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公开(公告)号：US20170349543A1
公开(公告)日：2017-12-07
申请号：US15597049
申请日：2017-05-16
Inventor： Daniel J. Siegwart , Jason B. Miller
IPC: C07C311/32 , C07C309/14 , C12N15/113 , C12N15/11 , A61K48/00 , C12N2310/20
Abstract: The present disclosure provides one or more amino lipids such as an amino lipids containing a sulfonic acid or sulfonic acid derivative of the formulas: wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.
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公开(公告)号：US20170342503A1
公开(公告)日：2017-11-30
申请号：US15602004
申请日：2017-05-22
Inventor： David A. BOOTHMAN , Julio MORALES , Edward MOTEA , Praveen PATIDAR
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57415 , G01N33/57438
Abstract: The present disclosure is directed to methods of detecting XRN2 expression levels, copy number and mutation status, particularly in cancer cells. The methods permit physicians to tailor therapies to subject having certain genotypes/phenotypes, and to exclude therapies unlikely to be effective.
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公开(公告)号：US09820762B2
公开(公告)日：2017-11-21
申请号：US14401548
申请日：2013-05-16
Inventor： Jeffrey A. Cadeddu , Stephen P. Faddegon , Heather E. Beardsley , Yung K. Tan , Ephrem O. Olweny , Jeffrey Gahan , Jodi Antonelli , Margaret S. Pearle , Raul Fernandez
IPC: A61B17/22 , A61B17/221 , A61B17/225 , A61B17/00
CPC classification number: A61B17/221 , A61B17/22031 , A61B17/225 , A61B17/2251 , A61B2017/00287 , A61B2017/2215
Abstract: Devices and methods for removal of calculus (including for example, kidney stones) are disclosed. In an embodiment, a device for removal of kidney stones includes a substantially sealable pouch that can be inserted into the kidney for capturing a kidney stone. The pouch is also designed to permit fragmentation of the kidney stone inside the pouch, while preventing kidney stone fragments from escaping from the pouch. As a result, the likelihood of dispersing stone fragments during fragmentation of a large stone is greatly lessened.
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公开(公告)号：US20170316179A1
公开(公告)日：2017-11-02
申请号：US15581727
申请日：2017-04-28
Inventor： Robert J. DIMEFF
CPC classification number: G06F19/3481 , G06F19/3418 , G06Q10/06 , G06Q50/22
Abstract: Systems and methods for monitoring performance of prescribed exercises. Particular embodiments allow clinicians and other exercise experts the ability to qualitatively and quantitatively follow compliance outside of subjective reporting, of the individual performing the prescribed exercises by accurately assessing range of motion, speed and path efficiency.
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公开(公告)号：US20170313739A1
公开(公告)日：2017-11-02
申请号：US15653397
申请日：2017-07-18
Inventor： Susan L. MOOBERRY , Jiangnan PENG , April L. RISINGER , Jing LI
IPC: C07J71/00 , C07D493/08 , A61K36/894 , A61K31/585
CPC classification number: C07J71/001 , A61K31/585 , A61K36/894 , C07D493/08 , C07J71/0005
Abstract: The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.
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Patent Agency Ranking
公开(公告)号：US09801944B2
公开(公告)日：2017-10-31
申请号：US15261245
申请日：2016-09-09
Inventor： Daniel J. Siegwart , Jing Hao , Kejin Zhou , Jason Miller , Petra Kos , Lian Xue
IPC: A61K47/34 , C07H21/02 , C07H21/04 , A61K47/28 , A61K47/22 , C08G65/48 , C08G63/91 , A61K31/713 , A61K9/00 , A61K47/24 , C08G63/688 , C12N15/113 , A61K9/51
CPC classification number: A61K47/34 , A61K9/0019 , A61K9/5153 , A61K31/713 , A61K47/22 , A61K47/24 , A61K47/28 , C08G63/688 , C08G63/912 , C08G65/48 , C12N15/113 , C12N2310/14
Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
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公开(公告)号：US20170304926A1
公开(公告)日：2017-10-26
申请号：US15496606
申请日：2017-04-25
Inventor： Raymond C. Zowarka , Ben Rech , Joe Koo , Jon Hahne , David N. Prater , Charles E. Penney , Bryan Bunkowski , Siddharth Pratap
IPC: B23K11/24 , H02K5/16 , H02K5/14 , B23K11/02 , F16C19/18 , B23K11/00 , F16C27/04 , H02K31/02 , F16C33/32 , B23K101/28
CPC classification number: B23K11/241 , B23K11/002 , B23K11/02 , B23K31/02 , B23K31/027 , B23K2101/06 , B23K2101/28 , B23K2101/36 , B23K2103/04 , F16C19/184 , F16C19/543 , F16C27/04 , F16C33/32 , F16C33/62 , F16C2206/40 , F16C2380/26 , H02K5/14 , H02K5/165 , H02K31/02
Abstract: Described herein are methods and system for welding, for example, girders. The method may include activating a homopolar generator. The method may include applying a force to two metal girders at a desired coupling joint. The method may include generating an electrical pulse using the homopolar generator and conducting the electrical pulse to the desired coupling joint to increase a temperature of the girders. The method may include forming a weld at the desired coupling joint attaching the two metal girders at the desired coupling joint. In some embodiments, the homopolar generator may include a radial bearing rotor including a rotatable shaft and a bearing assembly. The bearing assembly may include nonmagnetic bearings. The homopolar generator may include a field coil. The homopolar generator may include a brush actuation mechanism which when activated engages a plurality of brush devices to the radial bearing rotor.
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公开(公告)号：US20170304623A1
公开(公告)日：2017-10-26
申请号：US15496444
申请日：2017-04-25
Inventor： Nitin TANDON
CPC classification number: A61N1/36082 , A61B5/0042 , A61B5/055 , A61B6/037 , A61B6/501 , A61B8/0808 , A61N1/0531 , A61N1/0534 , A61N1/36132 , A61N1/36153 , A61N1/36157 , A61N1/36171 , A61N1/36175
Abstract: This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.
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199.发明授权公开(公告)号：US09790274B2
公开(公告)日：2017-10-17
申请号：US14774795
申请日：2014-03-12
Inventor： Barrett R. Harvey , Kenneth L. Pinkston , Ali Azhdarina , Eva M. Sevick-Muraca
CPC classification number: C07K16/28 , A61K47/6803 , A61K47/6865 , A61K51/1066 , A61K51/1093 , C07K16/30 , C07K16/3053 , C07K2317/33 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57434 , G01N2333/705
Abstract: Embodiments of the invention provide high affinity recombinant EpCAM-binding antibodies. Methods of using a such antibodies as imaging agents, diagnostics and therapeutics are also provided. Dual-nuclear and fluorescently labeled or singly fluorescently labeled contrast agents promise the advantage of molecularly-guided surgical resection via surgical field near-infrared fluorescence (NIRF) imaging following (in the case of dual labeled agents) nuclear imaging for general localization. Currently, nodal staging of most cancers is performed following lymph node (LN) biopsy and dissection for subsequent pathological examination.
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公开(公告)号：US09789131B1
公开(公告)日：2017-10-17
申请号：US15494407
申请日：2017-04-21
Inventor： William S. Korinek , James D. Lechleiter , Theodore E. Liston
IPC: A61K31/7076
CPC classification number: A61K31/7076
Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
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