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21.发明授权Detection apparatus for detecting charged particles, methods for detecting charged particles and mass spectrometer 有权用于检测带电粒子的检测装置，用于检测带电粒子的方法和质谱仪公开(公告)号：US08642973B2
公开(公告)日：2014-02-04
申请号：US12909720
申请日：2010-10-21
IPC分类号： H01J37/244 , H01J49/02
CPC分类号： H01J37/244 , H01J49/025 , H01J2237/2444
摘要： Embodiments of the invention provide a detection apparatus for detecting charged particles having a charged particle detector for receiving and detecting either incoming charged particles or secondary charged particles generated from the incoming charged particles, a photon generator for generating photons in response to receiving at least some of the same incoming charged particles or secondary charged particles generated from the incoming charged particles as are received and detected by the charged particle detector, and a photon detector for detecting photons generated by the photon generator.
摘要翻译： 本发明的实施例提供了一种检测装置，用于检测具有带电粒子检测器的带电粒子的检测装置，用于接收和检测从进入的带电粒子产生的输入带电粒子或二次带电粒子;光子发生器，用于响应于接收至少一些 由带电粒子检测器接收和检测从进入的带电粒子产生的相同的进入带电粒子或二次带电粒子，以及用于检测由光子发生器产生的光子的光子检测器。
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22.发明授权公开(公告)号：US08642949B2
公开(公告)日：2014-02-04
申请号：US13413568
申请日：2012-03-06
IPC分类号： H01J37/301 , H01J49/04 , H01J49/24 , H01J3/18
CPC分类号： H01J49/062 , H01J3/14
摘要： An ion transfer arrangement for transporting ions between higher and lower pressure regions of the mass spectrometer comprises an ion transfer conduit 60. The conduit 60 has an inlet opening towards a relatively high pressure chamber 40 and an outlet 70 opening towards a relatively low pressure chamber. The conduit 60 also has at least one side wall surrounding an ion transfer channel 115. The side wall includes a plurality of apertures 140 formed in the longitudinal direction of the side wall so as to permit a flow of gas from within the ion transfer channel 115 to a lower pressure region outside of the side wall of the conduit 60.
摘要翻译： 用于在质谱仪的较高和较低压力区域之间输送离子的离子传递装置包括离子传递管道60.导管60具有朝向较高压力室40的入口开口和朝向较低压力室开口的出口70。 导管60还具有围绕离子传递通道115的至少一个侧壁。侧壁包括在侧壁的纵向方向上形成的多个孔140，以允许来自离子传递通道115内的气体流 到导管60的侧壁外侧的较低压力区域。
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公开(公告)号：US20130268212A1
公开(公告)日：2013-10-10
申请号：US13994312
申请日：2011-12-15
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J49/0036
摘要： The invention provides a data acquisition system and method for detecting ions in a mass spectrometer, comprising: a detection system for detecting ions comprising two or more detectors for outputting two or more detection signals in separate channels in response to ions arriving at the detection system; and a data processing system for receiving and processing the detection signals in separate channels of the data processing system and for merging the processed detection signals to construct a mass spectrum; wherein the processing in separate channels comprises removing noise from the detection signals by applying a threshold to the detection signals. The detection signals are preferably produced in response to the same ions, the signals being shifted in time relative to each other. The invention is suitable for a TOF mass spectrometer.
摘要翻译： 本发明提供了一种用于检测质谱仪中的离子的数据采集系统和方法，包括：用于检测包括两个或更多个检测器的离子的检测系统，用于响应于到达检测系统的离子在单独的通道中输出两个或更多个检测信号; 以及数据处理系统，用于在数据处理系统的单独信道中接收和处理检测信号，并且用于合并处理的检测信号以构建质谱; 其中在单独信道中的处理包括通过对检测信号应用阈值来从检测信号中去除噪声。 优选地，响应于相同的离子产生检测信号，信号在时间上相对于彼此移动。 本发明适用于TOF质谱仪。
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公开(公告)号：US20130240725A1
公开(公告)日：2013-09-19
申请号：US13989697
申请日：2011-11-24
申请人： Alexander A. Makarov
发明人： Alexander A. Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/405 , H01J49/4245 , H01J49/425 , H01J49/427
摘要： A method of selecting ions of interest from a beam of ions using an analyser, the method comprising: (i) providing an analyser comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an analyser axis z, each system comprising one or more electrodes, the outer system surrounding the inner; (ii) causing the beam of ions to fly through the analyser along a main flight path in the presence of an analyser field so as to undergo within the analyser at least one full oscillation in the direction of the analyser axis whilst orbiting about or oscillating between one or more electrodes of the inner field defining electrode system; (iii) providing one or more sets of electrodes adjacent the main flight path; (iv) constraining the arcuate divergence from the main flight path of ions of interest by applying one set of voltages to one or more of the sets of electrodes adjacent the main flight path when the ions of interest are in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path and applying one or more different sets of voltages to the said one or more sets of electrodes adjacent the main flight path when the ions of interest are not in the vicinity of at least one of said one or more sets of electrodes adjacent the main flight path; and: (v) ejecting the ions of interest from the analyser. Also provided is a charged particle analyser comprising the two opposing ion mirrors comprising inner and outer field-defining electrode systems elongated along an analyser axis z, and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyser whilst the beam orbits around the axis z, the analyser further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces.
