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公开(公告)号：US20080094623A1
公开(公告)日：2008-04-24
申请号：US11573799
申请日：2005-08-26
CPC分类号： G01J3/28 , G01J3/04 , G01J3/36 , G01J2003/047 , G01J2003/1278
摘要： The present invention provides an autonomous calibration of a multivariate based spectroscopic system that is preferably implemented as a multivariate based spectrometer. The spectroscopic system is based on a multivariate optical element that provides a spectral weighting of an incident optical signal. Spectral weighting is performed on the basis of spatial separation of spectral components and subsequent spatial filtering by means of a spatial light modulator. Calibration of the spectroscopic system is based on a dedicated calibration segment of the spatial light modulator, whose position corresponds to a characteristic calibration or reference wavelength of the incident optical signal. Preferably, the calibration or reference wavelength is given by the wavelength of the excitation radiation generated by the optical source that serves to induce scattering processes in a volume of interest.
摘要翻译： 本发明提供了基于多变量的光谱仪的多变量光谱系统的自主校准，其优选地被实现为基于多变量的光谱仪。 光谱系统基于提供入射光信号的光谱加权的多元光学元件。 基于光谱分量的空间分离和随后的空间光调制器的空间滤波进行光谱加权。 分光系统的校准基于空间光调制器的专用校准段，其位置对应于入射光信号的特征校准或参考波长。 优选地，校准或参考波长由用于感兴趣的体积中的散射过程的光源产生的激发辐射的波长给出。
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22.发明授权Spectroscopic analysis apparatus and method with excitation system and focus monitoring system 失效光谱分析装置及方法与激励系统和焦点监测系统公开(公告)号：US07583380B2
公开(公告)日：2009-09-01
申请号：US10547971
申请日：2004-03-01
IPC分类号： G01J3/30
CPC分类号： A61B5/0059 , A61B5/0068 , G01J3/44 , G01N21/65 , G02B21/241
摘要： The present invention relates to an analysis apparatus, in particular a spectroscopic analysis apparatus, for analyzing an object, such as blood of a patient, and a corresponding analysis method. To aim the confocal detection volume inside a blood vessel orthogonal polarized spectral imaging (OPSI) is used to locate blood capillaries in the skin. An imaging system (img) with slightly shifted imaging planes (i1, i2) for OPS imaging of blood vessels is proposed to provide auto-focusing. The confocal Raman detection plane (dp) is located in between these two imaging planes (i1, i2). Based on measured amount of defocus for the imaging planes (i1, i2), the focusing of the imaging system (img), the excitation system (exs) for exciting the target region and the detection plane (dp) is located inside the blood vessel (V). Thus, continuous auto-focusing with high accuracy can be achieved. The invention relates also to an optical tracking system for continuously tracking a point of a moving object (obj).
摘要翻译： 本发明涉及用于分析患者血液等物体的分析装置，特别是光谱分析装置以及相应的分析方法。 为了瞄准血管内的共焦检测体积，使用正交偏振光谱成像（OPSI）来定位皮肤中的毛细血管。 提出了一种具有稍微偏移的成像平面（i1，i2）用于血管的OPS成像的成像系统（img），以提供自动聚焦。 共焦拉曼检测平面（dp）位于这两个成像平面（i1，i2）之间。 基于测量的成像平面（i1，i2）的散焦量，成像系统（img）的聚焦，用于激发目标区域的激发系统（exs）和检测平面（dp）位于血管内 （V）。 因此，可以实现高精度的连续自动聚焦。 本发明还涉及用于连续跟踪移动物体（obj）的点的光学跟踪系统。
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公开(公告)号：US20080309940A1
公开(公告)日：2008-12-18
申请号：US12094698
申请日：2006-11-20
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.
