公开(公告)号：US08546750B2

公开(公告)日：2013-10-01

申请号：US12163030

申请日：2008-06-27

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/00

CPC classification number: H01J49/0422 ,  H01J49/04 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/06 ,  H01J49/26 ,  Y10T436/24

Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.

公开(公告)号：US07868289B2

公开(公告)日：2011-01-11

申请号：US11742203

申请日：2007-04-30

Applicant: Lisa Cousins ,  Gholamreza Javahery ,  Ilia Tomski

Inventor： Lisa Cousins ,  Gholamreza Javahery ,  Ilia Tomski

IPC: H01J49/42

CPC classification number: H01J49/063

Abstract: An ion guide includes a plurality of rods, arranged about an axis that extends lengthwise from one end to the other of the guide. The rods guide ions in a guide region along and about the axis. A conductive casing surrounds the rods. The casing and the rods are geometrically arranged to produce an axial electric field along the axis. Specifically, the geometry is such that a first constant applied DC voltage (UDC), applied to the rods, and a second constant applied DC voltage (UCASE) applied to the casing, produce a voltage gradient between said casing and said axis that has a different magnitude at different positions along said axis.

Abstract translation: 离子导向器包括多个杆，其围绕从引导件的一端到另一端纵向延伸的轴线布置。 杆沿引导区域沿轴线引导离子。 导电套管围绕着棒。 壳体和杆几何地布置成沿轴线产生轴向电场。 具体地，几何形状使得施加到杆的第一恒定施加的DC电压（UDC）和施加到壳体的第二恒定施加的DC电压（UCASE）在所述壳体和所述轴线之间产生电压梯度，所述电压梯度具有 沿着所述轴的不同位置处的不同大小。

公开(公告)号：US07858926B1

公开(公告)日：2010-12-28

申请号：US11409169

申请日：2006-04-21

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins

IPC: H01J49/24 ,  H01J49/40

CPC classification number: H01J49/4225 ,  H01J49/004 ,  H01J49/063

Abstract: A mass spectrometer includes an ion source and at least one vacuum stage, a means for delivering ions from the ion source to the vacuum stage, a collision cell, a detector, at least two multipole ion guide segments, and independent RF frequency and DC voltage sources applied to the multipole ion guide segments, the RF frequency and DC voltage sources being controlled independently of each other.

Abstract translation: 质谱仪包括离子源和至少一个真空级，用于将离子从离子源输送到真空级的装置，碰撞池，检测器，至少两个多极离子导向段以及独立的RF频率和DC电压 施加到多极离子导向段的源，RF频率和DC电压源彼此独立地控制。

公开(公告)号：US20100148059A1

公开(公告)日：2010-06-17

申请号：US12656701

申请日：2010-02-12

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

IPC: H01J49/26

CPC classification number: G01N30/7233 ,  H01J49/04 ,  H01J49/067 ,  H01J49/107

Abstract: An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.

Abstract translation: 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。

公开(公告)号：US07659505B2

公开(公告)日：2010-02-09

申请号：US12024752

申请日：2008-02-01

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Serguei Savtchenko

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Serguei Savtchenko

IPC: H01J49/26 ,  H01J49/10 ,  B01D59/44

CPC classification number: H01J49/10 ,  H01J49/24 ,  Y10S438/961

Abstract: An ion source and method for providing ionized particles to a molecular/atomic analyser, such as a mass spectrometer, are disclosed. The ion source includes a vessel defining a channel; a gas inlet extending from the gas source into the channel, for introducing a gas flow into the channel; a sample inlet extending into the channel for introducing sample within the channel; and an ionizer to ionize the sample in the channel. The vessel is sufficiently sealed to allow the channel to be pressurized, at a pressure in excess of 100 Torr. At least one gas source maintains the pressure of the channel at a pressure in excess of 100 Torr and the pressure exterior to the channel at a pressure in excess of 0.1 Torr and provides a gas flow that sweeps across the ionizer to guide and entrain ions from the ionizer to the outlet.

