利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

179 条记录 (耗时 0.033 秒)

    Extracellular matrix cancer vaccine adjuvant
    12.
    发明授权
    Extracellular matrix cancer vaccine adjuvant 有权

    公开(公告)号：US08802113B2

    公开(公告)日：2014-08-12

    申请号：US11875698

    申请日：2007-10-19

    申请人： William R. Wolter ,  Mark S. Suckow

    发明人： William R. Wolter ,  Mark S. Suckow

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/70 ,  A61K39/00 ,  A61K35/52

    CPC分类号： A61K39/0005 ,  A61K35/52 ,  A61K2039/585

    摘要： Compositions suitable for use as adjuvants in the preparation of vaccines, particularly those vaccines useful in the treatment of cancer, are provided. Methods for inhibiting tumor growth in an animal are also disclosed. Methods for immunizing an animal against cancer, such as prostate cancer, are also described. The adjuvants described are comprised of an extracellular matrix material, such as small intestinal submucosal (SIS) tissue. The preparations may take the form of sheets, gels, liquids (injectable), trocar, or other solid or semi-solid preparation. The invention provides for enhanced tumor inhibition of 2-fold or greater, compared to vaccine preparations without the extracellular matrix material, or from 4- to 5-fold, compared to preparations without the adjuvant promoting extracellular materials.

    Multiple sexed embryo production system for bovine mammals
    14.
    发明授权
    Multiple sexed embryo production system for bovine mammals 有权
    用于牛类哺乳动物的多性别胚胎生产系统

    公开(公告)号：US07629113B2

    公开(公告)日：2009-12-08

    申请号：US10081955

    申请日：2002-02-20

    申请人： George Seidel ,  Lisa Herickhoff ,  John Schenk

    发明人： George Seidel ,  Lisa Herickhoff ,  John Schenk

    IPC分类号： A61D19/02 ,  A01N1/00 ,  A01K67/00 ,  A61K35/52 ,  A61K35/48 ,  G01N33/00 ,  C12Q1/68

    CPC分类号： C12N5/0612 ,  A01K67/027 ,  A61D19/02 ,  C12N15/873 ,  G01N2015/149

    摘要： Improved insemination systems particularly adapted to use for sex-selected sperm sorting include systems which achieve superovulation and then multiple embryo production with sexed embryos. These systems combine with other techniques, including techniques for enhanced sheath fluid and other strategies which minimize stress on the sperm cells, and, potentially, a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and techniques for the process are described so that commercial application of sperms samples as well as the resulting animals may be achieved.

    摘要翻译： 特别适合用于性别选择的精子分选的改进的授精系统包括实现超排卵，然后用性别胚胎多次胚胎生产的系统。 这些系统与其他技术相结合，包括增强护套液的技术和使精子细胞压力最小化的其他策略，以及潜在的用于牛种的2.9％柠檬酸钠鞘溶液和用于马种的牛配子培养基。 描述了用于该方法的改进的收集系统和技术，从而可以实现精子样品的商业应用以及所得到的动物。

    Method for preserving sperm
    15.
    发明申请
    Method for preserving sperm 审中-公开
    保存精子的方法

    公开(公告)号：US20050233300A1

    公开(公告)日：2005-10-20

    申请号：US10835216

    申请日：2004-04-29

    申请人： Daniel Imoedemhe

    发明人： Daniel Imoedemhe

    IPC分类号： A01N1/00 ,  A01N1/02 ,  A61K35/52

    CPC分类号： A01N1/02 ,  A01N1/0284

    摘要： A method for preserving spermatozoa (sperm) by air-drying. A semen sample is received and the sperm are separated from contaminants in the semen sample. The sperm may be separated from the semen sample by layering the semen sample onto a two-layer discontinuous percoll layer followed by centrifugation or by centrifuging the semen sample. The sperm concentrate is spread onto a sterile plate and allowed to air dry. The air-dried sperm may be stored at 0° C. to 8° C. The air-dried sperm may be recovered by adding a warm physiological solution to the air-dried sperm. The recovered sperm may be used for in vitro fertilisation or for intracystoplasmic sperm injection (ICSI).

    摘要翻译： 通过风干保存精子（精子）的方法。 接受精液样品，精子与精液样品中的污染物分离。 通过将精液样品分层到两层不连续的过滤层上，然后离心或通过离心精液样品，将精子与精液样品分离。 将精子浓缩物铺在无菌板上并使其风干。 空气干燥的精子可以在0℃至8℃下储存。空气干燥的精子可以通过向空气干燥的精子中加入温暖的生理溶液来回收。 回收的精子可用于体外受精或用于体内精子注射（ICSI）。

    Cell-type specific methods and devices for the low temperature preservation of the cells of an animal species
    18.
    发明授权
    Cell-type specific methods and devices for the low temperature preservation of the cells of an animal species 失效
    用于动物物种细胞的低温保存的细胞型特异性方法和装置

    公开(公告)号：US5776769A

    公开(公告)日：1998-07-07

    申请号：US485311

    申请日：1995-06-07

    申请人： John K. Critser ,  D. Y. Gao ,  Robert J. Demeter

    发明人： John K. Critser ,  D. Y. Gao ,  Robert J. Demeter

    IPC分类号： A01N1/02 ,  A61K35/52 ,  C12M3/06 ,  C12M1/12

    CPC分类号： A01N1/0263 ,  A01N1/0221 ,  A61K35/52

    摘要： A mathematical model, and membranes and devices based upon that model, to optimize protocols for the addition or removal of cryoprotectant to or from biological cells. This disclosure describes the use of four equations to predict optimal protocols to add or remove cryoprotectant to or from biological cells. The equations particularly require experimentally found data, specific to cell-type and species, regarding the osmotic tolerance of the cells, where osmotic tolerance refers to the cells ability to shrink or swell to various changes in osmolality without injury. The equations further require the cryoprotectant permeability coefficient and the water permeability coefficient of the particular cells' plasma membrane. These coefficients are found with experimental data of the knetic volume change of the cell-type to a known concentration and temperature of cryoprotectant. Also disclosed are particularly preferred methods and devices to add or remove cryoprotectant to or from these cells based upon these equations.

    摘要翻译： 数学模型，以及基于该模型的膜和装置，以优化用于向生物细胞或从生物细胞添加或除去冷冻保护剂的方案。 本公开描述了使用四个方程来预测最终方案以向生物细胞或从生物细胞添加或除去冷冻保护剂。 方程式特别需要关于细胞类型和物种特异性的实验发现的数据，关于细胞的渗透性耐受性，其中渗透性是指细胞在不损伤的情况下收缩或膨胀到各种重量摩尔渗透压变化的能力。 方程进一步要求特定细胞质膜的冷冻保护剂渗透系数和水渗透系数。 发现这些系数与细胞类型的体积变化的实验数据与已知的冷冻保护剂浓度和温度有关。 还公开了基于这些方程特别优选的方法和装置，以向这些细胞添加或除去冷冻保护剂。