公开(公告)号：US20060228736A1

公开(公告)日：2006-10-12

申请号：US11397732

申请日：2006-04-05

Applicant: Toshinari Sakurai ,  Yoshihiro Yamashita

Inventor： Toshinari Sakurai ,  Yoshihiro Yamashita

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: C12Q1/6806 ,  C12Q2527/137 ,  C12Q2523/308 ,  C12Q2523/113

Abstract: The present invention provides a method which makes it possible to extract both a liquid sample for a biochemical examination and an immunological test and a blood cell sample for a nucleic acid test from one blood sample. Isolation of blood cells is carried out for the blood obtained by blood collection. To the isolated blood cell component, a solution is added, and furthermore, which is suspended. Thus, the obtained blood cell sample is freeze-preserved, or used for extraction of nucleic acid. A nucleic acid test is carried out with the use of the extracted nucleic acid. On the other hand, the isolated plasma component is freeze-preserved, or provided for a biochemical examination and an immunological test.

Abstract translation: 本发明提供一种能够从一个血液样品中提取用于生化检查和免疫测试的液体样品和用于核酸测试的血细胞样品的方法。 对通过采血获得的血液进行血细胞分离。 向分离的血细胞成分中加入溶液，此外，将其悬浮。 因此，将获得的血细胞样品冷冻保存，或用于提取核酸。 使用提取的核酸进行核酸试验。 另一方面，将分离的血浆成分冷冻保存，或提供用于生物化学检查和免疫测试。

公开(公告)号：US20050123965A1

公开(公告)日：2005-06-09

申请号：US10981521

申请日：2004-11-05

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai ,  Norihito Kuno ,  Kenko Uchida ,  Toshiaki Yokobayashi

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai ,  Norihito Kuno ,  Kenko Uchida ,  Toshiaki Yokobayashi

IPC: C12N15/09 ,  C12N15/10 ,  C12Q1/68 ,  C07H21/04

CPC classification number: C12N15/1006 ,  C12N15/101

Abstract: A method to extract RNA with high purity from biological materials containing RNA in a safe, rapid, and simple procedure and a method to analyze it are provided. The procedure includes the steps of mixing a biological material containing RNA with a predetermined concentration of a chaotropic agent and a predetermined concentration of an organic solvent, allowing the mixed solution to contact a nucleic acid-binding solid phase, washing the nucleic-acid binding solid-phase to which RNA is bound, and eluting RNA from the nucleic-acid binding solid-phase having the bound RNA. Furthermore, the obtained RNA is analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) or the like.

Abstract translation: 提供了一种以安全，快速，简单的方法从含有RNA的生物材料中提取高纯度RNA的方法和分析方法。 该方法包括以下步骤：将含有预定浓度的离液剂和预定浓度的有机溶剂的含有RNA的生物材料混合，使混合溶液与核酸结合固相接触，洗涤核酸结合固体 RNA结合的RNA，并从具有结合RNA的核酸结合固相中洗脱RNA。 此外，通过逆转录酶 - 聚合酶链反应（RT-PCR）等分析得到的RNA。

公开(公告)号：US06672827B2

公开(公告)日：2004-01-06

申请号：US10016590

申请日：2001-10-30

Applicant: Yoshihiro Yamashita ,  Manabu Nonaka ,  Takashi Kabasawa

Inventor： Yoshihiro Yamashita ,  Manabu Nonaka ,  Takashi Kabasawa

IPC: F04D1904

CPC classification number: F04D19/046 ,  F04D17/168 ,  F04D19/044

Abstract: To provide a small vacuum pump making it possible to efficiently perform evacuation from the atmosphere to a high vacuum (degree of vacuum: 10−5 Pa) by using a single pump unit. A turbo-molecular pump mechanism portion is arranged on the high-vacuum side, a volute pump mechanism portion is arranged on the atmosphere side, and a thread groove pump mechanism portion is arranged between the turbo-molecular pump mechanism portion and the volute pump mechanism portion. Further, rotor blades of the turbo-molecular pump mechanism portion, a rotor of the thread groove pump mechanism portion, and an impeller of the volute pump mechanism portion are integrally mounted to a single rotor shaft, which is rotated by a single motor.

