公开(公告)号：US09772305B2

公开(公告)日：2017-09-26

申请号：US13613672

申请日：2012-09-13

申请人： Nongjian Tao

发明人： Nongjian Tao

IPC分类号： G01N21/00 ,  G01N27/60 ,  B82Y35/00 ,  G01B11/00

CPC分类号： G01N27/60 ,  B82Y35/00 ,  G01B11/002

摘要： A system for analyzing a content of a sample material is presented. The system includes a fiber sensitized to a first substance, and at least one electrode configured to expose the fiber to an electric field. The system includes an optical sensor configured to detect a displacement of the fiber when the fiber is exposed to the electric field, and a processor configured to use the displacement of the fiber to characterize a content of the sample material.

公开(公告)号：US09347932B2

公开(公告)日：2016-05-24

申请号：US13877486

申请日：2011-10-03

申请人： Nongjian Tao ,  Francis Tsow ,  Anant Rai

发明人： Nongjian Tao ,  Francis Tsow ,  Anant Rai

IPC分类号： G01N33/497 ,  A61B5/087 ,  A61B5/083

CPC分类号： G01N33/497 ,  A61B5/083 ,  A61B5/087

摘要： The present invention describes a device and method for measuring flow rate from air flow using acoustic resonance. It is shown that the device can be used to measure breath flow rate and biomarker concentration within human breath.

摘要翻译： 本发明描述了一种用于使用声共振测量来自气流的流量的装置和方法。 显示该装置可用于测量人体呼吸中的呼吸流速和生物标志物浓度。

公开(公告)号：US20150369795A1

公开(公告)日：2015-12-24

申请号：US14761732

申请日：2014-01-21

申请人： Francis TSOW ,  Xiaojun XIAN ,  Erica FORZANI ,  Nongjian TAO ,  ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF

发明人： Francis Tsow ,  Xiaojun Xian ,  Erica Forzani ,  Nongjian Tao

IPC分类号： G01N33/497

CPC分类号： G01N33/497 ,  A61B5/0482 ,  A61B5/0816 ,  A61B5/083 ,  A61B5/087 ,  A61B5/7405

摘要： A system for measuring and tracking metabolic rate, physical activity and calorie intake. The metabolic rate is measured with a design that features an adaptive sampling mechanism for accurate breath sample collection, optimized flow rate measurement for minimizing backpressure while maximizing accuracy, humidity regulation and water condensation reduction mechanism for reliable performance, as well as breath temperature measurement for volume and humidity corrections. The system further comprises an improved algorithm for determining physical activity such as related energy expenditure, and a mechanism for tracking changes in food intake over time.

摘要翻译： 用于测量和跟踪代谢率，身体活动和卡路里摄入量的系统。 代谢率采用具有自适应采样机构的设计测量，用于精确的呼吸样本采集，优化的流量测量，以最大限度地提高背压，同时最大限度地提高精度，调节湿度和水凝缩减速机制，以获得可靠的性能，以及口气温度测量 和湿度校正。 该系统还包括用于确定身体活动的改进算法，例如相关的能量消耗，以及用于随时间跟踪食物摄取变化的机制。

公开(公告)号：US08668874B2

公开(公告)日：2014-03-11

申请号：US13322898

申请日：2010-06-02

申请人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A Iglesias

发明人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A Iglesias

IPC分类号： G01N33/00 ,  G01N33/62

CPC分类号： G01N27/27 ,  G01N21/05 ,  G01N21/783 ,  G01N31/223 ,  G01N33/0037 ,  Y02A50/245 ,  Y10T436/173845

摘要： A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

摘要翻译： 一种基于光电化学和光电信号检测的气相检测系统。 传感平台对于检测低ppbV浓度的氮氧化物特别强大。 光化学分析是由于化学反应发生在优化材料中的颜色发展。 电化学分析可以基于电化学传感器的掺杂水平或氧化还原电位变化; 光电化学检测可以基于电化学和光电化学方法的组合。 可以同时检测每个独立信号，提高检测的可靠性。

