公开(公告)号：US20160369269A1

公开(公告)日：2016-12-22

申请号：US14967165

申请日：2015-12-11

申请人： The Methodist Hospital

发明人： Haifa Shen ,  Mauro Ferrari ,  Jian Shen ,  Mingzhen Zhang

IPC分类号： C12N15/113 ,  A61K9/51 ,  A61K31/7088 ,  A61K9/50

CPC分类号： C12N15/113 ,  A61K9/5031 ,  A61K9/5146 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

摘要： Disclosed are methods and compositions containing functionalized nanoporous silicon particles, useful in a variety of diagnostic and/or therapeutic regimens for delivery of genetic constructs to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing into selected host cells one or more selected nucleic acid molecules. The present disclosure is also directed to a method of treating a tumor, comprising the step of administering to an individual one or more of the compositions and formulations thereof as described herein.

摘要翻译： 公开了含有官能化纳米多孔硅颗粒的方法和组合物，其可用于将遗传构建体递送到感兴趣的一个或多个细胞，组织和/或器官的各种诊断和/或治疗方案中。 还提供了将选择的宿主细胞引入一个或多个选择的核酸分子的方法。 本公开还涉及治疗肿瘤的方法，其包括向个体施用本文所述的一种或多种组合物和制剂的步骤。

公开(公告)号：US20160193476A1

公开(公告)日：2016-07-07

申请号：US14912004

申请日：2014-08-15

申请人： The Methodist Hospital ,  Cornell University

发明人： Santosh A. Helekar ,  Henning U. Voss

IPC分类号： A61N2/12 ,  A61B5/0476 ,  A61B5/00 ,  A61N2/06 ,  A61B5/05

CPC分类号： A61N2/12 ,  A61B5/0476 ,  A61B5/05 ,  A61B5/4064 ,  A61B5/6803 ,  A61N2/006 ,  A61N2/06

摘要： Apparatus for applying Transcranial Magnetic Stimulation (TMS) to an individual, wherein the apparatus comprises: a head mount for disposition on the head of an individual; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies comprises a permanent magnet, and at least one of (i) a movement mechanism for moving the permanent magnet and/or (ii) a magnetic shield shutter mechanism, for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of an individual so as to modify the natural electrical activity of the brain of the individual; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each individual, whereby to provide individual-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

摘要翻译： 用于将经颅磁刺激（TMS）施加到个体的装置，其中所述装置包括：用于设置在个人头部上的头部支架; 以及多个用于可拆卸地安装在所述头部安装件上的磁体组件，其中每个所述磁体组件包括永磁体，以及至少一个（i）用于移动所述永磁体的移动机构和/或（ii）磁屏蔽 快门机构，用于选择性地提供能够诱导个体脑中的弱电流的快速变化的磁场，以便改变个体的大脑的自然电活动; 其中选择安装在头架上的磁体组件的数量，它们在磁头安装上的各自定位以及它们选择性地提供快速变化的磁场，以便允许磁场的空间，强度和时间特性被定制 为每个人量身定制，从而提供个人特定的TMS治疗，以帮助诊断或绘制神经科学研究中的大脑功能。

公开(公告)号：US20150265369A1

公开(公告)日：2015-09-24

申请号：US14667269

申请日：2015-03-24

申请人： UNIVERSITY OF HOUSTON ,  THE METHODIST HOSPITAL

发明人： Marc GARBEY ,  Brian James DUNKIN ,  Barbara Lee BASS

IPC分类号： A61B19/00 ,  A61B1/313 ,  A61B6/03 ,  A61B5/06 ,  A61B5/055

摘要： Systems and methods for real time laparoscopic navigation. Exemplary embodiments can comprise scanning a structure of interest internal to a patient to provide image data; generating a first three-dimensional reconstruction of the structure of interest based on the image data; annotating the first three-dimensional reconstruction of the structure of interest with a plurality of reference points; obtaining spatial coordinates of the plurality of reference points during a laparoscopic procedure; and generating a second three-dimensional reconstruction of the structure of interest based on the spatial coordinates.

摘要翻译： 实时腹腔镜导航的系统和方法。 示例性实施例可以包括扫描患者内部感兴趣的结构以提供图像数据; 基于图像数据生成感兴趣结构的第一三维重建; 用多个参考点注释感兴趣结构的第一个三维重建; 在腹腔镜手术过程中获得多个参考点的空间坐标; 以及基于所述空间坐标生成所述感兴趣结构的第二三维重建。

公开(公告)号：US08926994B2

公开(公告)日：2015-01-06

申请号：US13708888

申请日：2012-12-07

申请人： The Methodist Hospital Research Institute

发明人： Rita Elena Serda ,  Ismail Mustafa Meraz ,  Jianhua Gu ,  Xiaojun Xia ,  Haifa Shen ,  Tong Sun ,  Mauro Ferrari

IPC分类号： A61K39/00 ,  A61K47/48 ,  A61K9/14

CPC分类号： A61K9/143 ,  A61K39/0011 ,  A61K47/48861 ,  A61K47/48876 ,  A61K47/6923 ,  A61K47/6927 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572

摘要： Disclosed are mesoporous silicon multi-stage vehicles that comprise liposomal-based second-stage particles, as well as pharmaceutical compositions and formulations including such vectors for use in a variety of diagnostic and therapeutic indications. In particular embodiments, MSV comprising ligand decorated second-stage particles are provided for therapeutic methods including, for example, treatment of mammalian cancers, including those of the human breast.