Abstract translation: 公开了用于向分子/原子分析仪（例如质谱仪）提供离子化颗粒的离子源和方法。 离子源包括限定通道的容器; 从气体源延伸到通道中的气体入口，用于将气流引入通道中; 延伸到通道中的样品入口，用于将样品引入通道内; 以及电离器，用于使通道中的样品电离。 容器被充分密封，以允许通道在超过100托的压力下被加压。 至少一个气体源将通道的压力保持在超过100托的压力和在超过0.1托的压力下的通道外部的压力，并提供扫过电离器以引导和夹带离子的气流 电离器到出口。

公开(公告)号：US20090218484A1

公开(公告)日：2009-09-03

申请号：US12437203

申请日：2009-05-07

Applicant: Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe ,  Ilia Tomski

Inventor： Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe ,  Ilia Tomski

IPC: B01D59/44

CPC classification number: H01J49/066

Abstract: An ion guide includes multiple stages. An electric field within each stage guides ions along a guide axis. Within each stage, amplitude and frequency, and resolving potential of the electric field may be independently varied. The geometry of the rods maintains a similarly shaped field from stage to stage, allowing efficient guidance of the ions along the axis. In particular, each rod segment of the ith of stage has a cross sectional radius ri, and a central axis located a distance Ri+ri from the guide axis. The ratio ri/Ri and is substantially constant along the guide axis, thereby preserving the shape of the field.

Abstract translation: 离子导向器包括多个阶段。 每个阶段内的电场沿引导轴引导离子。 在每个阶段内，可以独立地改变振幅和频率以及电场的分辨能力。 杆的几何形状保持了从阶段到阶段的类似形状的场，允许离子沿轴线的有效引导。 特别地，平台的第i个的每个杆段具有横截面半径ri，并且中心轴线定位于与引导轴线的距离Ri + ri。 比率ri / Ri并且沿引导轴线基本上恒定，从而保持场的形状。

公开(公告)号：US20070181800A1

公开(公告)日：2007-08-09

申请号：US11652649

申请日：2007-01-12

Applicant: Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

Inventor： Charles Jolliffe ,  Gholamreza Javahery ,  Lisa Cousins ,  Ilia Tomski

IPC: H01J49/00

CPC classification number: G01N30/7233 ,  H01J49/04 ,  H01J49/067 ,  H01J49/107

Abstract: An interface for mass spectrometers. The interface uses non coaxial sampling pathways of the analyte ion beam prior to entering the entrance of a mass spectrometer for decreasing chemical background, and can be done in such a way as to permit multiple sprayers, increasing sample throughput and sensitivity for LC/MS (liquid chromatography/MS). The interface includes an ion source having an exit from which a beam of analyte ions are emitted, a curtain plate and an aperture in the curtain plate member, an orifice plate having an orifice therein. The orifice plate is being spaced from the curtain plate member defining a flow passageway therebetween, and the aperture in the orifice plate is aligned with a sample entrance to a first vacuum stage of a mass spectrometer maintained substantially lower than atmospheric pressure. The aperture in the curtain plate member is non coaxially aligned with the orifice in the orifice plate and the interface includes a gas flow mechanism for directing a counter flow gas into the flow passageway.

Abstract translation: 质谱仪界面。 在进入质谱仪入口以减少化学背景之前，界面使用分析物离子束的非同轴取样路径，并且可以以允许多个喷雾器，增加LC / MS的样品通量和灵敏度的方式进行 液相色谱/质谱）。 该界面包括离子源，其具有从其分离的离子束射出的出口，帘板和帘板构件中的孔，其中具有孔口的孔板。 孔板与限定其间的流动通道的帘板构件间隔开，并且孔板中的孔与进入维持在基本上低于大气压的质谱仪的第一真空级的样品入口对准。 帘板构件中的孔与孔板中的孔不同轴地对准，并且界面包括用于将逆流气体引导到流动通道中的气流机构。

公开(公告)号：US09048076B2

公开(公告)日：2015-06-02

申请号：US14122534

申请日：2012-05-25

Applicant: William R. Stott ,  Gholamreza Javahery

Inventor： William R. Stott ,  Gholamreza Javahery

IPC: H01J49/04 ,  H01J49/00 ,  G01N1/22 ,  G01N1/24 ,  H01J49/02 ,  G01N1/02

CPC classification number: H01J49/0459 ,  G01N1/22 ,  G01N1/24 ,  G01N2001/022 ,  G01N2001/024 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04

Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapor molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.

