公开(公告)号：US20180360968A1

公开(公告)日：2018-12-20

申请号：US16056866

申请日：2018-08-07

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Masayuki SUZUKI ,  Hiroaki OKUTSU ,  Takashi YASUKOCHI ,  Yasunori TAKADA

IPC: A61K47/12 ,  A61K47/14 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K31/407 ,  A61M37/00 ,  A61K31/55

Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, isopropyl palmitate, and an adhesive base agent.

公开(公告)号：US20180085323A1

公开(公告)日：2018-03-29

申请号：US15554923

申请日：2016-02-22

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yoko FUJIWARA ,  Takashi YASUKOCHI ,  Yuka TAKAGI

IPC: A61K9/70 ,  A61K47/32 ,  A61K47/34 ,  A61K47/12 ,  A61K47/14 ,  A61M35/00

CPC classification number: A61K9/7061 ,  A61K9/7069 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/34 ,  A61M35/00

Abstract: A patch includes an adhesive layer and a release liner laminated on at least one surface of a backing. The adhesive layer comprises, as an adhesive base agent, at least one selected from the group consisting of acrylate-based adhesives and rubber-based adhesives, and the adhesive layer comprises 0.3 to 5% by mass of a nonfunctional silicone oil having a kinematic viscosity of 10 to 350 cSt at 25° C.

公开(公告)号：US09913970B2

公开(公告)日：2018-03-13

申请号：US14654029

申请日：2013-11-27

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shunsuke Arami ,  Makoto Ogura ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K9/00 ,  A61M5/145 ,  A61M5/158

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M5/1454 ,  A61M2005/14506 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0046

Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.

公开(公告)号：US20180055783A1

公开(公告)日：2018-03-01

申请号：US15565864

申请日：2016-04-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki UCHIDA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/4045 ,  A61K47/18

Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.

公开(公告)号：US20180036255A1

公开(公告)日：2018-02-08

申请号：US15551916

申请日：2016-02-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiichiro TSURU ,  Masayoshi MAKI

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/32 ,  A61K31/192

CPC classification number: A61K9/7038 ,  A61K9/70 ,  A61K31/192 ,  A61K45/00 ,  A61K47/10 ,  A61K47/32

Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.

公开(公告)号：US20170333690A1

公开(公告)日：2017-11-23

申请号：US15532836

申请日：2015-12-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Makoto OGURA ,  Naoki YAMAMOTO ,  Takashi KUMON

IPC: A61M37/00

Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.

公开(公告)号：US09789188B2

公开(公告)日：2017-10-17

申请号：US14433939

申请日：2013-10-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takuya Umemoto ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K47/12 ,  A61K31/551 ,  A61K9/70

CPC classification number: A61K47/12 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/551

Abstract: A patch comprising a support layer and an adhesive agent layer, wherein the adhesive agent layer comprises at least one drug selected from the group consisting of emedastine and pharmaceutically acceptable salts thereof, at least one adhesive agent selected from the group consisting of rubber-based adhesive agents and silicone-based adhesive agents, and an alkali metal fumarate as a cohesive force-improving agent for the adhesive agent layer.

公开(公告)号：US20170266427A1

公开(公告)日：2017-09-21

申请号：US15509398

申请日：2015-09-10

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shinpei NISHIMURA ,  Seiji TOKUMOTO

IPC: A61M37/00 ,  A61L31/16 ,  A61L31/08

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

公开(公告)号：US20170224630A1

公开(公告)日：2017-08-10

申请号：US15518847

申请日：2015-10-13

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Junji NOGUCHI ,  Eisuke HATANAKA ,  Hisakazu KURITA ,  Ryusuke FUDOJI ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K47/06 ,  C08F226/10 ,  C09J7/02 ,  A61K31/00 ,  C08F226/02 ,  C08K5/092

CPC classification number: A61K9/7053 ,  A61K9/7061 ,  A61K31/00 ,  A61K31/485 ,  A61K47/06 ,  A61K47/10 ,  C08F226/02 ,  C08F226/10 ,  C08K5/092

Abstract: A patch including: a support; and an adhesive layer disposed on at least one surface of the support, in which the adhesive layer includes: at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof; a higher aliphatic alcohol; and a non-cross-linking polyvinylpyrrolidone that does not contain vinyl acetate as a constituent monomer thereof.

公开(公告)号：US20160374956A1

公开(公告)日：2016-12-29

申请号：US15103449

申请日：2014-12-10

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Tomohiro SHINODA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K47/32 ,  A61K31/325

CPC classification number: A61K9/7084 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/137 ,  A61K31/27 ,  A61K31/325 ,  A61K31/551 ,  A61K47/32

Abstract: A multilayer-type patch comprising: a support layer; a drug reservoir layer; and an adhesive layer, wherein the drug reservoir layer comprises at least one drug selected from the group consisting of rivastigmine and pharmaceutically acceptable salts thereof, and a hydroxy group-containing acrylic-based polymer (A), the adhesive layer comprises at least one acrylic-based polymer (B) selected from the group consisting of carboxy group-containing alkyl (meth)acrylate copolymer and acrylic acid homopolymer, and a rubber-based adhesive base agent, a content of the drug in the drug reservoir layer in terms of rivastigmine in free form is 15 to 45% by mass relative to a total mass of the drug reservoir layer, and a total content of the acrylic-based polymer (B) in the adhesive layer is 7 to 18% by mass relative to a total mass of the adhesive layer.

Abstract translation: 一种装有覆盖材料的贴片，包括：贴片; 和覆盖材料，其中所述贴片包括支撑层和药物储存层，所述支撑层和药物储存层层叠在所述支撑层的一个表面上并且包含药物和药物储存剂基剂，所述覆盖材料包括覆盖层和粘合剂层 其叠层在覆盖层的一个表面上并且包含粘合剂基剂，贴片和覆盖材料以使得粘合剂层堆叠在支撑层的另一个表面上的方式布置，并且溶解度参数（SPa ），药物储库基剂的溶解度参数（SPb）和粘合剂基剂的溶解度参数（SPc）同时满足下述式（1）〜（3）所示的条件：0‰×SPa 'SPb‰¤1.5 2.0‰¤SPa'SPc‰2.8和1.0‰SPb'SPc‰2.8