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    Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities
    12.
    发明授权
    Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities 有权
    监测心肺合并症心力衰竭患者的方法和装置

    公开(公告)号：US08065010B2

    公开(公告)日：2011-11-22

    申请号：US12319642

    申请日：2009-01-08

    申请人： Marina V. Brockway ,  Donald L. Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth C. Beck

    发明人： Marina V. Brockway ,  Donald L. Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth C. Beck

    IPC分类号： A61N1/36

    CPC分类号： A61B5/087 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521

    摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

    摘要翻译： 系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。 基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。 如果未检测到心源性肺水肿，则基于由可植入或非可行的肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病， 植入式传感器。 在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。

    Glycemic control monitoring using implantable medical device
    13.
    发明授权
    Glycemic control monitoring using implantable medical device 有权
    使用可植入医疗器械的血糖控制监测

    公开(公告)号：US07731658B2

    公开(公告)日：2010-06-08

    申请号：US11839638

    申请日：2007-08-16

    申请人： Yousufali H. Dalal ,  Haresh G. Sachanandani ,  Gerrard M. Carlson

    发明人： Yousufali H. Dalal ,  Haresh G. Sachanandani ,  Gerrard M. Carlson

    IPC分类号： A61B5/02 ,  A61B5/00 ,  A61N1/00

    CPC分类号： A61B5/14503 ,  A61B5/0452 ,  A61B5/14532 ,  A61B7/04 ,  A61B2562/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2210/125 ,  A61M2230/201

    摘要： An apparatus for monitoring a patient's blood glucose level. The apparatus includes an implantable medical device having a controller and an implantable heart sounds sensor configured to transmit signals to the controller of the implantable medical device. The controller is configured to determine if a patient is hypoglycemic or hyperglycemic based on the signals from the heart sounds sensor. A method is also disclosed that includes sensing the patient's heart sounds, determining the amplitude of the S2 heart sound, determining the length of the interval from the S1 heart sound to the S2max heart sound, determining the length of the interval from the S1 heart sound to the S2end heart sound, and determining the patient's blood glucose status based on the patient's heart sounds.

    摘要翻译： 一种用于监测患者血糖水平的装置。 该装置包括具有控制器和可植入心音传感器的可植入医疗装置，其被配置为向可植入医疗装置的控制器发送信号。 控制器被配置为基于来自心脏声音传感器的信号来确定患者是否是低血糖或高血糖。 还公开了一种方法，其包括感测患者的心脏声音，确定S2心音的幅度，确定从S1心音到S2max心音的间隔的长度，确定从S1心音发出的间隔的长度 到S2end心音，并且基于患者的心脏声音来确定患者的血糖状态。

    GLYCEMIC CONTROL MONITORING USING IMPLANTABLE MEDICAL DEVICE
    15.
    发明申请
    GLYCEMIC CONTROL MONITORING USING IMPLANTABLE MEDICAL DEVICE 有权
    使用可植入医疗器械进行血液控制监测

    公开(公告)号：US20090048503A1

    公开(公告)日：2009-02-19

    申请号：US11839638

    申请日：2007-08-16

    申请人： Yousufali H. Dalal ,  Haresh G. Sachanandani ,  Gerrard M. Carlson

    发明人： Yousufali H. Dalal ,  Haresh G. Sachanandani ,  Gerrard M. Carlson

    IPC分类号： A61B5/145 ,  A61M5/14

    CPC分类号： A61B5/14503 ,  A61B5/0452 ,  A61B5/14532 ,  A61B7/04 ,  A61B2562/0219 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2210/125 ,  A61M2230/201

    摘要： An apparatus for monitoring a patient's blood glucose level. The apparatus includes an implantable medical device having a controller and an implantable heart sounds sensor configured to transmit signals to the controller of the implantable medical device. The controller is configured to determine if a patient is hypoglycemic or hyperglycemic based on the signals from the heart sounds sensor. A method is also disclosed that includes sensing the patient's heart sounds, determining the amplitude of the S2 heart sound, determining the length of the interval from the S1 heart sound to the S2max heart sound, determining the length of the interval from the S1 heart sound to the S2end heart sound, and determining the patient's blood glucose status based on the patient's heart sounds.

    摘要翻译： 一种用于监测患者血糖水平的装置。 该装置包括具有控制器和可植入心音传感器的可植入医疗装置，其被配置为向可植入医疗装置的控制器发送信号。 控制器被配置为基于来自心脏声音传感器的信号来确定患者是否是低血糖或高血糖。 还公开了一种方法，其包括感测患者的心脏声音，确定S2心音的幅度，确定从S1心音到S2max心音的间隔的长度，确定从S1心音发出的间隔的长度 到S2end心音，并且基于患者的心脏声音来确定患者的血糖状态。

    Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities
    16.
    发明授权
    Method and apparatus for monitoring heart failure patients with cardiopulmonary comorbidities 有权
    监测心肺合并症心力衰竭患者的方法和装置

    公开(公告)号：US07480528B2

    公开(公告)日：2009-01-20

    申请号：US10897856

    申请日：2004-07-23

    申请人： Marina Brockway ,  Donald Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth Beck

    发明人： Marina Brockway ,  Donald Hopper ,  Gerrard M. Carlson ,  Veerichetty Kadhiresan ,  Kenneth Beck

    IPC分类号： A61B5/0402

    CPC分类号： A61B5/087 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/4878 ,  A61N1/3627 ,  A61N1/36521

    摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.

