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11.发明申请公开(公告)号：US20050129700A1
公开(公告)日：2005-06-16
申请号：US10441624
申请日：2003-05-20
申请人： Ariella Rosengard
发明人： Ariella Rosengard
IPC分类号： A61K38/00 , A61K39/00 , C07H21/04 , C07K14/07 , C07K16/08 , C12Q1/70 , G01N33/569 , A61K39/42 , C07K16/10 , C12Q1/68
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07H21/04 , C07K16/081 , C07K2319/20 , C07K2319/21 , C12N2710/24122 , C12Q1/70 , C12Q1/705 , G01N33/56983 , G01N2333/07 , C12Q2531/113 , C12Q2521/301
摘要： Antibodies directed to SPICE and VCP which may be used for detection, prevention, and treatment of variola virus or vaccinia virus are provided. Recombinant SPICE and VCP proteins are also provided which are used for enhancing the immune response to variola or vaccinia virus and modulating of complement activation. Methods and kits for detecting nucleic acid sequences encoding SPICE and VCP are also provided.
摘要翻译： 提供了可用于检测，预防和治疗天花病毒或痘苗病毒的针对SPICE和VCP的抗体。 还提供了重组SPICE和VCP蛋白，其用于增强对天花或痘苗病毒的免疫应答和调节补体活化。 还提供了用于检测编码SPICE和VCP的核酸序列的方法和试剂盒。
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公开(公告)号：US20170114120A9
公开(公告)日：2017-04-27
申请号：US14663168
申请日：2015-03-19
IPC分类号： C07K16/08 , G01N33/569
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
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公开(公告)号：US09389232B2
公开(公告)日：2016-07-12
申请号：US14173550
申请日：2014-02-05
IPC分类号： C07K14/005 , G01N33/569 , A61K39/00
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C12N2710/24122 , C12N2710/24134 , G01N2333/07
摘要： This document provides methods and materials related to polypeptides present in a vaccinia virus (e.g., polypeptides that can be isolated from naturally processed and presented class I polypeptides originating from vaccinia virus, a member of the Orthopoxvirus family). For example, methods for generating a vaccine comprising one or more of vaccinia virus polypeptides disclosed herein for preventing or treating Orthopoxvirus infection are provided. In addition, kits related to the use of vaccinia polypeptides are provided.
摘要翻译： 本文件提供了与痘苗病毒中存在的多肽相关的方法和材料（例如可以从天然加工的和来源于痘苗病毒的I型多肽，正型疱疹病毒家族的成员分离的多肽）。 例如，提供了用于产生包含一种或多种本文公开的用于预防或治疗异痘病毒感染的痘苗病毒多肽的疫苗的方法。 此外，提供了与使用痘苗多肽有关的试剂盒。
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14.发明申请METHOD FOR PROMOTING THE SYNTHESIS OF COLLAGEN AND PROTEOGLYCAN IN CHONDROCYTES 审中-公开促进胶原和胶原蛋白合成的方法公开(公告)号：US20140255507A9
公开(公告)日：2014-09-11
申请号：US13821617
申请日：2011-10-11
申请人： Koichi Masuda , Mitsuru Naiki
发明人： Koichi Masuda , Mitsuru Naiki
IPC分类号： A61K35/36
CPC分类号： C12Q1/025 , A61K35/32 , A61K35/36 , A61K35/76 , G01N33/5082 , G01N2333/07
摘要： The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.
摘要翻译： 软骨细胞如椎间盘细胞，关节软骨细胞和半月板细胞中的胶原和蛋白聚糖的合成通过施用痘苗病毒接种的发炎组织的提取物来促进。
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公开(公告)号：US20130122512A1
公开(公告)日：2013-05-16
申请号：US13806979
申请日：2011-06-23
申请人： Tatsuro Mutoh , Yu Fukuda
发明人： Tatsuro Mutoh , Yu Fukuda
CPC分类号： C12Q1/6876 , G01N33/5023 , G01N33/5041 , G01N33/6854 , G01N2333/07
摘要： An object of the present invention is to provide a method for determination or evaluation of an extract from inflamed tissues inoculated with vaccinia virus where the enhancement of activation of neurotrophic factor such as BDNF in cultured cells or the enhancement of activation of proteins participating therein is used as an indicator. The present invention relates to a novel method for determination or evaluation of an extract from inflamed tissues inoculated with vaccinia virus and relates to a method for determination or evaluation of the extract where the enhancement of production of neurotrophic factor such as BDNF in cultured cells or the enhancement of activation of various proteins in intracellular signaling pathway participating in production of BDNF, etc. is used as an indicator.
