公开(公告)号：US06233525B1

公开(公告)日：2001-05-15

申请号：US09361098

申请日：1999-07-26

申请人： Robert W. Langley ,  John J. Keller ,  Steven Gage Urdahl

发明人： Robert W. Langley ,  John J. Keller ,  Steven Gage Urdahl

IPC分类号： G05B1300

CPC分类号： A61M1/30 ,  A61M1/02 ,  A61M1/303 ,  A61M1/307 ,  A61M1/3603 ,  A61M1/3609 ,  A61M1/3643 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/385 ,  A61M1/387 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/12 ,  A61M2205/50

摘要： A blood component collection system is disclosed with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameters. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

摘要翻译： 公开了具有优化能力的血液成分收集系统。 在一个实施例中，过程参数是根据输入/配置的预定血液成分产量导出的，并且其基于至少一个过程参数的最大化。 此后，使用这些导出的过程控制参数来执行血液成分收集过程。 在另一个实施例中，从至少一个其它过程控制参数的最大值的输入总程序时间导出过程参数，以便在该固定时间内使血液成分产量最大化。 此后，用这些导出的参数进行血液成分收集过程。

公开(公告)号：US5833866A

公开(公告)日：1998-11-10

申请号：US807820

申请日：1997-02-26

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B13/00 ,  B01D17/12 ,  A61M37/00

CPC分类号： A61M1/385 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3693 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D21/30 ,  B04B13/00 ,  B04B5/0442 ,  A61M1/30 ,  B01D2221/10

摘要： Systems and methods for separating platelets from blood derive the yield of platelets in real time as processing is accomplished. The systems and method determine an incremental blood volume processed during a succession of incremental time periods during the separation step. The systems and methods also estimate a separation efficiency for the separation device during each incremental time period, while also estimating a current count of platelets available from the donor during each incremental time period. The systems and methods multiply the determined incremental blood volume for each incremental time period by the estimated current count of platelets for each incremental time period by the estimated separation efficiency for each incremental time period, to derive an incremental platelet yield for each incremental time period. The systems and methods sum the incremental platelet yields over the succession of incremental time periods to obtain the derived yield of platelets. In this way, the systems and methods take into account the dynamic systemic and physiological changes that occur virtually continuously throughout the blood collection and separation process.

摘要翻译： 将血小板与血液分离的系统和方法可以在处理完成时实时获得血小板的产量。 系统和方法确定在分离步骤期间的连续增量时间段期间处理的增量血液体积。 系统和方法还估计在每个增量时间段期间分离装置的分离效率，同时还估计在每个增量时间段期间从供体获得的血小板的当前计数。 系统和方法将每个增量时间段的确定的增量血液体积乘以每个增量时间段的估计的血小板的当前计数值与每个增量时间段的估计分离效率相乘，以得出每个增量时间段的增量血小板产量。 系统和方法总结了递增时间段连续增加的血小板产量，以获得血小板的衍生产量。 以这种方式，系统和方法考虑到在血液收集和分离过程中几乎连续发生的动态全身和生理变化。

公开(公告)号：US09962478B2

公开(公告)日：2018-05-08

申请号：US15184492

申请日：2016-06-16

申请人： Fenwal, Inc.

发明人： Daniel R. Boggs ,  Kyungyoon Min ,  Lan T. Nguyen ,  John T. Foley ,  Brian C. Case

IPC分类号： A61M1/34 ,  A61M1/38 ,  A61M1/36

CPC分类号： A61M1/3455 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3496 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2205/3334 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/207 ,  G06F19/00

摘要： Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

公开(公告)号：US20170354770A1

公开(公告)日：2017-12-14

申请号：US15615962

申请日：2017-06-07

申请人： Fenwal, Inc.

