公开(公告)号：US5104866A

公开(公告)日：1992-04-14

申请号：US560229

申请日：1990-07-25

申请人： Kazuo Sakane ,  Nobuyoshi Yasuda ,  Shintaro Nishimura

发明人： Kazuo Sakane ,  Nobuyoshi Yasuda ,  Shintaro Nishimura

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/02 ,  C07D501/46

CPC分类号： A61K31/545

摘要： A water-soluble antibiotic composition which comprises crystals of a cephem compound of the following formula: ##STR1## wherein R.sup.1 is a residue of an aliphatic hydrocarbon which may have suitable substituent(s), andR.sup.2 is a heteronio (lower)alkyl, or an acid addition salt thereof, and a pharmaceutically acceptable carbonic acid salt.And a salt of new cephem compound derived from the above-mentioned cephem compound.

公开(公告)号：US5079369A

公开(公告)日：1992-01-07

申请号：US370873

申请日：1989-06-23

申请人： Takao Takaya ,  Takashi Masugi ,  Hisashi Takasugi ,  Hiromu Kochi

发明人： Takao Takaya ,  Takashi Masugi ,  Hisashi Takasugi ,  Hiromu Kochi

IPC分类号： C07D277/20 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D333/16 ,  C07D501/20

CPC分类号： C07D277/20 ,  C07D277/38 ,  C07D277/587 ,  C07D333/16

摘要： The compound of the formula: ##STR1## wherein R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, and R.sup.6 is amino or protected amino, or its reactive derivative at the carboxy group effective for transforming the carboxy group into a reactive N-acylating group, or a salt thereof.

公开(公告)号：US5045548A

公开(公告)日：1991-09-03

申请号：US550086

申请日：1990-07-09

申请人： Teruo Oku ,  Yoshio Kawai ,  Hiroshi Kayakiri ,  Kazuyoshi Kuratani ,  Masashi Hashimoto

发明人： Teruo Oku ,  Yoshio Kawai ,  Hiroshi Kayakiri ,  Kazuyoshi Kuratani ,  Masashi Hashimoto

IPC分类号： C12N9/99 ,  A61K31/085 ,  A61K31/12 ,  A61K31/165 ,  A61K31/275 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/47 ,  A61P1/00 ,  A61P1/16 ,  A61P9/08 ,  A61P9/10 ,  A61P13/02 ,  A61P15/00 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07C41/00 ,  C07C41/01 ,  C07C41/26 ,  C07C43/23 ,  C07C45/00 ,  C07C45/67 ,  C07C45/68 ,  C07C46/00 ,  C07C49/747 ,  C07C49/755 ,  C07C50/12 ,  C07C67/00 ,  C07C231/00 ,  C07C231/06 ,  C07C231/12 ,  C07C235/20 ,  C07C235/42 ,  C07C253/00 ,  C07C253/30 ,  C07C255/32 ,  C07C255/52 ,  C07C255/54 ,  C07D213/30 ,  C07D213/64 ,  C07D215/14 ,  C07D215/20 ,  C07D215/26 ,  C07D231/12 ,  C07D235/08 ,  C07D235/12 ,  C07D237/08 ,  C07D239/26 ,  C07D277/64 ,  C07D277/68 ,  C07D521/00 ,  C07F7/18

CPC分类号： C07D213/30 ,  C07C255/00 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C49/755 ,  C07D215/14 ,  C07D235/12 ,  C07D277/64 ,  C07F7/1856

摘要： The invention relates to a method of treating asthma comprising administering a compound of the formula: ##STR1## wherein A is ##STR2## R.sup.1 is quinolyl, R.sup.2 is hydrogen or lower alkyl,R.sup.3 is lower alkyl,X is hydrogen, halogen, hydroxy or lower alkyl,m is integer 1 or 2, andn is an integer 1 or 4, or pharmaceutically acceptable salts thereof.

