公开(公告)号：US08794450B2

公开(公告)日：2014-08-05

申请号：US12513189

申请日：2007-11-02

申请人： Dae-Sung Hur ,  Jun-Ha Park ,  Chan-Il Chung ,  Jun-Keun Chang

发明人： Dae-Sung Hur ,  Jun-Ha Park ,  Chan-Il Chung ,  Jun-Keun Chang

IPC分类号： B01D35/28 ,  B01D67/00 ,  G01N30/90 ,  B01L3/00

CPC分类号： B01D67/0062 ,  B01D35/28 ,  B01L3/502753 ,  G01N30/90

摘要： Disclosed is a channel filter for separating microparticles, and more particularly to a channel filter which can easily separate a sample having various sized microparticles by using a surface topology. In the disclosed channel filter, a topology having an upward/downward reference height from a sample inlet to an outlet is continuously or discontinuously formed, and thus it is possible to efficiently separate microparticles from a sample liquid.

摘要翻译： 公开了一种用于分离微粒的通道过滤器，更具体地说，涉及通过使用表面拓扑结构容易地分离具有各种尺寸的微粒的样品的通道过滤器。 在所公开的通道过滤器中，连续地或不连续地形成具有从样品入口到出口的向上/向下参考高度的拓扑，因此可以有效地从样品液体中分离微粒。

公开(公告)号：US20120282625A1

公开(公告)日：2012-11-08

申请号：US13512319

申请日：2010-11-26

申请人： Dae Sung Hur ,  Jong Hyun Oh ,  Jae Jeong Kim ,  Eun Hee Park

发明人： Dae Sung Hur ,  Jong Hyun Oh ,  Jae Jeong Kim ,  Eun Hee Park

IPC分类号： G01N21/64 ,  G01N33/53 ,  G01N33/566

CPC分类号： G01N21/05 ,  B01L3/502715 ,  B01L2400/086 ,  G01N21/0303 ,  G01N2021/0346

摘要： Disclosed is a microfluidic device comprising a microchannel through which fluid can flow. Protrusions are formed on the bottom surface of the microchannel. The microfluidic device increases detection sensitivity by improving optical characteristics and enhances the reactivity of biochemical reaction by slowing down the velocity of fluid flowing inside the microchannel.

摘要翻译： 公开了一种微流体装置，其包括流体可以流过的微通道。 突起形成在微通道的底表面上。 微流体装置通过改善光学特性来提高检测灵敏度，并通过减缓在微通道内流动的流体的速度来提高生化反应的反应性。

公开(公告)号：US08279374B2

公开(公告)日：2012-10-02

申请号：US12780031

申请日：2010-05-14

申请人： Hwa Joon Park ,  Jeoung Ku Hwang ,  Chan Il Chung ,  Cha Hee Kim ,  Min Sung Kim

发明人： Hwa Joon Park ,  Jeoung Ku Hwang ,  Chan Il Chung ,  Cha Hee Kim ,  Min Sung Kim

IPC分类号： H04N7/18 ,  H04N5/243 ,  H04N9/47

CPC分类号： G02B21/0008 ,  G02B21/16 ,  G02B21/368

摘要： The present invention relates to a fluorescent microscope and a remote control system thereof. The present invention reduces the size of the fluorescent microscope to facilitate transportation and management and be disposed in a narrow place such as the inside of the incubator or the clean bench, etc. and observes the samples through a remote control, thereby making it possible to improve the user convenience.

摘要翻译： 本发明涉及一种荧光显微镜及其遥控系统。 本发明减小了荧光显微镜的尺寸以便于运输和管理，并将其放置在诸如培养箱或清洁台等内部的狭窄处，并通过遥控器观察样品，从而使得可以 提高用户的便利性。

