公开(公告)号：US20050209602A1

公开(公告)日：2005-09-22

申请号：US10984566

申请日：2004-11-09

申请人： Bruce Bowman ,  Robert Kohler ,  Erik Martz ,  Daniel Melink ,  Khin Myint ,  Michael Ahrens ,  Jean-Charles Lehuec ,  John Sherman ,  Scott Hook ,  Dennis Johnson ,  Qi-Bin Bao ,  Robert Hudgins

发明人： Bruce Bowman ,  Robert Kohler ,  Erik Martz ,  Daniel Melink ,  Khin Myint ,  Michael Ahrens ,  Jean-Charles Lehuec ,  John Sherman ,  Scott Hook ,  Dennis Johnson ,  Qi-Bin Bao ,  Robert Hudgins

IPC分类号： A61B17/88 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/30 ,  A61F2/44 ,  A61F2/46

CPC分类号： A61B17/8805 ,  A61B17/8827 ,  A61B17/8836 ,  A61B2090/064 ,  A61F2/441 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30583 ,  A61F2002/4627 ,  A61F2002/465 ,  A61F2002/4663 ,  A61F2002/467 ,  A61F2002/4677 ,  A61F2002/4688 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2250/0098

摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.

摘要翻译： 一种用于将包含可流动的生物材料的容器流体耦合到模具的方法和装置。 根据第一操作参数控制可流动的生物材料流入模具的流动。 至少监测一个注射条件。 响应于达到阈值水平的一个或多个注入条件，可流动生物材料的流动根据第二操作参数来控制。 在可流动的生物材料的固化的至少一部分期间维持第二操作参数。 在一些实施例中，第二操作参数可以可选地包括允许可流动的生物材料的一部分从模具中排出。

公开(公告)号：US20090112326A1

公开(公告)日：2009-04-30

申请号：US12014560

申请日：2008-01-15

申请人： Jean-Charles Lehuec ,  Erik O. Martz

发明人： Jean-Charles Lehuec ,  Erik O. Martz

IPC分类号： A61F2/44

CPC分类号： A61B17/7062 ,  A61B17/7059 ,  A61B17/7097 ,  A61B17/8805 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4611 ,  A61F2/4684 ,  A61F2002/30014 ,  A61F2002/3008 ,  A61F2002/30184 ,  A61F2002/30448 ,  A61F2002/30481 ,  A61F2002/30538 ,  A61F2002/30556 ,  A61F2002/30563 ,  A61F2002/30566 ,  A61F2002/30571 ,  A61F2002/30578 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30594 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/4666 ,  A61F2002/4685 ,  A61F2002/4693 ,  A61F2210/0085 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2230/003 ,  A61F2250/0006 ,  A61F2250/0009 ,  A61F2250/0018 ,  A61F2250/0098

摘要： A system for forming a spinal prosthesis in situ within an intervertebral space located between first and second adjacent vertebrae includes at least one mold having at least one internal compartment adapted to receive at least one flowable biomaterial. The system also includes a retaining member adapted to secure the mold between the first and second vertebrae, the retaining member including first and second portions adapted to be engaged with first and second surfaces of the first and second vertebrae, respectively. The retaining member also includes an intermediate body operatively coupling the first portion to the second portion, the intermediate body adapted to be positioned in or adjacent to the intervertebral space. A biomaterial delivery apparatus is in fluid communication with the mold at a pressure sufficient for the mold to engage with the retaining member. The spinal prosthesis selectively position the first vertebrae relative to the second vertebrae.

摘要翻译： 一种用于在位于第一和第二相邻椎骨之间的椎间空间内原位形成脊椎假体的系统包括至少一个模具，其具有适于容纳至少一个可流动的生物材料的至少一个内部隔室。 该系统还包括适于将模具固定在第一和第二椎骨之间的保持构件，所述保持构件包括分别适于与第一和第二椎骨的第一和第二表面接合的第一和第二部分。 保持构件还包括可操作地将第一部分连接到第二部分的中间体，中间体适于定位在椎间空间中或邻近椎间空间。 生物材料输送装置在足以使模具与保持构件接合的压力下与模具流体连通。 脊椎假体相对于第二椎骨选择性地定位第一椎骨。

公开(公告)号：US20070038300A1

公开(公告)日：2007-02-15

申请号：US11277887

申请日：2006-03-29

申请人： Qi-Bin Bao ,  Robert Hudgins ,  Jeffrey Felt ,  Alexander Arsenyev ,  Hansen Yuan

