公开(公告)号：US20160175090A1

公开(公告)日：2016-06-23

申请号：US14907184

申请日：2014-07-24

Applicant: KOWA COMPANY, LTD.

Inventor： Kenichi Kobayashi ,  Genyo Midorikawa

IPC: A61F2/16

CPC classification number: A61F2/167 ,  A61F2/1662 ,  A61F2/1678

Abstract: Intraocular lens insertion apparatus includes a cylindrical body member configured to retain an intraocular lens, a fore-end opening provided for a tip of the body member, and a planate protrusion provided for a tip of the fore-end opening. Further, an end surface of the fore-end opening is an oblique surface which is oblique to a plane perpendicular to a central axis of the body member, and a fore-end area including a pair of lateral walls which are parallel to each other across the central axis is formed on a side of the tip of the fore-end opening.

Abstract translation: 眼内透镜插入装置包括构造成保持眼内透镜的圆柱形本体构件，设置在主体构件的尖端的前端开口，以及设置在前端开口的前端的平面突起。 此外，前端开口的端面是与垂直于主体构件的中心轴线的平面倾斜的倾斜面，包括彼此平行的一对侧壁的前端区域 中心轴形成在前端开口的前端的一侧。

公开(公告)号：US09242978B2

公开(公告)日：2016-01-26

申请号：US14427865

申请日：2013-09-25

Applicant: KOWA COMPANY, LTD.

Inventor： Takahisa Ogamino ,  Shin Tanikawa ,  Yoshiharu Miyake ,  Shinsuke Itoh ,  Yoshikazu Sawada

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/12 ,  A61K31/4155 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/497 ,  C07D417/14

CPC classification number: C07D417/14 ,  A61K31/4155 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/497 ,  C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: The present invention is to create a compound that selectively activates glucokinase in the liver, and in particular, to provide an agent for treating and preventing diabetes and impaired glucose tolerance, wherein the agent has a low hypoglycemia risk. A compound represented by the formula (1) as shown below, or a salt thereof, or a solvate of the compound or the salt:wherein, in the following formula (1), ring A represents a thiazolyl group, a pyridyl group, a pyrazyl group, or a pyrazolyl group; L represents —(CO)—, —(CS)—, or —SO2—; and R1 represents a C1-6 alkyl group, a hydroxy C1-6 alkyl group, a C1-6 alkoxy group, an amino group, a C1-6 alkylamino group, a hydroxyamino group, an N—C1-6 alkylcarbamoyl group, or a group represented by the formula (2) as shown below, wherein R3 represents a C1-6 alkyl group; and R2 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or a carboxyl group. The formulas are shown below:

Abstract translation: 本发明是产生选择性地激活肝脏中的葡萄糖激酶的化合物，特别是提供治疗和预防糖尿病和葡萄糖耐量降低的药剂，其中该药物具有低的低血糖风险。 由下式（1）表示的化合物或其盐或化合物或其盐的溶剂合物：其中，在下式（1）中，环A表示噻唑基，吡啶基， 吡唑基或吡唑基; L代表 - （CO） - ， - （CS） - 或-SO2-; 和R 1表示C 1-6烷基，羟基C 1-6烷基，C 1-6烷氧基，氨基，C 1-6烷基氨基，羟基氨基，N-C 1-6烷基氨基甲酰基或 由下式（2）表示的基团，其中R 3表示C 1-6烷基; R 2表示氢原子，卤素原子，C 1-6烷基，C 1-6烷氧基或羧基。 公式如下所示：

公开(公告)号：US20150272944A1

公开(公告)日：2015-10-01

申请号：US14741070

申请日：2015-06-16

Applicant: KOWA COMPANY, LTD.

Inventor： Toru Yokoyama ,  Taro Aoki

IPC: A61K31/4725 ,  A61K31/472

CPC classification number: A61K31/4725 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/472 ,  A61K45/06

Abstract: The present invention relates to hypotriglyceridemic agent containing HMG-CoA reductase inhibitor and cAMP protease inhibitor.

公开(公告)号：US20150209170A1

公开(公告)日：2015-07-30

申请号：US14678536

申请日：2015-04-03

Applicant: Kowa Company, Ltd.