公开(公告)号：US4963544A

公开(公告)日：1990-10-16

申请号：US347579

申请日：1989-05-05

申请人： Masayoshi Murata ,  Hideo Tsutsumi ,  Keiji Matsuda ,  Kohji Hattori ,  Takashi Nakajima

发明人： Masayoshi Murata ,  Hideo Tsutsumi ,  Keiji Matsuda ,  Kohji Hattori ,  Takashi Nakajima

IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/435 ,  A61K31/44 ,  A61K31/495 ,  A61K31/50 ,  A61K31/505 ,  A61P31/04 ,  C07D477/20 ,  C07D521/00

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D477/20 ,  Y02P20/55

摘要： 3-Pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene carboxylic acids substituted on the pyrrolidine by unsaturated heterocyclyl have been prepared.

公开(公告)号：US4963530A

公开(公告)日：1990-10-16

申请号：US171269

申请日：1988-03-21

申请人： Keiji Hemmi ,  Masahiro Neya ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

发明人： Keiji Hemmi ,  Masahiro Neya ,  Keisuke Imai ,  Natsuko Kayakiri ,  Masashi Hashimoto

IPC分类号： A61K38/55 ,  A61K38/00 ,  A61P9/12 ,  A61P43/00 ,  C07K1/06 ,  C07K1/113 ,  C07K5/06 ,  C07K5/065 ,  C07K14/81

CPC分类号： C07K5/06078 ,  A61K38/00 ,  Y02P20/55 ,  Y10S530/86

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is aryl optionally substituted with a substituent selected from the group consisting of halogen and halo(lower)alkyl; lower alkyl or cyclo(lower)alkyl; andR.sup.2 is hydrogen or lower alkyl, orR.sup.1 and R.sup.2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted with a substituent selected from the group consisting of lower alkyl and esterified carboxy,R.sup.3 is hydrogen or lower alkyl, andR.sup.4 is lower alkyl,and its pharmaceutically acceptable salt, a process for the preparation thereof and pharmaceutical composition comprising the same.

公开(公告)号：US4925849A

公开(公告)日：1990-05-15

申请号：US202526

申请日：1988-06-06

申请人： Youichi Shiokawa ,  Atsushi Akahane ,  Hirohito Katayama ,  Takafumi Mitsunaga

发明人： Youichi Shiokawa ,  Atsushi Akahane ,  Hirohito Katayama ,  Takafumi Mitsunaga

IPC分类号： A61K31/435 ,  A61P7/02 ,  A61P7/10 ,  A61P9/04 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  C07D471/04

CPC分类号： C07D471/04

摘要： The disclosure deals with a pyrazolopyridine compound of the formula ##STR1## wherein the variables are defined in the specification. The compounds are useful as a diuretic, antihypertensive agent, etc.

公开(公告)号：US4923857A

公开(公告)日：1990-05-08

申请号：US312061

申请日：1989-02-17

申请人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

发明人： Masayoshi Murata ,  Toshiyuki Chiba ,  Akira Yamada

IPC分类号： C07D477/00 ,  A61K31/397 ,  A61K31/40 ,  A61P31/04 ,  C07D477/14

CPC分类号： C07D477/14

摘要： The invention relates to an antimicrobial compound of the formula: ##STR1## in which R.sup.1 is carboxy or protected carboxy,R.sup.2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl,R.sup.3 and R.sup.4 are each hydrogen or lower alkyl, andR.sup.5 is saturated 4 to 6-membered heteromonocyclic group containing 1 to 4 nitrogen atom(s), saturated 5 or 6-membered heteromonocyclic group containing 1 to 2 oxygen atom(s) and 1 to 3 nitrogen atom(s) or saturated 5 or 6-membered heteromonocyclic group containing 1 to 2 sulfur atom(s) and 1 to 3 nitrogen atom(s), wherein said aliphatic heterocyclic group may be substituted by one or more suitable substituent(s) selected from a group consisting of hydroxy, protected hydroxy, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, halogen, lower alkoxy, lower alkyl, lower alkoxy(lower)alkyl, imino, protected imino, lower alkylamino, protected lower alkylamino, mono(or di)-(lower)alkylcarbamoyloxy, lower alkylidene, lower alkanimidoyl and imino-protective group, or pharmaceutically acceptable salts thereof.