发明人： Qi-Bin Bao ,  Robert Hudgins ,  Jeffrey Felt ,  Alexander Arsenyev ,  Hansen Yuan

IPC分类号： A61F2/44 ,  A61F2/46

CPC分类号： C08G18/4854 ,  A61B1/00165 ,  A61B17/00234 ,  A61B17/16 ,  A61B17/17 ,  A61B17/7097 ,  A61B2017/00535 ,  A61F2/07 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/30767 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/38 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2/82 ,  A61F2/945 ,  A61F2002/30016 ,  A61F2002/30024 ,  A61F2002/3008 ,  A61F2002/30235 ,  A61F2002/30563 ,  A61F2002/30578 ,  A61F2002/30583 ,  A61F2002/30601 ,  A61F2002/30841 ,  A61F2002/30929 ,  A61F2002/30957 ,  A61F2002/4233 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2210/0085 ,  A61F2230/0069 ,  A61F2250/0019 ,  A61F2250/0021 ,  A61F2250/0098 ,  A61L27/18 ,  A61L29/041 ,  A61L29/06 ,  A61L2430/38 ,  B01F2215/0039 ,  C08G18/10 ,  C08G18/69 ,  Y10S606/907 ,  Y10S606/91 ,  C08L83/04 ,  C08L75/04 ,  C08L23/00 ,  C08L67/02 ,  C08G18/3206

摘要： A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.

摘要翻译： 一种通过在盘内原位递送和固化生物材料来修复椎间盘的系统。 该系统包括具有可插入球囊和相关内腔的装置，对照和适配器，以及原位可固化生物材料（和相关的生物材料递送装置）。 该系统可以允许医生通过控制牵引和/或生物材料输送压力来确定用于生物材料递送的合适的终点，并且反过来，将气体中所需量的生物材料输送到气囊中，以实现改进的聚合物固化和植入特征。 还提供了一种通过使用这种系统来原位递送和固化生物材料来修复椎间盘的相关方法。 该系统可以用于以使得周围的盘组织基本上完整的方式植入假体总盘或假体椎间盘细胞核。

公开(公告)号：US20060265076A1

公开(公告)日：2006-11-23

申请号：US11268876

申请日：2005-11-08

申请人： Benjamin Carter ,  Erik Martz ,  Scott Hook ,  Mark Rydell ,  Ronald Burke ,  Robert Kohler ,  Steven Healy ,  Bruce Bowman ,  John Sherman ,  Jean-Charles Lehuec

发明人： Benjamin Carter ,  Erik Martz ,  Scott Hook ,  Mark Rydell ,  Ronald Burke ,  Robert Kohler ,  Steven Healy ,  Bruce Bowman ,  John Sherman ,  Jean-Charles Lehuec

IPC分类号： A61F2/44

CPC分类号： A61F2/4611 ,  A61B1/3135 ,  A61B17/3415 ,  A61B90/50 ,  A61B2017/00261 ,  A61B2017/3405 ,  A61B2017/3445 ,  A61B2017/3447 ,  A61B2017/3488 ,  A61F2/441 ,  A61F2002/4627 ,  A61M25/04 ,  A61M25/0662

摘要： A catheter holder designed to deliver a curable biomaterial to an intervertebral disc space. By securing the catheter to the catheter holder, the depth of insertion of the catheter into the disc space can be accurately controlled. The catheter holder optionally helps with insertion of a optional mold through the annulotomy and into the disc space created by the nuclectomy. The catheter holder helps keep the mold from being drawn too far into the disc space or pushed too far out of the disc space during polymer injection.

摘要翻译： 设计用于将可固化生物材料递送到椎间盘空间的导管支架。 通过将导管固定到导管支架上，可以精确地控制导管插入椎间盘空间的深度。 导管支架可选择地有助于插入可选模具通过瓣膜切开术并进入由切除切割术产生的椎间盘空间。 在聚合物注射期间，导管支架有助于保持模具不被太吸引到盘片空间中或被推到太远的盘片空间。