Abstract translation: 为了提供一种小型真空泵，可以通过使用单个泵单元有效地从大气排出至高真空（真空度：10 -5 Pa）。 在高真空侧配置有涡轮分子泵机构部，在气氛侧配置有涡旋泵机构部，在涡轮分子泵机构部和涡旋泵机构之间配置有螺纹槽泵机构部 一部分。 此外，涡轮分子泵机构部分的转子叶片，螺纹槽泵机构部分的转子和蜗壳泵机构部分的叶轮一体地安装到由单个电动机旋转的单个转子轴上。

公开(公告)号：US4566841A

公开(公告)日：1986-01-28

申请号：US556293

申请日：1983-11-30

Applicant: Kenji Ohmura ,  Tsutomu Miyata ,  Yoshihiro Yamashita ,  Minoru Noda

Inventor： Kenji Ohmura ,  Tsutomu Miyata ,  Yoshihiro Yamashita ,  Minoru Noda

IPC: B65G47/90 ,  B65G1/00 ,  H01L21/67 ,  H01L21/677 ,  B65G65/34

CPC classification number: H01L21/67781 ,  Y10S414/138

Abstract: Wafery works receiving or delivering device comprise a work supporting means having plural pairs of supporting grooves of a given pitch in order to support a column of wafery works; a transfer mechanism having the work supporting means mounted at the upper end thereof and reciprocatable between a stand-by position and a work receiving or delivering position; a pair of forks disposed in the region of the work receiving or delivering position and having supporting grooves of the same pitch as those of the work supporting means; a fork advancing mechanism such that for advancing the forks to the work receiving or delivering position such that the forks overlap the work supporting means and the supporting grooves thereof align with those of the work supporting means; and a mechanism which collectively hands over the works supported on the work supporting means or on the forks to the forks or the work supporting means by moving the work supporting means upward or downward relative to the forks.

Abstract translation: 接收或传送设备的Wafery工程包括具有多个给定间距的支撑槽的工件支撑装置，以便支撑一批晶圆工程; 传送机构，其具有安装在其上端处的工件支撑装置，并且能够在待机位置和工件接收或传送位置之间往复运动; 设置在工件接收或传送位置的区域中的一对叉，并具有与工件支撑装置相同的间距的支撑槽; 叉子前进机构，用于将叉推进到工件接收或传送位置，使得叉与工件支撑装置重叠，并且其支撑槽与工件支撑装置的那些对准; 以及通过相对于叉子向上或向下移动工件支撑装置，将支撑在工件支撑装置上的工具或叉子上的叉子或工件支撑装置交叉的机构。

公开(公告)号：US20140030167A1

公开(公告)日：2014-01-30

申请号：US13982768

申请日：2012-01-30

Applicant: Yoshihiro Yamashita ,  Shinya Matsuoka ,  Taku Sakazume ,  Yukinori Sakashita

Inventor： Yoshihiro Yamashita ,  Shinya Matsuoka ,  Taku Sakazume ,  Yukinori Sakashita

IPC: B01L3/02

CPC classification number: B01L3/0227 ,  G01N35/00693 ,  G01N35/1011 ,  G01N35/1016 ,  Y10T436/2575

Abstract: This invention provides an analyzer that has a liquid dispense pipette dispensing liquids with higher accuracy and precision at higher speeds. The analyzer includes a drive mechanism having a stepping motor as a power source. The drive mechanism transmits power from a rotation output shaft of the stepping motor to a moving unit for executing a target motion via at least one power transmission unit. The amount of idling of the moving unit stemming from the stepping motor getting driven in reverse is calculated from the amount of movement of the moving unit, from the amount of pulses fed to the stepping motor, and from the amount of remaining pulses so as to perform motion control of the drive mechanism accordingly.

Abstract translation: 本发明提供一种具有液体分配移液管的分析器，其以更高的速度以更高的精度和精度分配液体。 分析器包括具有作为电源的步进电机的驱动机构。 驱动机构通过至少一个动力传递单元将来自步进马达的旋转输出轴的动力传递到用于执行目标运动的移动单元。 从步进电动机反向驱动的移动单元的空转量根据移动单元的移动量，从馈送到步进电动机的脉冲量和剩余脉冲量计算，以便 相应地执行驱动机构的运动控制。

