公开(公告)号：US08962623B2

公开(公告)日：2015-02-24

申请号：US14001936

申请日：2012-02-29

Applicant: Rupa S. Shetty ,  Martha J. Kelly ,  Bin Liu ,  Jinming Zou ,  Kristofer K. Moffett ,  Younghee Lee ,  Dora Do-York Wong

Inventor： Rupa S. Shetty ,  Kevin J. Moriarity ,  Martha J. Kelly ,  Bin Liu ,  Jinming Zou ,  Kristofer K. Moffett ,  Younghee Lee

IPC: A61K31/5377 ,  C07D487/04 ,  C07D491/056 ,  C07D401/12 ,  C07D413/14 ,  C07D403/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14

CPC classification number: C07D413/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D407/14 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04 ,  C07D491/056

Abstract: A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk inhibitory activity, and is useful as a method for preventing and/or treating atopic dermatitis, and the like.

Abstract translation: 式（I）的化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其溶剂合物，N-氧化物或其前药具有Itk抑制活性，可用作预防和/或治疗特应性皮炎等的方法。

公开(公告)号：US08937048B2

公开(公告)日：2015-01-20

申请号：US13595250

申请日：2012-08-27

Applicant: Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

Inventor： Venkata Ramana Doppalapudi ,  Jing-Yu Lai ,  Bin Liu ,  Dingguo Liu ,  Joel Desharnais ,  Abhijit Suresh Bhat ,  Yanwen Fu ,  Bryan Douglas Oates ,  Gang Chen ,  Curt William Bradshaw

IPC: A61K38/10 ,  C07K14/00 ,  C07K14/515 ,  A61K47/48 ,  C07K14/71

CPC classification number: A61K47/48215 ,  A61K47/48246 ,  A61K47/48415 ,  A61K47/48507 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6811 ,  A61K47/6835 ,  C07K14/71

Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules.

Abstract translation: 本发明提供VEGF结合肽的各种用途，包括治疗与异常血管发生相关的疾病的方法。 此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。

公开(公告)号：US08865873B2

公开(公告)日：2014-10-21

申请号：US12724282

申请日：2010-03-15

Applicant: Bin Liu ,  James D. Marks

Inventor： Bin Liu ,  James D. Marks

IPC: C07K16/30 ,  A61K51/10 ,  C07K16/28

CPC classification number: C07K16/3069 ,  A61K51/1072 ,  A61K2039/505 ,  C07K16/005 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/77 ,  G01N33/5044 ,  G01N33/57434 ,  G01N33/6845 ,  G01N33/6854

Abstract: This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.

Abstract translation: 本发明提供允许使用激光捕获显微切割原位选择针对细胞（例如肿瘤细胞）的抗体的方法。 通过将抗体选择限于内化表位的结合物，产生一组靶向临床表现的前列腺癌抗原的噬菌体抗体。

公开(公告)号：US20140113377A1

公开(公告)日：2014-04-24

申请号：US14124447

申请日：2012-05-10

Applicant: Liang Hui Ji ,  Yan Bin Liu ,  John Chong Mei Koh ,  Long Hua Sun

Inventor： Liang Hui Ji ,  Yan Bin Liu ,  John Chong Mei Koh ,  Long Hua Sun

IPC: C12N15/80

CPC classification number: C12N15/80 ,  C07K14/38 ,  C12N15/1086

Abstract: The present invention relates to the application of isolated promoters and synthetic dominant selection constructs and enhancers for gene targeting for efficient production of genetically modified cells in a species selected from the Pucciniomycotina and Ustilaginomycotina subphyla, in particular, species selected from the Rhodosporidium, Sporisorium, Sporobolomyces or Ustilago genera.

Abstract translation: 本发明涉及分离的启动子和用于基因靶向的合成显性选择构建体和增强子的应用，用于在选自以下的物种中有效生产经遗传修饰的细胞：丝核菌和乌贼丝霉菌亚种，特别是选自红细菌属，孢子虫属，孢子孢子虫 或Ustilago属。

公开(公告)号：US08688715B1

公开(公告)日：2014-04-01

申请号：US13491092

申请日：2012-06-07

Applicant: Trystan G. Upstill ,  Abhishek Das ,  Srinivasan Venkatachary ,  Shravya R. Shetty ,  Bin Liu ,  Jack W. Menzel

Inventor： Trystan G. Upstill ,  Abhishek Das ,  Srinivasan Venkatachary ,  Shravya R. Shetty ,  Bin Liu ,  Jack W. Menzel

IPC: G06F17/30

CPC classification number: G06F17/3053 ,  G06F17/30554 ,  G06F17/30864 ,  G06F17/30867

Abstract: A method includes receiving a query that that is unstructured for a plurality databases; receiving data identifying resources that are determined to be responsive to the query, each resource associated with a search score that defines a respective position of the resource in an order of responsiveness to the query; determining, a service requirement from the terms of the query; determining, for each of the databases, a service requirement score for the database; for each resource that is associated with one of the databases, adjusting the search score based on the service requirement score for the database; generating search results, each search result identify a corresponding resource that was determined to be responsive to the query, and the search results being ordered according to the respective search scores and adjusted search scores of the resources.