公开(公告)号：US20060253199A1

公开(公告)日：2006-11-09

申请号：US11268856

申请日：2005-11-08

申请人： Jean-Charles Lehuec ,  John Sherman

发明人： Jean-Charles Lehuec ,  John Sherman

IPC分类号： A61F2/44

CPC分类号： A61F2/441 ,  A61B17/7062 ,  A61B17/7097 ,  A61B17/8816 ,  A61B17/8855 ,  A61F2/08 ,  A61F2/30907 ,  A61F2/442 ,  A61F2/4611 ,  A61F2002/30004 ,  A61F2002/30014 ,  A61F2002/30019 ,  A61F2002/30062 ,  A61F2002/30324 ,  A61F2002/30331 ,  A61F2002/30332 ,  A61F2002/30378 ,  A61F2002/30474 ,  A61F2002/30476 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30604 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2250/0014 ,  A61F2250/0018 ,  A61F2250/0036 ,  A61F2250/0048

摘要： A method of implanting an intervertebral prosthesis in a disc located between a pair of adjacent vertebrae of a patient. Damaged or diseased nucleus pulpous is removed from the disc using minimally invasive techniques. The adjacent vertebrae are positioned in a lordotic condition. A mold adapted to contain a biomaterial is positioned between the adjacent vertebrae. A flowable biomaterial is delivered into the mold using minimally invasive techniques so that the adjacent vertebrae are in the lordotic condition. The flowable biomaterial is allowed to at least partially cure so that the adjacent vertebrae are in a lordotic-neutral position. The step of positioning the pair of adjacent vertebrae in a lordotic condition may include positioning the patient in extension, displacing spinous processes of the adjacent vertebrae to a compressed configuration, suturing spinous processes of the adjacent vertebrae to a compressed configuration, and/or delivering the flowable biomaterial into the mold at sufficient pressure to distraction the adjacent vertebrae to a lordotic position. One or more preformed prostheses can be substituted for, or combined with, the mold.

摘要翻译： 将椎间假体植入位于患者的一对相邻椎骨之间的盘中的方法。 使用微创技术从椎间盘移除损伤或患病的髓核。 相邻的椎骨位于脊索状态。 适于容纳生物材料的模具位于相邻的椎骨之间。 使用微创技术将可流动的生物材料输送到模具中，使得相邻的椎骨处于脊索状态。 允许可流动的生物材料至少部分固化，使得相邻的椎骨处于脊索前体位置。 将一对相邻椎骨定位在脊柱前凸状态的步骤可包括定位患者延伸，将相邻椎骨的棘突移位成压缩构型，将相邻椎骨的棘突缝合到压缩构型，和/或递送 可流动的生物材料以足够的压力进入模具，以将相邻的椎骨分散到脊柱状位置。 一个或多个预制假体可以替代或与模具组合。

公开(公告)号：US20060253198A1

公开(公告)日：2006-11-09

申请号：US11268786

申请日：2005-11-08

申请人： Khin Myint ,  Erik Martz ,  Benjamin Carter ,  Ronald Burke

发明人： Khin Myint ,  Erik Martz ,  Benjamin Carter ,  Ronald Burke

IPC分类号： A61F2/44

CPC分类号： A61F2/441 ,  A61F2002/30062 ,  A61F2002/30578 ,  A61F2002/30583 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2210/0004 ,  A61F2210/0085

摘要： A multi-lumen mold is for the in situ formation of a prosthesis in an annulus located in an intervertebral disc space of a patient. The annulus has at least two openings formed by minimally invasive techniques and at least a portion of the nucleus pulposus is removed to form a nuclear cavity. The multi-lumen mold includes a mold adapted to be located in the nuclear cavity. A first lumen having a distal end is fluidly coupled to a flexible mold at a first location. At least a second lumen having a distal end fluidly coupled to the flexible mold at a second location. The first and second lumens are adapted to extend out through the openings in the annulus when the mold is positioned in the nuclear cavity. One or more securing members can be used to secure the mold in the intervertebral disc space. The securing members can engage with the annulus, the end plates, and/or another surface of a vertebrate.