公开(公告)号：US08491157B2

公开(公告)日：2013-07-23

申请号：US13044819

申请日：2011-03-10

Applicant: Hitoshi Oba ,  Naoki Nishimori ,  Akira Matsui ,  Nobuharu Ishikawa ,  Yoshihiro Yamashita ,  Takahiro Suga ,  Kosuke Sugiyama

Inventor： Hitoshi Oba ,  Naoki Nishimori ,  Akira Matsui ,  Nobuharu Ishikawa ,  Yoshihiro Yamashita ,  Takahiro Suga ,  Kosuke Sugiyama

IPC: F21S8/00

CPC classification number: G01N21/8806 ,  F21K9/20 ,  F21K9/90 ,  F21Y2103/33 ,  F21Y2107/00 ,  F21Y2115/10 ,  G03B15/05 ,  G03B2215/0539 ,  G03B2215/0567 ,  G03B2215/0575 ,  H05B33/0827 ,  H05K1/0278 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/189 ,  H05K3/0052 ,  H05K3/0058 ,  H05K2201/09081 ,  H05K2201/10106 ,  H05K2203/0228 ,  H05K2203/302 ,  Y10T29/49002

Abstract: To provide a method for manufacturing a plurality of types of illuminating devices having different specifications while reducing cost. A substrate includes a common flexible portion and a plurality of units bendable with respect to the common portion, where the common portion includes a pad that is extended in the horizontal direction in the plane of the drawing and that is arranged for every predefined interval. In the present manufacturing method, a substrate piece is created by cutting the substrate mounted with the light emitting element in a first direction, the common portion in the substrate piece is formed according to the illuminating device to be manufactured, the relative position of the individual portion with respect to the formed common portion is respectively positioned, and the wiring for supplying power to the pad in the substrate piece is formed.

Abstract translation: 提供一种在降低成本的同时制造具有不同规格的多种类型的照明装置的方法。 衬底包括共同的柔性部分和相对于公共部分可弯曲的多个单元，其中公共部分包括在图的平面中在水平方向上延伸并且每隔预定间隔布置的衬垫。 在本制造方法中，通过沿着第一方向切割安装有发光元件的基板来形成基板片，根据要制造的照明装置形成基片的公共部分，个体的相对位置 相对于形成的公共部分的部分分别定位，并且形成用于向基片中的焊盘供电的布线。

公开(公告)号：US20110222286A1

公开(公告)日：2011-09-15

申请号：US13044819

申请日：2011-03-10

Applicant: Hitoshi OBA ,  Naoki NISHIMORI ,  Akira MATSUI ,  Nobuharu ISHIKAWA ,  Yoshihiro YAMASHITA ,  Takahiro SUGA ,  Kosuke SUGIYAMA

Inventor： Hitoshi OBA ,  Naoki NISHIMORI ,  Akira MATSUI ,  Nobuharu ISHIKAWA ,  Yoshihiro YAMASHITA ,  Takahiro SUGA ,  Kosuke SUGIYAMA

IPC: F21S4/00 ,  F21V21/00 ,  H05K13/00

CPC classification number: G01N21/8806 ,  F21K9/20 ,  F21K9/90 ,  F21Y2103/33 ,  F21Y2107/00 ,  F21Y2115/10 ,  G03B15/05 ,  G03B2215/0539 ,  G03B2215/0567 ,  G03B2215/0575 ,  H05B33/0827 ,  H05K1/0278 ,  H05K1/028 ,  H05K1/0281 ,  H05K1/189 ,  H05K3/0052 ,  H05K3/0058 ,  H05K2201/09081 ,  H05K2201/10106 ,  H05K2203/0228 ,  H05K2203/302 ,  Y10T29/49002

Abstract: To provide a method for manufacturing a plurality of types of illuminating devices having different specifications while reducing cost. A substrate includes a common flexible portion and a plurality of units bendable with respect to the common portion, where the common portion includes a pad that is extended in the horizontal direction in the plane of the drawing and that is arranged for every predefined interval. In the present manufacturing method, a substrate piece is created by cutting the substrate mounted with the light emitting element in a first direction, the common portion in the substrate piece is formed according to the illuminating device to be manufactured, the relative position of the individual portion with respect to the formed common portion is respectively positioned, and the wiring for supplying power to the pad in the substrate piece is formed.