摘要翻译： 公开了包含基于脂质体的第二级颗粒的介孔硅多级载体，以及包含用于各种诊断和治疗适应症的载体的药物组合物和制剂。 在具体实施方案中，提供了包含配体装饰的第二阶段颗粒的MSV用于治疗方法，包括例如治疗哺乳动物癌症，包括人乳腺癌。

公开(公告)号：US20140100456A1

公开(公告)日：2014-04-10

申请号：US13842860

申请日：2013-03-15

申请人： The Methodist Hospital Research Institute

发明人： Joseph Joe Naoum

IPC分类号： A61B5/00

CPC分类号： A61B17/11 ,  A61B5/6848 ,  A61B6/508 ,  A61B2017/1107 ,  A61M1/3655 ,  A61M2205/04 ,  A61M2205/3515

摘要： Disclosed are vascular access devices, implantable dialysis grafts, and systems including them useful for improved access to implanted medical devices. Also disclosed are implantable hemodialysis vascular access graft devices that facilitate easy, accurate and reproducible cannulation or needle entry into the implanted device by magnetically-locating a portion of the graft that includes one or more paramagnetic materials operably defining the physical boundaries of the target cannulation site/entry port.

摘要翻译： 公开了血管通路装置，植入式透析移植物和包括它们的系统，其可用于改进对植入的医疗装置的接近。 还公开了可植入血液透析血管通路移植装置，其通过磁性定位移植物的一部分，其包括可操作地限定目标插管部位的物理边界的一个或多个顺磁材料，促进容易，精确和可再现的插管或针入口到植入装置 /进口。

公开(公告)号：US20140044646A1

公开(公告)日：2014-02-13

申请号：US13952576

申请日：2013-07-26

申请人： The Methodist Hospital Research Institute

发明人： King Chuen Li ,  Zheng Li ,  Feng Li

IPC分类号： A61K49/00 ,  A61K9/127 ,  A61K9/51 ,  A61K31/505 ,  A61K31/506

CPC分类号： A61K49/0021 ,  A61K9/127 ,  A61K9/51 ,  A61K31/505 ,  A61K31/506 ,  A61K45/06 ,  A61K47/55 ,  A61K47/60 ,  A61K49/0052 ,  A61K51/0459 ,  C07D239/14 ,  C07D403/14

摘要： Disclosed are multivalent, integrin-receptor antagonists that are useful in a variety of therapeutic, prophylactic, and/or diagnostic imaging modalities. In illustrative embodiments, such compounds have been prepared and utilized in the imaging, detection, localization, and/or quantitation of one or more samples of biological interest. Similarly, these compounds, as well as formulations comprising them, find utility in the prevention, treatment, and/or amelioration of one or more symptoms of a disease, abnormal condition, dysfunction, etc., including, for example proliferative diseases such as cancer in affected animals. In certain embodiments, fluorescently- or radio-labeled-non-peptidic, multivalent integrin αvβ3 compounds are provided. Compositions including such compounds have been shown to have utility in detecting, localizing, quantitating, and/or imaging integrin αvβ3 receptor-expressing cells, including, for example, cancer cells in vitro, in vivo, and/or in situ.

摘要翻译： 公开了可用于各种治疗，预防和/或诊断成像模式的多价整联蛋白 - 受体拮抗剂。 在说明性实施方案中，已经制备并利用这些化合物在一种或多种生物学兴趣的样品的成像，检测，定位和/或定量中。 类似地，这些化合物以及包含它们的制剂可用于预防，治疗和/或改善疾病，异常状况，功能障碍等的一种或多种症状，包括例如增殖性疾病如癌症 在受影响的动物。 在某些实施方案中，提供了荧光或放射性标记的非肽，多价整联蛋白α噬菌体3化合物。 已经显示包含这些化合物的组合物可用于在体外，体内和/或原位检测，定位，定量和/或整合整联蛋白α1表达受体的细胞，包括例如癌细胞。

