公开(公告)号：US07169251B2

公开(公告)日：2007-01-30

申请号：US10436657

申请日：2003-05-13

Applicant: Lingjie J Guo ,  Xing Cheng

Inventor： Lingjie J Guo ,  Xing Cheng

IPC: B82B3/00 ,  B82B1/00 ,  B37B37/02

CPC classification number: B81C1/00119 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0896 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/086 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C2201/0153 ,  B82Y30/00 ,  G01N2021/058 ,  Y10S977/78 ,  Y10S977/84 ,  Y10S977/882

Abstract: A method of forming nanofluidic enclosed channels includes providing a first substrate having a layer of a first material disposed thereon. A plurality of nanoscale slots is formed along a second substrate using nanolithography, etching, or other disclosed techniques. The first substrate is then bonded to the second substrate such that the layer of the first material on the first substrate is adjacent the plurality of slots on the second substrate to define a plurality of enclosed nanofluidic channels therethrough.

Abstract translation: 形成纳流体封闭通道的方法包括提供具有设置在其上的第一材料层的第一基底。 使用纳米光刻，蚀刻或其它公开的技术沿着第二基板形成多个纳米级槽。 然后将第一衬底接合到第二衬底，使得第一衬底上的第一材料层与第二衬底上的多个槽相邻以限定穿过其中的多个封闭的纳米流体通道。

公开(公告)号：US08197888B2

公开(公告)日：2012-06-12

申请号：US12112675

申请日：2008-04-30

Applicant: Hung-Jue Sue ,  Xing Cheng ,  Dazhi Sun ,  Huifeng Li ,  Chien-Chia Chu

Inventor： Hung-Jue Sue ,  Xing Cheng ,  Dazhi Sun ,  Huifeng Li ,  Chien-Chia Chu

IPC: B05D5/12 ,  B05D1/32

CPC classification number: B82Y30/00 ,  C08K3/041 ,  C08K3/22 ,  C08K3/346 ,  C09D7/70 ,  C08L63/00

Abstract: A dispersible nanocomposite comprising nanotubes associated with nanoplatelets. A method for creating an exfoliated nanotubes solution, aligning nanotubes and depositing them on a substrate or in matrix. In one embodiment, the method includes a nanocomposite of at least one nanotube electrostatically associated with at least one nanoplatelet. The nanoplatelets may be removed from the suspension by altering the ionic strength to create an exfoliated nanotube solution. The exfoliated nanotube solution for injection into microchannel templates and aligned deposition.

Abstract translation: 包含与纳米片相关的纳米管的可分散的纳米复合材料。 一种用于产生剥离的纳米管溶液的方法，将纳米管排列并将其沉积在基底或基质上。 在一个实施方案中，该方法包括与至少一个纳米血小板静电相关的至少一个纳米管的纳米复合物。 可以通过改变离子强度从悬浮液中除去纳米片，以产生剥离的纳米管溶液。 用于注入微通道模板和对准沉积的剥离的纳米管溶液。

公开(公告)号：US20090285853A1

公开(公告)日：2009-11-19

申请号：US12508075

申请日：2009-07-23

Applicant: Xing Cheng ,  Hyun Jung Park ,  Hong Jin

Inventor： Xing Cheng ,  Hyun Jung Park ,  Hong Jin

IPC: A61K39/12 ,  C12N15/00 ,  C12N7/01 ,  C12N15/63 ,  C07K14/005 ,  C07K16/08 ,  C07H21/04 ,  C07H21/02 ,  C07H21/00

CPC classification number: C07K14/005 ,  A61K2039/525 ,  A61K2039/5254 ,  C07K16/1027 ,  C12N2760/18522

Abstract: The complete polynucleotide sequence of the human respiratory syncytial virus subgroup B strain 9320 genome is provided. Proteins encoded by this polynucleotide sequence are also provided. Isolated or recombinant RSV (e.g., attenuated recombinant RSV), nucleic acids, and polypeptides, e.g., comprising mutations in the attachment protein G, are also provided, as are immunogenic compositions comprising such isolated or recombinant RSV, nucleic acids, and polypeptides. Related methods are also described.

