公开(公告)号：US20170218426A1

公开(公告)日：2017-08-03

申请号：US15484250

申请日：2017-04-11

Applicant: Accelerate Diagnostics, Inc.

Inventor： Alena Shamsheyeva ,  David C. Howson ,  Steven W. Metzger

IPC: C12Q1/18 ,  C12Q1/02

CPC classification number: C12Q1/18 ,  B01L3/502715 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2300/024 ,  B01L2300/0864 ,  B01L2300/0867 ,  C12M41/36 ,  C12Q1/02 ,  G16B5/00

Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.

公开(公告)号：US09714420B2

公开(公告)日：2017-07-25

申请号：US15003604

申请日：2016-01-21

Applicant: Accelerate Diagnostics, Inc.

Inventor： Steven W. Metzger ,  Kenneth Robert Hance

IPC: C12N13/00 ,  B03C5/00 ,  C12M1/00 ,  C12Q1/02 ,  G01N1/34 ,  G02B21/36 ,  C12Q1/24 ,  G01N33/49 ,  C12N7/02 ,  C12N7/00

CPC classification number: C12N13/00 ,  B03C5/005 ,  B03C2201/18 ,  B03C2201/26 ,  C12M47/12 ,  C12N7/00 ,  C12N7/02 ,  C12N2710/00051 ,  C12Q1/02 ,  C12Q1/24 ,  G01N1/34 ,  G01N33/491 ,  G02B21/361

Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.

公开(公告)号：US09657327B2

公开(公告)日：2017-05-23

申请号：US13843460

申请日：2013-03-15

Applicant: Accelerate Diagnostics, Inc.

Inventor： Steven W. Metzger ,  David C. Howson ,  David A. Goldberg ,  Daniel A. Buttry

IPC: G01N33/53 ,  C12Q1/18 ,  C12Q1/04 ,  G06F19/10

CPC classification number: C12Q1/18 ,  C12Q1/04 ,  G06F19/10

Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.

公开(公告)号：US20170023599A1

公开(公告)日：2017-01-26

申请号：US15283922

申请日：2016-10-03

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: G01N35/00 ,  C12Q1/68

CPC classification number: C12Q1/6841 ,  B01L3/545 ,  C12Q1/025 ,  G01N21/6458 ,  G01N35/00069 ,  G01N35/025 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2035/00158 ,  G01N2035/00346 ,  G01N2035/1032 ,  G02B7/28

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.

Abstract translation: 公开了一种用于自动化微生物鉴定和抗生素敏感性测试的系统，其包括试剂盒，试剂台，盒式磁带，载物台，移液器组件，光学检测系统和控制器。 该系统旨在动态调整电机怠速转矩以控制热负荷，并采用快速聚焦过程来确定单个微生物的真实聚焦位置。 该系统还可以使用动态稀释来量化样品中活的微生物的相对丰度，并促进微生物在定制培养基中的生长以用于快速，准确的抗微生物敏感性测试。 还公开了自动质量控制测试组件及其使用方法。

公开(公告)号：US20160348091A1

公开(公告)日：2016-12-01

申请号：US15236021

申请日：2016-08-12

Applicant: Accelerate Diagnostics, Inc.

Inventor： Steven W. Metzger ,  Kenneth Robert Hance

IPC: C12N13/00 ,  G01N33/49 ,  B03C5/00 ,  C12Q1/24

CPC classification number: C12N13/00 ,  B03C5/005 ,  B03C2201/18 ,  B03C2201/26 ,  C12M47/12 ,  C12N7/00 ,  C12N7/02 ,  C12N2710/00051 ,  C12Q1/02 ,  C12Q1/24 ,  G01N1/34 ,  G01N33/491 ,  G02B21/361

Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.

公开(公告)号：US20160289729A1

公开(公告)日：2016-10-06

申请号：US15085953

申请日：2016-03-30

Applicant: Accelerate Diagnostics, Inc.