公开(公告)号：US20130071942A1

公开(公告)日：2013-03-21

申请号：US13613672

申请日：2012-09-13

申请人： Nongjian Tao

发明人： Nongjian Tao

IPC分类号： G01N21/75

CPC分类号： G01N27/60 ,  B82Y35/00 ,  G01B11/002

摘要： A system for analyzing a content of a sample material is presented. The system includes a fiber sensitized to a first substance, and at least one electrode configured to expose the fiber to an electric field. The system includes an optical sensor configured to detect a displacement of the fiber when the fiber is exposed to the electric field, and a processor configured to use the displacement of the fiber to characterize a content of the sample material.

摘要翻译： 提出了一种用于分析样品材料含量的系统。 该系统包括对第一物质敏化的光纤，以及至少一个被配置为将光纤暴露于电场的电极。 该系统包括光学传感器，其被配置为当光纤暴露于电场时检测光纤的位移;以及处理器，其被配置为使用光纤的位移来表征样品材料的内容。

公开(公告)号：US08215170B2

公开(公告)日：2012-07-10

申请号：US11568209

申请日：2006-10-23

申请人： Nongjian Tao ,  Salah Boussaad

发明人： Nongjian Tao ,  Salah Boussaad

IPC分类号： G01N29/12

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/014 ,  G01N2291/0257 ,  Y10T29/49117 ,  Y10T29/49574

摘要： A device for sensing a chemical analyte is disclosed. The device is comprised of a vibrating structure having first and second surfaces and having an associated resonant frequency and a wire coupled between the first and second surfaces of the vibrating structure, wherein the analyte interacts with the wire and causes a change in the resonant frequency of the vibrating structure. The vibrating structure can include a tuning fork. The vibrating structure can be comprised of quartz. The wire can be comprised of polymer. A plurality of vibrating structures are arranged in an array to increase confidence by promoting a redundancy of measurement or to detect a plurality of chemical analytes. A method of making a device for sensing a chemical analyte is also disclosed.

摘要翻译： 公开了用于感测化学分析物的装置。 该装置包括具有第一和第二表面并且具有相关联的谐振频率的振动结构和耦合在振动结构的第一和第二表面之间的导线，其中分析物与导线相互作用并导致谐振频率的变化 振动结构。 振动结构可以包括音叉。 振动结构可以由石英组成。 电线可以由聚合物组成。 多个振动结构被布置成阵列以通过促进测量的冗余或检测多个化学分析物来增加置信度。 还公开了一种制造用于感测化学分析物的装置的方法。

公开(公告)号：US20110266161A1

公开(公告)日：2011-11-03

申请号：US13063499

申请日：2009-09-11

申请人： Nongjian Tao ,  Erica Forzani ,  Alvaro Diaz Aguilar

发明人： Nongjian Tao ,  Erica Forzani ,  Alvaro Diaz Aguilar

IPC分类号： G01N27/26 ,  B82Y99/00

CPC分类号： G01N27/4145 ,  G01N21/25 ,  G01N21/552 ,  G01N21/64

摘要： An integrated sensor is capable of detecting analytes using electrochemical (EC), electrical (E), and optical (O) signals or EC and O signals. The sensor introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.

摘要翻译： 集成传感器能够使用电化学（EC），电（E）和光（O）信号或EC和O信号来检测分析物。 该传感器引入了协同的新功能，并增强了对复杂基质中分析物的实时检测的灵敏度和选择性，包​​括在液体和气相中存在高浓度的干扰。

公开(公告)号：US20100253370A1

公开(公告)日：2010-10-07

申请号：US12601211

申请日：2008-05-23

申请人： Nongjian Tao ,  Erica S. Forzani

发明人： Nongjian Tao ,  Erica S. Forzani

IPC分类号： G01N27/00 ,  G01R27/08

CPC分类号： G01N27/27 ,  G01N27/3277

摘要： An integrated sensing device is capable of detecting analytes using electrochemical (EC) and electrical (E) signals. The device introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.

