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    Compounds for enhancing hypoxia inducible factor activity and methods of use
    11.
    发明授权
    Compounds for enhancing hypoxia inducible factor activity and methods of use 有权

    公开(公告)号：US09795587B2

    公开(公告)日：2017-10-24

    申请号：US14575387

    申请日：2014-12-18

    申请人： Cornell Research Foundation, Inc.

    发明人： Rajiv R. Ratan ,  Ambreena Siddiq ,  Juan Chavez

    IPC分类号： A61K31/352 ,  A61K31/343 ,  A61K31/24 ,  A61K31/58

    CPC分类号： A61K31/352 ,  A61K31/24 ,  A61K31/343 ,  A61K31/58

    摘要： The present invention relates to methods for enhancing Hypoxia inducible factor-1 (HIF) activity in a cell by contacting the cell with any one of the following compounds: 3,6-bis[2-(dimethylamino)ethoxy]-9h-xanthen-9-onedihydrochloride, 2,8-bis[dimethylaminoacetyl]dibenzofurin dihydrochloride hydrate, tilorone analog R-9536-DA, indoprofen, ciclopiroxolamine, tryptophan, ansindione, nabumetone, oxybendazole, albendazole, tropicamide, pramoxine hydrochloride, atenolol, mebendazole, carbetapentane citrate, monensin sodium, methoxyvone, hydroxyzine, phenazopyridine, clofoctol, ipraflavone, zomepirac, biochanin A, xylometazoline hydrochloride, fenbendazole, pirenzepine, triprolidine hydrochloride, daidzein, tripelennamine citrate, colchicines, aminopyridine, trimethoprim, helenine, hydroxyurea, amiodarone hydrochloride, clindamycin hydrochloride, sulfachlorpyridazine, mephenesin, semustine, clofivric acid, clofibrate, ibuprofen, hyoscyamime, nafcillin sodium, piperin, clidinium bromide, trioxsalen, hydralazine and HIF alpha protein fused to a carrier peptide.

    Devices and methods for pharmacokinetic-based cell culture system
    17.
    发明授权
    Devices and methods for pharmacokinetic-based cell culture system 有权
    基于药物动力学的细胞培养系统的装置和方法

    公开(公告)号：US09273276B2

    公开(公告)日：2016-03-01

    申请号：US13301261

    申请日：2011-11-21

    申请人： Michael Shuler ,  Gregory T. Baxter ,  Aaron Sin ,  Robert Andrew Harrison ,  Scott Meyers

    发明人： Michael Shuler ,  Gregory T. Baxter ,  Aaron Sin ,  Robert Andrew Harrison ,  Scott Meyers

    IPC分类号： C12M1/34 ,  C12M3/06 ,  C12M3/00 ,  C12M1/36 ,  G01N33/50 ,  C12N5/071 ,  C12N5/00

    CPC分类号： C12M41/46 ,  C12M23/16 ,  C12M23/44 ,  C12M41/48 ,  C12N5/0062 ,  C12N5/0671 ,  G01N33/5008 ,  G01N33/5067

    摘要： A cell culture method using an in vitro microscale cell culture device having a first microscale chamber containing cells attached to an inner surface of the chamber and cell culture medium in contact with the cells. The cells are maintained in culture in the in vitro microscale cell culture device while flowing culture medium through the first chamber at a controlled rate to provide a liquid residence time value for the cells in the first chamber of the in vitro microscale cell culture device that is comparable to a liquid residence time value obtained with respect to comparable cells in vivo, such that metabolism by the cells in culture in the in vitro microscale cell culture device is comparable to metabolism by comparable cells in vivo.

    摘要翻译： 一种使用体外微细胞培养装置的细胞培养方法，所述培养装置具有包含连接于所述腔室内表面的细胞的第一微量室和与细胞接触的细胞培养基。 将细胞在体外微量细胞培养装置中保持培养，同时以受控的速率流过培养基通过第一室，以提供体外微量细胞培养装置的第一室中的细胞的液体停留时间值，其为 相当于在体内相当的细胞获得的液体停留时间值，使得体外微量细胞培养装置中培养物中的细胞的代谢与体内相当的细胞的代谢相当。