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公开(公告)号：US08395115B2
公开(公告)日：2013-03-12
申请号：US12809867
申请日：2008-12-22
CPC分类号： H01J49/406 , H01J49/061 , H01J49/405
摘要： The present invention provides a method of reflecting ions in a multireflection time of flight mass spectrometer comprising providing an ion mirror having a plurality of electrodes, the ion mirror having a cross section with a first, minor axis (Y) and a second, major axis (X) each perpendicular to a longitudinal axis (Z) of the ion mirror which lies generally in the direction of time of flight separation of the ions in the mirror; guiding ions towards the ion mirror; applying a voltage to the electrodes so as to create an electric field which: (a) causes the mean trajectory of the ions to intersect a plane of symmetry of the ion mirror which contains the longitudinal (Z) and major axes (X) of the mirror; (b) causes the ions to reflect in the ion mirror; and (c) causes the ions to exit the ion mirror in a direction such that the mean trajectory of ions passing through the ion mirror has a component of movement in a direction (Y) perpendicular to and diverging from the said plane of symmetry thereof.
摘要翻译： 本发明提供一种在多反射飞行时间质谱仪中反射离子的方法，包括提供具有多个电极的离子反射镜，所述离子反射镜具有具有第一短轴（Y）和第二长轴（Y）的横截面 （X），每个垂直于离子镜的纵向轴线（Z），其通常位于反射镜中的离子的飞行时间分离方向上; 引导离子到离子镜; 向电极施加电压以产生电场：（a）使离子的平均轨迹与包含纵向（Z）和长轴（X）的离子镜的对称平面相交， 镜子; （b）使离子在离子反射镜中反射; 和（c）使得离子离开离子反射镜的方向，使得通过离子镜的离子的平均轨迹具有与所述对称平面垂直的方向（Y）和与其对称的发散方向的运动分量。
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26.发明授权Ion transfer tube having single or multiple elongate bore segments and mass spectrometer system 有权离子转移管具有单个或多个细长孔段和质谱仪系统公开(公告)号：US08309916B2
公开(公告)日：2012-11-13
申请号：US12858726
申请日：2010-08-18
IPC分类号： H01J49/26
CPC分类号： H01J49/0404
摘要： An ion transfer tube for a mass spectrometer comprises a tube member having an inlet end and an outlet end; and at least one bore extending through the tube member from the inlet end to the outlet end, the at least one bore having a non-circular cross section. A method of forming an ion transfer tube comprises the steps of providing a tube member having a length and an internal bore, the internal bore having a wall of circular cross section; and etching or eroding portions of the tube member adjacent to the wall so as to form an enlarged bore having a non-circular cross section.
摘要翻译： 用于质谱仪的离子转移管包括具有入口端和出口端的管构件; 以及至少一个孔，其从所述入口端延伸到所述管构件到所述出口端，所述至少一个孔具有非圆形横截面。 形成离子转移管的方法包括以下步骤：提供具有长度和内孔的管构件，所述内孔具有圆形横截面的壁; 并且蚀刻或侵蚀与壁相邻的管构件的部分，以便形成具有非圆形横截面的扩大孔。
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27.发明申请公开(公告)号：US20120138785A1
公开(公告)日：2012-06-07
申请号：US13375150
申请日：2010-05-27
CPC分类号： H01J49/40 , H01J49/406 , H01J49/4245
摘要： Methods and analysers useful for time of flight mass spectrometry are provided. A method of separating charged particles comprises the steps of: providing an analyser comprising two opposing mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner and defining therebetween an analyser volume, the mirrors creating an electrical field within the analyser volume comprising opposing electrical fields along z, the strength along z of the electrical field being a minimum at a plane z=0; causing a beam of charged particles to fly through the analyser, orbiting around the z axis within the analyser volume, reflecting from one mirror to the other at least once thereby defining a maximum turning point within a mirror; the strength along z of the electrical field at the maximum turning point being X and the absolute strength along z of the electrical field being less than |X|/2 for not more than ⅔ of the distance along z between the plane z=0 and the maximum turning point in each mirror; separating the charged particles according to their flight times; and ejecting at least some of the charged particles having a plurality of m/z from the analyser or detecting the at least some of charged particles having a plurality of m/z, the ejecting or detecting being performed after the particles have undergone the same number of orbits around the axis z.
