公开(公告)号：US20160306152A1

公开(公告)日：2016-10-20

申请号：US15132053

申请日：2016-04-18

Applicant: CANON KABUSHIKI KAISHA

Inventor： Koji Makara ,  Yoichi Otsuka ,  Masafumi Kyogaku ,  Hiroyuki Hashimoto

IPC: G02B21/00 ,  G01N21/64 ,  G01N21/65

CPC classification number: G02B21/008 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/65 ,  G01N2021/655 ,  G01N2201/06113 ,  G01N2201/105 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0064 ,  G02B21/0076

Abstract: A laser scanning microscope apparatus includes an irradiation unit including an objective lens, a photodetector unit, an XY-scanning unit, and a Z-scanning unit. The irradiation unit focuses a laser beam with the objective lens to a specimen. The photodetector unit detects light generated from a position irradiated with the laser beam focused. The XY-scanning unit scans the laser beam in an X-direction perpendicular to an optical axis of the objective lens and in a Y-direction perpendicular to the optical axis and the X-direction. The Z-scanning unit scans the laser beam in a Z-direction parallel to the optical axis. When acquiring XY-two-dimensional image data by detecting the light while scanning the irradiated position in the X-direction and the Y-direction, the apparatus detects the light while scanning the irradiated position also in the Z-direction.

Abstract translation: 激光扫描显微镜装置包括具有物镜，光电检测器单元，XY扫描单元和Z扫描单元的照射单元。 照射单元将具有物镜的激光束聚焦到样本。 光检测器单元检测从被聚焦的激光束照射的位置产生的光。 XY扫描单元在垂直于物镜的光轴的X方向和垂直于光轴和X方向的Y方向扫描激光束。 Z扫描单元沿平行于光轴的Z方向扫描激光束。 当通过在X方向和Y方向扫描照射位置时检测光来获取XY二维图像数据时，该装置也在沿Z方向扫描照射位置的同时检测光。

公开(公告)号：US20160203968A1

公开(公告)日：2016-07-14

申请号：US14989710

申请日：2016-01-06

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka ,  Masafumi Kyogaku

IPC: H01J49/06 ,  H01J49/12 ,  H01J49/04 ,  G01B11/26

CPC classification number: H01J49/061 ,  G01B11/26 ,  H01J49/0004 ,  H01J49/0431 ,  H01J49/12

Abstract: A probe displacement measuring apparatus includes a cantilever probe, a light irradiation unit configured to irradiate the probe with light, a light receiving element configured to receive reflected light obtained by reflecting light emitted by the light irradiation unit on a surface of the probe as a spot, and a displacement obtaining unit configured to obtain displacement of the probe in accordance with a position of the spot on the light receiving element. The light receiving element has first and second light receiving surfaces divided by a straight division line. An angle defined by a displacement direction of the spot on the light receiving element and the division line is 0° or more and 90° or less.

Abstract translation: 探针位移测量装置包括悬臂探针，被配置为用光照射探针的光照射单元，被配置为将通过将由光照射单元发射的光反射到探针的表面上而获得的反射光作为点的受光元件 以及位移获取单元，被配置为根据光接收元件上的光斑的位置获得探针的位移。 光接收元件具有由直线划分线划分的第一和第二光接收表面。 由光接收元件和分割线上的光斑的位移方向限定的角度为0°以上且90°以下。

公开(公告)号：US09287099B2

公开(公告)日：2016-03-15

申请号：US13973305

申请日：2013-08-22

Applicant: A SCHOOL CORPORATION KANSAI UNIVERSITY ,  CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka ,  Ryuichi Arakawa

IPC: H01J49/10 ,  H01J49/00 ,  G01N30/72 ,  H01J49/04 ,  H01J49/16 ,  B01D59/44 ,  H01J27/08

CPC classification number: H01J49/0027 ,  B01D59/44 ,  G01N30/7266 ,  H01J27/08 ,  H01J49/0454 ,  H01J49/168

Abstract: To achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. An ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the probe; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode.

Abstract translation: 当在大气压下离子化少量物质时，更容易实现软电离。 一种包含在液体中的物质的电离方法，包括：在探针和基底之间，将来自探针的液体供给到基底并形成由其中溶解有物质的液体制成的液体桥; 振荡探头; 以及在与液体接触的探针的导电部分和离子提取电极之间产生电场。

公开(公告)号：US09252004B2

公开(公告)日：2016-02-02

申请号：US14446771

申请日：2014-07-30

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka ,  Masafumi Kyogaku

IPC: G01Q30/00 ,  G01Q30/02 ,  G01Q30/12 ,  G01Q30/14 ,  H01J49/04 ,  H01J49/24 ,  H01J49/26 ,  H01J49/10 ,  H01J49/00

CPC classification number: H01J49/10 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0459 ,  H01J49/165 ,  H01J49/24 ,  H01J49/26

Abstract: A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.