发明人： Katherine N. Radwanski ,  Kyungyoon Min ,  Zahra R. Ali

IPC分类号： A61M1/02 ,  A61M1/36 ,  A61M1/30 ,  A61M1/38 ,  B01D61/14

CPC分类号： A61M1/02 ,  A61M1/0209 ,  A61M1/029 ,  A61M1/30 ,  A61M1/304 ,  A61M1/3633 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/38 ,  A61M1/382 ,  A61M1/385 ,  A61M2202/0071 ,  A61M2202/0427 ,  A61M2205/12 ,  A61M2205/33 ,  A61M2205/3306 ,  A61M2205/50 ,  B01D61/14 ,  B04B5/0442 ,  B04B7/00 ,  B04B11/06

摘要： Systems and methods are provided for depleting platelets from blood. The system includes a multi-stage blood separation chamber in which blood is separated into red blood cells and platelet-rich plasma. The platelet-rich plasma is conveyed from a first stage of the chamber to a second stage, where it is separated into platelets and platelet-poor plasma. The platelet-poor plasma is conveyed out of the chamber while the platelets are allowed to accumulate in the second stage of the chamber. When a controller of the system has determined that the maximum chamber capacity of platelets has been accumulated in the second stage of the chamber, the platelets are conveyed out of the chamber to a waste container. The cycle of separating blood into its components, accumulating platelets in the chamber, and then flushing the platelets from the chamber is repeated until a target platelet concentration of the blood is achieved.

公开(公告)号：US09393359B2

公开(公告)日：2016-07-19

申请号：US13840113

申请日：2013-03-15

申请人： Fenwal, Inc.

发明人： Daniel R. Boggs ,  Kyungyoon Min ,  Lan T. Nguyen ,  John T. Foley ,  Brian Case

IPC分类号： A61M1/36 ,  A61M1/38 ,  A61M1/34

CPC分类号： A61M1/3455 ,  A61M1/342 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3496 ,  A61M1/3672 ,  A61M1/38 ,  A61M1/385 ,  A61M2205/3334 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/207 ,  G06F19/00

摘要： Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

摘要翻译： 公开了用于进行治疗性红细胞交换程序的系统和方法。 一方面，一种系统包括用于使来自患者的全血流动的第一流动路径。 分离器与第一流路连通，用于从血浆中分离至少红细胞。 第二和第三流动路径与分离器连通，用于分离从分离器流出分离的血浆和红细胞。 流量控制器与流动路径相关联，以控制流动路径之间的流体连通。 控制器被配置为基于操作者输入的数据执行完成过程完成时实现剩余的患者细胞的目标部分，目标血细胞比容和目标患者流体体积变化的过程。

公开(公告)号：US06802982B2

公开(公告)日：2004-10-12

申请号：US10241617

申请日：2002-09-11

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： B04B1300

CPC分类号： A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/025 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/385 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D17/0217 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/26 ,  B01D21/262 ,  B01D21/34 ,  B01D2221/10 ,  B04B5/0442 ,  B04B7/08 ,  B04B13/00 ,  A61M2202/0071 ,  A61M2202/0092

摘要： Blood processing systems and methods convey whole blood from a donor into a centrifugal separation device for separation into red blood cells and a plasma constituent. The plasma constituent and red blood cells are removed from the separation device at least in part while whole blood is conveyed into the separation device. The systems and methods generate, at least in part while whole blood is conveyed into the separation device and plasma constituent and red blood cells are removed from the separation device, a control command affecting separation within the separation device based, at least in part, upon a factor representing hematocrit of red blood cells separated in the separation device.

摘要翻译： 血液处理系统和方法将全血从供体输送到离心分离装置中，以分离成红细胞和血浆成分。 至少部分地将血浆成分和红细胞从分离装置中移出，同时全血被输送到分离装置中。 系统和方法至少部分地产生全血被输送到分离装置中，并且等离子体组分和红细胞从分离装置中移除，影响分离装置内分离的控制指令至少部分地基于 表示在分离装置中分离的红细胞的血细胞比容的因子。

公开(公告)号：US20020046975A1

公开(公告)日：2002-04-25

申请号：US09981932

申请日：2001-10-17

发明人： Robert Warner Langley ,  Larry Joe Dumont

IPC分类号： B01D001/00

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/30 ,  A61M1/303 ,  A61M1/3696 ,  A61M2202/0415 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.