公开(公告)号：US20130293362A1

公开(公告)日：2013-11-07

申请号：US13797184

申请日：2013-03-12

申请人： THE METHODIST HOSPITAL RESEARCH INSTITUTE

发明人： Scott Edward Parazynski

IPC分类号： G08C19/16

CPC分类号： G06F3/0346 ,  A61B5/7475 ,  A61B34/30 ,  A61B34/37 ,  A61B34/74 ,  A61B2560/0487 ,  G05B2219/45123 ,  G06F3/0338 ,  G08C19/16

摘要： Disclosed is a controller including a first control member, a second control member that extends from a portion of the first control member, and a controller processor that is operable to produce a rotational movement output signal in response to movement of the first control member, and a translational movement output signal in response to movement of the second control member relative to the first control member. The rotational movement output signal may be any of a pitch movement output signal, a yaw movement output signal, and a roll movement output signal, and the translational movement output signal may be any of an x-axis movement output signal, a y-axis movement output signal, and a z-axis movement output signal. In exemplary embodiments, the first control member may be gripped and moved using a single hand, and the second control member may be moved using one or more digits of the single hand, thus permitting highly intuitive, single-handed control of multiple degrees of freedom, to and including, all six degrees of rotational and translational freedom without any inadvertent cross-coupling inputs.

摘要翻译： 公开了一种控制器，包括第一控制构件，从第一控制构件的一部分延伸的第二控制构件，以及可操作以响应于第一控制构件的移动产生旋转运动输出信号的控制器处理器，以及 响应于第二控制构件相对于第一控制构件的移动的平移运动输出信号。 旋转运动输出信号可以是音调移动输出信号，偏航运动输出信号和滚动移动输出信号中的任何一个，并且平移运动输出信号可以是x轴移动输出信号，y轴 移动输出信号和z轴移动输出信号。 在示例性实施例中，可以使用单手抓握和移动第一控制构件，并且可以使用单手的一个或多个数字来移动第二控制构件，从而允许对多个自由度的高度直观的单手控制 ，包括所有六个旋转和平移自由度，而没有任何无意的交叉耦合输入。

公开(公告)号：US20130288215A1

公开(公告)日：2013-10-31

申请号：US13804680

申请日：2013-03-14

申请人： The Methodist Hospital Research Institute

发明人： Edward Brian Butler ,  Craig Peter Fischer

IPC分类号： G09B23/28 ,  G06F19/00

CPC分类号： G09B23/28 ,  A61B34/25 ,  G06F19/321 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22 ,  G16H10/60 ,  G16H50/20 ,  G16H50/50

摘要： Systems, methods and apparatuses for generating and using representations of individual or aggregate human medical data.

摘要翻译： 用于生成和使用单个或总体人体医学数据的表示的系统，方法和装置。

公开(公告)号：US12115190B2

公开(公告)日：2024-10-15

申请号：US16975933

申请日：2019-02-27

申请人： THE METHODIST HOSPITAL

发明人： Wenhao Chen ,  Xian Chang Li

IPC分类号： A61K35/17 ,  A61K38/20 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  C07K14/47 ,  C07K16/28 ,  C12N5/0783 ,  C12N15/86

CPC分类号： A61K35/17 ,  A61K38/2013 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K14/4702 ,  C07K16/2827 ,  C12N5/0638 ,  C12N15/86 ,  A61K2039/505 ,  C12N2740/10043

摘要： Methods to treat cancer in a subject comprising administering to the subject a therapeutically effective amount of T-cells of the subject having increased IRF4 polypeptide expression compared to a control are disclosed. Also disclosed are methods of increasing tumor reactivity of a T-cell by increasing IRF4 polypeptide expression, and methods to predict the likelihood that a subject having cancer will respond therapeutically to administered T-cells having increased IRF4 polypeptide expression. Also disclosed are compositions comprising a T-cell and a viral vector encoding an IRF4 polypeptide. The compositions are methods are useful for treating numerous cancers in which higher level expression of IRF4 in T-cells would be beneficial. In some embodiments, activated tumor specific T-cells having increased IRF4 expression have greater infiltration in tumors and enhanced local immunological responses.

公开(公告)号：US20240199735A1

公开(公告)日：2024-06-20

申请号：US16936421

申请日：2020-07-22

申请人： The Methodist Hospital ,  Board of Regents, The University of Texas System

发明人： Stephen T.C. WONG ,  Jianting SHENG ,  Samuel C. MOK ,  Cecilia S. LEUNG ,  Tsz-Lun YEUNG

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  G01N33/574 ,  G01N33/58 ,  G01N33/60

CPC分类号： C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  G01N33/57449 ,  G01N33/582 ,  G01N33/60 ,  C07K2317/56

摘要： Disclosed are antibody compositions and methods for treatment mammalian cancers. Also disclosed are methods for use of the disclosed MFAP5-specific monoclonal antibodies and antigen-binding-fragments thereof, in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of mammalian cancer, including human ovarian and pancreatic cancers, in particular.