Inventor： Kazuhiko MATSUO ,  Hidefumi KOGA

IPC: A61F5/01

CPC classification number: A41D13/065 ,  A61F2/68 ,  A61F5/0109 ,  A61F5/0123 ,  A61F13/00 ,  A61F13/08 ,  A61F13/14 ,  A61F2002/7645 ,  A61F2210/0057

Abstract: A knee joint supporter which can improve the stability of the knee joint, reduce the wearer's fatigue and reduce the load on the patellar tendon includes a first anchor section formed by wrapping one end of a tubular knitted fabric around the wearer's thigh to tighten it with the fabric, a second anchor section formed by wrapping the other end of the fabric around the wearer's lower thigh to tighten it with the fabric, and a substantially U-shaped knitted supporting section joined to the first anchor section, covering the wearer's patella region and thus supporting the wearer's patella. In the circumferential direction of the fabric, the stretch resistance of the two anchor parts are larger than the stretch resistance of a base fabric section. In the length width direction of the fabric, the stretch resistance of the supporting section is larger than the stretch resistance of the base fabric section.

Abstract translation: 可以提高膝关节的稳定性的膝关节支撑件，减少穿着者的疲劳并减轻髌骨腱上的负荷，包括通过将管状针织物的一端围绕穿戴者的大腿缠绕而形成的第一锚定部， 织物，通过将织物的另一端缠绕在穿戴者的下大腿上以将其与织物收紧而形成的第二锚定部分，以及连接到第一锚固部分的覆盖穿着者髌骨区域的大致U形的针织支撑部分，因此 支持佩戴者的髌骨。 在织物的圆周方向上，两个锚固部件的拉伸阻力大于基布部分的拉伸阻力。 在织物的长度方向上，支撑部的拉伸阻力大于基布部的拉伸阻力。

公开(公告)号：US20150201828A1

公开(公告)日：2015-07-23

申请号：US14420511

申请日：2013-07-26

Applicant: Kowa Company, Ltd.

Inventor： Takuya Hara

IPC: A61B3/00 ,  A61B3/14 ,  A61B3/024

CPC classification number: A61B3/0025 ,  A61B3/0058 ,  A61B3/024 ,  A61B3/1225 ,  A61B3/14

Abstract: A perimeter 2 for measuring a visual field by conducting perimetry operations regarding measurement points RG of the subject eye 22a has means 17 for storing perimetry result, means 10, 24 for composing the perimetry result as a map image corresponding to a fundus and indicating it on the display 20, means 13 for obtaining and indicating a structure examination image PC1 of the subject eye 22a, means 16 for superimposing the map image MAP2 on the indicated structure examination image PC1 and indicating the superimposed as a composite image PC2, and means 15 for setting a concerned area NA on the composite image PC2, and means 21 for computing an evaluation value of the perimetry based upon the perimetry result.

Abstract translation: 用于通过对对象眼22a的测量点RG执行视野测量操作来测量视野的周长2具有用于存储视野测量结果的装置17，用于将视野测量结果构成为对应于眼底的地图图像并将其指示的装置10,24 显示器20，用于获取和指示被检眼22a的结构检查图像PC1的装置13，用于将地图图像MAP2叠加在指示的结构检查图像PC1上并指示叠加为合成图像PC2的装置16，以及用于 在合成图像PC2上设置有关区域NA，以及用于基于视野测量结果计算视野的评估值的装置21。

公开(公告)号：US20150157500A1

公开(公告)日：2015-06-11

申请号：US14411075

申请日：2013-06-28

Applicant: KOWA COMPANY, LTD.

Inventor： Genyo Midorikawa

IPC: A61F9/007

CPC classification number: A61F9/00736 ,  A61F2/167 ,  A61F2/1678

Abstract: The present invention is provided with: an approximately cylindrical nozzle body; a stage part which is provided in the nozzle body and houses an intraocular lens; a plunger which presses the intraocular lens housed in the stage part by the forward end thereof to discharge the intraocular lens into an eyeball; and a positioning member which restricts the initial position and posture of the intraocular lens by being mounted to the stage part from the outside. Rib sections are formed so as to extend in the front-back direction of the nozzle body at the outer periphery of the stage part, and side wall parts and rotation prevention wall parts are formed in the positioning member so as to sandwich the rib sections from both sides, thereby restricting the rotation of the positioning member with respect to the stage part.

Abstract translation: 本发明提供有：近似圆柱形的喷嘴体; 设置在所述喷嘴主体中并容纳人工晶状体的台部; 柱塞，其通过其前端按压容纳在台架部中的眼内透镜，以将眼内透镜排出眼球; 以及定位构件，其通过从外部安装到台架部分来限制眼内透镜的初始位置和姿势。 肋部形成为在台架部的外周沿喷嘴体的前后方向延伸，并且在定位部件上形成有侧壁部和旋转防止壁部，以将肋部从 从而限制定位构件相对于台架部的旋转。

公开(公告)号：US09045423B2

公开(公告)日：2015-06-02

申请号：US14274805

申请日：2014-05-12

Applicant: KOWA COMPANY, LTD.

Inventor： Masanori Ashikawa ,  Junya Tagashira ,  Akiyasu Koketsu ,  Toshiharu Morimoto ,  Takahiro Kitamura ,  Syunji Takemura ,  Gen Watanabe ,  Tatsuaki Nishiyama ,  Satoshi Goda ,  Masaki Yamabi ,  Takeshi Doi ,  Hiroyuki Ishiwata

IPC: A01N57/26 ,  A61K31/675 ,  C07D215/42 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/69 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  C07D405/12

CPC classification number: C07D215/42 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/69 ,  C07D215/233 ,  C07D215/44 ,  C07D215/46 ,  C07D215/48 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R1, R2, R2′, R3 and R3′ independently represent a hydrogen atom, a C1-6 alkyl group, or the like; R4, R5, R6, R7, R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or the like; A represents N—R11, a sulfur atom, or an oxygen atom; R11 represents a hydrogen atom, a C1-6 alkyl group, or the like; B represents a C6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

Abstract translation: 公开了具有低分子量且具有增强EPO产生活性和/或提高血红蛋白生成活性的化合物。 具体公开的是EPO生产增强剂和/或包含1-酰基-4-（取代的氧基，取代的氨基或取代的硫代）-1,2,3,4-四氢喹啉衍生物，更具体地是四氢喹啉化合物的血红蛋白生成增强剂 由通式（1）表示[其中R1，R2，R2'，R3和R3'独立地表示氢原子，C1-6烷基等; R 4，R 5，R 6，R 7，R 8，R 9和R 10独立地表示氢原子，卤素原子，C 1-6烷基等; A表示N-R11，硫原子或氧原子; R 11表示氢原子，C 1-6烷基等; B表示C 6-14芳基或5至10元杂环基; n表示0或1的整数]，四氢喹啉化合物的盐或四氢喹啉化合物或其盐的溶剂合物。

公开(公告)号：US20150094439A1

公开(公告)日：2015-04-02

申请号：US14397352

申请日：2013-04-30

Applicant: KOWA COMPANY, LTD.

Inventor： Masahiro Tamura ,  Takahide Oshita

IPC: C07C245/08 ,  A61L27/16 ,  C08F220/68

CPC classification number: C07C245/08 ,  A61F2/16 ,  A61F2002/16965 ,  A61L27/16 ,  A61L27/50 ,  A61L2430/16 ,  C08F220/00 ,  C08F220/60 ,  C08F220/68 ,  C09B29/0003 ,  C09B29/12 ,  C09B69/106 ,  C08L33/26

Abstract: A polymerizable UV-absorbing colorant monomer is provided, which is excellent in stability under alkaline conditions and which is available for a useful material polymer for an intraocular lens. A compound, which is represented by the following general formula (1), is used as a polymerizable UV-absorbing monomer available for a material polymer for an intraocular lens: (in the general formula (1), R1 is a hydrogen atom, a hydroxy group, a carboxy group, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a sulfonic acid group, or a benzyloxy group, R2 is a hydrogen atom, a hydroxy group, or an alkoxy group having 1 to 4 carbon atoms, and R3 is represented by the following formula (2)): (in the general formula (2), R4 is a hydrogen atom or a methyl group, and R5 is a single bond or an alkylene group having 1 to 4 carbon atoms which may have a substituent or substituents.)

