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241.发明申请公开(公告)号：US20190030054A1
公开(公告)日：2019-01-31
申请号：US16130522
申请日：2018-09-13
Inventor： Siyoung YANG , Jimin JEON , Li-Jung KANG , Chanmi CHO
IPC: A61K31/702 , A61P19/02 , A61P17/00
Abstract: Provided are a composition for inhibiting immune cell proliferation, including sialyllactose or a derivative thereof as an active ingredient, and a method of inhibiting immune cell proliferation, wherein the composition and the method may decrease expression of chemokines, decrease expression of pro-inflammatory cytokines, decrease production of inflammatory mediators, decrease expression of COX2, and decrease production of PEG2, and therefore, may be useful for the prevention or treatment of atopic dermatitis or arthritis.
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公开(公告)号：US10183140B2
公开(公告)日：2019-01-22
申请号：US15434320
申请日：2017-02-16
Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
Inventor： Kilyeon Lee , Moongu Lee , Yongho Jeon , Jaeseung Kim
IPC: A61M5/178 , A61M5/00 , A61B17/34 , A61M5/32 , A61M19/00 , A61M5/42 , A61M11/00 , A61M5/142 , A61M5/158 , A61M5/168
Abstract: The present invention relates to an apparatus and a method for local anesthesia and, more specifically, to an apparatus and a method for local anesthesia, which precisely indicate an anesthesia region and enable injection to be administered around the anesthesia region through a plurality of anesthesia needles. According to the present invention, the fear and pain of a subject to be anesthetized can be reduced since the affected part of the subject to be anesthetized can be anesthetized by injecting a plurality of syringes all at once, and an injection can be precisely administered to a region at which an injection is to be administered since the affected part can be precisely indicated by a provided laser pointer.
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243.发明申请公开(公告)号：US20180353559A1
公开(公告)日：2018-12-13
申请号：US16066986
申请日：2016-12-14
Inventor： Sung Moon OH , Ga Hui OH , Young-Joon PARK , Minsun CHANG
IPC: A61K36/25 , A23L33/105 , A61P5/24
CPC classification number: A61K36/25 , A23L33/105 , A61P5/24
Abstract: Provided is a composition for preventing and treating a menopausal disorder containing extracts of Dendropanax morbifera LEV. as an active ingredient. Specifically, the extracts of Dendropanax morbifera LEV. exhibit a significant ER agonist activity within a cell, and exhibit a very potent ER agonist (full agonist) activity with an EC50 value of about 100 μg/ml. Thus, the extracts of Dendropanax morbifera LEV. comprising a high content of plant metabolites similar to estrogen can be useful as hormone replacement therapy capable of improving various symptoms derived from a deficiency of estrogen in menopausal women.
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公开(公告)号：US10121565B2
公开(公告)日：2018-11-06
申请号：US14556344
申请日：2014-12-01
Inventor： Kyungsang Cho , Sangwook Kim , Donghyeok Choi
Abstract: A nanoparticle multilayer thin film is provided in which nanoparticles which are not electrically insulated from each other are spaced apart from one another at a reduced distance. The nanoparticle multilayer film includes: at least one first nanoparticle layer including first nanoparticles that are surface-modified with a cationic metal-chalcogenide compound; and at least one second nanoparticle layer including second nanoparticles that are surface-modified with an anionic metal-chalcogenide compound, wherein the first nanoparticle layer and the second nanoparticle layer are alternately stacked upon one another.
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公开(公告)号：US20180302149A1
公开(公告)日：2018-10-18
申请号：US15956257
申请日：2018-04-18
Inventor： Ikmo PARK , Jaejin LEE , Ta Son XUAT
IPC: H04B7/185 , H02S10/40 , H02S99/00 , H01L31/0475 , H01Q1/36
CPC classification number: H04B7/18515 , H01L27/142 , H01L31/046 , H01L31/0475 , H01Q1/288 , H01Q1/364 , H01Q1/44 , H01Q9/0428 , H01Q9/065 , H01Q9/26 , H01Q21/26 , H01Q25/001 , H02S10/40 , H02S99/00
Abstract: Disclosed is a solar cell integrated with a radio wave transceiving apparatus. A solar cell integrated with a radio wave transceiving apparatus according to an exemplary embodiment of the present disclosure may include a substrate; a solar cell in which a plurality of unit cells is periodically arranged on the upper surface of the substrate to form a metasurface; and a crossed dipole type radiator positioned on the solar cell.
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Patent Agency Ranking
公开(公告)号：US10085976B2
公开(公告)日：2018-10-02
申请号：US15212054
申请日：2016-07-15
Inventor： Sang Myun Park , Yu Ree Choi
Abstract: This invention provides a method of treating a neurodegenerative disease selected from the group consisting of Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, comprising administering a pharmaceutically effective amount of an agent capable of suppressing expression or activity of SHP-1/-2 (Src homology region 2 domain-containing phosphatase-1/-2) or FcγRIIB (IgG Fc receptor II-B) to a subject having the neurodegenerative disease, wherein the agent capable of suppressing expression of SHP-1/-2 or FcγRIIB is selected from the group consisting of miRNA, siRNA, shRNA, antisense oligonucleotide, and a combination thereof capable of specifically binding to mRNA of SHP-1/-2 or FcγRIIB, and the agent capable of suppressing activity of SHP-1/-2 or FcγRIIB is selected from the group consisting of an antibody, an aptamer, an antagonist, and a combination thereof capable of specifically binding to a protein of SHP-1/-2 or FcγRIIB.