摘要翻译： 本发明的目的是提供一种用于确定或评估接种痘苗病毒的发炎组织的提取物的方法，其中使用培养细胞中增强神经营养因子如BDNF的活化或者使用其中参与蛋白质的活化的增强 作为指标。 本发明涉及一种用于确定或评估接种痘苗病毒的发炎组织的提取物的新方法，涉及一种用于测定或评估提取物的方法，其中增强培养细胞中BDNF等神经营养因子的产生，或 使用参与BDNF生产的细胞内信号通路中各种蛋白质的活化增强作为指标。
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公开(公告)号：US20110243840A1
公开(公告)日：2011-10-06
申请号：US13038613
申请日：2011-03-02
IPC分类号： A61K51/00 , C07K16/08 , C07K16/46 , A61K39/395 , A61K49/16 , A61P31/20 , A61P37/04 , A61P43/00 , C12Q1/70
CPC分类号： C07K16/081 , A61K39/00 , A61K2039/505 , A61K2039/545 , C07K14/005 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2710/24122 , G01N33/56983 , G01N2333/07
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Orthopoxviruses. The invention provides such antibodies, fragments of such antibodies retaining B5 or A33 binding ability, fully human antibodies retaining B5 or A33 binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和正痘病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体保留B5或A33结合能力的片段，完全人抗体保留B5或A33结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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公开(公告)号：US06982156B2
公开(公告)日：2006-01-03
申请号：US10441624
申请日：2003-05-20
申请人： Ariella M. Rosengard
发明人： Ariella M. Rosengard
IPC分类号： A61K39/42 , A61K39/395
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07H21/04 , C07K16/081 , C07K2319/20 , C07K2319/21 , C12N2710/24122 , C12Q1/70 , C12Q1/705 , G01N33/56983 , G01N2333/07 , C12Q2531/113 , C12Q2521/301
摘要： Antibodies directed to SPICE and VCP which may be used for detection, prevention, and treatment of variola virus or vaccinia virus are provided. Recombinant SPICE and VCP proteins are also provided which are used for enhancing the immune response to variola or vaccinia virus and modulating of complement activation. Methods and kits for detecting nucleic acid sequences encoding SPICE and VCP are also provided.
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公开(公告)号：US06783759B2
公开(公告)日：2004-08-31
申请号：US10108311
申请日：2002-03-27
申请人： Ariella M. Rosengard
发明人： Ariella M. Rosengard
IPC分类号： A61K3942
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07H21/04 , C07K16/081 , C07K2319/21 , C12N2710/24122 , C12Q1/70 , G01N33/56983 , G01N2333/07
摘要： Antibodies directed to SPICE which may be used for detection, prevention, and treatment of variola virus are provided. Recombinant SPICE and VCP proteins are also provided which are used for enhancing the immune response to variola virus. Furthermore, modulation of complement activation by administering recombinant SPICE and VCP is provided.
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公开(公告)号：US09447466B2
公开(公告)日：2016-09-20
申请号：US13806979
申请日：2011-06-23
申请人： Tatsuro Mutoh , Yu Fukuda
发明人： Tatsuro Mutoh , Yu Fukuda
CPC分类号： C12Q1/6876 , G01N33/5023 , G01N33/5041 , G01N33/6854 , G01N2333/07
摘要： An object of the present invention is to provide a method for determination or evaluation of an extract from inflamed tissues inoculated with vaccinia virus where the enhancement of activation of neurotrophic factor such as BDNF in cultured cells or the enhancement of activation of proteins participating therein is used as an indicator. The present invention relates to a novel method for determination or evaluation of an extract from inflamed tissues inoculated with vaccinia virus and relates to a method for determination or evaluation of the extract where the enhancement of production of neurotrophic factor such as BDNF in cultured cells or the enhancement of activation of various proteins in intracellular signaling pathway participating in production of BDNF, etc. is used as an indicator.
摘要翻译： 本发明的目的是提供一种用于确定或评估接种痘苗病毒的发炎组织的提取物的方法，其中使用培养细胞中增强神经营养因子如BDNF的活化或者使用其中参与蛋白质的活化的增强 作为指标。 本发明涉及一种用于确定或评估接种痘苗病毒的发炎组织的提取物的新方法，涉及一种用于测定或评估提取物的方法，其中增强培养细胞中BDNF等神经营养因子的产生，或 使用参与BDNF生产的细胞内信号通路中各种蛋白质的活化增强作为指标。
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20.发明申请公开(公告)号：US20140322700A1
公开(公告)日：2014-10-30
申请号：US14284259
申请日：2014-05-21
申请人： Holger KOST
发明人： Holger KOST
IPC分类号： C12Q3/00 , C12N7/00 , G01N33/569
CPC分类号： C12Q3/00 , C12N7/00 , C12N2760/16011 , C12N2760/16111 , C12N2760/16211 , C12Q1/04 , G01N33/56983 , G01N2333/07 , G01N2333/11
摘要： The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination of the concentration of virus particles and/or virus antigens in a sample.
摘要翻译： 本发明提供了一种确定样品中病毒颗粒和/或病毒抗原浓度的方法。 特别地，本发明涉及确定样品中流感病毒颗粒/流感病毒抗原的浓度。 本发明还涉及离子交换基质用于测定样品中病毒颗粒和/或病毒抗原浓度的用途。
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