摘要翻译： 用于生产血液成分产品的方法和装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每个产量来提供确定的产量。 因此，当收集的血液成分被包装时，确定的产量与之相关联，从而提供血液成分产品。

公开(公告)号：US6059979A

公开(公告)日：2000-05-09

申请号：US960674

申请日：1997-10-30

申请人： Richard I. Brown

发明人： Richard I. Brown

IPC分类号： A61K35/14 ,  A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  B01D17/02 ,  B01D17/038 ,  B01D17/12 ,  B01D21/24 ,  B01D21/26 ,  B04B5/04 ,  B04B7/08 ,  B04B13/00

CPC分类号： A61M1/3696 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3603 ,  A61M1/3624 ,  A61M1/3672 ,  A61M1/3693 ,  A61M1/385 ,  B01D17/0217 ,  B01D21/34 ,  B04B13/00 ,  B04B5/0442 ,  B04B7/08 ,  A61M1/025 ,  A61M2202/0415 ,  A61M2202/0427 ,  A61M2205/331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355 ,  A61M2205/3393 ,  B01D21/2405 ,  B01D21/245 ,  B01D21/262 ,  B01D2221/10

摘要： Blood processing systems and methods separate whole blood into red blood cells and a plasma constituent within a rotating centrifugal separation device. The systems and methods convey whole blood into the separation device through an inlet path including a pump operable at a prescribed rate. The systems and methods remove plasma constituent from the separation device through an outlet path including a pump operable at a prescribed rate. The systems and methods derive a value H.sub.b representing an apparent hematocrit of whole blood entering the separation device, where: ##EQU1## and where H.sub.rbc is a value relating to hematocrit of red blood cells in the separation device. The systems and methods generate outputs and control commands based, at least in part, upon H.sub.b.

摘要翻译： 血液处理系统和方法将全血分离成红细胞和旋转离心分离装置内的等离子体成分。 系统和方法通过包括可以规定速率操作的泵的入口路径将全血输送到分离装置中。 系统和方法通过包括以规定速率操作的泵的出口路径从分离装置中除去等离子体成分。 系统和方法导出表示进入分离装置的全血的明显血细胞比容的值Hb，其中：Hrbc是与分离装置中红细胞的血细胞比容有关的值。 系统和方法至少部分地基于Hb生成输出和控制命令。

公开(公告)号：US5611997A

公开(公告)日：1997-03-18

申请号：US457840

申请日：1995-06-01

申请人： Robert W. Langley ,  Larry J. Dumont

发明人： Robert W. Langley ,  Larry J. Dumont

IPC分类号： A61M1/02 ,  A61M1/30 ,  A61M1/36 ,  G01N33/00 ,  G06F15/00

CPC分类号： A61M1/385 ,  A61M1/02 ,  A61M1/303 ,  A61M1/3696 ,  A61M1/30 ,  A61M2205/50 ,  Y10T436/101666 ,  Y10T436/115831 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield of the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield of the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield may be associated therewith, thereby providing a blood component product.

摘要翻译： 血液成分制品的制造装置。 在一个实施例中，从全血源收集多个预定类型的血液成分。 使用至少两种在线产量测定技术来确定收获的血液成分的产量。 一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。 预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每一种产生提供确定的产量。 因此，当收集的血液成分被包装时，所确定的产量可能与之相关，从而提供血液成分产品。

公开(公告)号：US20240293604A1

公开(公告)日：2024-09-05

申请号：US18606761

申请日：2024-03-15

申请人： Haemonetics Corporation

发明人： Michael Ragusa

IPC分类号： A61M1/38 ,  A61M1/34 ,  A61M1/36

CPC分类号： A61M1/38 ,  A61M1/3644 ,  A61M1/385 ,  A61M1/3496 ,  A61M1/3626 ,  A61M1/3672 ,  A61M1/3693 ,  A61M2202/0415 ,  A61M2205/3306 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2230/207

摘要： A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume.