公开(公告)号：US06953667B2

公开(公告)日：2005-10-11

申请号：US10054988

申请日：2002-01-25

申请人： Paul A. Moore ,  Steven M. Ruben ,  Henrik S. Olsen ,  Yanggu Shi ,  Craig A. Rosen ,  Kimberly A. Florence ,  Daniel R. Soppet ,  David W. LaFleur ,  Gregory A. Endress ,  Reinhard Ebner ,  George Komatsoulis ,  Roxanne D. Duan

发明人： Paul A. Moore ,  Steven M. Ruben ,  Henrik S. Olsen ,  Yanggu Shi ,  Craig A. Rosen ,  Kimberly A. Florence ,  Daniel R. Soppet ,  David W. LaFleur ,  Gregory A. Endress ,  Reinhard Ebner ,  George Komatsoulis ,  Roxanne D. Duan

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P25/02 ,  A61P25/12 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  C07K16/22 ,  C07K17/02 ,  C12N9/96

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US06936691B2

公开(公告)日：2005-08-30

申请号：US09832129

申请日：2001-04-11

申请人： Michele Fiscella ,  Ping Wei ,  David W. LaFleur ,  Henrik S. Olsen ,  Kevin P. Baker ,  Reinhard Ebner ,  George A. Komatsoulis ,  Craig A. Rosen ,  Steven M. Ruben ,  Roxanne D. Duan ,  Paul E. Young ,  Kimberly A. Florence ,  Paul A. Moore ,  Charles E. Birse ,  Jian Ni ,  Daniel R. Soppet ,  Yanggu Shi

发明人： Michele Fiscella ,  Ping Wei ,  David W. LaFleur ,  Henrik S. Olsen ,  Kevin P. Baker ,  Reinhard Ebner ,  George A. Komatsoulis ,  Craig A. Rosen ,  Steven M. Ruben ,  Roxanne D. Duan ,  Paul E. Young ,  Kimberly A. Florence ,  Paul A. Moore ,  Charles E. Birse ,  Jian Ni ,  Daniel R. Soppet ,  Yanggu Shi

IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K48/00 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P27/02 ,  A61P35/00 ,  C07K14/47 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/19 ,  C07K1/00

CPC分类号： B82Y5/00 ,  C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US08334365B2

公开(公告)日：2012-12-18

申请号：US11759843

申请日：2007-06-07

申请人： Craig A. Rosen ,  David W. LaFleur

发明人： Craig A. Rosen ,  David W. LaFleur

IPC分类号： C07K14/00 ,  C12P21/00

CPC分类号： C12N9/96 ,  A61K38/00 ,  C07K14/765 ,  C07K2319/00 ,  C12N15/62

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20120122762A1

公开(公告)日：2012-05-17

申请号：US13359199

申请日：2012-01-26

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

IPC分类号： A61K38/17 ,  C12N15/63 ,  C07K14/435 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  C12P21/00 ,  G01N33/68 ,  C12N15/85 ,  C12N15/70 ,  C12N1/21 ,  C12N5/10 ,  A61P7/00 ,  A61P35/00 ,  A61P13/12 ,  A61P9/00 ,  A61P11/00 ,  A61P17/02 ,  A61P25/00 ,  A61P5/00 ,  A61P15/00 ,  A61P31/00 ,  A61P1/00 ,  C12N15/12

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20090011983A1

公开(公告)日：2009-01-08

申请号：US11745580

申请日：2007-05-08

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

IPC分类号： A61K38/00 ,  C12N15/11 ,  C12N15/00 ,  C12N15/63 ,  C12N5/06 ,  C12Q1/00 ,  A61P43/00 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/00 ,  C07K16/18 ,  C12P21/04

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20090005301A1

公开(公告)日：2009-01-01

申请号：US11759448

申请日：2007-06-07

申请人： Jian Ni ,  Reinhard Ebner ,  David W. LaFleur ,  Paul A. Moore ,  Henrik S. Olsen ,  Craig A. Rosen ,  Steven M. Ruben ,  Daniel R. Soppet ,  Paul E. Young ,  Yanggu Shi ,  Kimberly A. Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie L. Fischer ,  Ann M. Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory A. Endress ,  Patrick J. Dillon ,  Kenneth C. Carter ,  Laurie A. Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John M. Greene

发明人： Jian Ni ,  Reinhard Ebner ,  David W. LaFleur ,  Paul A. Moore ,  Henrik S. Olsen ,  Craig A. Rosen ,  Steven M. Ruben ,  Daniel R. Soppet ,  Paul E. Young ,  Yanggu Shi ,  Kimberly A. Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie L. Fischer ,  Ann M. Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory A. Endress ,  Patrick J. Dillon ,  Kenneth C. Carter ,  Laurie A. Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John M. Greene

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N15/85 ,  C07K16/18 ,  C12Q1/68 ,  A61K38/14 ,  A61K31/7088 ,  G01N33/68 ,  C12P21/02 ,  C12N15/00 ,  C12N5/10

CPC分类号： C07K14/47 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US06569992B1

公开(公告)日：2003-05-27

申请号：US09369247

申请日：1999-08-05

申请人： David W. LaFleur ,  Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David W. LaFleur ,  Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： A61K3800

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US06566325B2

公开(公告)日：2003-05-20

申请号：US09904615

申请日：2001-07-16

申请人： Paul A. Moore ,  Steven M. Ruben ,  Henrik S. Olsen ,  Yanggu Shi ,  Craig A. Rosen ,  Kimberly A. Florence ,  Daniel R. Soppet ,  David W. LaFleur ,  Gregory A. Endress ,  Reinhard Ebner ,  George Komatsoulis ,  Roxanne D. Duan

发明人： Paul A. Moore ,  Steven M. Ruben ,  Henrik S. Olsen ,  Yanggu Shi ,  Craig A. Rosen ,  Kimberly A. Florence ,  Daniel R. Soppet ,  David W. LaFleur ,  Gregory A. Endress ,  Reinhard Ebner ,  George Komatsoulis ,  Roxanne D. Duan

IPC分类号： C07K1400

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

公开(公告)号：US08216569B2

公开(公告)日：2012-07-10

申请号：US11980495

申请日：2007-10-31

申请人： Craig A. Rosen ,  Vivian R. Albert ,  Steven M. Ruben ,  Ruth E. Wager

发明人： Craig A. Rosen ,  Vivian R. Albert ,  Steven M. Ruben ,  Ruth E. Wager

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/22

CPC分类号： C07K16/22 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/52 ,  C07K16/24 ,  C07K2317/21 ,  C07K2317/622 ,  C12N2799/026 ,  G01N33/574 ,  G01N33/74 ,  Y02A50/41 ,  Y02A50/422 ,  Y10S435/81

摘要： Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more VEGF-2 antibodies or fragments or variants thereof.

公开(公告)号：US08168205B2

公开(公告)日：2012-05-01

申请号：US12635794

申请日：2009-12-11

申请人： Charles A. Kunsch ,  Gil H. Choi ,  Patrick J. Dillon ,  Craig A. Rosen ,  Steven C. Barash ,  Michael R. Fannon ,  Brian A. Dougherty

发明人： Charles A. Kunsch ,  Gil H. Choi ,  Patrick J. Dillon ,  Craig A. Rosen ,  Steven C. Barash ,  Michael R. Fannon ,  Brian A. Dougherty

IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/38

CPC分类号： C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K14/315

摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.

摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。