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21.
公开(公告)号:US12138283B2
公开(公告)日:2024-11-12
申请号:US16413278
申请日:2019-05-15
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Sang-Heon Kim , Seokheon Hong , Seung Ja Oh , Kwi Deok Park
IPC: A61K35/28 , A61K9/16 , C12N5/0775
Abstract: Provided is a method of preparing a three-dimensional cell spheroid, the method including forming the cell spheroid by co-culturing adipose-derived stem cells or mesenchymal stem cells with hepatocytes. According to the cell spheroid prepared by the method, the secretome secreted by the adipose-derived stem cells affects hepatocyte maturation, and therefore, hepatic functions of the finally formed three-dimensional cell spheroid, i.e., organoid, may be enhanced. Further, a composition including a culture medium of the adipose-derived stem cells may prevent or treat liver diseases including hepatitis, hepatotoxicity, cholestasis, fatty liver, etc., and may enhance hepatic functions.
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公开(公告)号:US20240366495A1
公开(公告)日:2024-11-07
申请号:US18404121
申请日:2024-01-04
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Young Tae PARK , Jisu PARK , Huitae MIN , Taehyun KIM , Jin-Woo KIM , Tae Jung KIM , Jin Chul KIM , Jung Yeob HAM
IPC: A61K8/9789 , A61K36/185 , A61Q19/08
Abstract: The present invention relates to a use of a fermentation product of Lacticaseibacillus casei of cannabis stems and an extract thereof for ameliorating skin wrinkles caused by photoaging, and to an anti-wrinkle cosmetic composition or pharmaceutical composition including the fermentation product.
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23.
公开(公告)号:US20240365522A1
公开(公告)日:2024-10-31
申请号:US18641747
申请日:2024-04-22
Inventor: Yury Gogotsi , Babak Anasori , Mohamed H. Alhabeb , Christine B. Hatter , Chong Min Koo , Soon Man Hong , Faisal Shahzad
IPC: H05K9/00 , C01B32/921 , H01B1/20 , H01L23/29 , H01L23/552
CPC classification number: H05K9/0088 , H01B1/20 , H01L23/295 , H01L23/552 , H05K9/0084 , C01B32/921 , C01P2002/20 , C01P2002/72 , C01P2004/03 , C01P2004/04 , C01P2006/40 , H01L2924/3025
Abstract: The present disclosure is directed to materials which provide electromagnetic shielding and methods of providing such electromagnetic shielding. In particular, the present disclosure describes the use of two-dimensional transition metal carbide, nitride, and carbonitride materials for this purpose.
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24.
公开(公告)号:US20240360457A1
公开(公告)日:2024-10-31
申请号:US18765587
申请日:2024-07-08
Inventor: HoWon J. Kim , In-San Kim , Jay S. Kim , Sun Hwa Kim , Ick Chan Kwon , Jong Won Lee , Yoo Soo Yang , Hong Yeol Yoon
IPC: C12N15/113 , A61P35/00
CPC classification number: C12N15/1138 , A61P35/00 , C12N2310/11 , C12N2310/531
Abstract: Therapeutic compounds for red blood cell-mediated delivery of an active pharmaceutical ingredient to a cancer cell are described. The therapeutic compounds are configured to bind CD47 on the surface of a red blood cell and to be subsequently transferred to CD47 on the surface of the cancer cell, the therapeutic compound ultimately being internalized by the cancer cell via endocytosis.
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公开(公告)号:US20240352401A1
公开(公告)日:2024-10-24
申请号:US18521797
申请日:2023-11-28
Applicant: Korea Institute of Science and Technology
Inventor: Sun Mi LEE , Jiwon Kim , Hyeoncheol Son , Ja Kyong Ko , Gyeongtaek Gong , Jung Ho Ahn , Youngsoon Um
CPC classification number: C12N1/165 , C12N9/0008 , C12N15/815 , C12R2001/645 , C12Y102/01003
Abstract: The present disclosure discloses a strain having resistance by neutralizing furfural, an inhibitor derived from lignocellulosic biomass, based on a technique using aldehyde dehydrogenase and a method of using the same. According to the present disclosure, furfural, an inhibitor derived from lignocellulosic biomass, is neutralized based on a technique using aldehyde dehydrogenase, so that a resistant strain overexpresses aldehyde dehydrogenase (EcAldH) in Yarrowia lipolytica, which has the ability to produce yeast oil, and has resistance to furfural, a biomass-derived inhibitor. Accordingly, even in the medium containing furfural, it can provide excellent strain growth and yeast oil production ability.
