公开(公告)号：US20090041803A1

公开(公告)日：2009-02-12

申请号：US12202528

申请日：2008-09-02

Applicant: Ning-Sun Yang ,  Jeng-Hwan Wang ,  Wen-Chi Wei

Inventor： Ning-Sun Yang ,  Jeng-Hwan Wang ,  Wen-Chi Wei

IPC: A61K39/00 ,  A61K36/00 ,  C12N5/06 ,  A61P31/00

CPC classification number: A61K36/8945 ,  A61K38/00 ,  A61K2300/00

Abstract: An extract from a tuber of a Dioscorea plant is disclosed. Also disclosed is a composition containing an extract from a tuber of a Dioscorea plant, as well as methods of using the extract and composition.

Abstract translation: 披露薯a植物块茎的提取物。 还公开了含有薯a植物的块茎的提取物的组合物，以及使用提取物和组合物的方法。

公开(公告)号：US07468429B2

公开(公告)日：2008-12-23

申请号：US11349592

申请日：2006-02-07

Applicant: Jei-Fu Shaw ,  Guan-Chiun Lee ,  Shye-Jye Tang

Inventor： Jei-Fu Shaw ,  Guan-Chiun Lee ,  Shye-Jye Tang

IPC: C07H21/04 ,  C12N9/16 ,  C12P21/00

CPC classification number: C12N9/20 ,  C07K2319/00

Abstract: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to CTG codons in the wild-type DNA. Each of the universal serine codons, independently, is TCT, TCC, TCA, TCG, AGT, or AGC. The Candida rugosa lipase can be Candida rugosa lipase 1, 2, 3, 4, 5, or 8.

Abstract translation: 本发明的特征在于分离的核酸，其包含编码假丝酵母假单胞菌脂肪酶的突变DNA，其中突变DNA与编码假丝酵母脂肪酶的野生型DNA具有80％同一性，并且包括至少12个（例如13,15 ，17或全部）对应于野生型DNA中的CTG密码子的通用丝氨酸密码子。 每个通用丝氨酸密码子独立地是TCT，TCC，TCA，TCG，AGT或AGC。 假丝酵母粗脂肪酶可以是1号，2号，3号，4号，5号或8号念珠菌。

公开(公告)号：US20080274087A1

公开(公告)日：2008-11-06

申请号：US11462426

申请日：2006-08-04

Applicant: Hung Li ,  Woei-Cherng Shyu ,  Dah-Ching Ding ,  Shin-Zong Lin

Inventor： Hung Li ,  Woei-Cherng Shyu ,  Dah-Ching Ding ,  Shin-Zong Lin

IPC: C12N5/08 ,  C12N5/06 ,  A61K36/00 ,  A61K35/50 ,  A61P25/28 ,  A61P25/00

CPC classification number: C12N5/0605 ,  A61K35/12

Abstract: A cultured pluripotent animal cell that is CD13+, CD90+, and CD117−. Also disclosed are methods for making the cell and methods of treating a brain tissue damage and increasing the expression level of a neuraltrophic factor in a subject.

Abstract translation: 培养的多能动物细胞，CD13 +，CD90 +和CD117-。 还公开了用于制备细胞的方法和治疗脑组织损伤并增加受试者中神经营养因子的表达水平的方法。

公开(公告)号：US20080266548A1

公开(公告)日：2008-10-30

申请号：US11789769

申请日：2007-04-25

Applicant: Chau-Hwang Lee ,  Chun-Chieh Wang

Inventor： Chau-Hwang Lee ,  Chun-Chieh Wang

IPC: G01N21/00 ,  G06F15/00

CPC classification number: G01N21/45 ,  G01B9/04 ,  G01B11/0633 ,  G01N21/8422 ,  G01N2021/4126

Abstract: An imaging, differential optical sectioning interference microscopy (DOSIM) system and method for measuring refractive indices and thicknesses of transparent thin-films. The refractive index and thickness are calculated from two interferometric images of the sample transparent thin-film having a vertical offset that falls within the linear region of an axial response curve of optically sectioning microscopy. Here, the images are formed by a microscope objective in the normal direction, i.e., in the direction perpendicular to the latitudinal surface of the thin-film. As a result, the lateral resolution of the transparent thin-film is estimated based on the Rayleigh criterion, 0.61λ/NA.

Abstract translation: 用于测量透明薄膜的折射率和厚度的成像，差分光学切片干涉显微镜（DOSIM）系统和方法。 折射率和厚度由具有落在光学切片显微镜的轴向响应曲线的线性区域内的垂直偏移的样品透明薄膜的两个干涉图像计算。 这里，图像由显微镜物镜沿正交方向，即在与薄膜的纬向表面垂直的方向上形成。 结果，透明薄膜的横向分辨率基于Rayleigh标准估计，为0.61λ/ NA。

公开(公告)号：US07411060B2

公开(公告)日：2008-08-12

申请号：US10717573

申请日：2003-11-21

Applicant: Jen-Leih Wu ,  Guor Mour Her

Inventor： Jen-Leih Wu ,  Guor Mour Her

IPC: C07H21/04 ,  A01K67/033

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A01K2217/058 ,  A01K2227/40 ,  A01K2267/03 ,  C07K14/461 ,  C07K14/475 ,  C12N15/8509

Abstract: The present invention relates to expression control sequences of a vertebrate liver fatty acid binding protein (L-FABP) gene that, when operably linked to a reporter (e.g., a heterologous reporter, such as the green fluorescent protein (GFP)), directly express the reporter in a fashion that mimics the liver-specific development of the L-FABP gene in the vertebrate.

