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    USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI
    21.
    发明申请
    USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI 审中-公开
    用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的药物的用途和方法

    公开(公告)号：US20100047190A1

    公开(公告)日：2010-02-25

    申请号：US12519451

    申请日：2007-12-18

    Applicant: Andreas Reindl ,  Christine Lang ,  Mewes Boettner ,  Markus Veen

    Inventor： Andreas Reindl ,  Christine Lang ,  Mewes Boettner ,  Markus Veen

    IPC: A61K9/68 ,  A61K8/99 ,  A61Q11/00

    CPC classification number: C12N1/20 ,  A23G3/366 ,  A23G4/123 ,  A23L33/135 ,  A61K8/99 ,  A61K35/747 ,  A61Q11/00 ,  C12R1/225

    Abstract: The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.

    Abstract translation: 本发明涉及属于乳酸菌群或其突变体或衍生物的微生物的用途，其特征在于能够特异性结合属于变形链球菌链球菌属的细菌，其中特异性结合是 （i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成，用于制备用于治疗或预防由变形链球菌变异链球菌变异链球菌引起的龋齿的抗焦虑性组合物。 优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变种链球菌属组的细菌混合; （c）在允许形成所述微生物的聚集体和变种链球菌组的细菌的条件下温育步骤（b）中获得的混合物; 和（d）通过颗粒的发生检测聚集体。 本发明的另一方面是预防或治疗由变形链球菌变形链球菌以外的变形链球菌引起的龋齿的方法，包括给予属于所述乳酸菌群的微生物，其特征在于，所述微生物能够特异性结合属于 变体链球菌或所述微生物的突变体，衍生物，类似物或片段。

    Means and Methods for Preventing and/or Treating Caries
    25.
    发明申请
    Means and Methods for Preventing and/or Treating Caries 有权
    预防和/或治疗龋齿的方法和方法

    公开(公告)号：US20080193427A1

    公开(公告)日：2008-08-14

    申请号：US11662347

    申请日：2005-09-09

    Applicant: Bruno Kaesler ,  Rolf Knoll ,  Mewes Boettner ,  Eckhard Budde ,  Christine Lang ,  Martin Ryser ,  Markus Veen

    Inventor： Bruno Kaesler ,  Rolf Knoll ,  Mewes Boettner ,  Eckhard Budde ,  Christine Lang ,  Martin Ryser ,  Markus Veen

    IPC: A61K35/74 ,  C12N1/20 ,  A61Q11/00 ,  A61P43/00

    CPC classification number: A61K8/99 ,  A23G3/366 ,  A23G4/123 ,  A23K50/10 ,  A23K50/30 ,  A23K50/40 ,  A23K50/50 ,  A23K50/70 ,  A23K50/75 ,  A23K50/80 ,  A23L7/10 ,  A23L33/135 ,  A23V2002/00 ,  A23Y2220/63 ,  A23Y2220/73 ,  A23Y2240/49 ,  A61K8/0216 ,  A61K8/042 ,  A61K8/60 ,  A61K35/747 ,  A61Q11/00 ,  C12N1/20 ,  C12R1/225 ,  A23V2200/312 ,  A23V2200/3204

    Abstract: The present invention relates to a microorganism belonging to the group of lactic acid bacteria characterized in that it is capable of specifically binding to Streptococcus mutans, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with Streptococcus mutans which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and Streptococcus mutans and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is an analog or fragment of said microorganism which is thermally inactivated or lyophilized, wherein said analog or fragment retains the capability of specifically binding to Streptococcus mutans. In addition, the present invention encompasses compositions and additives for food, feed or drinks comprising the microorganism belonging to the group of lactic acid bacteria which specifically bind to Streptococcus mutans or an analog or fragment thereof. Moreover, uses of said microorganism or said analog or fragment thereof for the preparation of an anticariogenic or pharmaceutical composition or anticariogenic food or feedstuff as well as methods for producing said compositions or food or feedstuff are provided by the present invention.

