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公开(公告)号：US20160326147A1
公开(公告)日：2016-11-10
申请号：US15148225
申请日：2016-05-06
发明人： Elisabetta ARMANI , Gabriele AMARI , Wesley BLACKABY , Herve VAN DE POEL , Charles BAKER-GLENN , Naimisha TRIVEDI
IPC分类号： C07D409/12 , C07D409/14 , A61K31/4436 , A61K31/4439 , A61K31/4545 , C07D453/02 , A61K31/439
CPC分类号： C07D409/12 , A61K31/439 , A61K31/4436 , A61K31/4439 , A61K31/4545 , C07D409/14 , C07D453/02 , C07D471/08
摘要： Compounds of formula (I) are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.
摘要翻译： 式（I）化合物既是磷酸二酯酶4（PDE4）酶抑制剂和毒蕈碱M3受体拮抗剂，也可用于预防和/或治疗以气道阻塞为特征的呼吸道疾病。
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公开(公告)号：US20150353561A1
公开(公告)日：2015-12-10
申请号：US14731786
申请日：2015-06-05
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K9/0075 , A61K9/008 , A61K31/519
摘要： Compounds of formula (I), described herein, exhibit human neutrophil elastase inhibitory properties, and are useful for the treatment of diseases and conditions in which HNE is implicated.
摘要翻译： 本文所述的式（I）化合物显示人嗜中性粒细胞弹性蛋白酶抑制性质，并且可用于治疗涉及HNE的疾病和病症。
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公开(公告)号：US20150018321A1
公开(公告)日：2015-01-15
申请号：US14496136
申请日：2014-09-25
IPC分类号： C07D213/79 , A61K31/44 , C07D213/38 , C07D401/12 , A61K31/4545 , A61K31/455 , A61K31/4439 , A61K31/5377 , C07D405/12 , A61K31/4433 , A61K31/4709 , C07D473/08 , A61K31/522 , A61K31/538 , A61K45/06 , C07D213/80 , C07D213/30
CPC分类号： C07D213/30 , A61K31/44 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/522 , A61K31/5377 , A61K31/538 , A61K45/06 , C07D213/38 , C07D213/61 , C07D213/79 , C07D213/80 , C07D213/89 , C07D401/12 , C07D405/12 , C07D417/12 , C07D473/04 , C07D473/08
摘要： Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
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24.发明申请1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS 有权作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基亚胺醇衍生物公开(公告)号：US20140155391A1
公开(公告)日：2014-06-05
申请号：US14097445
申请日：2013-12-05
IPC分类号： C07D295/155 , A61M15/00 , A61M16/14 , C07D213/89
CPC分类号： C07D295/155 , A61M15/0065 , A61M15/009 , A61M16/14 , C07D213/61 , C07D213/89 , C07D401/12 , C07D407/12 , C07D417/12
摘要： Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.
摘要翻译： 本文所述的式（I）化合物是磷酸二酯酶4（PDE4）酶的抑制剂，并且可用于预防和/或治疗以气道阻塞为特征的过敏性疾病状态或呼吸道疾病。
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25.发明申请DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS 有权1-苯基-2-吡啶基亚胺醇作为磷酸二酯酶抑制剂的衍生物公开(公告)号：US20130102576A1
公开(公告)日：2013-04-25
申请号：US13655903
申请日：2012-10-19
发明人： Elisabetta ARMANI , Gabriele Amari , Carmelida Capaldi , Laura Carzaniga , Elena La Porta , Matilde Guala
IPC分类号： A61K31/4425 , C07D401/12 , A61K31/4439 , C07D473/06 , A61K31/522 , A61K31/498 , A61K31/502 , C07D413/14 , A61K31/5377 , C07D417/14 , A61K31/541 , A61K31/56 , A61P11/00 , A61P11/06 , A61P37/00 , A61P17/00 , A61M15/00 , A61M11/00 , A61M16/14 , C07D213/89
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/04
摘要： Compounds, pyridine N-oxides, and pharmaceutically acceptable salts of formula (I) are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme and for preventing and/or treating diseases of the respiratory tract characterized by airway obstruction, such as asthma or COPD.
摘要翻译： 化合物，吡啶N-氧化物和式（I）的药学上可接受的盐可用作磷酸二酯酶4（PDE4）酶的抑制剂，并且用于预防和/或治疗以气道阻塞为特征的呼吸道疾病如哮喘或COPD 。
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公开(公告)号：US20230063121A1
公开(公告)日：2023-03-02
申请号：US17784557
申请日：2020-12-10
发明人： Gabriele AMARI , Elisabetta ARMANI , Mafalda PAGANO , Luca RAVEGLIA , Marta GIULIANI , Claudia BEATO
IPC分类号： C07D417/12 , C07D239/94 , C07D413/14 , C07D409/12 , C07D413/12 , C07D417/14
摘要： The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
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公开(公告)号：US20230043672A1
公开(公告)日：2023-02-09
申请号：US17784539
申请日：2020-12-10
IPC分类号： C07D417/14 , C07D417/12
摘要： The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are aromatic amido derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.
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公开(公告)号：US20180354945A1
公开(公告)日：2018-12-13
申请号：US15987277
申请日：2018-05-23
发明人： Carmelida CAPALDI , Elisabetta ARMANI , Christopher HURLEY , Barbara Giuseppina AVITABILE-WOO , Roberta LANARO , Neil Stuart JENNINGS
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61P11/00
摘要： Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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公开(公告)号：US20170183345A1
公开(公告)日：2017-06-29
申请号：US15388350
申请日：2016-12-22
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
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30.发明申请公开(公告)号：US20170152256A1
公开(公告)日：2017-06-01
申请号：US15316401
申请日：2014-06-04
发明人： Gabriele AMARI , Elisabetta ARMANI , Mauro RICCABONI , Andrea RIZZI , Charles BAKER-GLENN , Wesley BLACKABY , Herve VAN DE POEL , Ben WHITTAKER
IPC分类号： C07D453/02
CPC分类号： C07D453/02 , C07D453/00
摘要： The invention relates to novel 3,5-dichloro,4-(3,4-(cyclo-) alkoxyphenyl)-2-carbonyloxy)ethyl)pyridine compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.
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