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    Methods, systems, and computer-readable media for accelerated base calling
    194.
    发明授权
    Methods, systems, and computer-readable media for accelerated base calling 有权

    公开(公告)号：US10676787B2

    公开(公告)日：2020-06-09

    申请号：US14880439

    申请日：2015-10-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Benjamin Donnet

    IPC: C12Q1/6869 ,  G16B25/00

    Abstract: Embodiments disclose methods, systems, and computer-readable media for accelerated base calling of sequencing data. These methods may be adapted to accelerate sequence determination for data arising from a variety of different nucleic acid sequencing platforms. In various embodiments, configurable logic circuits such as FPGAs and GPUs may be adapted to perform raw signal processing, basecalling, and/or sequence determination operations providing further enhancements to the sequence analysis methods.

    ION-SENSING CHARGE-ACCUMULATION CIRCUITS AND METHODS
    196.
    发明申请
    ION-SENSING CHARGE-ACCUMULATION CIRCUITS AND METHODS 审中-公开

    公开(公告)号：US20200158684A1

    公开(公告)日：2020-05-21

    申请号：US16677662

    申请日：2019-11-07

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Keith G. FIFE

    IPC: G01N27/414 ,  G01N27/30

    Abstract: An ion-sensitive circuit can include a charge accumulation device, to accumulate a plurality of charge packets as a function of an ion concentration of a fluid, and at least one control and readout transistor, to generate an output signal as a function of the accumulated plurality of charge packets, the output signal representing the ion concentration of the solution. The charge accumulation device can include a first charge control electrode above a first electrode semiconductor region, an electrically floating gate structure above a gate semiconductor region and below an ion-sensitive passivation surface, a second charge control electrode above a second electrode semiconductor region, and a drain diffusion region. The first control electrode can control entry of charge into a gate semiconductor region in response to a first control signal. The ion-sensitive passivation surface can be configured to receive the fluid. The second charge control electrode can control transmission of the plurality of charge packets out of the gate semiconductor region and into the drain diffusion region in response to a second control signal. The drain diffusion region can receive the plurality of charge packets from the gate semiconductor region via the second electrode semiconductor region.

    Windowed sequencing
    197.
    发明授权
    Windowed sequencing 有权

    公开(公告)号：US10655175B2

    公开(公告)日：2020-05-19

    申请号：US16153898

    申请日：2018-10-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Todd Rearick ,  Mark Milgrew ,  Jonathan Schultz ,  Chris Papalias ,  Kim Johnson

    IPC: C12Q1/6874 ,  G16B30/00

    Abstract: In one implementation, a method is described. The method includes determining an operational characteristic of sensors of a sensor array. The method further includes selecting a group of sensors in the array based on the operational characteristic of sensors in the group. The method further includes enabling readout of the sensors in the selected group. The method further includes receiving output signals from the enabled sensors, the output signals indicating chemical reactions occurring proximate to the sensors of the sensor array.

    CHEMICALLY-SENSITIVE SENSOR ARRAY CALIBRATION CIRCUITRY
    199.
    发明申请
    CHEMICALLY-SENSITIVE SENSOR ARRAY CALIBRATION CIRCUITRY 审中-公开

    公开(公告)号：US20200132622A1

    公开(公告)日：2020-04-30

    申请号：US16677666

    申请日：2019-11-08

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Jonathan ROTHBERG ,  Wolfgang HINZ ,  Kim JOHNSON ,  James BUSTILLO

    IPC: G01N27/414 ,  G01N33/543 ,  C12Q1/6818 ,  H01L27/088 ,  H01L29/78 ,  C12Q1/6874

    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

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