Abstract translation: 一种方法包括接收对于多个数据库是非结构化的查询; 接收识别被确定为响应于所述查询的资源的数据，每个资源与搜索分数相关联，所述搜索分数以响应于所述查询的顺序定义所述资源的相应位置; 确定来自查询条款的服务要求; 为每个数据库确定数据库的服务需求分数; 对于与其中一个数据库相关联的每个资源，根据数据库的服务需求分数调整搜索分数; 生成搜索结果，每个搜索结果标识被确定为响应于该查询的对应资源，并且根据相应的搜索分数和资源的调整的搜索分数对搜索结果进行排序。

公开(公告)号：US08669055B2

公开(公告)日：2014-03-11

申请号：US12903176

申请日：2010-10-12

Applicant: Guillermo C. Bazan ,  Bin Liu

Inventor： Guillermo C. Bazan ,  Bin Liu

IPC: C12Q1/68 ,  C12M1/34 ,  C07H19/00 ,  C07H21/04 ,  C07H21/02 ,  G01N21/64

CPC classification number: C12Q1/6818 ,  C12Q2563/119 ,  C12Q2565/101 ,  C12Q2565/519 ,  C12Q2565/607 ,  C12Q2523/313

Abstract: The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. In some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.

Abstract translation: 本发明还涉及共轭聚合物，以及如本文所述使用它们的方法，制品和组合物。 在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。 提供的测定包括确定样品中靶生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。 该方法可以在衬底上进行。 这些方法可以以阵列格式在基底上进行，其可以是传感器。 在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。 在一些方面，提供生物测定，其中在所有置换中，能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。 多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。 本文进一步描述了本发明的其它变型。

公开(公告)号：US08597634B2

公开(公告)日：2013-12-03

申请号：US12676511

申请日：2007-09-04

Applicant: Weidong Zhou ,  Qingjiang Xiao ,  Li Sun ,  Tiebing Wang ,  Bin Liu ,  Song Lin ,  Min Liu ,  Fenghong Yin ,  Lu Zhuang ,  Lifang Lei

Inventor： Weidong Zhou ,  Qingjiang Xiao ,  Li Sun ,  Tiebing Wang ,  Bin Liu ,  Song Lin ,  Min Liu ,  Fenghong Yin ,  Lu Zhuang ,  Lifang Lei

IPC: A61K38/21 ,  A61K38/00 ,  A61K39/385 ,  C07K14/56

CPC classification number: C07K14/56 ,  A61K38/00 ,  A61K47/60 ,  Y02A50/473

Abstract: The present invention relates to interferon (IFN)-α2a modified at a specific Lys residue with Y-shaped branched polyethylene glycol (PEG) derivative and the preparation thereof, as well as the use of the prepared IFN-α2a modified by PEG at a single amino acid residue in medicines.

Abstract translation: 本发明涉及在具有Y型支链聚乙二醇（PEG）衍生物的特定Lys残基修饰的干扰素（IFN）-α2a及其制备方法，以及使用经单PEG修饰的IFN-α2a 药物中的氨基酸残基。

公开(公告)号：US20130170073A1

公开(公告)日：2013-07-04

申请号：US13370421

申请日：2012-02-10

Applicant: Da peng ZHAO ,  Xiong Fei WEI ,  Bin LIU ,  Shengxiang CHEN

Inventor： Da peng ZHAO ,  Xiong Fei WEI ,  Bin LIU ,  Shengxiang CHEN

IPC: G11B33/08

CPC classification number: G11B5/5582

Abstract: The present invention directs an anti-shock method for head stack assembly which carries a slider for flying on a disk for operation, and the anti-shock method includes: inputting a constant current to a head disk interface sensor which is deposited in the slider; obtaining a changing voltage of the head disk interface sensor, which is changed with the temperature of the head disk interface sensor as the slider is shocked; outputting the changing voltage to a controller with a threshold set therein; if the changing voltage is bigger than the threshold for a specified number of times, the controller is triggered to control the head stack assembly to stop operating and load on a ramp beside the disk; while if the changing voltage is small than the threshold for said specified number of times, the controller is not be triggered and the head stack assembly still operates.

