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公开(公告)号：US20240085363A1
公开(公告)日：2024-03-14
申请号：US18388179
申请日：2023-11-08
Applicant: Trustees of Dartmouth College
Inventor： Katherine A. Mirica , Lukasz K. Mendecki , Michael Ko , Zheng Meng , Robert M. Stolz , Aileen Eagleton
IPC: G01N27/327 , C07F1/08 , C07F15/00 , C07F15/04 , C07F15/06
CPC classification number: G01N27/3278 , C07F1/08 , C07F15/006 , C07F15/04 , C07F15/06 , G01N27/3277 , B82Y30/00
Abstract: In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.
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公开(公告)号：US11924573B2
公开(公告)日：2024-03-05
申请号：US16085847
申请日：2017-03-15
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Eric R. Fossum , Saleh Masoodian
CPC classification number: H04N25/79 , H01L27/00 , H01L27/14621 , H01L27/14627 , H01L27/14634 , H01L27/14636 , H01L27/1464 , H01L27/14645 , H01L28/00 , H04N25/75 , H04N25/77
Abstract: Some embodiments provide a Quanta Image Sensor (QIS) comprising 3D vertically-stacked photosensor array and readout circuitry. In some embodiments, an imaging array comprises a plurality of single-bit or multi-bit jots, and readout circuitry in electrical communication with the imaging array and configured to quantize, for each jot, an analog signal corresponding to the electrical signal of the jot, wherein the imaging system is configured as a 3D vertically integrated circuit with the imaging array stacked vertically above the readout circuitry. The imaging array may be configured as an array of clusters with respect to the readout circuitry, each cluster configured as an array of n by m jots. The imaging array may include a further image processing circuitry layer disposed below the readout circuitry layer. Neighboring layers may be implemented on separate substrates and/or in a common substrate.
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公开(公告)号：US20240067927A1
公开(公告)日：2024-02-29
申请号：US18492221
申请日：2023-10-23
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Charles L. Sentman
IPC: C12N5/0783 , A61K35/17 , A61K39/00
CPC classification number: C12N5/0636 , A61K35/17 , A61K39/0011 , A61K2035/124 , A61K2039/5156 , A61K2039/585 , C12N2501/515 , C12N2511/00
Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
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24.发明公开公开(公告)号：US20240000316A1
公开(公告)日：2024-01-04
申请号：US18229086
申请日：2023-08-01
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Petr BRUZA , Brian POGUE
CPC classification number: A61B5/0071 , A61B5/7425 , G01N21/645 , A61B2560/0233 , A61B2576/00 , G01N2021/6471
Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter device is between the tissue and the electronic camera with fluorescent imaging and stimulus wavelength settings. an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue. Then image processor derives a fluorescence lifetime signal from the received temporal fluorescence signals and derives from these fluorescence lifetime signals biochemical property images of the tissue.
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公开(公告)号：US11857837B2
公开(公告)日：2024-01-02
申请号：US17055412
申请日：2019-05-17
Applicant: Trustees of Dartmouth College
Inventor： Emily Wechsler , Ryan Halter , John A. Batsis
IPC: A63B24/00 , A63B21/00 , A63B21/055
CPC classification number: A63B24/0062 , A63B21/00043 , A63B21/0552 , A63B21/4035 , A63B2220/17 , A63B2220/51 , A63B2220/62 , A63B2220/833 , A63B2225/50
Abstract: Devices and methods are disclosed for remote clinical monitoring performance of exercises using an instrumented resistance device (100). An example device (100) includes a resistance band (120) having a first end (122) and a second end (124). A first handle (130) connected to the first end (122) and a second handle (140) connected to the second end (124) of the resistance band (120). The device (100) further includes a force sensing assembly (150) positioned between the first handle (130) and the first end (122). The force sensing assembly (150) includes a force sensor (156) connected to the resistance band (120), a microcontroller (182) connected to the force sensor (156) to receive a set of load force measurements from the force sensor (156), and a communication module (184) connected to the microcontroller (182) to transmit the set of load force measurements to a local data receiving device (170).
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Patent Agency Ranking
26.发明授权公开(公告)号：US11857571B2
公开(公告)日：2024-01-02
申请号：US16994795
申请日：2020-08-17
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Charles Sentman , Michael Battles
CPC classification number: A61K35/17 , A61K47/6835 , A61K51/1045 , A61K51/1096 , A61P35/00 , C07K16/2809 , C07K16/2833 , C07K16/2851 , A61K2039/505 , C07K2317/31 , C07K2317/622 , C07K2319/03
Abstract: Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders associated with MICA and/or MICB expression are provided.