摘要翻译： 集成的感测装置能够使用电化学（EC）和电（E）信号来检测分析物。 该设备引入了协同的新功能，并增强了对复杂基质中分析物的实时检测的灵敏度和选择性，包​​括在液体和气相中存在高浓度的干扰。

公开(公告)号：US07132837B1

公开(公告)日：2006-11-07

申请号：US10929134

申请日：2004-08-26

申请人： Nongjian Tao

发明人： Nongjian Tao

IPC分类号： G01R27/08 ,  G01N27/453

CPC分类号： G01R27/02 ,  G01N27/3278

摘要： A conductivity measurement system measures conductivity of molecules. A substance to be measured is applied to the first and second electrodes. A potential is applied across the electrodes. A computer-controlled motion controller moves a first electrode relative to a second electrode in discrete steps. In a first step, the electrodes are brought together in physical contact to form a plurality of molecular junctions. The electrodes are separated by a first distance which breaks a first molecular junction. The electrodes are separated by a second distance which breaks a second molecular junction. A conductivity measure is taken at each step. The process of separating the electrodes continues until conductivity measure is zero. The conductivity of one molecule corresponds to a last non-zero conductivity measurement prior to a zero conductivity measurement.

摘要翻译： 电导率测量系统测量分子的电导率。 要测量的物质被施加到第一和第二电极。 在电极上施加电位。 计算机控制的运动控制器以离散步骤相对于第二电极移动第一电极。 在第一步骤中，将电极物理接触在一起形成多个分子结。 电极被分开第一距离，其破坏第一分子结。 电极分开第二个距离，破坏了第二个分子结。 在每个步骤中进行电导率测量。 分离电极的过程继续进行，直到电导率测量为零。 一个分子的电导率对应于在零电导率测量之前的最后一个非零电导率测量。

公开(公告)号：US06784999B1

公开(公告)日：2004-08-31

申请号：US10031659

申请日：2001-11-13

申请人： Nongjian Tao ,  Salah Boussaad ,  Wenlue Huang

发明人： Nongjian Tao ,  Salah Boussaad ,  Wenlue Huang

IPC分类号： G01N2100

CPC分类号： G01N21/553

摘要： A device and method of detecting surface plasmon resonance for sensing molecules or conformational changes in molecules with high resolution and fast response time is disclosed. Light from a light source (14) is focused through a prism onto a metal thin film (15) on which sample molecules to be detected are adsorbed. The total internal reflection of the laser/incident light is collected with a differential position or intensity sensitive photo-detecting device instead of a single cell or an array of photo-detectors (12) that are widely used in previous works. The ratio of the differential signal to the sum signal of the differential position or intensity sensitive photo-detecting device (12) provides an accurate measurement of the shift in the surface plasmon resonance angle caused by the adsorption of molecules onto the metal films (15) or by conformational changes in the adsorbed molecules. The present invention requires no numerical fitting to determine the resonant angle and the setup is compact and immune to background light, The methods and sensors of this invention can be used in numerous biological, biochemical, and chemical applications such as measuring subtle conformational changes in molecules and electron transfer reactions can be studied.

摘要翻译： 公开了一种用于检测表面等离子体共振以用于感测分子的分子或构象变化的装置和方法，其具有高分辨率和快速响应时间。 来自光源（14）的光通过棱镜聚焦到金属薄膜（15）上，待测样品分子被吸附在其上。 激光/入射光的全部内部反射是用差分位置或强度敏感的光检测装置代替在以前的工作中广泛使用的单个电池或光电检测器阵列（12）来收集的。 微分信号与差分位置或强度敏感光检测装置（12）的和信号的比率提供了由分子吸附到金属膜（15）上引起的表面等离子体共振角的偏移的精确测量， 或通过吸附分子的构象变化。 本发明不需要数值拟合来确定共振角，并且设置是紧凑的并且不受背景光的影响。本发明的方法和传感器可用于许多生物学，生物化学和化学应用，例如测量分子中微妙的构象变化 并可以研究电子转移反应。