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公开(公告)号：US20180237541A1
公开(公告)日：2018-08-23
申请号：US15944505
申请日：2018-04-03
Inventor： Yong Sung KIM , Hye Ji CHOI , Eun Sil SUNG
CPC classification number: C07K16/46 , A61K2039/505 , C07K16/00 , C07K16/2878 , C07K16/468 , C07K2317/31 , C07K2317/526 , C07K2317/622 , C07K2319/30
Abstract: Disclosed are a CH3 domain variant pair of an antibody, a method for preparing same, and a use thereof. A mutation is induced in the CH3 domain so as to improve a yield of forming a heterodimer heavy chain constant region of an antibody. The CH3 domain heterodimer forms a heterodimer heavy chain constant region with a high efficiency of 90 to 95% or more and also has outstanding heat stability. A heterodimer heavy chain constant region including the CH3 domain heterodimer can construct a bispecific monoclonal antibody which simultaneously recognizes two kinds of antigens. The CH3 domain heterodimer and the bispecific antibody or fusion protein of an antibody constant region comprising same can be usefully applied to the treatment or prevention of a disease associated with a target antigen or a target protein.
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248.发明授权公开(公告)号：US10016400B2
公开(公告)日：2018-07-10
申请号：US14876826
申请日：2015-10-07
Inventor： Yun-Hoon Choung , Yeon Ju Kim
IPC: A61K31/436 , A61K31/7036 , A23L33/10
CPC classification number: A61K31/436 , A23L33/10 , A61K31/7036
Abstract: A pharmaceutical or health food includes rapamycin as an active ingredient, the pharmaceutical or health food being applied for prevention, improvement, and treatment of ototoxic hearing loss caused by an aminoglycoside-based antibiotic, sudden sensorineural hearing loss, and noise induced hearing loss. The pharmaceutical or health food is also applied to a pharmaceutical composite preparation of an aminoglycoside-based antibiotic and rapamycin, the pharmaceutical composite preparation reducing a side effect of the aminoglycoside-based antibiotic.
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249.发明申请公开(公告)号：US20180177434A1
公开(公告)日：2018-06-28
申请号：US15855504
申请日：2017-12-27
Inventor： Jin Hong KIM , Myung Hoon SUNWOO , Jung Won LEE
IPC: A61B5/103 , G06T7/00 , G06T7/90 , A61B5/145 , A61B5/1455
CPC classification number: A61B5/1034 , A61B5/0077 , A61B5/14546 , A61B5/1455 , A61B5/6898 , A61B5/7264 , A61B2576/00 , G06T7/0012 , G06T7/90 , G06T2207/10024 , G06T2207/30041
Abstract: Disclosed are image based jaundice analyzing method and apparatus. The image based jaundice analyzing method according to an exemplary embodiment of the present disclosure includes: receiving an image for jaundice diagnosis obtained by photographing a specific body part of a user and a reference object in a location where the user is currently located; generating color distortion information representing a degree of color distortion of the reference object included in the image for jaundice diagnosis; generating a correction image for jaundice diagnosis by correcting the color distortion of the image for jaundice diagnosis based on the color distortion information; and diagnosing a jaundice symptom of the user using the correction image for jaundice diagnosis.
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250.发明授权公开(公告)号：US10004736B2
公开(公告)日：2018-06-26
申请号：US15017470
申请日：2016-02-05
Inventor： You Sun Kim
IPC: A61K31/506 , A61K31/635 , A61K38/06 , A61K31/45 , G01N33/68 , A61K45/06 , A61K31/4178
CPC classification number: A61K31/506 , A61K31/4178 , A61K31/45 , A61K31/635 , A61K38/06 , A61K45/06 , G01N33/6893 , G01N2333/912 , G01N2800/20 , A61K2300/00
Abstract: The present invention relates to methods of preventing or treating skin necroptosis diseases, including administering to subjects receptor-interacting protein kinase-3 (RIP3)-mixed lineage kinase domain-like protein (MLKL) pathway blockers or dabrafenib, and method of diagnosing of skin necroptosis diseases, including detecting phosphorylated MLKL. The RIP3-MLKL pathway blockers according to the present invention directly suppress RIP3 overexpressing in skin necroptosis diseases, or inhibit phosphorylation and translocation to plasma membranes of MLKL, subsequently induced therefrom, thereby effectively preventing skin cell death via necroptosis. Thus, the present invention can prevent or treat a variety of skin diseases caused by necroptosis.
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