摘要翻译： 提供了可用于飞行时间质谱的方法和分析仪。 分离带电粒子的方法包括以下步骤：提供包括两个相对的反射镜的分析器，每个反射镜包括沿着轴线z细长的内部和外部场限定电极系统，外部系统围绕内部并且在其间限定分析器体积， 在分析器体积内产生包括沿着z的相对电场的电场，在z = 0的平面处电场z的强度是最小的; 使得带电粒子束飞过分析器，围绕分析器体积内的z轴轨道运动，从一个反射镜至另一个反射镜至少一次，从而限定了反射镜内的最大转折点; 在最大转折点处的电场z的强度为X，电场z的绝对强度小于| X | / 2，不超过z = 0和 每个镜子的最大转折点; 根据飞行时间分离带电粒子; 并且从分析器中排出具有多个m / z的至少一些带电粒子或者检测至少一些具有多个m / z的带电粒子，在粒子经历相同数目之后执行喷射或检测 绕z轴的轨道。
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28.发明申请Detection Apparatus for Detecting Charged Particles, Methods for Detecting Charged Particles and Mass Spectrometer 有权用于检测带电粒子的检测装置，检测带电粒子的方法和质谱仪公开(公告)号：US20110095177A1
公开(公告)日：2011-04-28
申请号：US12909507
申请日：2010-10-21
IPC分类号： H01J49/00
CPC分类号： H01J49/025 , H01J49/40 , H01J2237/2444
摘要： Embodiments of the invention provide a detection apparatus for detecting charged particles having a secondary particle generator for generating secondary charged particles in response to receiving incoming charged particles, a charged particle detector for receiving and detecting secondary charged particles generated by the secondary particle generator, a photon generator for generating photons in response to receiving secondary charged particles generated by the secondary particle generator, and a photon detector for detecting the photons generated by the photon generator.
摘要翻译： 本发明的实施例提供了一种用于检测带有二次粒子发生器的带电粒子的检测装置，用于响应于接收进入的带电粒子而产生二次带电粒子，用于接收和检测由二次粒子发生器产生的二次带电粒子的带电粒子检测器， 用于响应于由二次粒子发生器产生的接收二次带电粒子而产生光子的发生器，以及用于检测由光子发生器产生的光子的光子检测器。
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公开(公告)号：US06903334B1
公开(公告)日：2005-06-07
申请号：US10804849
申请日：2004-03-19
CPC分类号： H01J49/164 , H01J49/06
摘要： Mass spectrometers, ion sources and methods for providing and transporting analyte ions derived from a sample to ion optics. A sample chamber is configured to receive a sample plate supporting a sample, and an illumination source is configured to illuminate the sample to generate analyte ions and particles. A matrix-protecting interface is located between the sample plate and the ion optics, and configured such that the shortest travel path between the illuminated portion of the sample plate and the sampling aperture or input of the ion optics is substantially obstructed. Alternatively, a gas flow directed at an angle from zero to 90 degrees relative to the main axis of the ion optics and away from the ion optics influences particles generated by the action of the illumination source away from the ion optics, and a voltage source extracts analyte ions of interest.
摘要翻译： 质谱仪，离子源和用于提供和运送衍生自样品的分析物离子到离子光学器件的方法。 样品室被配置为接收支撑样品的样品板，并且照明源被配置为照射样品以产生分析物离子和颗粒。 矩阵保护界面位于样品板和离子光学器件之间，并被配置为使得样品板的照射部分与采样孔或离子光学器件的输入之间的最短行进路径基本上被阻挡。 或者，相对于离子光学器件的主轴并离开离子光学器件从零到90度的角度的气流影响由离子光学器件的照明源的作用产生的颗粒，并且电压源提取 感兴趣的分析物离子。
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公开(公告)号：US10074528B2
公开(公告)日：2018-09-11
申请号：US13994312
申请日：2011-12-15
CPC分类号： H01J49/025 , H01J49/0036
摘要： The invention provides a data acquisition system and method for detecting ions in a mass spectrometer, comprising: a detection system for detecting ions comprising two or more detectors for outputting two or more detection signals in separate channels in response to ions arriving at the detection system; and a data processing system for receiving and processing the detection signals in separate channels of the data processing system and for merging the processed detection signals to construct a mass spectrum; wherein the processing in separate channels comprises removing noise from the detection signals by applying a threshold to the detection signals. The detection signals are preferably produced in response to the same ions, the signals being shifted in time relative to each other. The invention is suitable for a TOF mass spectrometer.
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