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公开(公告)号：US20190225573A1
公开(公告)日：2019-07-25
申请号：US16300436
申请日：2017-05-11
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Bruce Blough , Ann Decker , Richard Rothman
IPC: C07C211/28 , A61P25/30
Abstract: The disclosure provides monoamine neurotransmitter releaser and/or monoamine uptake inhibitor compounds having biogenic amine transporter activity but lacking substantial activity at 5-HT2 receptor subtypes. The phenethylamine or vinylogous phenethylamine compounds of the disclosure are useful in treating diseases, conditions and/or disorders mediated by activity of one or more of the monoamine neurotransmitters.
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公开(公告)号：US20190211268A1
公开(公告)日：2019-07-11
申请号：US16358652
申请日：2019-03-19
Applicant: Research Triangle Institute
Inventor： Matthew Von Holle , John R. Carpenter , David C. Dayton
CPC classification number: C10B53/02 , C10B49/10 , C10B49/16 , C10B57/06 , C10C5/00 , C10G1/06 , C10G1/08 , C10L1/02 , Y02E50/13 , Y02E50/14 , Y02E50/30 , Y02E50/32 , Y02T50/678
Abstract: This invention is directed to the discovery of a reactive catalytic fast pyrolysis (RCFP) process utilizing hydrogen at low pressures.
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公开(公告)号：US10286383B2
公开(公告)日：2019-05-14
申请号：US15808514
申请日：2017-11-09
Applicant: Research Triangle Institute
Inventor： Jian-ping Shen , Marty Lail , Brian Turk , Paul D. Mobley , Jason S. Norman , Laura Douglas , Jonathan Peters
IPC: B01J23/04 , B01J23/78 , B01J23/835 , B01J23/89 , C01B3/40 , C07C29/156 , B01J23/74 , B01J23/76 , B01J23/889 , B01J23/00 , B01J23/80 , B01J23/83 , B01J35/00 , C07C2/84 , C07C5/42 , C07D301/03 , C10G27/00 , C10J3/72 , C01B32/40 , C07C9/06 , C07C11/02 , C07C11/04 , C07C11/06 , C07C11/22 , C07C13/20 , C07C15/46 , C07C31/04 , C10J3/46 , B01J37/03 , B01J37/14 , B01J37/18
Abstract: This invention is directed to novel mixed transition metal iron (II/III) catalysts for the extraction of oxygen from CO2 and the selective reaction with organic compounds.
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公开(公告)号：US20190070104A1
公开(公告)日：2019-03-07
申请号：US15770722
申请日：2016-10-25
Applicant: RESEARCH TRIANGLE INSTITUTE
Inventor： Leah Marie Johnson , Stephanie Lynn Swarner , Ginger Denison Rothrock , Ariane Van Der Straten Ponthoz , Brian Rhys Stoner
Abstract: The disclosure provides biomedical devices comprising indicator agents sensitive to the environment of use, methods of using same to enhance adherence to a treatment or usage regimen, and systems for monitoring compliance of use of the biomedical device. The biomedical device may be an intravaginal ring comprised of biocompatible polymeric material having indicator agent incorporated therein capable of producing a detectable change in response to a stimulus within the vaginal environment.
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公开(公告)号：US20190031951A1
公开(公告)日：2019-01-31
申请号：US16071024
申请日：2017-01-17
Applicant: Research Triangle Institute
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Sarah Dorothy Shepherd , Nicolas Daniel Huffman , Jeffrey Brent Mecham
Abstract: The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.
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Patent Agency Ranking
公开(公告)号：US20180325781A1
公开(公告)日：2018-11-15
申请号：US15918026
申请日：2018-03-12
Inventor： Leah Marie Johnson , Ginger Denison Rothrock , Sarah Dorothy Shepherd , Sandra Cordel O'Buckley , Andrea Gail Neely
CPC classification number: A61K6/0067 , A61K6/0002 , A61K9/006 , A61K9/06 , A61K9/5026 , A61K31/00 , A61K47/42 , A61K47/46 , A61K2300/00
Abstract: The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
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公开(公告)号：US10100059B2
公开(公告)日：2018-10-16
申请号：US15374386
申请日：2016-12-09
Applicant: Research Triangle Institute
Inventor： Scott P. Runyon , Rangan Maitra , Sanju Narayanan , James Barnwell Thomas , Kenneth S. Rehder , Srinivas Olepu
IPC: C07D491/107 , C07D231/14 , C07D401/12 , C07D401/14 , C07D487/08 , C07D405/12 , C07D417/12 , C07D413/12 , C07D409/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D403/14 , C07D403/12 , C07D471/08 , A61K45/06 , A61K31/454 , A61K31/415 , A61K31/5377 , A61K31/497 , A61K31/4439 , A61K31/55 , A61K31/427 , A61K31/422 , C07D417/14 , A61K31/4196 , A61K31/4245 , A61K31/439
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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218.发明授权公开(公告)号：US10087211B2
公开(公告)日：2018-10-02
申请号：US15341573
申请日：2016-11-02
Applicant: RESEARCH TRIANGLE INSTITUTE , The United States of America, as represented by the Secretary, Department of Health and Human Services
Inventor： Scott P. Runyon , Michael Rogawski , Edgar Cook , John Kepler , Hernan Navarro , Rafal Kaminski , Matthew Orr
Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
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公开(公告)号：US20180265518A1
公开(公告)日：2018-09-20
申请号：US15983519
申请日：2018-05-18
Applicant: Research Triangle Institute
Inventor： Scott P. RUNYON , Rangan MAITRA , Sanju NARAYANAN , James Barnwell THOMAS , Kenneth S. REHDER , Srinivas OLEPU
IPC: C07D491/107 , C07D403/04 , A61K31/5377 , C07D401/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D409/04 , C07D403/12 , C07D417/12 , C07D403/06 , C07D231/14 , C07D471/08 , C07D413/12 , C07D401/14 , C07D417/14 , A61K45/06 , C07D487/08 , C07D407/12 , A61K31/55 , A61K31/427 , A61K31/422 , A61K31/415 , A61K31/4245 , A61K31/4196 , A61K31/454 , A61K31/497 , A61K31/4439 , A61K31/439 , C07D413/04
CPC classification number: C07D491/107 , A61K31/415 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/497 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/08 , C07D487/08
Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
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公开(公告)号：US20180258340A1
公开(公告)日：2018-09-13
申请号：US15975205
申请日：2018-05-09
Applicant: Research Triangle Institute
Inventor： Ginger D. Rothrock , Leah Marie Johnson
CPC classification number: C09K8/588 , B01J13/14 , B82Y30/00 , B82Y40/00 , C09K8/03 , C09K8/516 , C09K8/536 , C09K8/58 , C09K8/584 , C09K8/70 , C09K8/92 , C09K2208/10 , E21B43/16
Abstract: The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a carrier element forming an outer shell that defines an inner core. The core can include a reactive agent that is adapted to react with the shell, particularly at an inner interface of the shell with the core materials. The reaction can provide an inside-out degradation of the shell and release of one or more materials therein. The reactive agent may be separated from the shell, such as using a phase change material (PCM). Upon reaching specific environmental conditions, the PCM can change so as the release the reactive agent for reaction with the shell. The systems can be used in various methods to deliver a material to various environments, including underground reservoirs.
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