公开(公告)号：US20150190464A1

公开(公告)日：2015-07-09

申请号：US14413685

申请日：2013-07-09

申请人： N.V. Nutricia

发明人： Claudia Catharina Maria Van Den Braak ,  Thomas Ludwig ,  Marcel Minor ,  Rudolph Eduardus Maria Verdurmen ,  Hilde Ruis

IPC分类号： A61K38/17 ,  A23J3/16 ,  A23J3/10 ,  A61K38/16 ,  A23L1/305

CPC分类号： A61K38/1709 ,  A23J3/10 ,  A23J3/14 ,  A23J3/16 ,  A23L33/17 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K38/011 ,  A61K38/018 ,  A61K38/168 ,  A23V2200/08 ,  A23V2200/32 ,  A23V2250/54246 ,  A23V2250/5488 ,  A23V2250/548

摘要： The present invention relates to a process of producing a composition comprising at least two different proteins, of which at least one is a coagulating protein and at least one is an anti-coagulating protein, comprising the steps of: a) heat-sterilising a first liquid component comprising said coagulating protein, b) heat-sterilising a second liquid component comprising said anti-coagulating protein, and c) mixing said first component with said second component to obtain a mixture thereof. The obtained mixture is useful as a food constituent having reduced coagulation in the upper gastro-intestinal tract, more in particular in the stomach.

摘要翻译： 本发明涉及一种制备包含至少两种不同蛋白质的组合物的方法，其中至少一种是凝血蛋白质，至少一种是凝血蛋白质，其包括以下步骤：a）将第一 包含所述凝固蛋白的液体组分，b）对包含所述抗凝血蛋白质的第二液体组分进行加热灭菌，和c）将所述第一组分与所述第二组分混合以获得其混合物。 所得混合物可用作在上胃肠道中减少凝血的食物成分，特别是在胃中。

公开(公告)号：US20140296162A1

公开(公告)日：2014-10-02

申请号：US13994222

申请日：2011-12-16

申请人： Matthijs Leonard Joseph Van Der Zande ,  Gerrit Jan Waterink

发明人： Matthijs Leonard Joseph Van Der Zande ,  Gerrit Jan Waterink

IPC分类号： A23L1/29 ,  A61K38/16

CPC分类号： A23L1/3053 ,  A23J3/08 ,  A23J3/16 ,  A23L33/115 ,  A23L33/16 ,  A23L33/17 ,  A23L33/175 ,  A23L33/18 ,  A23L33/185 ,  A23L33/19 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A23V2250/70 ,  A61K31/20 ,  A61K33/06 ,  A61K35/20 ,  A61K38/011 ,  A61K38/018 ,  A61K38/02 ,  A61K38/168 ,  A23V2200/302 ,  A23V2250/54252 ,  A23V2250/1578 ,  A23V2250/161 ,  A23V2250/18 ,  A23V2200/316 ,  A23V2200/16

摘要： The invention relates to a sterilized liquid or semi-solid acid enteral composition comprising per 100 ml 9 to 20 g of non-hydrolysed globular proteins, fat and at least 100 mg of divalent metal cations and having a pH ranging between 3 and 5. The invention further relates to a method for preparing a composition according to the invention, comprising a step wherein at least the non-hydrolysed globular proteins are subjected to a direct steam injection (DSI) at specific holding values, such as a holding temperature of 100 to 140° C. during a holding time of about 0.5 to 10 seconds, followed by a homogenization step and a sterilization step The composition according to the invention has a reduced astringency and can be used for medical purposes, such as for stimulating muscle protein synthesis in a mammal, in particular for treating sarcopenia, and for specific groups of people, such as elderly and sportsman.