Abstract translation: 提供了一种可聚合的UV吸收着色剂单体，其在碱性条件下的稳定性优异，并且可用于眼内透镜的有用材料聚合物。 使用由以下通式（1）表示的化合物作为可用于眼内透镜材料聚合物的可聚合的UV吸收单体：（在通式（1）中，R 1是氢原子， 羟基，羧基，碳原子数1〜8的烷基，碳原子数1〜8的烷氧基，磺酸基或苄氧基，R2是氢原子，羟基或烷氧基 具有1至4个碳原子的基团，R 3由下式（2）表示）：（在通式（2）中，R 4是氢原子或甲基，R 5是单键或亚烷基 具有1至4个可具有取代基的碳原子。）

公开(公告)号：US20150085258A1

公开(公告)日：2015-03-26

申请号：US14395641

申请日：2013-10-18

Applicant: SHINSHU UNIVERSITY ,  KOWA COMPANY, LTD.

Inventor： Kazuo Ichikawa ,  Kiyoshi Tanaka ,  Tanaka Yoshiki Tanaka

IPC: A61B3/06 ,  A61B3/00

CPC classification number: A61B3/066 ,  A61B3/0041 ,  A61B3/032

Abstract: [Problem] To be able to accurately measure color vision and color-viewing field for different colors.[Solution] The color-viewing function measuring means (1) pertaining to the present invention displays a plurality of chromatically colored targets (A11, . . . ) (for example, Landolt rings) in an achromatic background (B), the brightness of the targets (A11, . . . ) being set so as to be substantially equal to the brightness of the background (B). When vision or the viewing field is measured with this color-viewing function measuring means (1), vision and viewing field can be accurately measured for different colors.

Abstract translation: [问题]能够准确测量不同颜色的色彩和色彩。 [解决方案]本发明的色彩观察功能测量装置（1）在无彩色背景（B）中显示多个色彩色的目标（A11，...）（例如，Landolt环），亮度 目标（A11，...）被设置为基本上等于背景（B）的亮度。 当使用该色彩观察功能测量装置（1）测量视觉或观看场景时，可以精确地测量不同颜色的视觉和观看场景。

公开(公告)号：US20150031568A1

公开(公告)日：2015-01-29

申请号：US14354036

申请日：2012-10-24

Applicant: KOWA COMPANY, LTD.

Inventor： Katsumi Yabusaki

IPC: G01N33/579

CPC classification number: G01N33/579 ,  G01N21/59 ,  G01N21/82

Abstract: Provided is a technique which can detect a physiologically active substance of biological origin or measure the concentration of the physiologically active substance of biological origin with higher accuracy or within a shorter period even when a sample that contains the physiologically active substance of biological origin at an extremely low concentration or a sample that contains a component capable of interfering with an AL is used. Microparticles capable of adsorbing a specific physiologically active substance, e.g., an endotoxin, is dispersed in a sample containing the specific physiologically active substance to cause the adsorption of the specific physiologically active substance onto the microparticles, thereby concentrating the specific physiologically active substance in the sample. Subsequently, the microparticles are separated and collected, then are reacted with an AL to cause an aggregation reaction, and the aggregation is detected by an optical means. In this manner, the measurement of the specific physiologically active substance can be carried out.

Abstract translation: 本发明提供一种可以检测生物来源的生理活性物质的技术，即使在生物来源的生物活性物质极端地含有的样品时也能够以更高的精度或更短的时间内测定生物来源的生理活性物质的浓度 使用低浓度或含有能够干扰AL的成分的样品。 能够吸附特定的生理活性物质例如内毒素的微粒分散在含有特定生理活性物质的样品中，以使特定的生理活性物质吸附到微粒上，从而将特定的生理活性物质浓缩在样品中 。 随后，分离并收集微粒，然后与AL反应引起聚集反应，并且通过光学装置检测聚集。 以这种方式，可以进行特定的生理活性物质的测量。