公开(公告)号：US20090131789A1

公开(公告)日：2009-05-21

申请号：US12094933

申请日：2006-09-28

Applicant: Jens Fehre ,  Bernd Granz ,  Markus Lanski ,  Ralf Nanke

Inventor： Jens Fehre ,  Bernd Granz ,  Markus Lanski ,  Ralf Nanke

IPC: A61B8/00 ,  A61N5/10

CPC classification number: A61B8/12 ,  A61N5/1002 ,  A61N5/1027 ,  A61N5/1048 ,  A61N5/1049 ,  A61N2005/1058

Abstract: In a method and a device for x-ray brachytherapy, a probe is inserted into the interior of the body of a subject, the probe carrying at its distal end an x-ray source that radiates x-rays into an exposure area in the body of the subject outside of the probe. The probe also contains an x-ray array that generates an ultrasound image representing at least a portion of the exposure area. A display device displays the ultrasound image to allow identification of the exposure area in the ultrasound image.

Abstract translation: 在用于x射线近距离放射治疗的方法和装置中，将探针插入到受试者的身体的内部，探针在其远端处携带x射线源，将x射线辐射到体内的暴露区域 的探头外。 探针还包含产生表示曝光区域的至少一部分的超声波图像的X射线阵列。 显示装置显示超声图像以允许识别超声图像中的曝光区域。

公开(公告)号：US20090060844A1

公开(公告)日：2009-03-05

申请号：US12203201

申请日：2008-09-03

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61K49/18

CPC classification number: A61K49/1866 ,  A61K49/16 ,  A61K49/1875 ,  B82Y5/00

Abstract: In a method for imaging a prostate tumor in which a contrast agent that can be distributed via the circulatory system is administered to the patient, the contrast agent contains at least one type of biomarkers which are bound to a ferromagnetic particle and specifically bind to a target molecule typical of the tumor and formed within the tumor or in a tissue adjacent to the tumor. The imaging ensues with the use of magnetic resonance tomography.

Abstract translation: 在用于对可以通过循环系统分布的造影剂给予患者的前列腺肿瘤成像方法中，造影剂含有至少一种类型的结合于铁磁颗粒并特异性结合靶的生物标志物 典型的肿瘤分子，并在肿瘤内或与肿瘤相邻的组织中形成。 使用磁共振断层扫描成像。

公开(公告)号：US07281429B2

公开(公告)日：2007-10-16

申请号：US10535804

申请日：2003-10-07

Applicant: Bernd Granz ,  Ralf Nanke

Inventor： Bernd Granz ,  Ralf Nanke

IPC: G01D5/32

CPC classification number: A61B17/22029 ,  A61B17/22 ,  G01H9/00

Abstract: An optical hydrophone for measurement of the acoustic pressure distribution in a fluid medium has a light source that illuminates an area of a boundary region between an optically transparent body and the fluid medium. A light receiver measures the intensity of the light reflected from the illuminated area as a measurement of acoustic pressure, due to changes in the index of refraction of the fluid medium that are caused by the acoustic pressure. The illuminated area is smaller than the boundary surface formed between the optically transparent body and the fluid medium, thereby giving the hydrophone a longer service light and a high spatial resolution capacity.

Abstract translation: 用于测量流体介质中的声压分布的光学水听器具有照亮光学透明体和流体介质之间的边界区域的区域的光源。 由于由声压引起的流体介质的折射率的变化，光接收器测量从照明区域反射的光的强度作为声压的测量值。 照明区域小于在光学透明体和流体介质之间形成的边界面，从而使水听器具有更长的使用光和高的空间分辨能力。

公开(公告)号：US20180279981A1

公开(公告)日：2018-10-04

申请号：US15764558

申请日：2016-08-09

Applicant: Jens Fehre ,  Alexander Gemmel ,  Andreas Limmer ,  Ralf Nanke

Inventor： Jens Fehre ,  Alexander Gemmel ,  Andreas Limmer ,  Ralf Nanke

IPC: A61B6/00

Abstract: The invention relates to a mobile C-arm system (C1), at least comprising at least three wheels, at least two wheels each having an electric motor, wherein the electric motor has a stator (S) and a rotor (R), the stator (S) being connected to a wheel suspension (T) of the wheel and the rotor (R) being surrounded peripherally by a running wheel (L).