摘要翻译： 本发明涉及一种无菌液体或半固体酸肠内组合物，其包含每100毫升9-20克非水解球状蛋白质，脂肪和至少100mg二价金属阳离子，pH值在3至5之间。 本发明还涉及一种制备根据本发明的组合物的方法，其包括至少将所述非水解球状蛋白质以特定保持值（例如保持温度为100至 在约0.5至10秒的保持时间内保持140℃，然后进行均化步骤和灭菌步骤根据本发明的组合物具有减少的涩味，并且可用于医学目的，例如用于刺激肌肉蛋白质合成 哺乳动物，特别是用于治疗肌肉减少症，以及针对特定群体的老年人和运动员。

公开(公告)号：US08758769B2

公开(公告)日：2014-06-24

申请号：US12083195

申请日：2007-08-28

申请人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

发明人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

IPC分类号： A61K36/02 ,  A61K8/97

CPC分类号： A61K8/975 ,  A61K38/011 ,  Y10S435/814 ,  Y10S514/893

摘要： Disclosed is a composition for preventing and treating acetaminophen induced liver injury including the protein extracted from Porphyra yezoensis. The protein(s), separated and purified from hot water extracts of Porphyra yezoensis, having the molecular weight of 14 kDa measured by sodium dodecyl sulfate polyacrylamide gel electrophoresis, has an excellent effect for inhibiting the oxidative injury of liver tissue and cell apoptosis of liver cells induced by acetaminophen.

摘要翻译： 公开了一种用于预防和治疗对乙酰氨基酚诱发的肝损伤的组合物，包括从紫菜属中提取的蛋白质。 通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳测定的具有14kDa分子量的紫菜紫菜热水提取物中分离纯化的蛋白质对抑制肝组织氧化损伤和肝细胞凋亡具有极好的作用 对乙酰氨基酚诱导的细胞。

公开(公告)号：US08025907B2

公开(公告)日：2011-09-27

申请号：US12460505

申请日：2009-07-20

申请人： William A. Belfer

发明人： William A. Belfer

IPC分类号： A01N65/00 ,  A61K31/74

CPC分类号： A61K8/64 ,  A61K8/97 ,  A61K36/23 ,  A61K36/28 ,  A61K36/82 ,  A61K38/011 ,  A61K38/39 ,  A61Q19/08 ,  A61K2300/00

摘要： A cosmetic composition consists of a combination of peptides that regenerate the dermal matrix and a rapid acting muscle relaxant derived from the extract of the plant, Acmella oleracea. By limiting cutaneous deformation caused by the contraction of facial muscles the extract increases the efficiency of the peptides in reducing expression lines.

摘要翻译： 化妆品组合物由再生真皮基质的肽的组合和源自植物提取物Acmella oeracea的快速作用的肌肉松弛剂组成。 通过限制由面部肌肉收缩引起的皮肤变形，提取物增加肽在减少表达系中的效率。

公开(公告)号：US20100152422A1

公开(公告)日：2010-06-17

申请号：US12083195

申请日：2007-08-28

申请人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

发明人： Taek-Jeong Nam ,  Mi-Jin Kwon ,  Hye-Jung Hwang

IPC分类号： C07K14/415

CPC分类号： A61K8/975 ,  A61K38/011 ,  Y10S435/814 ,  Y10S514/893

摘要： The present invention relates to a composition for preventing and treating acetaminophen induced liver injury comprising the protein extracts from porphyra yezoensis. The protein separated and purified from hot water extracts of porphyra yezoensis and having the molecular weight of 14 kDa measured by sodium dodecyl sulfate polyacrylamide gel electrophoresis manner has an excellent effect for inhibiting the oxidative injury of the liver tissue and the cell apoptosis of the liver cell induced by acetaminophen.

摘要翻译： 本发明涉及一种用于预防和治疗对乙酰氨基酚诱发的肝损伤的组合物，其包含来自紫花苜蓿的蛋白质提取物。 通过十二烷基硫酸钠聚丙烯酰胺凝胶电泳方法测定的分离纯度为十五烷基硫酸钠的分子量为14kDa的紫花苜蓿热水提取物，对抑制肝组织氧化损伤和肝细胞凋亡具有极好的疗效 由对乙酰氨基酚诱导。

公开(公告)号：US20030007938A1

公开(公告)日：2003-01-09

申请号：US10077152

申请日：2002-02-15

发明人： Loren R. Pickart

IPC分类号： A61K007/04 ,  A61K038/16

CPC分类号： A61Q3/00 ,  A61K8/19 ,  A61K8/64 ,  A61K8/645 ,  A61K8/65 ,  A61K33/24 ,  A61K33/34 ,  A61K36/48 ,  A61K38/011 ,  A61K38/012 ,  A61K38/014 ,  A61K38/018 ,  A61K2800/58 ,  Y10S514/887 ,  A61K2300/00

摘要： Fingernail and toenail growth and repair are stimulated using an ionic metal-peptide complex. This also improves nail smoothness, strength and esthetic beauty. The peptide-ionic metal complex is comprised of an ionic metal selected from copper (II) or tin (II) and salts thereof, and the peptide component can be a acid, base, enzymatic, bacteria, or yeast hydrolyzate casein, collagen, elastin, meat products, silk protein, soybean protein, or other proteins or a chemically synthesized peptide that binds ionic metals, such as copper (II).