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26.
公开(公告)号:US20240351220A1
公开(公告)日:2024-10-24
申请号:US18328094
申请日:2023-06-02
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Jeongryul KIM , Keri KIM , Hong Jun CHO , Sang Kyung KIM
CPC classification number: B25J15/0028 , B25J9/1045
Abstract: A gripper for gripping a target has a first support section, a second support section spaced apart from the first support section in a direction of a rotation center axis, and a plurality of elastic wires supported across the first support section and the second support section. A first grip area surrounded by the plurality of elastic wires is formed between the first support section and the second support section upon a relative rotation of the first support section and the second support section around the rotation center axis, and the first grip area becomes narrower until all the plurality of elastic wires come into contact with the target by the relative rotation of the first support section and the second support section, and the plurality of elastic wires is tightened to grip the target entering the first grip area.
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27.
公开(公告)号:US12122999B2
公开(公告)日:2024-10-22
申请号:US17745416
申请日:2022-05-16
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Heh-In Im , Sangjoon Lee , Ji Eun Choi
IPC: C12N15/113 , A61P25/28
CPC classification number: C12N15/113 , A61P25/28 , C12N2310/14 , C12N2310/531
Abstract: Disclosed is a composition for preventing or treating a degenerative brain disease. The composition includes, as an active ingredient, a MECP2 inhibitor for treating the degenerative brain disease, a polynucleotide encoding the MECP2 inhibitor or a recombinant virus containing the MECP2 inhibitor. The composition is useful for the treatment of a degenerative brain disease (particularly Alzheimer's syndrome) caused by beta-amyloid. In addition, the composition is effective in improving or ameliorating deterioration of cognitive functions and social deficits caused by Alzheimer's syndrome.
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公开(公告)号:US20240316800A1
公开(公告)日:2024-09-26
申请号:US18468949
申请日:2023-09-18
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Yongseok IHN , Junwon LEE , Sungwook YANG , Donghyun HWANG
CPC classification number: B25J19/021 , A61B34/30 , A61B2034/2061
Abstract: A forceps unit and a forceps apparatus are provided. The forceps unit according to an aspect of the present disclosure may comprise a base portion connected to a motor; a grasping portion disposed in front of the base portion and grasping a surgical instrument; a connecting portion connecting the base portion and the grasping portion; and a plurality of optical fibers, wherein some of the plurality of optical fibers are fixed to the grasping portion and others of the plurality of optical fibers are fixed to the base portion, wherein the plurality of optical fibers may include a first optical fiber disposed in a central region of the grasping portion and second to fifth optical fibers radially disposed with respect to the first optical fiber, and the first optical fiber may protrude further forward than the second to fifth optical fibers.
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29.
公开(公告)号:US20240307477A1
公开(公告)日:2024-09-19
申请号:US18441653
申请日:2024-02-14
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Chu Won NHO , Myungsuk KIM , Yunseong NAM
IPC: A61K36/739 , A61K9/00 , A61K31/704 , A61P1/16
CPC classification number: A61K36/739 , A61K9/0056 , A61K31/704 , A61P1/16 , A61K2236/33 , A61K2236/331 , A61K2236/333
Abstract: The present invention relates to a composition for preventing or treating liver fibrosis, which includes a Sanguisorba officinalis extract as an active ingredient, and more particularly, to a composition for preventing or treating liver fibrosis, which includes a Sanguisorba officinalis extract or ziyuglycoside. The Sanguisorba officinalis extract or ziyuglycoside of the present invention inhibits liver fibrosis and the expression of a liver fibrosis-related gene, so it may be effectively used in the composition for preventing or treating liver fibrosis.
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30.
公开(公告)号:US20240285717A1
公开(公告)日:2024-08-29
申请号:US18435415
申请日:2024-02-07
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Myung Suk KIM , Sang Hoon JUNG , Hye Jin KO , Tam Thi LE , Ngoc Bao NGUYEN , Wook Bin LEE
IPC: A61K36/752 , A61P21/00
CPC classification number: A61K36/752 , A61P21/00
Abstract: The present invention relates to a composition for the prevention or treatment of a muscle disease, comprising an extract of Ponciri Fructus. The extract of the present invention has the effect of increasing the expression of genes related to myotube cell differentiation and/or athletic performance, increasing muscle weight, and/or improving athletic performance.
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