Inventor： William L. Richards ,  Austin Ashby ,  Matthew Ketterer ,  Kevin Marshall ,  Josh Harrison ,  Matthew Mette ,  Paul Richards ,  Wayne Showalter ,  Jasmin Cote ,  Phillip C. Halbert ,  Solene Bourgeois ,  Steven W. Metzger ,  Ken Hance ,  Meghan Mensack ,  Carlos Michel ,  Elke Allers ,  Dulini Gamage ,  Landon Prisbrey ,  Oleg Gusyatin ,  Alena Shamsheyeva ,  Ben Turng ,  Andrew Ghusson ,  Kurt Reinhardt

IPC: C12Q1/02 ,  G01N35/02 ,  H04N5/232 ,  C12Q1/04 ,  B01L3/00 ,  G01N35/10 ,  G01N1/38

CPC classification number: C12Q1/025 ,  B01L3/527 ,  B01L2300/0893 ,  C12Q1/04 ,  G01N1/38 ,  G01N15/06 ,  G01N21/6458 ,  G01N35/025 ,  G01N35/1002 ,  G01N2015/0693 ,  G01N2021/6419 ,  G01N2035/00346 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0446 ,  G01N2035/0455 ,  G01N2035/1032 ,  G02B7/28 ,  H04N5/23212

Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.

Abstract translation: 公开了一种用于自动化微生物鉴定和抗生素敏感性测试的系统，其包括试剂盒，试剂台，盒式磁带，载物台，移液器组件，光学检测系统和控制器。 该系统旨在动态调整电机怠速转矩以控制热负荷，并采用快速聚焦过程来确定单个微生物的真实聚焦位置。 该系统还可以使用动态稀释来量化样品中活的微生物的相对丰度，并促进微生物在定制培养基中的生长以用于快速，准确的抗微生物敏感性测试。

公开(公告)号：US20160138067A1

公开(公告)日：2016-05-19

申请号：US15003604

申请日：2016-01-21

Applicant: Accelerate Diagnostics, Inc.

Inventor： Steven W. Metzger ,  Kenneth Robert Hance

IPC: C12Q1/02 ,  G02B21/36 ,  G01N1/34

CPC classification number: C12N13/00 ,  B03C5/005 ,  B03C2201/18 ,  B03C2201/26 ,  C12M47/12 ,  C12N7/00 ,  C12N7/02 ,  C12N2710/00051 ,  C12Q1/02 ,  C12Q1/24 ,  G01N1/34 ,  G01N33/491 ,  G02B21/361

Abstract: Methods and systems for purifying cells and/or viruses are provided. The sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the cells and/or viruses in the well. The cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the cells and/or viruses may be retained in the well by embedding in the medium. The medium including the embedded cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface.

Abstract translation: 提供了用于纯化细胞和/或病毒的方法和系统。 将样品加入到置于介质中的孔中。 在整个介质上施加电势以使污染物进入孔的一个或多个壁，并将细胞和/或病毒保留在孔中。 细胞和/或病毒可以从孔中去除，并且任选地粘附或固定在表面上或被检测。 在一个实施方案中，细胞和/或病毒可以通过包埋在培养基中而保留在孔中。 包含嵌入细胞和/或病毒的培养基可以被切除或以其它方式去除并转移到载玻片或其它固体表面。

公开(公告)号：US20140278136A1

公开(公告)日：2014-09-18

申请号：US14209917

申请日：2014-03-13

Applicant: Accelerate Diagnostics, Inc.

Inventor： Alena Shamsheyeva ,  David C. Howson ,  Steven W. Metzger

IPC: C12Q1/18

CPC classification number: C12Q1/18 ,  B01L3/502715 ,  B01L2200/04 ,  B01L2200/0647 ,  B01L2300/024 ,  B01L2300/0864 ,  B01L2300/0867 ,  C12M41/36 ,  C12Q1/02 ,  G06F19/12

Abstract: This disclosure is related to systems and methods for rapid determination of microorganism growth and antimicrobial agent susceptibility and/or resistance.

Abstract translation: 本公开涉及用于快速测定微生物生长和抗微生物剂敏感性和/或抗性的系统和方法。