公开(公告)号：US20190240594A1

公开(公告)日：2019-08-08

申请号：US16267579

申请日：2019-02-05

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： R. KENNETH MARCUS ,  TERRI F. BRUCE ,  LEI WANG ,  SISI HUANG ,  TYLER Y. SLONECKI ,  RHONDA REIGERS POWELL

IPC: B01D15/32 ,  G01N33/50 ,  G01N1/40

CPC classification number: B01D15/327 ,  A61K35/68 ,  B01J20/262 ,  B01J20/28023 ,  B01J20/285 ,  B01J20/286 ,  B01J2220/54 ,  C07K14/47 ,  G01N1/405 ,  G01N33/5005

Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)

公开(公告)号：US10026962B2

公开(公告)日：2018-07-17

申请号：US14150374

申请日：2014-01-08

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION ,  GEORGIA TECH RESEARCH CORPORATION

Inventor： Gleb Yushin ,  Igor Luzinov ,  Bogdan Zdyrko ,  Oleksandr Magazynskyy ,  Igor Kovalenko

IPC: H01M4/62 ,  H01M4/133 ,  H01M4/134 ,  H01M2/16

Abstract: A silicon-based anode comprises an alginate-containing binder. The many carboxy groups of alginate bind to a surface of silicon, creating strong, rigid hydrogen bonds that withstand battery cycling. The alginate-containing binder provides good performance to the anode by (1) improving the capacity of the anode in comparison to other commercially-available binders, (2) improving Columbonic efficiency during charging and discharging cycles, and (3) improving stability during charging and discharging cycles.

公开(公告)号：US20170369847A1

公开(公告)日：2017-12-28

申请号：US15543701

申请日：2016-01-15

Applicant: Clemson University Research Foundation ,  MUSC Foundation for Research Development ,  The University of Chicago

Inventor： Ying Mei ,  Tan Yu ,  Dylan Richards ,  Donald R. Menick ,  Bozhi Tian

IPC: C12N5/077 ,  A61K35/34 ,  G01N33/50 ,  A61L27/30 ,  A61L27/38

CPC classification number: C12N5/0657 ,  A61K35/34 ,  A61L27/306 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/3886 ,  A61L2400/12 ,  A61L2430/20 ,  C12N2503/02 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/10 ,  G01N33/5061

Abstract: Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.

公开(公告)号：US20170258457A1

公开(公告)日：2017-09-14

申请号：US15352108

申请日：2016-11-15

Applicant: Clemson University Research Foundation

Inventor： Heather W. Dunn ,  Kathryn A. Elliott ,  Thomas R. Scott ,  Matthew Burns

IPC: A61B10/02 ,  C12Q1/68

CPC classification number: A61B10/0233 ,  A61B2010/0208 ,  A61B2503/40 ,  C12Q1/6806

Abstract: A method for correlation attributes of mature mammals tissue to pre-pubescent mammals is provided. The method comprises providing a biopsy needle with a bore diameter of at least 0.9081 mm (20 gauge) to less than 2.413 mm (13 gauge) with a specimen notch, of at least 2 mm to no more than 16 mm; inserting the needle into said mammalian tissue of a pre-pubescent living mammal and extracting a sample tissue.

公开(公告)号：US20170164929A1

公开(公告)日：2017-06-15

申请号：US15441845

申请日：2017-02-24

Applicant: Clemson University Research Foundation

Inventor： David Kwartowitz ,  Erika Trent ,  Fuad Mefleh ,  Vipul Pai Raikar ,  Delphine Dean

IPC: A61B8/08 ,  A61B8/00 ,  A61B6/00

CPC classification number: A61B8/485 ,  A61B6/463 ,  A61B8/0875 ,  A61B8/4209 ,  A61B8/429 ,  A61B8/5223

Abstract: Adaptors for ultrasound probes can have an adaptor body can have an open lower end that allows a distal end of the ultrasound probe to extend therethrough to contact skin of a patient. The adaptor can include a plurality of spaced apart resilient members held by the adaptor body that, in operation, are able to change in length such that the resilient members translate from a first longer length to a second shorter length when the probe applies compressive force to the target tissue.

公开(公告)号：US20160289495A1

公开(公告)日：2016-10-06

申请号：US15037214

申请日：2014-08-06

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Marek W. Urban ,  Ying Yang

IPC: C09D175/08 ,  C09D5/00 ,  C08G18/40 ,  C08G18/24 ,  C08B37/08 ,  C08G18/72

CPC classification number: C09D175/08 ,  C08B11/02 ,  C08B37/00 ,  C08B37/003 ,  C08B37/0045 ,  C08B37/0075 ,  C08G18/242 ,  C08G18/3215 ,  C08G18/4081 ,  C08G18/4833 ,  C08G18/6484 ,  C08G18/72 ,  C09D5/00 ,  C09D175/04

Abstract: The present invention provides alkyl substituted polysaccharide compositions and methods of repairing substrates involving use of the alkyl substituted polysaccharide compositions.