Abstract translation: 提供一种在降低成本的同时制造具有不同规格的多种类型的照明装置的方法。 衬底包括共同的柔性部分和相对于公共部分可弯曲的多个单元，其中公共部分包括在图的平面中在水平方向上延伸并且每隔预定间隔布置的衬垫。 在本制造方法中，通过沿着第一方向切割安装有发光元件的基板来形成基板片，根据要制造的照明装置形成基片的公共部分，个体的相对位置 相对于形成的公共部分的部分分别定位，并且形成用于向基片中的焊盘供电的布线。

公开(公告)号：US20110097240A1

公开(公告)日：2011-04-28

申请号：US12996449

申请日：2009-06-09

Applicant: Yoshihiro Yamashita ,  Taku Sakazume

Inventor： Yoshihiro Yamashita ,  Taku Sakazume

IPC: G01N30/00

CPC classification number: G01N33/54326 ,  G01N35/0098 ,  G01N2035/0436 ,  G01N2035/0446

Abstract: This invention provides an analyzer that uses magnetic particles, the analyzer being capable of removing inhibitors within a short time and reducing an analytical time. Magnetic particles 3 within a pre-washing solution accommodated in a reaction container 127 are aggregated by a magnet 4 disposed near the outside of the reaction container 127. The reaction container 127 is repetitively rotated by a container-rotating gear driving motor 9, thereby to impart vibration to the aggregated magnetic particles 3. The vibration changes relative positions of the magnetic particles densely populated by magnetic fields, and thus the inhibitors and other substances included in the magnetic particle aggregate can be removed from the magnetic particles.

Abstract translation: 本发明提供了一种使用磁性颗粒的分析仪，该分析仪能够在短时间内除去抑制剂并减少分析时间。 容纳在反应容器127内的预洗液中的磁性颗粒3被设置在反应容器127的外侧附近的磁体4聚集。反应容器127通过容器旋转齿轮驱动电动机9反复旋转，由此 对聚集的磁性颗粒3施加振动。振动改变由磁场密集填充的磁性颗粒的相对位置，因此可以从磁性颗粒中去除包含在磁性颗粒聚集体中的抑制剂和其它物质。

公开(公告)号：US20090186345A1

公开(公告)日：2009-07-23

申请号：US12073079

申请日：2008-02-29

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai

IPC: C12Q1/68

CPC classification number: C12N15/1006

Abstract: According to the present invention, purified nucleic acids are isolated without the complete removal of components of a washing reagent. Also, nucleic acids are isolated in an elution reagent by allowing a washing reagent comprising at least one component constituting a reaction solution that can be applied to a reaction involving nucleic acids to come into contact with a nucleic-acid-adsorbing solid phase so as to wash the solid phase, separating the washing reagent from the solid phase in a manner such that a certain amount of the washing reagent is allowed to remain in the solid phase, and allowing an elution reagent to come into contact with the nucleic-acid-adsorbing solid phase.

Abstract translation: 根据本发明，纯化的核酸被分离而没有完全去除洗涤剂的组分。 此外，通过使包含构成反应溶液的至少一种成分的洗涤剂，可以用于涉及核酸的反应与核酸吸附固相接触，从而在洗脱剂中分离核酸，从而 洗涤固相，将洗涤剂与固相分离，使得允许一定量的洗涤剂保留在固相中，并使洗脱剂与核酸吸附接触 固相。

公开(公告)号：US07486409B2

公开(公告)日：2009-02-03

申请号：US11586002

申请日：2006-10-25

Applicant: Yoshihiro Yamashita ,  Hirotaka Nakashima ,  Masahiro Kawachi

Inventor： Yoshihiro Yamashita ,  Hirotaka Nakashima ,  Masahiro Kawachi

IPC: G01B11/14

CPC classification number: G01B11/026

Abstract: In a sensor head, parallel rays or approximately parallel rays are generated by a pair of condenser lenses that reciprocate according to vibrations of a collimate lens and a tuning fork, and go out from a light port. To the light port, a lens holder in which an objective lens is supported is detachably attached. The light from the light port is processed to measurement beams that are condensed by the objective lens to a predetermined position.

Abstract translation: 在传感器头中，通过一对聚光透镜产生平行光线或大致平行光线，该聚光透镜根据准直透镜和音叉的振动而往复运动，并从光端口出射。 对于光端口，可拆卸地安装有支撑物镜的透镜架。 来自光端口的光被处理成由物镜会聚到预定位置的测量光束。