Abstract translation: 提供了人呼吸道合胞病毒亚组B株9320基因组的完整多核苷酸序列。 还提供了由该多核苷酸序列编码的蛋白质。 还提供了分离或重组的RSV（例如减毒的重组RSV），核酸和多肽，例如包含附着蛋白G中的突变，包含这种分离的或重组的RSV，核酸和多肽的免疫原性组合物也是如此。 还描述了相关方法。

公开(公告)号：US07374864B2

公开(公告)日：2008-05-20

申请号：US10545456

申请日：2004-02-13

Applicant: Lingjie J. Guo ,  Xing Cheng

Inventor： Lingjie J. Guo ,  Xing Cheng

IPC: G03C5/00

CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  G03F1/50

Abstract: A method of fabricating a device including imprinting a mold having a protrusion against a substrate having a resist layer such that the protrusion engages the resist layer. The mold further has a mask member positioned generally adjacent the resist layer. Radiation energy is then transmitted through the mold and into the resist layer; however, the mask member substantially prevents transmission of the radiation energy therethrough, thereby defining an unexposed area in the resist layer. Once the mold is removed from the substrate, which consequently forms a first feature from nanoimprinting, the unexposed area of resist layer is removed through dissolving in a developer solution.

Abstract translation: 一种制造器件的方法，包括将具有突起的模具压印在具有抗蚀剂层的基底上，使得突起与抗蚀剂层接合。 模具还具有通常邻近抗蚀剂层定位的掩模构件。 然后将辐射能量透过模具并进入抗蚀剂层; 然而，掩模构件基本上防止辐射能量透过，从而在抗蚀剂层中限定未曝光区域。 一旦将模具从基底上移除，从而形成纳米压印的第一特征，则通过溶解在显影剂溶液中去除抗蚀剂层的未曝光区域。

公开(公告)号：US20070059497A1

公开(公告)日：2007-03-15

申请号：US10513704

申请日：2002-05-08

Applicant: Xudong Huang ,  Li-Rong Bao ,  Xing Cheng ,  Lingjie Guo ,  Stella Pang

Inventor： Xudong Huang ,  Li-Rong Bao ,  Xing Cheng ,  Lingjie Guo ,  Stella Pang

IPC: B05D5/12 ,  B41M5/00 ,  B05D3/12

CPC classification number: G03F7/0002 ,  B29C33/42 ,  B82Y10/00 ,  B82Y40/00 ,  H05K3/0079 ,  Y10T428/24802

Abstract: The present invention relates to a method for imprinting a micro-/nano-structure on a substrate, the method comprising (a) providing a mold containing a desired pattern or relief for a microstructure; (b) applying a polymer coating to the mold; and (c) transferring the polymer coating from the mold to a substrate under suitable temperature and pressure conditions to form an imprinted substrate having a desired micro-/nano-structure thereon.

Abstract translation: 本发明涉及一种用于将微/纳米结构压印在基底上的方法，所述方法包括（a）提供含有微结构的所需图案或凹凸的模具; （b）将聚合物涂层施加到模具上; 和（c）在合适的温度和压力条件下将聚合物涂层从模具转移到基底上以形成其上具有所需微/纳米结构的印迹基底。

公开(公告)号：US20050176130A1

公开(公告)日：2005-08-11

申请号：US10672302

申请日：2003-09-26

Applicant: Hong Jin ,  Bin Lu ,  Xing Cheng ,  Helen Zhou

Inventor： Hong Jin ,  Bin Lu ,  Xing Cheng ,  Helen Zhou

IPC: A61K20060101 ,  A61K6/00 ,  A61K35/76 ,  A61K39/00 ,  A61K39/155 ,  A61P31/14 ,  C07K14/135 ,  C12N7/01 ,  C12N7/04 ,  C12N15/00 ,  C12N15/45 ,  C12N15/86 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/569

CPC classification number: C12N7/045 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/543 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2800/40 ,  G01N33/56983 ,  G01N2469/20 ,  G01N2500/00

Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.

Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。