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公开(公告)号:US20190278075A1
公开(公告)日:2019-09-12
申请号:US16404633
申请日:2019-05-06
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine
Abstract: In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.
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公开(公告)号:US20180231753A1
公开(公告)日:2018-08-16
申请号:US15943595
申请日:2018-04-02
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine
IPC: G02B21/00 , G02B21/36 , G01N33/80 , G01N15/14 , G06K9/00 , G01T1/02 , G01N11/00 , G03H1/00 , G01B9/02 , G03H1/04 , G01N15/00 , C12M1/34 , G01N15/10 , G06T7/00
CPC classification number: G02B21/0008 , C12M41/36 , G01B9/02041 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N15/1475 , G01N33/80 , G01N2011/008 , G01N2015/0069 , G01N2015/1006 , G01N2015/1486 , G01N2015/149 , G01T1/02 , G02B21/00 , G02B21/0004 , G02B21/361 , G02B21/365 , G03H2001/005 , G03H2001/045 , G06K9/00127 , G06K9/00147 , G06T7/0012 , G06T2207/10056 , G06T2207/30242 , Y10S435/808
Abstract: Among other things, a method comprises imaging a sample displaced between a sensor surface and a surface of a microscopy sample chamber to produce an image of at least a part of the sample. The image is produced using lensless optical microscopy, and the sample contains at least blood from a subject. The method also comprises automatically differentiating cells of different types in the image, generating a count of one or more cell types based on the automatic differentiation, and deriving a radiation dose the subject has absorbed based on the count.
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公开(公告)号:US09720217B2
公开(公告)日:2017-08-01
申请号:US14698532
申请日:2015-04-28
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
CPC classification number: G02B21/0008
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号:US20150241679A1
公开(公告)日:2015-08-27
申请号:US14698532
申请日:2015-04-28
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
CPC classification number: G02B21/0008
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
Abstract translation: 除其他之外,成像装置具有像素的光敏阵列,并且与阵列相关联的表面被配置为接收样本,其中至少一部分样本与表面的距离相当于小于平均值的大约一半 像素的宽度。
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公开(公告)号:US12174358B2
公开(公告)日:2024-12-24
申请号:US17931414
申请日:2022-09-12
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine , Joel Ironstone , Christopher Gillespie
Abstract: A base assembly includes an imaging sensor having a sensor surface to receive a sample, and a platform connected to the base assembly. The base assembly includes (a) an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface and (b) a movement portion movable toward and away from the base assembly. The platform and the base assembly are configured to limit contact between the sample and the base assembly other than at the sensor surface.
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公开(公告)号:US11947096B2
公开(公告)日:2024-04-02
申请号:US17712959
申请日:2022-04-04
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine , Peter Hodges Gregson
IPC: G02B21/00
CPC classification number: G02B21/0008
Abstract: Among other things, an imaging device has a photosensitive array of pixels, and a surface associated with the array is configured to receive a specimen with at least a part of the specimen at a distance from the surface equivalent to less than about half of an average width of the pixels.
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公开(公告)号:US11719700B2
公开(公告)日:2023-08-08
申请号:US17349682
申请日:2021-06-16
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine
IPC: G01N33/58 , G01N33/50 , G01N21/77 , G01N33/53 , G01N33/543 , G01N33/569
CPC classification number: G01N33/585 , G01N21/77 , G01N33/5094 , G01N33/5302 , G01N33/543 , G01N33/54366 , G01N33/56983 , G01N33/587 , G01N33/588
Abstract: Two or more upconverting particles are attached to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-particle complex including the unit of the chemical component and two or more corresponding upconverting particles. The sample is illuminated by input light having a first wavelength. Light is received at an imaging sensor, the received light including output light generated by at least a portion of the upconverting particles attached to the units of the chemical component, the output light having a second wavelength that is shorter than the first wavelength. One or more images of the sample are captured from the received light. Based on the captured one or more images, a presence or a level of the chemical component in the sample is determined.
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公开(公告)号:US20230110857A1
公开(公告)日:2023-04-13
申请号:US17931414
申请日:2022-09-12
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine , Joel Ironstone , Christopher Gillespie
Abstract: A base assembly includes an imaging sensor having a sensor surface to receive a sample, and a platform connected to the base assembly. The base assembly includes (a) an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface and (b) a movement portion movable toward and away from the base assembly. The platform and the base assembly are configured to limit contact between the sample and the base assembly other than at the sensor surface.
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公开(公告)号:US20220206282A1
公开(公告)日:2022-06-30
申请号:US17696704
申请日:2022-03-16
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine , Hershel Macaulay , Noah Hymes-Vandermeulen
Abstract: Among other things, a first surface is configured to receive a sample and is to be used in a microscopy device. There is a second surface to be moved into a predefined position relative to the first surface to form a sample space that is between the first surface and the second surface and contains at least part of the sample. There is a mechanism configured to move the second surface from an initial position into the predefined position to form the sample space. When the sample is in place on the first surface, the motion of the second surface includes a trajectory that is not solely a linear motion of the second surface towards the first surface.
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公开(公告)号:US20210311037A1
公开(公告)日:2021-10-07
申请号:US17349682
申请日:2021-06-16
Applicant: Alentic Microscience Inc.
Inventor: Alan Marc Fine
IPC: G01N33/543 , G01N33/50 , G01N21/77 , G01N33/53
Abstract: Two or more upconverting particles are attached to each unit of one or more units of a chemical component in a sample, to form, for each unit of the chemical component, a multi-particle complex including the unit of the chemical component and two or more corresponding upconverting particles. The sample is illuminated by input light having a first wavelength. Light is received at an imaging sensor, the received light including output light generated by at least a portion of the upconverting particles attached to the units of the chemical component, the output light having a second wavelength that is shorter than the first wavelength. One or more images of the sample are captured from the received light. Based on the captured one or more images, a presence or a level of the chemical component in the sample is determined.
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