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21.发明申请公开(公告)号：US20160186102A1
公开(公告)日：2016-06-30
申请号：US14907707
申请日：2014-09-19
Applicant: DANISCO US INC.
Inventor： Guoqing Liu , Ling Hua , Zhen Qian , Danfeng Song , Zhongmei Tang , Xi Zhiyong , Bo Zhang , Zhengzheng Zou , Wei Xu , Richard R. Bott
CPC classification number: C11D3/386 , C12N9/2417 , C12Y302/01001
Abstract: Disclosed are compositions and methods relating to alpha-amylase from a subset of Exiguobacterium. The compositions and methods are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.
Abstract translation: 公开了与来自Exiguobacterium的子集的α-淀粉酶有关的组合物和方法。 组合物和方法可用于例如淀粉液化和糖化，用于清洁衣物，餐具洗涤和其它应用中的淀粉污渍，用于织物加工（例如脱浆），用于改善消化率的动物饲料中，以及烘烤和酿造 。
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公开(公告)号：US20150141316A1
公开(公告)日：2015-05-21
申请号：US14406499
申请日：2013-05-24
Applicant: Danisco US Inc.
Inventor： Richard R. Bott , Luis G. Cascao-Pereira , David A. Estell , Marc Kolkman , David E. Wildes
CPC classification number: C12N9/2414 , A23L2/382 , A23V2002/00 , C11D3/386 , C11D11/0017 , C11D11/0023 , C12N9/2417 , C12N9/242 , C12P19/02 , C12P19/14 , C12Y302/01001
Abstract: Described are variants of alpha-amylase enzymes for use in industrial processes, such as liquefaction of starch. The alpha-amylase variants have increased specific activity allowing the more rapidly reduction of peak viscosity during liquefaction processes. The alpha-amylase is modified by introducing into the amino sequence of a parent Family 13 alpha-amylase polypeptide a mutation at an amino acid residue in the starch-binding groove; wherein the starch-binding groove is formed by amino acid residues in the alpha-helix preceding the first beta-strand in the A domain, the loop between the sixth alpha-helix and the seventh beta-strand in the A domain, the loop between the seventh alpha-helix and the eighth beta-strand in the A domain, and the loop connecting the A domain and the C domain; and wherein the mutation alters the binding of starch to the variant alpha amylase polypeptide compared to the parental alpha amylase polypeptide.
Abstract translation: 描述了用于工业过程中的α-淀粉酶的变体，例如淀粉的液化。 α-淀粉酶变体具有增加的比活性，允许在液化过程期间峰值粘度的更快速降低。 通过在母体家族13α-淀粉酶多肽的氨基酸序列中引入淀粉结合槽中的氨基酸残基处的突变来修饰α-淀粉酶; 其中淀粉结合槽由A结构域中的第一个β链之前的α-螺旋中的氨基酸残基形成，A结构域中的第六个α-螺旋和第七个β链之间的环， A域中的第七个α-螺旋和第八个β链，以及连接A结构域和C结构域的环; 并且其中所述突变改变了与亲本α-淀粉酶多肽相比淀粉与变体α淀粉酶多肽的结合。
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公开(公告)号：US12146122B2
公开(公告)日：2024-11-19
申请号：US18301460
申请日：2023-04-17
Applicant: DANISCO US INC.
Inventor： Joshua Roy Basler , Michael Stoner , James T. Kellis, Jr. , Adam Garske , David Marquez , Katherine Augustyn , Priyanka Chandrasekaran , Miles Christopher Scotcher , Lilia Maria Babe , Richard R. Bott , David A. Estell , Gudrun Vogtentanz , Sina Pricelius , Jian Yao
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US20240229001A1
公开(公告)日：2024-07-11
申请号：US18487157
申请日：2023-10-16
Applicant: Danisco US Inc.
Inventor： Lilia M Babe , Richard R. Bott , Roopa Santosh Ghirnikar , Frits Goedegebuur , Xiaogang Gu , Marc Anton Bernhard Kolkman , Jian Yao , Shukun Yu
CPC classification number: C12N9/54 , C11D3/386 , C12Y304/24 , C12Y304/24027
Abstract: Aspects of the present compositions and methods relate to novel metalloproteases polynucleotides encoding the novel metalloprotease, compositions and methods for use thereof.