Abstract translation: 质谱装置包括：保持要离子化的样品的保持台，识别要离子化的样本的一部分的探针;提取通过使样本离子获得的离子的离子提取电极;将液体供给到 在试样和探针之间形成试样和探针之间的液桥，振动单元，其振动探针和保持台之一;电场产生单元，其在探针和离子提取电极之间产生电场 质量分析由离子提取电极提取的离子的质谱分析单元，以及同步单元，其被配置为使从该部分产生离子的时间与质谱分析单元测量离子的时间同步。

公开(公告)号：US20150034817A1

公开(公告)日：2015-02-05

申请号：US14446771

申请日：2014-07-30

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka ,  Masafumi Kyogaku

IPC: H01J49/10 ,  H01J49/24 ,  H01J49/26 ,  H01J49/00

CPC classification number: H01J49/10 ,  H01J49/0004 ,  H01J49/0027 ,  H01J49/0459 ,  H01J49/165 ,  H01J49/24 ,  H01J49/26

Abstract: A mass spectrometry apparatus includes a holding table that holds a specimen to be ionized, a probe that identifies a portion of the specimen to be ionized, an ion extraction electrode that extracts ions obtained by ionizing the specimen, a liquid supplying unit that supplies liquid to between the specimen and the probe to form a liquid bridge between the specimen and the probe, a vibrating unit that vibrates one of the probe and the holding table, an electric field generating unit that generates an electric field between the probe and the ion extraction electrode, a mass spectrometry unit that mass analyzes ions extracted by the ion extraction electrode, and a synchronization unit configured to synchronize a time at which ions are generated from the portion with a time at which the mass spectrometry unit measures the ions.

公开(公告)号：US20140072476A1

公开(公告)日：2014-03-13

申请号：US14016633

申请日：2013-09-03

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka

IPC: H01J49/14

CPC classification number: H01J49/145 ,  H01J49/0454 ,  H01J49/0463 ,  H01J49/165

Abstract: A sample and a reagent are disposed separately. The reagent is taken into a liquid at a leading end of a needle, and a voltage is applied thereto to turn the liquid into fine liquid droplets. The sample is irradiated with laser light to cause the sample to be emitted into a space in the form of fine particles. The fine liquid droplets and the fine particles are brought into contact in the space to obtain ionized fine particles.

Abstract translation: 样品和试剂分开设置。 将试剂置于针的前端的液体中，向其施加电压，将液体变成细液滴。 用激光照射样品，使样品以微粒的形式发射到空间中。 微细液滴和微粒在空间中接触以获得电离的细颗粒。

公开(公告)号：US20140070094A1

公开(公告)日：2014-03-13

申请号：US14018119

申请日：2013-09-04

Applicant: CANON KABUSHIKI KAISHA

Inventor： Yoichi Otsuka

IPC: H01J49/16 ,  H01J49/26

CPC classification number: H01J49/16 ,  H01J49/0004 ,  H01J49/26

Abstract: An ionization device includes: a holding portion configured to hold a sample; a probe configured to arrange a liquid on a surface of the sample to form a liquid bridge between the probe and the sample; an electrode configured to form, at the probe, a Taylor cone for ionizing a substance contained in the sample, and to release the ionized substance from the Taylor cone; a voltage applying unit configured to apply a voltage to the electrode; and a light source configured to emit laser light that irradiates the Taylor cone. A mass spectrometer including the ionization device, and an image display system including the mass spectrometer are also disclosed.

Abstract translation: 电离装置包括：保持部，被配置为保持样品; 探针，被配置为在样品的表面上布置液体，以在探针和样品之间形成液体桥; 电极，被配置为在所述探针处形成用于离子化所述样品中所含物质的泰勒锥并从所述泰勒锥体释放所述离子化物质; 电压施加单元，被配置为向所述电极施加电压; 以及被配置为发射照射泰勒锥的激光的光源。 还公开了包括电离装置的质谱仪和包括质谱仪的图像显示系统。

公开(公告)号：US20130341279A1

公开(公告)日：2013-12-26

申请号：US13973305

申请日：2013-08-22

Applicant: CANON KABUSHIKI KAISHA ,  A SCHOOL CORPORATION KANSAI UNIVERSITY

Inventor： Yoichi Otsuka ,  Ryuichi Arakawa

IPC: H01J49/00 ,  B01D59/44 ,  H01J27/08

CPC classification number: H01J49/0027 ,  B01D59/44 ,  G01N30/7266 ,  H01J27/08 ,  H01J49/0454 ,  H01J49/168

Abstract: To achieve soft ionization more easily when a slight amount of substance is ionized under an atmosphere pressure. An ionization method for a substance contained in a liquid, including: supplying the liquid to a substrate from a probe and forming a liquid bridge made of the liquid containing the substance dissolved therein, between the probe and the substrate; oscillating the probe; and generating an electric field between an electrically conductive portion of the probe in contact with the liquid and an ion extraction electrode.