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公开(公告)号：US11772020B2
公开(公告)日：2023-10-03
申请号：US17819969
申请日：2022-08-16
Applicant: EMD Millipore Corporation
Inventor： Maybelle Woo , David Yavorsky , John Amara , Nripen Singh , Kwok-Shun Cheng
CPC classification number: B01D39/1623 , B01D29/66 , B01D39/163 , B01D2239/0407 , B01D2239/0654 , B01D2239/086
Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.
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公开(公告)号：US11703132B2
公开(公告)日：2023-07-18
申请号：US17438244
申请日：2020-06-17
Applicant: EMD MILLIPORE CORPORATION
Inventor： Brian Pereira
CPC classification number: F16K3/26 , F16K27/041
Abstract: A valve having a body having a first section and a second section; an extended flange attached to the second section of the body or disposed as an integral part of the second section of the body; an elongate bore extending through the body and having a proximal end and a distal end; a longitudinally displaceable plunger disposed in and extending along the bore, the plunger having a proximal end and a distal end and having a first position displaced toward the distal end of the bore and a second position displaced toward the proximal end of the bore; a diaphragm seal attached to the proximal end of the plunger and sealing the bore at the proximal end thereof; a gland seal sealing the bore at a location intermediate the diaphragm seal and the distal end of the bore; the plunger extending through and being sealingly secured to the gland seal; a fluid transfer opening in the bore between the diaphragm seal and the gland seal; longitudinal displacement of the plunger moving the diaphragm seal to open the bore, the gland seal stretching to accommodate the displacement of and maintain a seal about the plunger, a fluid flow path being established between the open proximal end of the bore and the fluid transfer opening, wherein longitudinal displacement of the plunger towards its first position moves the diaphragm to open the bore. The valve further comprises an extended flange having a surface that is approximately coplanar with a surface of the second position when the plunger is displaced toward the proximal end of the bore, creating a zero dead leg position.
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公开(公告)号：US20230211291A1
公开(公告)日：2023-07-06
申请号：US18183609
申请日：2023-03-14
Applicant: EMD Millipore Corporation
Inventor： Elizabeth M. Goodrich , Akshat Gupta , Herbert Lutz
CPC classification number: B01D61/146 , B01D61/18 , B01D61/22 , B01D65/02 , B01D2311/04 , B01D2311/08 , B01D2311/25 , B01D2313/18 , B01D2313/243 , B01D2313/50 , B01D2315/10 , B01D2315/14 , B01D2315/16 , B01D2317/022 , B01D2317/04 , B01D2321/16
Abstract: Processes and systems for filtering a liquid sample are provided. Batches of a liquid sample can be routed to two or more cycling tanks (e.g., first and second cycling tanks). Upon filling a first cycling tank, a first batch of the liquid sample can be routed to a filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the first cycling tank or to a collection vessel. Upon filling a second cycling tank, a second batch of the liquid sample is routed to the filtration assembly by a continuous diafiltration process that includes routing produced retentate back to the second cycling tank or to the collection vessel. The filling and continuous diafiltration of batches of the liquid sample continues to alternate between the two or more cycling tanks until a total product volume is processed.
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公开(公告)号：US11679340B2
公开(公告)日：2023-06-20
申请号：US16349806
申请日：2018-03-06
Applicant: EMD Millipore Corporation
Inventor： Sebastien Cirou , Christine Abouayad El Idrissi
CPC classification number: B01D15/08 , G01N30/20 , G01N2030/027 , G01N2030/328 , G01N2030/8813
Abstract: The invention concerns an installation for treatment of biological liquid by chromatography, extending in a longitudinal direction and comprising a supply valve (20b), a supply pump (30) downstream of the valve, instrument members downstream of the pump including distribution valves (81a-c, 82a-c, 83a-c) and devices (78a-c, 85a-c, 86a-c) for measuring physico-chemical parameters of the liquid, chromatography columns (99a-c) downstream of the instrument members and pipes connecting the valve, the pump, the instrument members and the columns so as to form at least one supply line for biological liquid to treat of a treatment circuit of said installation, the chromatography columns being disposed relative to each other in a direction of extension generally transverse to said generally longitudinal direction of extension of the installation.