摘要翻译： 使用离子金属 - 肽复合物刺激指甲和趾甲生长和修复。 这也提高了指甲的光滑度，强度和美感。 肽 - 离子金属络合物由选自铜（II）或锡（II）的离子金属及其盐组成，肽组分可以是酸，碱，酶，细菌或酵母水解物酪蛋白，胶原，弹性蛋白 ，肉制品，丝蛋白，大豆蛋白质或其它蛋白质或化学合成的肽结合离子金属如铜（II）。

公开(公告)号：US20190209647A1

公开(公告)日：2019-07-11

申请号：US16099289

申请日：2017-05-08

申请人： NOVINTETHICAL PHARMA SA

发明人： Miguel Angel ALONSO COHEN ,  Marco DI FULVIO

IPC分类号： A61K38/16 ,  A61K38/01 ,  C07K1/107 ,  A61K47/64 ,  A61P35/00 ,  A61K47/61 ,  A61P1/04 ,  A61P29/00 ,  A61K9/00

CPC分类号： A61K38/168 ,  A61K9/0053 ,  A61K38/01 ,  A61K38/011 ,  A61K47/61 ,  A61K47/64 ,  A61P1/04 ,  A61P29/00 ,  A61P35/00 ,  C07K1/1077

摘要： The invention provides a process for preparing a protein-polysaccharide conjugated product comprising: (a) preparing a mixture comprising pea protein, polysaccharide, and an appropriate polar solvent; wherein: the weight ratio between polysaccharide and protein is comprised from 20:80 to 60:40, and the pH of the solution is comprised from 8.0 to 10.5; and performing a Maillard reaction by heating the solution resulting from step (a) at an appropriate temperature for the necessary period of time to conjugate the protein and the polysaccharide. The invention further provides a conjugated product obtainable by the process of the invention, as well as pharmaceutical compositions comprising the conjugate and to their use in the treatment in gastrointestinal disorders. The conjugate of the invention shows a remarkable improvement in preventing and/or treating intestinal diseases, such as mucositis.

公开(公告)号：US20170071996A1

公开(公告)日：2017-03-16

申请号：US15252528

申请日：2016-08-31

申请人： INFINITUS (CHINA) COMPANY LTD.

发明人： Yong ZHOU ,  Xiaolei GUO ,  Chung Wah MA

IPC分类号： A61K36/52 ,  A61K31/685 ,  A23L33/105 ,  A61K36/185 ,  A61K36/076 ,  A61K36/77 ,  A61K38/01 ,  A61K31/185

CPC分类号： A61K36/52 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/185 ,  A61K31/685 ,  A61K36/076 ,  A61K36/185 ,  A61K36/62 ,  A61K36/77 ,  A61K38/011 ,  A61K2236/15 ,  A61K2236/19 ,  A61K2236/331 ,  A61K2236/53 ,  A61K2300/00

摘要： The present invention relates to the technical field of health food, and discloses a memory improving composition and the preparation method and use thereof. The composition is made from Arillus Longan, Poria, Semen Nelumbinis, enzymatic extract of Semen Juglandis, phosphatidylserine and taurine. In the present invention, the sovereign drug Arillus Longan is combined with ministerial drugs Poria and Semen Nelumbinis to synergistically achieve the effect of nourishing heart for tranquillization and tonifying kidney & invigorating spleen. They are further combined with enzymatic extract of Semen Juglandis improving brain metabolism and enhances memory, functional factor phosphatidylserine increasing fluidity and enhances plasticity of cell membrane, and taurine improving memory, to achieve the purpose of memory improvement together. All kinds of raw materials are medicine homologous and new resource food, which are safe, have no toxic and side effects, and thus can be consumed as health food over a long period of time.