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24.发明申请公开(公告)号：US20120170824A1
公开(公告)日：2012-07-05
申请号：US13320358
申请日：2010-05-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
IPC分类号： G06K9/00
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： The invention provides a system (102) for accurately detecting a patient's (114) movement during imaging procedures. The system comprises a camera (126) for providing a stream of camera images of a part of a patient's exterior (206). The system (102) furthermore comprises a fiducial element (116), which fiducial element (116) is mountable on said part of the patient's exterior (206), and which fiducial element (116) is detectable in the stream of camera images, and an image processor (128) for detecting a displacement of the fiducial element based on consecutive camera images comprised in at least the stream of camera images and for generating an output signal (129) indicative for said displacement. Herein, the fiducial element (116) has an in-plane stiffness which is substantially larger than an in-plane stiffness of said part of the patient's exterior. In addition, the fiducial element (116) and said part of the patient's exterior are provided with substantially equal outer in-plane dimensions.
摘要翻译： 本发明提供一种用于在成像过程期间准确地检测患者（114）运动的系统（102）。 该系统包括用于提供患者外部（206）的一部分的相机图像流的照相机（126）。 所述系统（102）还包括基准元件（116），所述基准元件（116）可安装在所述患者外部部分（206）的所述部分上，并且所述基准元件（116）在相机图像流中是可检测的，以及 图像处理器（128），用于基于包括在至少相机图像流中的连续相机图像来检测基准元素的位移，并且用于生成指示所述位移的输出信号（129）。 这里，基准元件（116）具有的面内刚度基本上大于患者外部部分的平面内刚度。 此外，基准元件（116）和患者外部的所述部分设置有基本上相等的外部平面外尺寸。
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公开(公告)号：US07671973B2
公开(公告)日：2010-03-02
申请号：US10596564
申请日：2004-12-16
IPC分类号： G01N33/48
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/14552 , G01J3/36 , G01N21/65 , G01N33/49
摘要： The present invention provides an optical analysis system for determining an amplitude of a principal component of an optical signal. The principal component is indicative of the concentration of a particular compound or various compounds of a substance that is subject to spectroscopic analysis. The optical signal is subject to wavelength selective weighting and wavelength selective spatial separation specified by a weighting function. The optical signal is preferably separated into two parts that corresponding to a positive and negative spectral band of the weighting function, respectively. The separation provides separate detection of the separated parts of the optical signal without significant loss of intensity, thereby providing an improved signal to noise ratio of the determined principal component. Separation and weighting of the optical signal is realized by two multivariate optical elements.
摘要翻译： 本发明提供了一种用于确定光信号的主分量的幅度的光学分析系统。 主要成分指示特定化合物或受光谱分析的物质的各种化合物的浓度。 光信号经受由加权函数指定的波长选择加权和波长选择性空间分离。 光信号优选分为对应于加权函数的正和负光谱带的两部分。 分离提供对光信号的分离部分的单独检测，而没有明显的强度损失，从而提供确定的主要分量的改善的信噪比。 光信号的分离和加权由两个多元光学元件实现。
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公开(公告)号：US20080309941A1
公开(公告)日：2008-12-18
申请号：US12094802
申请日：2006-11-20
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume; coupling transmission input light (65) from a transmission light source into the receiving volume, with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45); detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium (45) is realized. The object of the invention is realized in that the method further comprises the following steps:—coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium (45) and with the combination of the geometry input light (70, 75, 80) and the interface (60) being chosen for creating a contrast between the turbid medium (45) and its surroundings; detection of the contrast (60) between the turbid medium (45) and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium (45) using a the detected contrast (60). The system for imaging an interior of a turbid medium (45) and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.
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公开(公告)号：US07230674B2
公开(公告)日：2007-06-12
申请号：US11373503
申请日：2006-03-13
CPC分类号： G03F7/70983 , G03F7/70808 , G03F7/70916 , G03F7/70933
摘要： A lithographic apparatus includes a radiation system that provides a beam of radiation, and a support structure that supports a patterning structure. The patterning structure is configured to pattern the beam of radiation according to a desired pattern. The apparatus also includes a substrate support that supports a substrate, and a projection system that projects the patterned beam onto a target portion of the substrate. The projection system includes an optical element that has a beam exit area through each of which the patterned beam passes. The apparatus further includes a fluid cleaning system that cleans a fluid to be introduced into a region in between the optical element and the substrate. The fluid cleaning system includes a fluid inlet, a fluid outlet, and a cleaning zone disposed between the inlet and outlet. The cleaning zone includes a nucleated surface provided with a plurality of nucleation sites.