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公开(公告)号：US11856408B2
公开(公告)日：2023-12-26
申请号：US17514245
申请日：2021-10-29
Applicant: Trustees of Dartmouth College
Inventor： Timothy J. Pierson , Jonathan F. Alter
IPC: H04L29/06 , H04W12/50 , H04W76/10 , H04B17/318 , H04L43/16 , H04W12/06 , H04L9/32 , H04W12/041 , G16Y30/10
CPC classification number: H04W12/50 , G16Y30/10 , H04B17/318 , H04L9/3236 , H04L43/16 , H04W12/041 , H04W12/06 , H04W76/10 , H04L2209/80
Abstract: Methods of pairing devices wirelessly that include matching received-signal-strength information regarding signal-strength patterns received by differing devices desired to be paired. In some embodiments, signal-strength patterns are based on a user moving an object so as to intentionally create multipath Fresnel-zone propagation disturbances. During pairing, the devices exchange their received-signal-strength information with one another and compare the received-signal-strength information that they receive from another device to the received-signal-strength information that they generated themselves based on the multipath Fresnel-zone propagation disturbances. When the two sets of receive-signal-strength information substantially match one another, the devices determine the presence of a trusted relationship. Methods for assisting with the wireless pairing are also disclosed. Disclosed methods can be encoded in software/firmware, and such software/firmware can be stored in devices desired to include disclosed wireless pairing functionality.
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公开(公告)号：US11852605B2
公开(公告)日：2023-12-26
申请号：US17252003
申请日：2019-06-21
Applicant: Trustees of Dartmouth College
Inventor： Katherine A. Mirica , Lukasz K. Mendecki , Michael Ko , Zheng Meng , Robert M. Stolz , Aileen Eagleton
CPC classification number: G01N27/3278 , C07F1/08 , C07F15/006 , C07F15/04 , C07F15/06 , G01N27/3277 , B82Y30/00 , B82Y35/00 , B82Y40/00 , G01N2333/575
Abstract: In some embodiments, the present disclosure pertains to methods of detecting an analyte in a sample by associating the sample with an electrode that includes a metal-organic framework. After association, the redox properties of the electrode are evaluated. Thereafter, the presence or absence of the analyte in the sample is detected by correlating the redox properties of the electrode to the presence or absence of the analyte. In some embodiments, the present disclosure pertains to electrodes that include a metal-organic framework and an electrode surface. In particular embodiments of the present disclosure, the metal-organic framework is associated with the electrode surface. Additional embodiments of the present disclosure pertain to methods of making the electrodes of the present disclosure by associating a metal-organic framework with an electrode surface. In some embodiments, the methods of the present disclosure also include a step of mixing the metal-organic framework with a polymer.
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公开(公告)号：US11814527B2
公开(公告)日：2023-11-14
申请号：US16605651
申请日：2018-04-27
Applicant: Trustees of Dartmouth College
Inventor： Chenfeng Ke , Pengfei Zhang , Longyu Li , Qianming Lin
IPC: C09D11/102 , B33Y70/00 , B29C64/314 , B33Y40/10 , B33Y10/00 , B33Y80/00 , B29C64/106 , B29K105/00
CPC classification number: C09D11/102 , B29C64/314 , B33Y40/10 , B33Y70/00 , B29C64/106 , B29K2105/0061 , B33Y10/00 , B33Y80/00
Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.
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30.发明授权公开(公告)号：US11808763B2
公开(公告)日：2023-11-07
申请号：US16492128
申请日：2018-03-07
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Amogha Tadimety , John X. J. Zhang
IPC: G01N33/543 , G01N21/552 , G01N33/553 , B82Y15/00 , B82Y30/00
CPC classification number: G01N33/54373 , G01N21/554 , G01N33/54346 , G01N33/553 , B82Y15/00 , B82Y30/00
Abstract: A method of making a plasmon-resonance biosensor includes conjugating precious metal nanorods with form factor at least 1.5 with a biological probe material. Microfluidic chambers of volume under 0.025 microliter are formed over a substrate, and an aqueous suspension of the conjugated nanorods is injected into the chambers. The nanorods are organized in rows and aligned in long dimension along the rows. The biosensor is configured to be read by obtaining an optical absorption spectrum upon exposure to the analyte. The biosensor includes precious metal nanorods organized in rows with long dimension approximately parallel to the rows. The nanorods are conjugated with biological probes capable of binding to an analyte, the probes may be an aptamer, an antibody, a protein-nucleic acid (PNA), a complimentary DNA, or an enzyme having a binding site.
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