Abstract translation: 本发明提供烷基取代多糖组合物和修复涉及使用烷基取代多糖组合物的底物的方法。

公开(公告)号：US20160046964A1

公开(公告)日：2016-02-18

申请号：US14844654

申请日：2015-09-03

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： Brian Keith Ward

IPC: C12P3/00

CPC classification number: C12P3/00

Abstract: Disclosed are methods for forming ammonia and ammonium that can be utilized in certifiably organic farming productions according to most if not all known certification standards. Also disclosed are bioreactors that can be utilized in carrying out disclosed methods. Methods and systems utilize obligate anaerobic bacteria to breakdown organic protein substrates, i.e., compounds containing bound nitrogen, to provide nitrogen in an unbound plant available form, and particularly, ammonia and/or ammonium. Obligate anaerobic bacteria include high ammonia producing bacteria such as Peptostreptococcus anaerobius, Clostridium sticklandii, and Clostridium aminophilum.

Abstract translation: 公开了用于形成氨和铵的方法，其可以根据大多数（即使不是所有已知的认证标准）可用于有机农业生产。 还公开了可用于实施公开的方法的生物反应器。 方法和系统利用专性厌氧细菌来分解有机蛋白质底物，即含有结合氮的化合物，以提供未结合植物可利用形式的氮，特别是氨和/或铵。 有义务的厌氧菌包括高产氨菌，如消化不良链球菌（Clotostreptococcus anaerobius），粘菌芽孢杆菌（Clostridium sticklandii）和氨基梭菌（Clostridium aminophilum）。

公开(公告)号：US20150265409A1

公开(公告)日：2015-09-24

申请号：US14730984

申请日：2015-06-04

Applicant: Clemson University Research Foundation ,  University of South Carolina ,  Kim John Chillag

Inventor： Eric Montgomery Lucas ,  John David DesJardins ,  Kim John Chillag ,  Frank Richard Voss

IPC: A61F2/38

CPC classification number: A61F2/3845 ,  A61F2/30 ,  A61F2/32 ,  A61F2/3804 ,  A61F2/3836 ,  A61F2/384 ,  A61F2/385 ,  A61F2/40 ,  A61F2/42 ,  A61F2/4202 ,  A61F2/4261 ,  A61F2002/30079 ,  A61F2002/30329 ,  A61F2002/30492 ,  A61F2002/30565 ,  A61F2002/30607 ,  A61F2002/30622 ,  A61F2002/30632 ,  A61F2002/30668 ,  A61F2002/3813 ,  A61F2002/482 ,  A61F2250/0006 ,  A61F2250/0008 ,  A61F2250/0073

Abstract: Total knee replacements for hinged knee implants include a tibial member, a femoral member, a hinge assembly having a laterally extending axle configured to hingedly attach the femoral member to the tibial member, and a lock mechanism in communication with the hinge assembly. The lock mechanism is configured to (i) lock the femoral member in alignment with the tibial member for a full extension or other defined stabile walking configuration to thereby allow an arthrodesis or stiff knee gait and (ii) unlock to allow the femoral and tibial members to pivot relative to each other for flexion or bending when not ambulating.

Abstract translation: 用于铰接膝盖植入物的全膝关节置换包括胫骨构件，股骨构件，具有被构造成将股骨构件铰接地附接到胫骨构件的横向延伸的轴的铰链组件，以及与铰链组件连通的锁定机构。 锁定机构构造成（i）锁定股骨构件与胫骨构件对准以用于完全延伸或其他限定的稳定行走构型，从而允许关节固定术或僵硬的膝盖步态，并且（ii）解锁以允许股骨和胫骨构件 相对于彼此枢转以在不行走时弯曲或弯曲。

公开(公告)号：US20250163437A1

公开(公告)日：2025-05-22

申请号：US18949053

申请日：2024-11-15

Applicant: Clemson University Research Foundation

Inventor： Andrei Alexandrov ,  Rui Che ,  Bhoomi Mirani ,  Monireh Mohammadpanah

IPC: C12N15/66 ,  C12N15/10 ,  C12N15/85

Abstract: This invention is directed to methods and compositions for bacteria-free preparation, assembly and expression of heterologous products in eukaryotic cells, including an in vitro method for joining ends of one or more linear double-stranded nucleic acid molecules to form a circular double-stranded nucleic acid construct for use in transfection, electroporation, nucleofection, and/or other form of delivery of the circular nucleic acid construct into a eukaryotic cell, as well as methods for making and compositions comprising the nucleic acid molecules and nucleic acid constructs for use in the methods disclosed herein.

公开(公告)号：US20250147732A1

公开(公告)日：2025-05-08

申请号：US18500670

申请日：2023-11-02

Applicant: Regents of the University of Minnesota ,  Clemson University Research Foundation

Inventor： Keshab K. Parhi ,  Weihang Tan ,  Sin-Wei Chiu ,  Antian Wang ,  Yingjie Lao

IPC: G06F7/72 ,  G06F17/14

Abstract: A method comprises receiving a modulus for a number-theoretic transform of a polynomial and selecting a plurality of prime moduli whose product forms the modulus for the number-theoretic transform, wherein the plurality of prime moduli are selected by giving preference to prime moduli having fewer ones in a binary representation of the prime moduli. For each prime modulus in the plurality of prime moduli: dividing a coefficient of the polynomial into segments and performing modular reduction of the segments relative to the prime modulus. Performing the modular reduction of at least one segment comprises implementing a multiplication of a value by a modular reduction of a base value relative to the prime modulus using a shift-add-unit having a smaller area requirement than a modular multiplier. A modular reduction of the coefficient relative to the prime modulus is determined based on the modular reductions of the segments.