公开(公告)号：US20110243795A1

公开(公告)日：2011-10-06

申请号：US13079299

申请日：2011-04-04

申请人： Ji-Young PARK

发明人： Ji-Young PARK

IPC分类号： G01N33/48

CPC分类号： B01L3/502746 ,  B01L2200/0636 ,  B01L2200/0684 ,  B01L2300/0809 ,  B01L2300/089 ,  B01L2400/0406 ,  B01L2400/086

摘要： A chip for analyzing fluid being moved without an outside power source is disclosed. A chip for analyzing fluid being moved without an outside power source according to the present invention comprises: a pre-treatment portion into which a target-being analyzed substance is injected and received; a channel portion through which the fluid received in the pre-treatment portion is moved and in which specific reaction of the fluid such as an antigen-antibody reaction is conducted; and a washing portion into which the fluid passing through the channel portion is received wherein the pre-treatment portion includes: a specimen injection portion into which the fluid is injected; a first buffer portion having a step difference with respect to the specimen injection portion for the fluid to be firstly received; and at least one specimen leading guide which is provided between the specimen injection portion and the first buffer portion and destroys surface tension of the fluid flow moving from the specimen injection portion to the first buffer portion side and thus stabilizes flow surface of the fluid. According to the present invention, a moving pattern of the fluid passing through a channel portion is formed evenly and thus bubble creation is decreased and reproducibility thereof is ensured and further a signal detection from a target-being analyzed substance is performed easily.

摘要翻译： 公开了一种用于分析未经外部电源移动的流体的芯片。 根据本发明的用于分析未被外部动力源移动的流体的芯片包括：预处理部分，其中注入和接收目标分析物质; 在预处理部分中接收的流体被移动的通道部分，并且进行诸如抗原 - 抗体反应之类的流体的特异性反应; 以及洗涤部，所述流体通过所述流路部的流体被容纳在所述洗涤部中，所述预处理部包括：注入所述流体的试样注入部; 第一缓冲部，其相对于要首先接收的流体的样本注入部分具有阶差; 以及至少一个样本引导引导件，其设置在检体注入部和第一缓冲部之间，破坏从检体注入部向第一缓冲部侧移动的流体流的表面张力，由此稳定流体的流动面。 根据本发明，通过通道部分的流体的移动图形被均匀地形成，从而降低了气泡产生并且确保了其再现性，并且进一步容易地执行来自目标分析物质的信号检测。

公开(公告)号：US20240295487A1

公开(公告)日：2024-09-05

申请号：US18270795

申请日：2022-01-25

申请人： NANOENTEK, INC.

发明人： Chan Il CHUNG ,  Hyoung Seop LEE ,  Sanghwa AHN

IPC分类号： G01N15/1433 ,  G01N15/01 ,  G01N15/14

CPC分类号： G01N15/1433 ,  G01N15/1456 ,  G01N15/01 ,  G01N2015/1486

摘要： In a fine particle counting method using a multi-channel sample chip and a fine particle counting apparatus implementing the method, a plurality of samples is observable in a short period of time and even when warpage occurs during a manufacturing process as a sample chip becomes larger, the warpage is corrected so as to count fine particles accurately. Problems that a focal distance of each channel is not constant due to warpage occurring in a chip having a plurality of channels, and thus it takes a lot of time to obtain an image by obtaining a focus value for each channel may be solved. A problem that since an amount of sample injected into each channel is small, a sample dries out when an image is not quickly obtained and used for counting, thereby causing the occurrence of measurement error may be prevented.

公开(公告)号：US20230122274A1

公开(公告)日：2023-04-20

申请号：US17911600

申请日：2021-03-10

申请人： NANOENTEK, INC.

发明人： Seok Joo KAN ,  Yu Rae KIM ,  Chan Il CHUNG ,  Seok Ki YUN

IPC分类号： B01L3/00

摘要： A fluid analysis chip according to an embodiment can be produced by a simple process of adhering upper and lower plates using OCA film. The fluid analysis chip can be used with the inner height and shape precisely controlled to conform to a variety of requirements, and can enhance reliability due to greater adhesiveness than in the conventional chip.

公开(公告)号：US10758877B2

公开(公告)日：2020-09-01

申请号：US15757523

申请日：2016-08-30

申请人： NANOENTEK, INC.