摘要翻译： 多腔模具用于在位于患者的椎间盘空间中的环中原位形成假体。 所述环具有通过微创技术形成的至少两个开口，并且去除髓核的至少一部分以形成核腔。 多腔模具包括适于位于核腔内的模具。 具有远端的第一管腔在第一位置处流体地联接到柔性模具。 至少第二内腔具有在第二位置处与柔性模具流体耦合的远端。 当模具定位在核腔中时，第一和第二内腔适于延伸穿过环形空间中的开口。 可以使用一个或多个固定构件将模具固定在椎间盘空间中。 固定构件可与环形物，端板和/或脊椎动物的另一表面接合。

公开(公告)号：US07077865B2

公开(公告)日：2006-07-18

申请号：US10365842

申请日：2003-02-13

申请人： Qi-Bin Bao ,  Robert Garryl Hudgins ,  Jeffrey C. Felt ,  Alexander Arsenyev ,  Hansen A. Yuan

发明人： Qi-Bin Bao ,  Robert Garryl Hudgins ,  Jeffrey C. Felt ,  Alexander Arsenyev ,  Hansen A. Yuan

IPC分类号： A61F2/44

CPC分类号： C08G18/4854 ,  A61B1/00165 ,  A61B17/00234 ,  A61B17/16 ,  A61B17/17 ,  A61B17/7097 ,  A61B2017/00535 ,  A61F2/07 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/30767 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/38 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2/82 ,  A61F2/945 ,  A61F2002/30016 ,  A61F2002/30024 ,  A61F2002/3008 ,  A61F2002/30235 ,  A61F2002/30563 ,  A61F2002/30578 ,  A61F2002/30583 ,  A61F2002/30601 ,  A61F2002/30841 ,  A61F2002/30929 ,  A61F2002/30957 ,  A61F2002/4233 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2210/0085 ,  A61F2230/0069 ,  A61F2250/0019 ,  A61F2250/0021 ,  A61F2250/0098 ,  A61L27/18 ,  A61L29/041 ,  A61L29/06 ,  A61L2430/38 ,  B01F2215/0039 ,  C08G18/10 ,  C08G18/69 ,  Y10S606/907 ,  Y10S606/91 ,  C08L83/04 ,  C08L75/04 ,  C08L23/00 ,  C08L67/02 ,  C08G18/3206

摘要： A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.

公开(公告)号：US07001431B2

公开(公告)日：2006-02-21

申请号：US10365868

申请日：2003-02-13

申请人： Qi-Bin Bao ,  Robert Garryl Hudgins ,  Jeffrey C. Felt ,  Alexander Arsenyev ,  Hansen A. Yuan

发明人： Qi-Bin Bao ,  Robert Garryl Hudgins ,  Jeffrey C. Felt ,  Alexander Arsenyev ,  Hansen A. Yuan

IPC分类号： A61F2/44

CPC分类号： C08G18/4854 ,  A61B1/00165 ,  A61B17/00234 ,  A61B17/16 ,  A61B17/17 ,  A61B17/7097 ,  A61B2017/00535 ,  A61F2/07 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/30767 ,  A61F2/3099 ,  A61F2/32 ,  A61F2/38 ,  A61F2/4081 ,  A61F2/4202 ,  A61F2/441 ,  A61F2/442 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2/82 ,  A61F2/945 ,  A61F2002/30016 ,  A61F2002/30024 ,  A61F2002/3008 ,  A61F2002/30235 ,  A61F2002/30563 ,  A61F2002/30578 ,  A61F2002/30583 ,  A61F2002/30601 ,  A61F2002/30841 ,  A61F2002/30929 ,  A61F2002/30957 ,  A61F2002/4233 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2210/0085 ,  A61F2230/0069 ,  A61F2250/0019 ,  A61F2250/0021 ,  A61F2250/0098 ,  A61L27/18 ,  A61L29/041 ,  A61L29/06 ,  A61L2430/38 ,  B01F2215/0039 ,  C08G18/10 ,  C08G18/69 ,  Y10S606/907 ,  Y10S606/91 ,  C08L83/04 ,  C08L75/04 ,  C08L23/00 ,  C08L67/02 ,  C08G18/3206

摘要： A system for repairing an intervertebral disc by delivering and curing a biomaterial in situ within the disc. The system includes both a device, having an insertable balloon and related lumen, controls and adapters, as well as an in situ curable biomaterial (and related biomaterial delivery means). The system can allow the doctor to determine a suitable endpoint for biomaterial delivery, by controlling distraction and/or biomaterial delivery pressure, and in turn, to deliver a desired quantity of biomaterial to the balloon in order to achieve improved polymer cure and implant characteristics. Also provided is a related method for repairing an intervertebral disc by using such a system to deliver and cure the biomaterial in situ. The system can be used to implant a prosthetic total disc, or a prosthetic disc nucleus in a manner that leaves the surrounding disc tissue substantially intact.