Abstract translation: 本发明涉及当与报告物（例如，异源报告物，例如绿色荧光蛋白（GFP））可操作地连接时，脊椎动物肝脏脂肪酸结合蛋白（L-FABP）基因的表达控制序列直接表达 记者以模仿L-FABP基因在脊椎动物肝脏特异性发育的方式。

公开(公告)号：US20080175876A1

公开(公告)日：2008-07-24

申请号：US12013518

申请日：2008-01-14

Applicant: Jei-Fu Shaw ,  Yu-Ting Chen ,  Lien-Hua Hsu

Inventor： Jei-Fu Shaw ,  Yu-Ting Chen ,  Lien-Hua Hsu

IPC: A61K8/02 ,  C12N9/00 ,  C07H21/04 ,  C12N15/00 ,  C12N1/34 ,  A01H5/00 ,  C12N5/00 ,  A61K38/43 ,  A61K47/00 ,  A61K9/68

CPC classification number: C12N15/8281 ,  A61K8/64 ,  A61K38/00 ,  A61Q17/005 ,  C12N9/2442 ,  C12N15/8282 ,  C12Y302/01014

Abstract: Disclosed herein are novel chitinase polypeptides and nucleic acids encoding the polypeptides. Also disclosed are related vectors, host cells, compositions, and uses.

Abstract translation: 本文公开了新型几丁质酶多肽和编码多肽的核酸。 还公开了相关载体，宿主细胞，组合物和用途。

公开(公告)号：US20080125576A1

公开(公告)日：2008-05-29

申请号：US11873241

申请日：2007-10-16

Applicant: Yu-Chan CHAO ,  Tzu-Ching Lee

Inventor： Yu-Chan CHAO ,  Tzu-Ching Lee

IPC: C07K14/00

CPC classification number: C12N7/00 ,  C07K2319/00 ,  C12N15/86 ,  C12N2710/14122 ,  C12N2710/14143 ,  C12N2720/12022 ,  C12N2770/32122 ,  C12N2810/40 ,  C12N2830/00 ,  C12N2830/60

Abstract: A fusion protein containing a polyhedrin of a virus and a foreign polypeptide sequence. Also disclosed are a recombinant occlusion body containing the fusion protein, an isolated nucleic acid containing a sequence encoding the fusion protein, and a recombinant virus containing the nucleic acid. Within the scope of this invention are related expression vectors, host cells, compositions, and preparation methods.

Abstract translation: 含有病毒多角体蛋白和外来多肽序列的融合蛋白。 还公开了含有融合蛋白的重组闭塞体，含有编码融合蛋白的序列的分离的核酸和含有核酸的重组病毒。 在本发明的范围内是相关的表达载体，宿主细胞，组合物和制备方法。

公开(公告)号：US20080119443A1

公开(公告)日：2008-05-22

申请号：US11481131

申请日：2006-07-03

Applicant: Wen-Shan Li ,  Yi-Ching Wang ,  Hsueh-Fen Juan

Inventor： Wen-Shan Li ,  Yi-Ching Wang ,  Hsueh-Fen Juan

IPC: A61K31/58 ,  C07J51/00 ,  C07J1/00

CPC classification number: C07J1/00 ,  C07J51/00

Abstract: Certain chemical entities chosen from compounds of Formula I: and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof are described. Pharmaceutical compositions comprising at least one chemical entity chosen from compounds of Formula I and a pharmaceutically acceptable vehicle are described. Also described are methods for inhibiting α-2,3-sialyltransferase activity in cells, and methods for treating a patient having a disease responsive to inhibition of α-2,3-sialyltransferase activity.

Abstract translation: 描述了选自式I化合物的某些化学实体及其药学上可接受的盐，溶剂化物，螯合物，非共价复合物，前药及其混合物。 描述了包含至少一种选自式I化合物和药学上可接受的载体的化学实体的药物组合物。 还描述了抑制细胞中α-2,3唾液酸转移酶活性的方法，以及用于治疗患有对2,3-唾液酸转移酶活性的抑制有响应的疾病的患者的方法。

公开(公告)号：US20080050382A1

公开(公告)日：2008-02-28

申请号：US11767120

申请日：2007-06-22

Applicant: Yuan-Tsong Chen ,  Wen-Hung Chung ,  Shuen-lu Hung

Inventor： Yuan-Tsong Chen ,  Wen-Hung Chung ,  Shuen-lu Hung

IPC: A61K39/395 ,  A61K31/70 ,  A61P43/00 ,  G01N33/48 ,  G01N33/53

CPC classification number: G01N33/564 ,  G01N2800/104 ,  G01N2800/245

Abstract: Disclosed are uses of granulysin in methods of diagnosing or treating autoimmune disorders.

Abstract translation: 公开了颗粒溶素在诊断或治疗自身免疫性疾病的方法中的用途。

公开(公告)号：US07323546B2

公开(公告)日：2008-01-29

申请号：US10863637

申请日：2004-06-08

Applicant: Shu-Mei Liang ,  Jei-Ming Peng ,  Chi-Ming Liang

Inventor： Shu-Mei Liang ,  Jei-Ming Peng ,  Chi-Ming Liang

IPC: C07K14/00 ,  A61K39/00

CPC classification number: C07K14/005 ,  A61K31/7088 ,  A61K38/162 ,  A61K39/00 ,  A61K39/12 ,  A61K39/135 ,  A61K2039/523 ,  C07K1/1136 ,  C12N2770/32122 ,  C12N2770/32133

Abstract: An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.

Abstract translation: 口蹄疫病毒的分离的水溶性VP1多肽和编码该多肽的核酸。 还公开了含有多肽或核酸的药物组合物和诱导凋亡和治疗凋亡相关病症的相关方法。