摘要翻译： 本发明涉及保健食品的技术领域，并且公开了一种记忆改善组合物及其制备方法和用途。 该组合物由龙眼龙眼，茯苓，精液奈瑟菌，精液提取物，磷脂酰丝氨酸和牛磺酸制成。 在本发明中，龙眼主药药物茯苓和精液Nelumbinis与茯苓和精液Nelumbinis结合起来，协同实现滋养心脏镇静和补肾益肾的作用。 进一步与Semen Juglandis的酶促提取物结合，改善脑代谢，增强记忆力，功能因子磷脂酰丝氨酸增加流动性，增强细胞膜的可塑性，提高记忆力，达到记忆改善的目的。 各种原料均为药物同源和新资源食品，安全无毒副作用，可长期作为保健食品食用。

公开(公告)号：US20160069867A1

公开(公告)日：2016-03-10

申请号：US14477213

申请日：2014-09-04

申请人： SHISEIDO COMPANY, LTD.

发明人： Yosuke Tojo ,  Masato lino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Hisashi Mori

IPC分类号： G01N33/50 ,  A61K36/28 ,  A61K36/9068 ,  C12Q1/68 ,  A61K38/01

CPC分类号： C12Q1/6876 ,  A61K8/645 ,  A61K8/97 ,  A61K36/28 ,  A61K36/899 ,  A61K36/9068 ,  A61K38/011 ,  A61K2800/782 ,  A61Q19/00 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/148 ,  C12Q2600/158 ,  G01N33/5044 ,  G01N33/6812 ,  G01N2333/968 ,  G01N2333/99 ,  G01N2800/20 ,  A61K2300/00

摘要： The object of the invention is to develop a screening method for drugs having effects of increasing skin barrier function in in vitro experimentation, and to evaluate skin barrier function for skin. Serine racemase activity and/or expression level are used as an indicator to allow screening of candidate drugs.

摘要翻译： 本发明的目的是开发一种在体外实验中具有增加皮肤屏障功能作用的药物的筛选方法，并评估皮肤的皮肤屏障功能。 使用丝氨酸消旋酶活性和/或表达水平作为候选药物筛选的指标。

公开(公告)号：US20150315233A1

公开(公告)日：2015-11-05

申请号：US14650253

申请日：2013-12-02

申请人： Duolikun MAMUTE

发明人： Duolikun MAMUTE

IPC分类号： C07K1/14 ,  C07K14/415

CPC分类号： C07K1/145 ,  A61K36/8945 ,  A61K38/011 ,  A61K2236/00 ,  C07K14/415

摘要： A method for preparing for glycoprotein in Chinese yam to enhance the activity of metabolic enzymes of brain mitochondria may include steps of: grinding the Chinese yam into fine powers; adding water into the fine powers and heating up to 50-100° C. to form a mixture, and the amount of water is 2 to 5 times as much as the Chinese yam; extracting the mixture twice, and combining the two extracting solutions; concentrating the extracting solution and adding 95% ethyl alcohol to obtain a first mixed liquid with 60-75% ethyl alcohol concentration and white sediments start to appear; separating the white sediments from a first supernate; adding 95-98% ethyl alcohol in the first supernate to obtain a second mixed liquid with 90-95% ethyl alcohol concentration and brown emplastic sediments start to appear; removing a second supernate; and collecting and drying the brown sediments to obtain brown glycoprotein in Chinese yam.

摘要翻译： 一种在山药中制备糖蛋白以增强脑线粒体代谢酶活性的方法可能包括以下步骤：将山药粉碎成精细的功能; 加入水中，加热至50-100℃，形成混合物，水份为山药的2〜5倍; 提取混合物两次，并结合两种提取溶液; 浓缩提取液，加入95％乙醇，得到60-75％乙醇浓度的第一混合液，白色沉淀物开始出现; 将白色沉淀物与第一上清液分离; 在第一上清液中加入95-98％乙醇，得到90-95％乙醇浓度的第二混合液体，棕色发育沉积物开始出现; 去除第二上清液; 收集和干燥棕色沉淀物，在山药中获得褐色糖蛋白。