公开(公告)号：US20050209601A1

公开(公告)日：2005-09-22

申请号：US10984493

申请日：2004-11-09

申请人： Bruce Bowman ,  Robert Kohler ,  Erik Martz ,  Daniel Melink ,  Khin Myint ,  Michael Ahrens ,  Jean-Charles Lehuec ,  John Sherman ,  Scott Hook ,  Dennis Johnson ,  Qi-Bin Bao ,  Robert Hudgins

发明人： Bruce Bowman ,  Robert Kohler ,  Erik Martz ,  Daniel Melink ,  Khin Myint ,  Michael Ahrens ,  Jean-Charles Lehuec ,  John Sherman ,  Scott Hook ,  Dennis Johnson ,  Qi-Bin Bao ,  Robert Hudgins

IPC分类号： A61B17/88 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/30 ,  A61F2/44 ,  A61F2/46

CPC分类号： A61B17/8805 ,  A61B17/8827 ,  A61B17/8836 ,  A61B2090/064 ,  A61F2/441 ,  A61F2/4601 ,  A61F2/4611 ,  A61F2002/30062 ,  A61F2002/3008 ,  A61F2002/30583 ,  A61F2002/4627 ,  A61F2002/465 ,  A61F2002/4663 ,  A61F2002/467 ,  A61F2002/4677 ,  A61F2002/4688 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2250/0098

摘要： A method and apparatus for fluidly coupling a reservoir containing a flowable biomaterial to a mold. The flow of the flowable biomaterial into the mold is controlled in accordance with a first operating parameter. At least one injection condition is monitored. The flow of the flowable biomaterial is controlled in accordance with a second operating parameter in response to one or more of the injection conditions reaching a threshold level. The second operating parameter is maintained during at least a portion of the curing of the flowable biomaterial. In some embodiments, the second operating parameter may optionally include permitting a portion of the flowable biomaterial to be expelled from the mold.

公开(公告)号：US08092536B2

公开(公告)日：2012-01-10

申请号：US12203727

申请日：2008-09-03

申请人： Michael Ahrens ,  Erik O. Martz

发明人： Michael Ahrens ,  Erik O. Martz

IPC分类号： A61F2/44

CPC分类号： A61F2/441 ,  A61B17/7094 ,  A61B17/7095 ,  A61B17/7097 ,  A61B17/8811 ,  A61F2002/30004 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30079 ,  A61F2002/3008 ,  A61F2002/30092 ,  A61F2002/30144 ,  A61F2002/30177 ,  A61F2002/302 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/3025 ,  A61F2002/30252 ,  A61F2002/30261 ,  A61F2002/30273 ,  A61F2002/30289 ,  A61F2002/30471 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30586 ,  A61F2002/30588 ,  A61F2002/30677 ,  A61F2002/30841 ,  A61F2002/30878 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/448 ,  A61F2002/4495 ,  A61F2002/4629 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0085 ,  A61F2210/009 ,  A61F2220/0091 ,  A61F2230/0017 ,  A61F2230/0056 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2230/0071 ,  A61F2230/0073 ,  A61F2230/0082 ,  A61F2230/0086 ,  A61F2230/0091 ,  A61F2250/0014 ,  A61F2250/003 ,  A61F2250/0098 ,  A61F2310/00011 ,  A61F2310/00023 ,  A61F2310/00179

摘要： An assembly for the in situ formation of a prosthesis in an intervertebral disc space between adjacent vertebrae of a patient. At least one retention structure is located in the intervertebral disc space. A distal end of at least one lumen is located proximate the at least one retention structure. One or more in situ curable biomaterials are delivered to the intervertebral disc space through the first lumen and into engagement with the retention structure. The retention structure serves to retain at least a portion of the biomaterial in the intervertebral disc space by surface tension, adhesion, mechanical capture, friction, viscosity, and/or a variety of other mechanisms. The at least partially cured biomaterial and the at least one retention structure cooperate to comprise the prosthesis.

摘要翻译： 用于在患者的相邻椎骨之间的椎间盘间隙中原位形成假体的组件。 至少一个保留结构位于椎间盘空间中。 至少一个内腔的远端位于至少一个保持结构附近。 一个或多个原位可固化生物材料通过第一内腔被输送到椎间盘空间并与保留结构接合。 保持结构用于通过表面张力，粘附力，机械捕获，摩擦，粘度和/或各种其它机制将至少一部分生物材料保留在椎间盘空间中。 所述至少部分固化的生物材料和所述至少一个保留结构配合以构成所述假体。