摘要翻译： 光刻设备包括提供辐射束的辐射系统和支撑图案化结构的支撑结构。 图形结构被配置为根据期望的图案对辐射束进行图案化。 该装置还包括支撑基板的基板支撑件和将图案化的光束投影到基板的目标部分上的投影系统。 投影系统包括光学元件，该光学元件具有通过图案化光束通过的每一个的光束出射区域。 该装置还包括清洁被引入到光学元件和基板之间的区域中的流体的流体清洁系统。 流体清洁系统包括流体入口，流体出口和布置在入口和出口之间的清洁区域。 清洁区包括具有多个成核位点的成核表面。
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公开(公告)号：US09955927B2
公开(公告)日：2018-05-01
申请号：US13320358
申请日：2010-05-10
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Michael Cornelis Van Beek , Peter-Andre Redert , Frederik Jan De Bruijn , Drazenko Babic , Robert Johannes Frederik Homan , Ralph Braspenning , Wei Pien Lee , Karl Catharina Van Bree , Caifeng Shan
CPC分类号： A61B6/025 , A61B6/4423 , A61B6/4441 , A61B6/5247 , A61B90/361 , A61B90/39 , A61B2090/376
摘要： A system for accurately detecting a patient's movement during imaging procedures includes a camera for providing a stream of camera images of a part of a patient's exterior and a fiducial element mountable on part of the patient's exterior. The fiducial element is detectable in the stream of images. An image processor is configured to detect a displacement of the fiducial element based on consecutive images including in at least the stream of images and to generate an output signal indicative of the displacement. The fiducial element has an in-plane stiffness which is substantially larger than an in-plane stiffness of the part of the patient's exterior. In addition, the fiducial element and the part of the patient's exterior are provided with substantially equal outer in-plane dimensions.
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公开(公告)号：US20100002233A1
公开(公告)日：2010-01-07
申请号：US12447669
申请日：2007-10-24
申请人： Maarten Marinus Johannes Wilhelm Van Herpen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
发明人： Maarten Marinus Johannes Wilhelm Van Herpen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312 , A61B2562/146
摘要： The invention relates to imaging of a turbid medium, for example in connection with optical mammography. A device for imaging a turbid medium (20) is disclosed, the device comprising: a holder (20) arranged for receiving the turbid medium and a matching fluid (21); one or more radiation sources (24) and one or more photodetectors (25). The matching fluid is a vapor with one or more optical properties of the matching fluid substantially matching the corresponding one or more optical properties of the turbid medium. In an embodiment, the matching fluid (21) is a composite vapor comprising at least two components.
摘要翻译： 本发明涉及例如结合光学乳腺摄影术的混浊介质的成像。 公开了一种用于对浑浊介质（20）进行成像的装置，该装置包括：安置用于接收混浊介质的保持器（20）和匹配流体（21）; 一个或多个辐射源（24）和一个或多个光电检测器（25）。 匹配流体是具有匹配流体的一个或多个光学性质的蒸气，其基本上与混浊介质的对应的一个或多个光学特性相匹配。 在一个实施例中，匹配流体（21）是包括至少两个组分的复合蒸气。
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公开(公告)号：US20080300472A1
公开(公告)日：2008-12-04
申请号：US12094670
申请日：2006-11-17
IPC分类号： A61B5/1455
CPC分类号： A61B5/4312 , A61B5/0091 , A61B5/1455 , A61B5/14551
摘要： Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
摘要翻译： 公开了一种用于浑浊介质的光学成像的方法和装置。 该方法包括在混浊介质中以参考血氧饱和度（SaO2）从混浊介质发出的光的参考光强度的参考测量值，以及用于根据测量的参考光强度重建浊度介质的参考图像的参考成像步骤。 此外，该方法包括在浑浊培养基中以对比血氧饱和度（SaO2）水平从浑浊培养基发出的光的对比度强度的对比度测量，以及用于从所测量的重量中重建浑浊培养基的对比度图像的对比度成像步骤 对比强度。 对比图像与混浊介质的参考图像之间进行比较。
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