公开(公告)号：US09521994B2

公开(公告)日：2016-12-20

申请号：US12774798

申请日：2010-05-06

Applicant: Ali Kamen ,  Wolfgang Wein ,  Parmeshwar Khurd ,  Mamadou Diallo ,  Ralf Nanke ,  Jens Fehre ,  Berthold Kiefer ,  Martin Requardt ,  Clifford Weiss

Inventor： Ali Kamen ,  Wolfgang Wein ,  Parmeshwar Khurd ,  Mamadou Diallo ,  Ralf Nanke ,  Jens Fehre ,  Berthold Kiefer ,  Martin Requardt ,  Clifford Weiss

IPC: A61B8/00 ,  G06K9/00 ,  A61B10/02 ,  A61B17/00 ,  A61B17/34 ,  A61B18/00

CPC classification number: A61B10/0241 ,  A61B8/4254 ,  A61B34/20 ,  A61B2017/00274 ,  A61B2017/00694 ,  A61B2017/3413 ,  A61B2018/00547 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2090/367 ,  A61B2090/374 ,  A61B2090/378

Abstract: In a method for image guided prostate cancer needle biopsy, a first registration is performed to match a first image of a prostate to a second image of the prostate. Third images of the prostate are acquired and compounded into a three-dimensional (3D) image. The prostate in the compounded 3D image is segmented to show its border. A second registration and then a third registration different from the second registration is performed on distance maps generated from the prostate borders of the first image and the compounded 3D image, wherein the first and second registrations are based on a biomechanical property of the prostate. A region of interest in the first image is mapped to the compounded 3D image or a fourth image of the prostate acquired with the second modality.

Abstract translation: 在用于图像引导的前列腺癌针活检的方法中，首先进行配准以将前列腺的第一图像与前列腺的第二图像相匹配。 获取前列腺的第三图像并将其复合成三维（3D）图像。 复合3D图像中的前列腺被分割以显示其边界。 在从第一图像和复合3D图像的前列腺边界产生的距离图上执行与第二登记不同的第二登记，然后第三登记，其中第一和第二登记基于前列腺的生物力学性质。 将第一图像中的感兴趣区域映射到复合3D图像或用第二模态获取的前列腺的第四图像。

公开(公告)号：US09282942B2

公开(公告)日：2016-03-15

申请号：US13939393

申请日：2013-07-11

Applicant: Thomas Mertelmeier ,  Ralf Nanke

Inventor： Thomas Mertelmeier ,  Ralf Nanke

IPC: A61B6/00 ,  A61B6/04 ,  A61B6/02

CPC classification number: A61B6/502 ,  A61B6/025 ,  A61B6/0414

Abstract: In this device and the associated method, a connection unit that can be attached to an arm bearing an x-ray source and an x-ray receiver is fashioned such that said connection unit compensates for a pivot movement of the arm so that a compression unit arranged at the connection unit remains stationary during a pivot movement.

Abstract translation: 在该装置和相关联的方法中，可以将连接单元连接到具有x射线源和X射线接收器的臂上，使得所述连接单元补偿臂的枢转运动，使得压缩单元 布置在连接单元处的枢转运动期间保持静止。

公开(公告)号：US09232885B2

公开(公告)日：2016-01-12

申请号：US13805205

申请日：2011-05-11

Applicant: Jens Fehre ,  Ralf Nanke

Inventor： Jens Fehre ,  Ralf Nanke

IPC: A61B5/05 ,  A61B1/04 ,  A61B5/00 ,  G01N21/64 ,  G06K9/00

CPC classification number: A61B1/043 ,  A61B1/041 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/4205 ,  G01N21/6408 ,  G01N21/6486 ,  G06K9/00147 ,  G06K2209/053

Abstract: In a method and apparatus for detecting tumorous cell tissue in a gastrointestinal tract, electromagnetic radiation is emitted in a locally defined manner from an endoscope onto cell tissue and, after deactivation of the radiation, the decay of the inherent fluorescence intensity of the irradiated cell tissue, excited by the electromagnetic radiation, is detected, with temporal and spectral resolution and with a known scanning rate for at least one wavelength. From the intensity measurement values obtained in this manner, the difference autocorrelation function of the intensity decay is determined, from which a fractal dimension for the irradiated cell tissue is determined. The value of the fractal dimension is used to classify the irradiated cell tissue as to a degree to which the cell tissue is tumorous.

