Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abstract:
In a method for verifying manufacturing accuracy, a point cloud of a workpiece is read. A first determined point is determined according to the first point of the point cloud and a second determined point is determined according to the final point of the point cloud. A first line, a second line, and a third line are all located by respectively connecting the first point and the first determined point, the final point and the second determined point, and the first determined point and the second determined point. Qualification of the workpiece is determined by measuring a first angle of the first line and the third line, a second angle of the second line and the third line, a first distance between the first determined point and the second line, and a second distance between the second determined point and the first line.
Abstract:
Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein, such as leukemia and lymphoma, are disclosed.
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abstract:
N-Benzoyl arylsulfonamides having the formula are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and methods of treatment of diseases during which occurs expression of one or more than one of an anti-apoptotic protein family member using the compounds.
Abstract:
A multi-component curable composition which is reactive upon admixing of the components and which comprises: (i) an acrylic polymer having acetoacetoxy functionality; and (ii) an acetoacetoxy functional derivative of a low molecular weight polyol; and (iii) a crosslinking component comprising at least one imine functional compound having an average of at least two imine groups per molecule which are reactive with acetoacetoxy functionality.
Abstract:
An apparatus, thermal storage system and method for heat exchange using a tube-type heat exchanger. A rod or rods are propelled to moves over the inner surface of the tube. The moving rod is in contact with a first process liquid which is adjacent the inner surface as a falling film or by flooding the interior of the tube. The flooded mode is particularly useful where the tube is non-vertical or the heat exchanger is used to make an ice slurry for HVAC systems serving high-rise buildings. Multiple such rod and tube assemblies are operated simultaneously using a drive plate powered to execute an orbital motion in a plane generally orthogonal to the rods. In one form the plate is coupled via a crank to equiangularly space spaced rods in each tube. This form of orbital drive allows the use of a device to develop an auxiliary radial force, such as spring mounts extending between a central, rotating shaft mounted in each tube and the rod or rods for that tube. This auxiliary radial force supplements the centrifugal force to produce a self-alignment of the rods in a tube-parallel orientation, even when they are driven by a single drive plate positioned at one end of the tubes. Without a spring loading, the rods are preferably mounted to be movable radially, for example suspended through holes in, and driven by, a plate to executes an orbital motion or at recesses in the rod in radially directed slots in an arm rotated by a tube-mounted crank. For freezer applications, a tubular jacket surrounds the tube to form an annular thermosyphon region for a boiling refrigerant. In a thermal storage system using such exchangers, a movable warm water return nozzle return nozzle melts a floating ice mass uniformly.
Abstract:
Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.