    摘要翻译： 系统接收指示由多个传感器感测到的心肺疾病的信号，并且基于该信号提供对心肺病状态的监测和自动鉴别诊断。 基于由可植入传感器感测到的一个或多个信号来检测心源性肺水肿。 如果没有检测到心源性肺水肿，则基于由可植入或非可行性肺动脉血流检测的呼吸信号测量的强制肺活量（FVC）参数和强制呼气量（FEV）参数，每个都检测到阻塞性肺疾病和限制性肺部疾病， 植入式传感器。 在一个实施例中，可植入医疗装置感测指示心肺病的信号，外部系统通过执行自动检测算法基于这些信号来检测心肺病。

    Classifying tachyarrhythmia using time interval between ventricular depolarization and mitral valve closure
    17.
    发明授权
    Classifying tachyarrhythmia using time interval between ventricular depolarization and mitral valve closure 有权
    使用心室去极化和二尖瓣关闭之间的时间间隔来分类快速性心律失常

    公开(公告)号：US07177685B2

    公开(公告)日：2007-02-13

    申请号：US10618261

    申请日：2003-07-11

    申请人： William C. Lincoln ,  Gerrard M. Carlson

    发明人： William C. Lincoln ,  Gerrard M. Carlson

    IPC分类号： A61N1/365 ,  A61N1/39 ,  A61B5/04

    CPC分类号： A61B5/0464 ,  A61B5/04525 ,  A61N1/362

    摘要： A cardiac rhythm management system measures a time interval between a first fiducial marker indicative of a ventricular depolarization (e.g., a Q-wave, an R-wave, etc.) and a second fiducial marker indicative of a subsequent mitral valve closure (MVC) occurring during the same cardiac cycle. Such time intervals are used for detecting atrioventricular (AV) dissociation. The AV dissociation may, in turn, be used for discriminating between a supraventricular tachyarrhythmia (SVT) and a ventricular tachyarrhythmia (VT) or for any other diagnostic or therapeutic purpose. The AV dissociation and/or SVT/VT discrimination information may be communicated from an implantable cardiac rhythm management device to an external interface and/or used to determine the nature of therapy delivered to the subject. In a further example, amplitudes indicative of the MVCs are also used for determining whether AV dissociation exists.

    摘要翻译： 心律管理系统测量指示心室去极化（例如，Q波，R波等）的第一基准标记与指示随后的二尖瓣关闭（MVC）的第二基准标记之间的时间间隔， 发生在同一心脏周期。 这样的时间间隔用于检测房室（AV）解离。 AV解离反过来可用于区分室上性快速性心律失常（SVT）和室性快速性心律失常（VT）或任何其他诊断或治疗目的。 AV解离和/或SVT / VT鉴别信息可以从可植入心律管理装置传递到外部界面和/或用于确定递送给对象的治疗的性质。 在另一示例中，指示MVC的幅度也用于确定AV解离是否存在。

    Phonocardiographic image-based atrioventricular delay optimization
    18.
    发明授权
    Phonocardiographic image-based atrioventricular delay optimization 有权
    基于心音图像的房室延迟优化

    公开(公告)号：US07123962B2

    公开(公告)日：2006-10-17

    申请号：US10307896

    申请日：2002-12-02

    申请人： Krzysztof Z. Siejko ,  Gerrard M. Carlson ,  William C. Lincoln ,  Andrew P. Kramer

    发明人： Krzysztof Z. Siejko ,  Gerrard M. Carlson ,  William C. Lincoln ,  Andrew P. Kramer

    IPC分类号： A61N1/365

    CPC分类号： A61B7/04 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/3682 ,  A61N1/3684

    摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance to allow, among other things, diagnosis of cardiac conditions and evaluation of therapies treating the cardiac conditions. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The diagnosis and/or therapy evaluation are performed by observing or detecting at least an occurrence of a particular heart sound related to a cardiac time interval or a trend of a particular time interval between an electrical event and a mechanical event over the cardiac time interval.

    摘要翻译： 心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像，以允许除了别的以外，还可以诊断心脏状况和评估治疗心脏病症的疗法。 心音图像包括表示多个心动周期的一组声传感器信号段。 每个声学传感器信号段包括指示心脏的机械事件和心脏电气事件的表示的心脏声音。 诊断和/或治疗评估通过观察或检测与心脏时间间​​隔相关的特定心音的发生，或者在心脏时间间​​隔上的电事件和机械事件之间的特定时间间隔的趋势。