Abstract translation: 在用于检测胃肠道中的肿瘤细胞组织的方法和装置中，电磁辐射以局部限定的方式从内窥镜发射到细胞组织上，并且在辐射失活之后辐射细胞组织的固有荧光强度的衰减 被电磁辐射激发，被检测到，具有时间和光谱分辨率，并具有用于至少一个波长的已知扫描速率。 根据以这种方式获得的强度测量值，确定强度衰减的差分自相关函数，确定照射的细胞组织的分形维数。 分形维数的值用于将照射的细胞组织分类为细胞组织肿瘤程度。

公开(公告)号：US20150031986A1

公开(公告)日：2015-01-29

申请号：US14011984

申请日：2013-08-28

Applicant: Philipp Bernhardt ,  Martin Hoheisel ,  Thomas Mertelmeier ,  Ralf Nanke ,  Marcus Radicke

Inventor： Philipp Bernhardt ,  Martin Hoheisel ,  Thomas Mertelmeier ,  Ralf Nanke ,  Marcus Radicke

IPC: A61B6/12

CPC classification number: A61B6/12 ,  A61B6/4441 ,  A61B6/4458 ,  A61B6/484

Abstract: A medical instrument is provided for use with a phase contrast imaging. The medical instrument includes at least one component, which has a strong small angle scattering of x-rays. Furthermore, a corresponding x-ray recording system with phase contrast imaging for recording an examination object may include such a medical instrument.

Abstract translation: 提供了一种用于相位成像的医疗仪器。 该医疗仪器包括至少一个部件，其具有强烈的小角度X射线散射。 此外，具有用于记录检查对象的相位对比成像的对应的X射线记录系统可以包括这样的医疗器械。

公开(公告)号：US20100240993A1

公开(公告)日：2010-09-23

申请号：US12727357

申请日：2010-03-19

Applicant: Thorsten Bergsdorf ,  Christian Chaussy ,  Ralf Nanke ,  Stefan Thueroff

Inventor： Thorsten Bergsdorf ,  Christian Chaussy ,  Ralf Nanke ,  Stefan Thueroff

IPC: A61B8/00

CPC classification number: A61B5/145 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4381 ,  A61B8/0833 ,  A61B17/22004 ,  A61N2007/0039 ,  G01N33/57407

Abstract: In a method and medical apparatus to determine a tumor characteristic related to a body region of a patient, the body region is exposed to acoustic energy that mechanically irritates the body region. A first value of a characteristic value of the patient that is correlated with the irritation is determined at a first point in time. A second value of the characteristic value is determined at a second point in time after the first point in time and after the exposure. The tumor characteristic is determined from the change between first value and second value.

Abstract translation: 在用于确定与患者的身体区域相关的肿瘤特征的方法和医疗装置中，身体区域暴露于机械刺激身体区域的声能。 在第一时间点确定与刺激相关的患者的特征值的第一值。 在第一时间点和曝光后的第二时间点确定特征值的第二值。 根据第一值和第二值之间的变化确定肿瘤特征。

公开(公告)号：US20090062645A1

公开(公告)日：2009-03-05

申请号：US12203198

申请日：2008-09-03

Applicant: Jens Fehre ,  Ralf Nanke ,  Martin Stetter

Inventor： Jens Fehre ,  Ralf Nanke ,  Martin Stetter

IPC: A61B8/13 ,  A61B5/00

CPC classification number: A61N7/00 ,  A61B5/055 ,  A61B5/4381 ,  A61B8/08

Abstract: In a method for diagnosis and treatment of a patient with a tumor relating to prostate cancer, the following steps are implemented. A differential diagnosis of prostate cancer versus prostatitis and/or BPH is conducted on a patient using a cost-effective diagnosis method. If prostate cancer is diagnosed in the patient using a cost-effective measurement method, a characteristic value for the tumor aggressiveness of the prostate cancer is determined. A watchful waiting treatment is implemented with the patient given a characteristic value below a predeterminable first limit value. The size and position of the tumor is determined using a cost-effective method given a characteristic value above the first limit value. A cost-effective ultrasonic theranosis or a conventional therapy is conducted for a size below a second predeterminable limit value. The presence of metastases in the patient is checked, with a cost-intensive method generating image information, for a size above the second limit value. A metastasis treatment is implemented in the event that metastases are present. In the event that no metastases are present, a tumor treatment based on the aforementioned image information generated is implemented.

Abstract translation: 在用于诊断和治疗患有与前列腺癌相关的肿瘤的患者的方法中，实施以下步骤。 使用成本效益的诊断方法对患者进行前列腺癌与前列腺炎和/或BPH的鉴别诊断。 如果使用成本有效的测量方法在患者中诊断前列腺癌，则确定前列腺癌的肿瘤侵袭性的特征值。 给予患者给予低于可预定的第一极限值的特征值的注意等待治疗。 使用给定特征值高于第一极限值的成本有效的方法确定肿瘤的大小和位置。 以低于第二预定极限值的尺寸进行成本有效的超声治疗或常规治疗。 检查患者中转移灶的存在，以成本密集型方法产生图像信息，尺寸高于第二限制值。 在存在转移的情况下实施转移治疗。 在不存在转移的情况下，实现基于上述生成的图像信息的肿瘤治疗。