中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

39 records (took 0.022 seconds)

    Probes for biochemical tests
    21.
    发明授权
    Probes for biochemical tests 有权

    公开(公告)号：US11199555B2

    公开(公告)日：2021-12-14

    申请号：US16421015

    申请日：2019-05-23

    Applicant: Access Medical Systems, LTD.

    Inventor： Hong Tan ,  Ming Xia ,  Yushan Tan ,  Jun Chen ,  Erhua Cao ,  Genqian Li ,  Robert F. Zuk

    IPC: G01N35/00 ,  G01N33/74 ,  B01L3/00 ,  G01N33/543 ,  G01N35/02 ,  G01N35/04

    Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

    Electrochemiluminescent detection system
    24.
    发明授权
    Electrochemiluminescent detection system 有权

    公开(公告)号：US10718764B2

    公开(公告)日：2020-07-21

    申请号：US15255558

    申请日：2016-09-02

    Applicant: Access Medical Systems, LTD.

    Inventor： Robert F. Zuk ,  Hong Tan

    IPC: G01N33/543 ,  G01N33/533 ,  G01N33/53 ,  G01N21/76 ,  G01N27/327 ,  G01N33/553 ,  G01N21/75

    Abstract: The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise. The present invention is also directed to an electrochemiluminescent detection system for measuring a chemiluminescent signal on a probe tip.

    Systems for immunoassay tests
    25.
    发明授权
    Systems for immunoassay tests 有权

    公开(公告)号：US10345319B2

    公开(公告)日：2019-07-09

    申请号：US15784966

    申请日：2017-10-16

    Applicant: Access Medical Systems, LTD.

    Inventor： Hong Tan ,  Ming Xia ,  Yushan Tan ,  Jun Chen ,  Erhua Cao ,  Genqian Li ,  Robert F. Zuk

    IPC: B65G47/90 ,  G01N35/00 ,  B01L3/00 ,  G01N33/543 ,  G01N35/02 ,  G01N35/04

    Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

    Cartridge assembly tray for immunoassay tests
    26.
    发明授权
    Cartridge assembly tray for immunoassay tests 有权

    公开(公告)号：US10161945B2

    公开(公告)日：2018-12-25

    申请号：US15475998

    申请日：2017-03-31

    Applicant: Access Medical Systems, LTD.

    Inventor： Hong Tan ,  Yongli Ren ,  Ming Xia ,  Genqian Li

    IPC: B01L9/00 ,  G01N35/00 ,  B01L3/00 ,  G01N33/53 ,  G01N33/536 ,  G01N35/04

    Abstract: This invention relates to a cartridge assembly tray for conducting automated biochemical tests, such as immunoassay tests. The tray comprises a base member, a hinged frame and a locking mechanism. The base member includes a plurality of slots within the base member. Each of the plurality of slots is to receive a test cartridge. The hinged frame is coupled to the base member. The hinged frame is capable to rotate to an opened position or a closed position. The hinged frame includes a horizontal push bar configured to apply a downward force to test cartridges received in the plurality of slots when the hinged frame is in the closed position. The locking mechanism is to lock the hinged frame in the closed position when the hinged frame rotates to the closed position.

    Optical sensor of bio-molecules using thin-film interferometer
    28.
    发明授权
    Optical sensor of bio-molecules using thin-film interferometer 有权
    使用薄膜干涉仪的生物分子的光学传感器

    公开(公告)号：US08940238B2

    公开(公告)日：2015-01-27

    申请号：US14095120

    申请日：2013-12-03

    Applicant: Access Medical Systems, Ltd.

    Inventor： Hong Tan ,  Yushan Tan ,  Erhua Cao ,  Ming Xia ,  Robert F. Zuk

    IPC: G01N21/00 ,  G01B9/02 ,  G02B6/26 ,  G02B6/36 ,  G01N21/45 ,  G01N21/77 ,  G02B6/00 ,  G01N21/63

    CPC classification number: G01N21/7703 ,  G01J3/45 ,  G01N21/45 ,  G01N21/648 ,  G01N21/8507 ,  G01N2021/7779 ,  G01N2201/062 ,  G01N2201/08 ,  G02B6/262 ,  G02B6/30

    Abstract: The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.

    Abstract translation: 本发明涉及一种用于基于薄膜光谱干涉检测样品中的分析物的组件。 组件包括波导，光耦合到波导的单片基板，以及直接结合到整体式基板的感测侧的薄膜层。 单片基板的折射率高于薄膜层的透明材料的折射率。 当样品中的分析物分子结合到涂覆在薄膜层上的分析物结合分子时，从第一反射表面和第二反射表面反射到波导中的光之间的光谱干涉变化。

    Luminescent polymer cyclic amplification
    29.
    发明授权
    Luminescent polymer cyclic amplification 有权
    发光聚合物循环扩增

    公开(公告)号：US08647889B2

    公开(公告)日：2014-02-11

    申请号：US13676970

    申请日：2012-11-14

    Applicant: Access Medical Systems, Ltd.

    Inventor： Robert F. Zuk ,  Hong Tan

    IPC: G01N33/563 ,  G01N33/544 ,  G01N33/53

    CPC classification number: G01N33/54393 ,  G01N21/76 ,  G01N27/3277 ,  G01N33/5306 ,  G01N33/533 ,  G01N33/5438 ,  G01N33/553 ,  G01N2021/757

    Abstract: The present invention is directed to a luminescent immunoassay method for detecting an analyte in a liquid sample with high sensitivity. The invention provides a unique combination of (i) using a probe having a small sensing surface area for binding analyte molecules, (ii) using a high molecular weight branched polymer conjugated with multiple binding molecules and multiple luminescent labels, and (iii) cycling the probe having immunocomplex formed back to the reagent vessel and amplification vessel 1-10 times and repeating the reaction with the reagent and the amplification polymer, to improve the sensitivity of detection level. For each cycling, the luminescent signal is increased significantly over the noise.

    Abstract translation: 本发明涉及一种用于以高灵敏度检测液体样品中的分析物的发光免疫测定方法。 本发明提供了以下独特的组合：（i）使用具有小的感测表面积的探针来结合分析物分子，（ii）使用与多个结合分子共轭的高分子量支化聚合物和多个发光标记，以及（iii） 将具有免疫复合物的探针形成回试剂容器和扩增容器1-10次，并重复与试剂和扩增聚合物的反应，以提高检测水平的灵敏度。 对于每个循环，发光信号在噪声上显着增加。

Patent Agency Ranking