Abstract translation: 本发明引导了一种用于磁头堆叠组装的抗冲击方法，其具有用于在盘上进行操作的滑块，并且抗冲击方法包括：将恒定电流输入到沉积在滑块中的磁头盘接口传感器; 获得磁头盘接口传感器的变化的电压，随着滑块被震动，头磁盘接口传感器的温度随着磁头盘接口传感器的温度而改变; 将变化的电压输出到其中设置有阈值的控制器; 如果变化的电压大于阈值达指定次数，则控制器被触发以控制磁头堆叠组件停止操作并加载在磁盘旁边的斜坡上; 而如果变化的电压小于所述指定次数的阈值，则控制器不被触发并且磁头堆叠组件仍然运行。

公开(公告)号：US20130149104A1

公开(公告)日：2013-06-13

申请号：US13479906

申请日：2012-05-24

Applicant: Shun-Chen Chang ,  Wen-Bin Liu

Inventor： Shun-Chen Chang ,  Wen-Bin Liu

IPC: F04D29/32 ,  F04D19/00

CPC classification number: F04D25/082 ,  F04D19/002 ,  F04D19/026 ,  F04D25/022 ,  F04D25/024 ,  F04D25/026 ,  F04D25/12 ,  F04D25/166 ,  F04D29/541

Abstract: A recirculation fan includes a casing, a covering member, and a fan assembly. The casing has a base. The covering member is coupled with the casing to define an accommodation space. The fan assembly is disposed within the accommodation space, and includes a first impeller, a second impeller, a motor, and a plurality of magnetic elements. The second impeller is located beside the first impeller. The motor is fixed on the base of the casing and connected with the first impeller for driving rotation of the first impeller. The magnetic elements are arranged between the first impeller and the second impeller. A wind force generated by the first impeller and a magnetic torque resulted from a magnetic vortex of the magnetic elements cause contactless rotation of the second impeller.

Abstract translation: 再循环风扇包括壳体，覆盖构件和风扇组件。 外壳有一个底座。 覆盖构件与壳体联接以限定容纳空间。 风扇组件设置在容纳空间内，并且包括第一叶轮，第二叶轮，马达和多个磁性元件。 第二个叶轮位于第一个叶轮旁边。 电动机固定在壳体的底部上并与第一叶轮连接，用于驱动第一叶轮的转动。 磁性元件布置在第一叶轮和第二叶轮之间。 由第一叶轮产生的风力和由磁性元件的磁涡流产生的磁力矩引起第二叶轮的非接触式旋转。

公开(公告)号：US08420407B2

公开(公告)日：2013-04-16

申请号：US12772508

申请日：2010-05-03

Applicant: Rong Zhang ,  Zili Xie ,  Bin Liu ,  Xiangqian Xiu ,  Henan Fang ,  Hong Zhao ,  Xuemei Hua ,  Ping Han ,  Peng Chen ,  Youdou Zheng

Inventor： Rong Zhang ,  Zili Xie ,  Bin Liu ,  Xiangqian Xiu ,  Henan Fang ,  Hong Zhao ,  Xuemei Hua ,  Ping Han ,  Peng Chen ,  Youdou Zheng

IPC: H01L21/00 ,  H01L21/469 ,  H01L21/8246

CPC classification number: C23C16/0272 ,  C23C16/34 ,  C30B25/02 ,  C30B29/38 ,  H01L21/0242 ,  H01L21/02458 ,  H01L21/02502 ,  H01L21/0262

Abstract: A kind of growth method of Fe3Nin the MOCVD system, comprising following process: 1) make the surface nitridation of sapphire substrate; 2) pump in carrier gas N2, ammonia and organic gallium sources, and grow low temperature GaN buffer on substrate; 3) raise temperature and grow the GaN supporting layer; 4) pump in FeCp2 as Fe sources, then grow Fe3N on the GaN supporting layer; the Fe3N granular films and the Fe3N single crystal films are obtained.

Abstract translation: MOCVD系统中Fe3N的一种生长方法，包括以下过程：1）使蓝宝石衬底的表面氮化; 2）在载气N2，氨和有机镓源中泵送，并在衬底上生长低温GaN缓冲液; 3）升高温度并生长GaN支撑层; 4）将FeCp2泵作为Fe源，然后在GaN支撑层上生长Fe3N; 得到Fe 3 N粒状膜和Fe 3 N单晶膜。