发明人： Yu-Rae Kim

IPC分类号： B01F13/08 ,  G01N1/38 ,  B01F15/02 ,  B01L3/00 ,  B01F13/00 ,  H02N11/00 ,  G01N35/10 ,  G01N35/00

摘要： Disclosed are a sample pretreatment module and a sample pretreatment method using the same. The sample pretreatment module including: a body having a chamber for accommodating a sample therein; a cap coupled to one end of the body; a dotting substrate provided to have at least some portion of it dotted with the reagent and be inserted into the chamber; a discharge tip movably coupled to the other end of the body for discharging a sample accommodated in the chamber; a permanent magnet provided to be inserted in the chamber and mix the sample by rotating owing to a magnetic force acting in accordance with a change in a magnetic field externally applied; and a moving unit movably provided in the cap and pressing the sample in the chamber according to the movement to discharge the sample to the outside.

公开(公告)号：US10145841B2

公开(公告)日：2018-12-04

申请号：US14379664

申请日：2013-02-20

申请人： NANOENTEK, INC.

发明人： Chan Il Chung ,  Chang Seop Lee ,  Jeoung Ku Hwang ,  Jong Sik Jeong

IPC分类号： G01N33/543 ,  G01N33/53

摘要： The present invention provides a method for detecting an antigen in an analysis sample, the method including: (a) contacting an analysis sample with a detection antibody with which a marker generating a detectable signal is combined and which specifically binds to the antigen; (b) contacting a capture antibody with the resultant product of step (a), the capture antibody specifically binding to an antigen to be detected; (c) contacting the detection antibody, with which the marker generating a detectable signal is combined, with a reference substance which is bound to a surface of a solid substrate and which includes an epitope to which the detection antibody specifically binds; (d) measuring signals generated from the markers of the resultant product of step (b) and the resultant product of step (c); and (e) analyzing the measured signals to determine the presence or absence and amount of the antigen in the analysis sample. The method for detecting an antigen of the present invention can control the flow and the reaction time of an analysis sample, thereby improving sensitivity and minimizing the influences by the concentration of the analysis sample or the temperature of the detection reaction, and thus improving stability, reliability, and reproducibility of data, when compared with the conventional method for detecting an antigen. Accordingly, the method and apparatus for detecting an antigen of the present invention can be easily operated without specialized skills, thereby instantly obtaining the presence or absence and amount of detection antigen in the analysis sample through on-site diagnosis.

公开(公告)号：US20150253561A1

公开(公告)日：2015-09-10

申请号：US14425333

申请日：2013-09-05

申请人： NANOENTEK, INC.

发明人： Jae-Hwa Lee ,  Sang-Hwa Ahn

IPC分类号： G02B21/36 ,  G02B21/04 ,  G02B21/08

CPC分类号： G02B21/365 ,  G02B21/04 ,  G02B21/08 ,  G02B21/24 ,  G02B21/361

摘要： Disclosed is a microscope and a method of controlling the same. According to the one or more of the embodiments of the present inventions relating to the microscope, an optical module for observing cells may be separated from a control module to be disposed in a narrow space such as the inside of an incubator or the inside of a clean bench, and is capable of observing cells while measuring a distribution of the cells (confluence) in a predetermined cycle.

摘要翻译： 公开了一种显微镜及其控制方法。 根据与显微镜相关的本发明的一个或多个实施例，用于观察细胞的光学模块可以与控制模块分离以设置在诸如孵化器内部或内部的狭窄空间中 并且能够在以预定的周期测量细胞分布（汇合）的同时观察细胞。

公开(公告)号：US20150101422A1

公开(公告)日：2015-04-16

申请号：US14401140

申请日：2013-05-14

申请人： NANOENTEK, INC.

发明人： Dae Sung Hur ,  Jae Jeong Kim ,  Yu Rae Kim

IPC分类号： G01N1/00 ,  G01N33/48

CPC分类号： G01N1/00 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/089 ,  B01L2400/086 ,  G01N33/48 ,  G01N35/08 ,  G01N2001/002

摘要： The present invention relates to a sample analyzing chip. The chip can prevent upper and lower substrates of a channel from being attached to each other due to deflection on a micro channel and can solve the problem of the sample drying up within a measuring time of a target. Also, the chip can prevent bubbles from being generated in a central portion of the micro channel.

摘要翻译： 本发明涉及一种样品分析芯片。 该芯片可以防止通道上的上下基板由于微通道上的偏转而彼此附接，并且可以在目标的测量时间内解决样品干燥的问题。 此外，芯片可以防止在微通道的中心部分产生气泡。