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    ILLUMINATOR SYSTEMS HAVING LIGHT EMITTING DIODES WITH UV ACTIVATION
    22.
    发明申请
    ILLUMINATOR SYSTEMS HAVING LIGHT EMITTING DIODES WITH UV ACTIVATION 有权

    公开(公告)号：US20210356397A1

    公开(公告)日：2021-11-18

    申请号：US17314406

    申请日：2021-05-07

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： Stephen Swihart ,  Evan Thrush ,  Kevin McDonald

    IPC: G01N21/64 ,  H05B45/10 ,  H05B45/20 ,  G01N21/31 ,  G01N21/33

    Abstract: An imaging system including an illuminator apparatus or an epi-illumination apparatus that has LEDs for illuminations is provided for stain-free gel activation and fluorescent sample visualization. The illuminator apparatus includes a housing, a light source array disposed on at least one side surface of the housing and including at least one plurality of LEDs having each LED individually operable to output light of a predetermined color within a range of wavelengths, and a controller for controlling ranges of operational parameters of the at least one plurality of LEDs. The light emitted from the light source array incidents upon a sample having a gel that includes a product of UV light induced reaction between tryptophan and a haloalkane and the light emitted from the light source array includes ultraviolet (UV) light to excite a fluorescent response of the sample.

    Heated image sensor window
    24.
    发明授权
    Heated image sensor window 有权

    公开(公告)号：US10186539B2

    公开(公告)日：2019-01-22

    申请号：US14875898

    申请日：2015-10-06

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： Evan Thrush ,  Steve Swihart ,  Hari Jayamohan

    IPC: H04N1/00 ,  H01L27/146 ,  H01L23/34 ,  H01L31/024 ,  G01N21/15 ,  G01N21/64 ,  G01N21/76

    Abstract: An image sensor assembly having a sensor window positioned in front of an image sensor, having structure and/or characteristics to prevent the formation of condensation on the sensor window. Structure to prevent the formation of condensation includes thin films which can have anti-condensation, anti-reflective, electrically conductive, and/or thermally conductive properties. The sensor window can further have a textured surface to displace water so as to avoid condensation formation on the window surface. The sensor window, and in some embodiments a frame, can be maintained at an elevated temperature proximate to the image sensor during operation to prevent the formation of condensation.

    Non-destructive read operations with dynamically growing images
    25.
    发明授权
    Non-destructive read operations with dynamically growing images 有权

    公开(公告)号：US10104307B2

    公开(公告)日：2018-10-16

    申请号：US15667435

    申请日：2017-08-02

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Steve Swihart ,  Evan Thrush ,  Boaz Ran

    IPC: H04N7/12 ,  H04N11/02 ,  H04N11/04 ,  H04N5/235 ,  H04N5/355 ,  H04N5/361 ,  H04N5/365 ,  G01N21/76 ,  G01N21/64 ,  G01N21/27

    Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

    Series absorbance glass and interference filters
    27.
    发明授权
    Series absorbance glass and interference filters 有权

    公开(公告)号：US09841378B2

    公开(公告)日：2017-12-12

    申请号：US14699755

    申请日：2015-04-29

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： Evan Thrush ,  Steve Swihart ,  Neeraj Bhatt

    IPC: G01N21/64

    CPC classification number: G01N21/6456 ,  G01N21/6486 ,  G01N2021/6439 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/062 ,  G01N2201/0627 ,  G01N2201/0638 ,  G01N2201/12

    Abstract: An imaging assembly and processing system that includes a sample platform having a target region which can hold a sample, where the sample can be marked with fluorescent or phosphorescent markers. The imaging assembly can have an excitation light module proximate to the sample platform that emits light to excite the markers, and a lens module positioned to receive emission light from excited markers in target region. At least one series filter assembly or interference filter can be arranged in front of, behind, or both in front of and behind the lens module. The assembly includes a light sensor and a processor and imaging module configured to process data captured by the light sensor. Images of the sample are generated based on the emission light from the sample that transmit through and are filtered by the lens assembly and series filter assembly or interference filter.

    Digital imaging with masked pixels
    29.
    发明授权
    Digital imaging with masked pixels 有权

    公开(公告)号：US09774804B2

    公开(公告)日：2017-09-26

    申请号：US14563411

    申请日：2014-12-08

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Boaz Ran ,  Steve Swihart ,  Evan Thrush ,  Itay Barak

    IPC: H04N5/361 ,  H04N5/365

    CPC classification number: H04N5/361 ,  H04N5/365

    Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.

    NON-DESTRUCTIVE READ OPERATIONS WITH DYNAMICALLY GROWING IMAGES
    30.
    发明申请
    NON-DESTRUCTIVE READ OPERATIONS WITH DYNAMICALLY GROWING IMAGES 有权
    非破坏性阅读操作与动态增长图像

    公开(公告)号：US20150172526A1

    公开(公告)日：2015-06-18

    申请号：US14563355

    申请日：2014-12-08

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Steve Swihart ,  Evan Thrush ,  Boaz Ran

    IPC: H04N5/235 ,  H04N5/357 ,  H04N5/374 ,  H04N5/359 ,  H04N5/361 ,  H04N5/232

    CPC classification number: H04N5/2355 ,  G01N21/272 ,  G01N21/6408 ,  G01N21/6456 ,  G01N21/76 ,  H04N5/2173 ,  H04N5/2353 ,  H04N5/35545 ,  H04N5/361 ,  H04N5/365

    Abstract: Methods and digital imaging devices disclosed herein are adapted to capture images of a specimen in a chemical reaction using a series of short exposures of light emissions from the specimen over a period of time. The series of short exposures is captured using an array of pixels of an image sensor in the digital imaging device that are configured for performing continuous non-destructive read operations to read out a set of non-destructive read images of the specimen from the pixel array. In one embodiment, images are captured by delaying the read out until at or near the end of the chemical reaction to reduce read noise in the images. The signals read out from the image sensor can be continuously monitored and the capturing of images can be discontinued either automatically or based on a command from a user. The captured images can then be displayed in a graphical display.

    Abstract translation: 本文公开的方法和数字成像装置适于在一段时间内使用来自样品的一系列短的曝光来捕获化学反应中的样本的图像。 使用数字成像设备中的图像传感器的像素阵列来捕获一系列短曝光，其被配置为执行连续的非破坏性读取操作，以从像素阵列读出样本的一组非破坏性读取图像 。 在一个实施例中，通过延迟读出直到化学反应结束或接近化学反应结束来捕获图像，以减少图像中的读取噪声。 可以连续地监视从图像传感器读出的信号，并且可以自动地或基于来自用户的命令中断图像的捕获。 然后可以在图形显示中显示捕获的图像。

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