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    Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer
    23.
    发明申请
    Biosensor with One-Dimensional Sub-Diffraction-Limited Apertures Composed of a Grid and a Polarizer 有权
    具有由网格和偏振器组成的一维子衍射限制光圈的生物传感器

    公开(公告)号：US20090001284A1

    公开(公告)日：2009-01-01

    申请号：US12158347

    申请日：2006-12-11

    申请人： Maarten van Herpen ,  Dirk J. Broer ,  Emiel Peeters ,  Derk J.W Klunder ,  Hendrik R. Stapert

    发明人： Maarten van Herpen ,  Dirk J. Broer ,  Emiel Peeters ,  Derk J.W Klunder ,  Hendrik R. Stapert

    IPC分类号： G01J1/58

    CPC分类号： G01N21/648 ,  Y10T436/11

    摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).

    摘要翻译： 公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。 在本发明的上下文中，生物传感器包括定义为孔阵列的格栅（120），孔格具有第一尺寸，第二维度高于介质中的激发光（102）的衍射极限，偏振器（ 115）和位于选自以下的体积中的发光体（117）：栅格（120）的孔内的体积，狭缝阵列（120）和偏振器（115）之间的体积和 延伸到偏振器（115）的体积，其中提供沿第一方向延伸的透射轴的格栅（120）和提供沿第二方向延伸的透射轴的偏振器（115），第一方向和第二方向基本上 垂直于彼此垂直，其中所述激发辐射（102）被极化，使得其基本上被所述至少一个格栅（120）和偏振器（115）中的一个所抑制，并且基本上不被所述o 该至少一个格栅（120）和偏振器（115）。

    Elastomeric stamp, patterning method using such a stamp and method for producing such a stamp
    26.
    发明申请
    Elastomeric stamp, patterning method using such a stamp and method for producing such a stamp 审中-公开
    弹性印模，使用这种印模的图案化方法和制造这种印章的方法

    公开(公告)号：US20070145632A1

    公开(公告)日：2007-06-28

    申请号：US10575797

    申请日：2004-10-07

    申请人： Emiel Peeters ,  Dirk Broer ,  Fredericus Van Den Heuvel ,  Dirk Burdinski

    发明人： Emiel Peeters ,  Dirk Broer ,  Fredericus Van Den Heuvel ,  Dirk Burdinski

    IPC分类号： B29C33/40

    CPC分类号： G03F7/0002 ,  B41K1/50 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  H05K3/12

    摘要： An elastomeric stamp (10) for printing a pattern on a substrate (500) with an ink (520) is at least partially formed from a first material such as PDMS. The stamp comprises a first surface (12) in a first plane, a second surface (14) in a second plane and a third surface (16) extending from the first surface (12) to the second surface (14). The first surface (12) typically forms to the contact surface of a protruding feature of the stamp (10), whereas the third surface (16) typically forms the edge of such a feature. The first surface (12) comprises a barrier layer (22) being substantially impermeable to the ink (520). Optionally, the second surface (14) may carry a further barrier layer (24) to suppress gas phase diffusion of the ink (520). In contrast, the third surface (16) is permeable to the ink (520). Consequently, a stamp (10) is obtained that is highly suitable for edge transfer lithography type patterning. The first material of the stamp serves as an ink reservoir, thus reducing the re-inking frequency of the stamp, and the layer (22) prevents unwanted diffusion of the ink (520) to the areas of the substrate (500) into contact with the stamp (10), thus 20 improving the feature definition on the substrate surface.

    摘要翻译： 用于用油墨（520）在基底（500）上印刷图案的弹性印模（10）至少部分地由诸如PDMS的第一材料形成。 印模包括在第一平面中的第一表面（12），在第二平面中的第二表面（14）和从第一表面（12）延伸到第二表面（14）的第三表面（16）。 第一表面（12）通常形成到印模（10）的突出特征的接触表面，而第三表面（16）通常形成这种特征的边缘。 第一表面（12）包括对油墨（520）基本不可渗透的阻挡层（22）。 可选地，第二表面（14）可携带另外的阻挡层（24）以抑制油墨（520）的气相扩散。 相比之下，第三表面（16）对墨水是可渗透的（520）。 因此，获得了非常适合于边缘转印光刻型图案化的印模（10）。 印模的第一材料用作墨水储存器，从而减小印模的再墨水频率，并且所述层（22）防止墨（520）对基板（500）的区域的不期望的扩散与基板（500）的区域接触 印模（10），从而改善了基板表面上的特征定义。

    Patterned cell sheets and a method for production of the same
    29.
    发明授权
    Patterned cell sheets and a method for production of the same 有权
    图案化电池片及其制造方法

    公开(公告)号：US09267109B2

    公开(公告)日：2016-02-23

    申请号：US12746767

    申请日：2008-12-05

    申请人： Emiel Peeters ,  Roel Penterman ,  Ralph Kurt ,  Dirk Jan Wilfred Broer

    发明人： Emiel Peeters ,  Roel Penterman ,  Ralph Kurt ,  Dirk Jan Wilfred Broer

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2535/10 ,  C12N2539/10

    摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.

    摘要翻译： 本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在暴露于脱模剂之后洗涤细胞片以除去已经被脱模剂影响的细胞，并且在第二细胞类型已经去除了已经被脱模剂影响的细胞之后剩余的间隙。

    Photo-responsive layer and layer assembly
    30.
    发明授权
    Photo-responsive layer and layer assembly 有权
    光响应层和层组件

    公开(公告)号：US08921806B2

    公开(公告)日：2014-12-30

    申请号：US13497568

    申请日：2010-10-06

    申请人： Dirk Jan Broer ,  Emiel Peeters

    发明人： Dirk Jan Broer ,  Emiel Peeters

    IPC分类号： C02F1/32 ,  C02F5/10 ,  A61L2/10 ,  C09K19/58 ,  C09K19/24 ,  C09K19/54 ,  C09K19/20 ,  C09K19/04

    CPC分类号： C02F1/325 ,  C02F2201/326 ,  C02F2209/40 ,  C09K19/2007 ,  C09K19/24 ,  C09K19/54 ,  C09K19/588 ,  C09K2019/0448 ,  C09K2219/03

    摘要： The present invention relates to a photo-responsive layer and layer assembly which can be used for controlling a flow of liquid for example in a water-purification device. The photo-responsive layer according to the invention comprises a first domain comprising a first material comprising molecules having a photo-responsive moiety, wherein the first domain of the photo-responsive layer is capable of undergoing a reversible geometrical change when said photo-responsive moiety is exposed to photo-activating illumination, such as UV-radiation. The photo-responsive layer is useful in UV controlled membranes e.g. for water purification.

    摘要翻译： 本发明涉及一种可用于控制例如在水净化装置中的液体流动的光响应层和层组件。 根据本发明的光响应层包括第一结构域，其包含包含具有光敏响部分的分子的第一材料，其中光响应层的第一结构域能够在所述光响应部分 暴露于诸如UV辐射的光激活照明。 光响应层可用于UV控制膜，例如 用于水净化。