公开(公告)号：US4922597A

公开(公告)日：1990-05-08

申请号：US251460

申请日：1988-09-30

申请人： Kohji Ikeda ,  Akira Tsuji ,  Yoshiyuki Sunaga

发明人： Kohji Ikeda ,  Akira Tsuji ,  Yoshiyuki Sunaga

IPC分类号： A61M5/32

CPC分类号： A61M5/3205 ,  A61M2005/3208 ,  Y10T29/53687

摘要： A box for disposing of used injection needles comprising a case having an opening whereinto a tip portion of a syringe is inserted, a movable member, and a fixed member, both members being arranged in the case. A hub of an injection needle inserted through the opening of the case is firmly held by holding portions of movable member and fixed member due to elasticity of the hub itself. The rotation of the syringe causes the injection needle to be removed from the syringe, and the removed injection needle, which is not pulled out together with the syringe and remains in the holding portions due to holding effect of the holding portions, can be dropped into the case by the operation of a rod outside the case.

公开(公告)号：US4349552A

公开(公告)日：1982-09-14

申请号：US111643

申请日：1980-01-14

申请人： Takao Takaya ,  Zenzaburo Tozuka

发明人： Takao Takaya ,  Zenzaburo Tozuka

IPC分类号： C07D239/54 ,  C07D239/553 ,  C07D317/70 ,  C07D333/38 ,  C07D239/30

CPC分类号： C07D239/553 ,  C07C265/00 ,  C07D317/70 ,  C07D333/38 ,  Y10S514/908

摘要： A compound of the formula: ##STR1## wherein R is a bridged alicyclic group selected from the group consisting of norbornyl, norbornenyl, bicyclo[2,2,2]-heptyl and adamantyl optionally substituted by at least one substituent selected from the group consisting of lower alkyl, carboxy, lower alkoxycarbonyl, alkylidenedioxy, N,N-di(lower)alkylcarbamoyl, amino, loweralkoxycarbonylamino and halogen. The present compound is useful in the therapeutic treatment of cancer in human beings and animals.

摘要翻译： 下式的化合物，其中R是选自降冰片基，降冰片烯基，降冰片烯基，双环[2,2,2] - 庚基和金刚烷基的桥连脂环基，任选被至少一个选自以下的取代基取代的金刚烷基： 低级烷基，羧基，低级烷氧基羰基，亚烷基二氧基，N，N-二（低级）烷基氨基甲酰基，氨基，低级烷氧基羰基氨基和卤素。 本发明化合物可用于治疗人类和动物中的癌症。

公开(公告)号：US5173493A

公开(公告)日：1992-12-22

申请号：US495119

申请日：1990-03-19

申请人： Masayuki Kato ,  Kiyotaka Ito ,  Hisashi Takasugi

发明人： Masayuki Kato ,  Kiyotaka Ito ,  Hisashi Takasugi

IPC分类号： A61K31/435 ,  A61K31/437 ,  A61P1/00 ,  A61P1/04 ,  A61P1/08 ,  A61P3/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/02 ,  A61P25/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04

CPC分类号： C07D471/04 ,  Y02P20/55

摘要： The invention relates to compounds for treatment of nausea and vomiting, of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkenyl or N,N-di(lower)alkylaminomethyl,R.sup.2 is hydrogen, lower alkyl or halogen,R.sup.3 is imidazolyl or pyridyl, each of which may have substituent(s) selected from lower alkyl and imino-protective group, andR.sup.4 is hydrogen, lower alkyl, lower alkenyl or hydroxy(lower)alkyl and R.sup.5 is hydrogen, hydroxy or lower alkanoyloxy, orR.sup.4 and R.sup.5 are linked together to form an additional bond,or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及用于治疗恶心和呕吐的化合物，其中R1是氢，低级烷基，低级烯基或N，N-二（低级）烷基氨基甲基，R2是氢，低级烷基或卤素，R3是 咪唑基或吡啶基，其各自可以具有选自低级烷基和亚氨基保护基的取代基，并且R4是氢，低级烷基，低级烯基或羟基（低级）烷基，R5是氢，羟基或低级烷酰氧基，或 R4和R5连接在一起形成另外的键，或其药学上可接受的盐。