    Abstract translation: 本发明涉及属于该乳酸菌群的微生物，其特征在于能够特异性结合变形链球菌，其特异性结合是（i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成。 优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变形链球菌混合; （c）在允许形成所述微生物和变形链球菌的聚集体的条件下培养步骤（b）中获得的混合物，和（d）通过颗粒的发生检测聚集体。 本发明的另一方面是所述微生物的类似物或片段，其被热灭活或冻干，其中所述类似物或片段保留特异性结合变形链球菌的能力。 此外，本发明包括用于食品，饲料或饮料的组合物和添加剂，其包含特异性结合变形链球菌的乳酸菌群的微生物或其类似物或片段。 此外，本发明提供了所述微生物或其所述类似物或其片段用于制备抗焦虑药物或药物组合物或抗癌食品或饲料的用途，以及用于生产所述组合物或食物或饲料的方法。

    Method for the production of zymosterol and/or the biosynthetic intermediate and/or subsequent products thereof in transgenic organisms
    26.
    发明申请
    Method for the production of zymosterol and/or the biosynthetic intermediate and/or subsequent products thereof in transgenic organisms 审中-公开
    用于在转基因生物体中生产季戊四醇和/或生物合成中间体和/或其后续产物的方法

    公开(公告)号：US20060088903A1

    公开(公告)日：2006-04-27

    申请号：US10503253

    申请日：2003-01-22

    Applicant: Christine Lang ,  Markus Veen

    Inventor： Christine Lang ,  Markus Veen

    IPC: C12P33/00 ,  A01H1/00 ,  C12N1/18 ,  C12N1/21

    CPC classification number: C12P5/007 ,  C12N15/52 ,  C12N15/81 ,  C12P7/02 ,  C12P7/04 ,  C12P33/00

    Abstract: The present invention relates to a method for preparing zymosterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts, which, compared to the wild type, have an increased lanosterol-C14-demethylase activity and increased HMG-CoA-reductase activity, to the nucleic acid constructs required for preparing the genetically modified organisms and to the genetically modified organisms themselves, in particular yeasts.

    Abstract translation: 本发明涉及通过培养与野生型相比具有增加的羊毛甾醇-C14-脱甲基酶活性和增加的HMG的生物体，特别是酵母来制备季戊四醇和/或其生物合成中间体和/或其次级产物的方法 -CoA还原酶活性，对于制备转基因生物体和转基因生物本身，特别是酵母所需的核酸构建体。

    USE AND METHODS FOR PREVENTING AND/OR TREATING ORAL MALODOUR
    29.
    发明申请
    USE AND METHODS FOR PREVENTING AND/OR TREATING ORAL MALODOUR 有权
    用于预防和/或治疗口腔恶性肿瘤的用途和方法

    公开(公告)号：US20110097284A1

    公开(公告)日：2011-04-28

    申请号：US12997035

    申请日：2009-05-19

    Applicant: Mewes Böttner ,  Christine Lang ,  Markus Veen ,  Michael Schilling ,  Andreas Reindl

    Inventor： Mewes Böttner ,  Christine Lang ,  Markus Veen ,  Michael Schilling ,  Andreas Reindl

    IPC: A61K9/68 ,  C12N1/20 ,  A61K8/99 ,  A61P1/02

    CPC classification number: C12R1/23 ,  A61K8/99 ,  A61Q11/00

    Abstract: Described is a microorganism belonging to the group of lactic acid bacteria which is able to drastically reduce the peptide concentration in saliva thereby depleting the substrate used by anaerobic microorganisms of the oral micro-flora which are the causative agent for oral malodour. Moreover, described is a microorganism belonging to the group of lactic acid bacteria which is able to stimulate the growth of Streptococcus salivarius but does not stimulate the growth of Streptococcus mutans and/or Porphyromonas gingivalis. Also described are compositions containing the above-mentioned microorganisms, their use for preventing and/or treating oral malodour and/or halitosis and to methods for preventing and/or treating oral malodour and/or halitosis.

    Abstract translation: 描述了属于乳酸菌群的微生物，其能够显着降低唾液中的肽浓度，从而消耗作为口腔恶臭致病因子的口腔微生物群的厌氧微生物所使用的底物。 此外，描述了属于乳酸菌群的微生物，其能够刺激唾液链球菌的生长，但不刺激变形链球菌和/或牙龈卟啉单胞菌的生长。 还描述了含有上述微生物的组合物，其用于预防和/或治疗口腔恶臭和/或口臭的用途，以及用于预防和/或治疗口腔恶臭和/或口臭的方法。

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