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公开(公告)号：US20230123639A1
公开(公告)日：2023-04-20
申请号：US18066610
申请日：2022-12-15
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Gabriel Tkacik , Onur Y. Kas , Ajish Potty , Jigneshkumar Patel
Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 μm to about 0.03 μm, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 μm to about 100 μm, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.
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Patent Agency Ranking
公开(公告)号：US11590439B2
公开(公告)日：2023-02-28
申请号：US14890774
申请日：2014-09-02
Applicant: EMD Millipore Corporation
Inventor： Maybelle Woo , David Yavorksy , John Amara , Nripen Singh , Kwok-Shun Cheng
Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyaeryionitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased creased binding capacity for soluble impurities such as DNA and host eel! proteins from biological/cell culture feed-streams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.
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公开(公告)号：US20230017950A1
公开(公告)日：2023-01-19
申请号：US17778663
申请日：2020-11-18
Applicant: EMD MILLIPORE CORPORATION
Inventor： Jijun GE , Xiaozhu ZHOU , Gabriel TKACIK
Abstract: The present application relates to an unsupported, permanently hydrophilic filtration membrane, and its method of formation. The membrane comprises a polymeric matrix material and a cross-linked polyoxazoline hydrophilic additive blended throughout said matrix material.
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公开(公告)号：US11547957B2
公开(公告)日：2023-01-10
申请号：US16610595
申请日：2018-04-18
Applicant: EMD Millipore Corporation
Inventor： Ronald Tuccelli , John Caulmare , Melissa Holstein , Kristen Cotoni , Christopher Gillespie
Abstract: Methods of maintaining narrow residence time distributions in continuous flow systems, particularly applicable to virus inactivation such as during a protein purification process. Fluid sample is introduced into an axial flow channel and caused to flow therein in discrete packets or zones to minimize residence time distribution and axial dispersion. Embodiments described herein obviate or minimize the need for using large tanks or reservoirs for performing virus inactivation during a protein purification process; reduce the overall time required for virus inactivation, and/or reduce the overall physical space required to perform the virus inactivation operation during a protein purification process, which in turn reduces the overall footprint for the purification process.
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公开(公告)号：US11504646B2
公开(公告)日：2022-11-22
申请号：US17008690
申请日：2020-09-01
Applicant: EMD Millipore Corporation
Inventor： Nripen Singh , Kwok-Shun Cheng
Abstract: A process for the primary clarification of feeds, including chemically treated flocculated feeds, containing the target biomolecules of interest such as mAbs, mammalian cell cultures, or bacterial cell cultures, using a primary clarification depth filtration device without the use of a primary clarification centrifugation step or a primary clarification tangential flow microfiltration step. The primary clarification depth filtration device contains a porous depth filter having graded porous layers of varying pore ratings. The primary clarification depth filtration device filters fluid feeds, including chemically treated flocculated feeds containing flocculated cellular debris and colloidal particulates having a particle size distribution of approximately about 0.5 μm to 200 μm, at a flow rate of about 10 litres/m2/hr to about 100 litres/m2/hr. Kits and methods of using and making the same are also provided.
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公开(公告)号：US20220323300A1
公开(公告)日：2022-10-13
申请号：US17639973
申请日：2020-09-09
Applicant: James DEE , George GAGNE , Daniel LAMOTHE , EMD Millipore Corporation
Inventor： Shannon Cleveland , Marina Varlamova , John Saragosa , David DeCoste , Benjamin Cacace , Daniel Lamothe , George Gagne , James Dee , Wilson Moya , Stefano Berti Perez
Abstract: A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.
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