Abstract translation: 公开了用于在不接触受试者的情况下检测被检物体上的目标物质的方法和装置。 至少一个空气喷射器将被分析物从受试者的表面吹入气流，夹带分析物的气流。 解吸通道在通过解吸通道行进的气流的一部分中从分析物解吸分子。 电离器在气流的一部分形成来自蒸气分子的离子。 至少一个质谱仪分析离子以检测目标物质。 该流动不间断地从受试者移动到至少一个质谱仪。 解吸通道导致足够数量的分子从分析物解吸，使得至少一个质谱仪能够检测目标物质。

公开(公告)号：US08334507B1

公开(公告)日：2012-12-18

申请号：US11435034

申请日：2006-05-16

Applicant: Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

Inventor： Craig M. Whitehouse ,  David G. Welkie ,  Gholamreza Javahery ,  Lisa Cousins ,  Sergey Rakov

IPC: H01J49/42 ,  H01J49/26 ,  B01D59/44

CPC classification number: H01J49/147 ,  H01J49/0054

Abstract: Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.

Abstract translation: 提供了能够使低能电子和正电子与样品离子相互作用的装置和方法，以便分别在多极离子导向结构内的电子俘获解离（ECD）和正电子俘获解离（PCD）。 最近已经发现，许多生物分子通过ECD的质子化离子的碎裂通常沿着不被其它解离方法接近的断裂途径进行，导致分子结构信息不容易获得。 然而，这种分析仅限于昂贵的傅里叶变换离子回旋共振（FTICR）质谱仪; 在常用的多极离子导向结构中的ECD的实现是由于RF场在这种装置内的干扰效应而成问题的。 本文描述的装置和方法成功地克服了这些困难，并且允许ECD（和PCD）在多极离子导向器中单独进行，或者与传统的离子碎裂方法组合进行。 因此，提供了利用多极离子导向器的质谱仪的改进的分析性能和功能性。

公开(公告)号：US08080785B2

公开(公告)日：2011-12-20

申请号：US12230949

申请日：2008-09-08

Applicant: Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

Inventor： Gholamreza Javahery ,  Lisa Cousins ,  Charles Jolliffe

IPC: H01J49/00

CPC classification number: H01J49/0045

Abstract: A high pressure collision cell for use in a mass spectrometer. The high pressure collision cell has a cell length L selected to be in a range such that upon application of voltages to a pair of opposed elongate electrically conducting electrodes there is produced an electric field of sufficient strength across the collision cell length L in to aid in directing ions entering the collision cell to along a transverse flow axis. The pressure in the collision cell is maintained in a range from about 50 mTorr to 1000 mTorr and wherein the collision cell length L and the pressure are selected such that a target thickness, defined as a product of the collision cell length L and the pressure, is maintained in a range from about 0.2 to about 2 mm-Torr.

Abstract translation: 用于质谱仪的高压碰撞池。 高压碰撞池具有选择为在一定范围内的电池长度L，使得在向一对相对的细长导电电极施加电压时，产生跨越冲击电池长度L的足够强度的电场，以帮助 引导进入碰撞池的离子沿着横向流动轴。 碰撞池中的压力保持在约50mTorr至1000mTorr的范围内，并且其中选择碰撞池长度L和压力，使得定义为碰撞池长度L和压力的乘积的目标厚度， 维持在约0.2至约2mm-Torr的范围内。