. The synthetic hydrophilic polymer may be mono- or multifunctionally activated, but is preferably difunctionally activated, resulting in the formation of a crosslinked collagen matrix. The second step comprises modifying the collagen-synthetic polymer matrix according to one or more of the following methods: further crosslinking the matrix using a multifunctionally activated synthetic polymer, conjugating the matrix using a monofunctionally activated synthetic polymer, coupling biologically active molecules or glycosaminoglycans to the matrix, crosslinking the matrix using conventional chemical crosslinking agents, or modifying the collagen in the matrix by means of various chemical reactions. An optional third step may include further modification of the collagen-synthetic polymer matrix by covalently binding, for example, biologically active molecules or glycosaminoglycans to the matrix by means of available active groups on the synthetic hydrophilic polymers. Collagen-synthetic polymer matrices prepared according to the methods of the present invention have very low immunogenicity and can therefore be used to prepare biocompatible implants for use in a variety of medical applications.

公开(公告)号：US5752974A

公开(公告)日：1998-05-19

申请号：US574050

申请日：1995-12-18

申请人： Woonza M. Rhee ,  Richard A. Berg ,  George H. Chu ,  Frank A. DeLustro ,  Dan M. Jolivette ,  Kimberly A. McCullough

发明人： Woonza M. Rhee ,  Richard A. Berg ,  George H. Chu ,  Frank A. DeLustro ,  Dan M. Jolivette ,  Kimberly A. McCullough

IPC分类号： A61K38/17 ,  A61F2/00 ,  A61K31/726 ,  A61K31/77 ,  A61K38/00 ,  A61L24/04 ,  A61L24/10 ,  A61L26/00 ,  A61L27/00 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L31/04 ,  A61P15/18 ,  A61B17/00

CPC分类号： A61L31/044 ,  A61L24/043 ,  A61L24/102 ,  A61L26/0033 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  A61L31/041 ,  A61F2310/00365 ,  A61L2400/06 ,  A61L2430/36

摘要： Methods for completely or partially blocking, augmenting, sealing, or filling various biological lumens and voids within the body of a patient are disclosed. Lumens include arteries, veins, intestines, Fallopian tubes, and trachea. Voids include various lesions, fissures, diverticulae, cysts, fistulae, aneurysms, or other undesirable voids that may exist within a patient's body. In the most general method of the invention, an effective amount of a biomaterial is administered (e.g., via injection, catheter, or surgical implantation) into the lumen or void. Preferred biomaterial compositions for use in the present invention are disclosed.

摘要翻译： 公开了在患者体内完全或部分阻断，增强，密封或填充各种生物腔和空隙的方法。 流明包括动脉，静脉，肠，输卵管和气管。 空隙包括可能存在于患者体内的各种病变，裂隙，憩室，囊肿，瘘，动脉瘤或其它不希望的空洞。 在本发明最通用的方法中，将有效量的生物材料（例如通过注射，导管或手术植入）施用于内腔或空腔。 公开了用于本发明的优选生物材料组合物。