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公开(公告)号：US11946080B2
公开(公告)日：2024-04-02
申请号：US16309267
申请日：2017-06-18
Applicant: DANISCO US INC
Inventor： Richard R. Bott , David A. Estell , Frits Goedegebuur , Harm Mulder , Sina Pricelius
CPC classification number: C12N9/54 , C11D3/386 , C12Y304/21062
Abstract: Disclosed herein is one or more subtilisin variants, nucleic acids encoding same, and compositions and methods related to the production and uses thereof, including one or more subtilisin variants that has improved stability and/or soil removal compared to one or more reference subtilisin.
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Patent Agency Ranking
公开(公告)号：US20240093124A1
公开(公告)日：2024-03-21
申请号：US18301460
申请日：2023-04-17
Applicant: DANISCO US INC.
Inventor： Joshua Roy Basler , Michael Stoner , James T. Kellis, Jr. , Adam Garske , David Marquez , Katherine Augustyn , Priyanka Chandrasekaran , Miles Christopher Scotcher , Lilia Maria Babe , Richard R. Bott , David A. Estell , Gudrun Vogtentanz , Sina Pricelius , Jian Yao
CPC classification number: C11D3/386 , C12N9/54 , C12N15/52 , C12Y304/21062
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US20180237761A1
公开(公告)日：2018-08-23
申请号：US15736401
申请日：2016-06-17
Applicant: DANISCO US INC.
Inventor： Lilia Maria Babe , Richard R. Bott , David A. Estell , Harm Mulder , Frits Goedegebuur , Jian Yao , Sina Pricelius , Miles Scotcher
CPC classification number: C12N9/54 , C11D3/386 , C11D3/38663 , C12Y304/21062
Abstract: Disclosed herein is one or more subtilisin variant, nucleic acid encoding same, and compositions and methods related to the production and use thereof, including one or more Bacillus gibsonii-clade subtilisin variant that has improved stability and/or soil removal compared to one or more reference subtilisin.
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公开(公告)号：US20160319266A1
公开(公告)日：2016-11-03
申请号：US15104219
申请日：2014-12-12
Applicant: DANISCO US INC.
Inventor： Marc Kolkman , Rie Mejldal , Frits Goedegebuur , Lilia Maria Babe , Anja Hemmingsen Kellett-Smith , Harm Mulder , Richard R. Bott , Miles Christopher Scotcher
Abstract: The present disclosure relates to serine proteases cloned from Bacillus gibsonii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
Abstract translation: 本公开涉及从芽孢杆菌（Gibsonii）克隆的丝氨酸蛋白酶及其变体。 含有丝氨酸蛋白酶的组合物适用于清洁织物和硬表面，以及各种工业应用。
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公开(公告)号：US20160312204A1
公开(公告)日：2016-10-27
申请号：US15103248
申请日：2014-12-12
Applicant: DANISCO US INC.
Inventor： Marc Kolkman , Rie Mejldal , Anja Hemmingsen Kellett-Smith , Lilia Maria Babe , Richard R. Bott
Abstract: The present disclosure relates to serine proteases cloned from Bacillus akibai and Bacillus clarkii, and variants thereof. Compositions containing the serine proteases are suitable for use in cleaning fabrics and hard surfaces, as well as in a variety of industrial applications.
Abstract translation: 本公开涉及从芽孢杆菌akibai和克拉克氏杆菌克隆的丝氨酸蛋白酶及其变体。 含有丝氨酸蛋白酶的组合物适用于清洁织物和硬表面，以及各种工业应用。
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公开(公告)号：US09029116B2
公开(公告)日：2015-05-12
申请号：US14015740
申请日：2013-08-30
Applicant: Danisco US Inc.
Inventor： Wolfgang Aehle , Richard R. Bott , Igor Nikoaev , Martijn Scheffers , Piet Van Solingen , Casper Vroemen
CPC classification number: C12N9/2428 , C12N15/09 , C12Y302/01003 , Y02E50/17
Abstract: The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also provides enzyme compositions comprising the variant glucoamylases; DNA constructs comprising polynucleotides encoding the variants; and methods of producing the glucoamylase variants in host cells.
Abstract translation: 本发明涉及葡糖淀粉酶变体。 特别地，本发明涉及葡糖淀粉酶的淀粉结合结构域（SBD）中的变体。 本发明还涉及与相应的母体葡糖淀粉酶相比具有改变的性质（例如，改善的热稳定性和/或增加的比活性）的变体。 本发明还提供了包含变体葡糖淀粉酶的酶组合物; 包含编码变体的多核苷酸的DNA构建体; 以及在宿主细胞中产生葡糖淀粉酶变体的方法。
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