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    ANTI-INFECTIVE AGENTS
    22.
    发明申请
    ANTI-INFECTIVE AGENTS 有权
    抗感染药物

    公开(公告)号：US20080214528A1

    公开(公告)日：2008-09-04

    申请号：US11777692

    申请日：2007-07-13

    Applicant: Rolf Wagner ,  Pamela L. Donner ,  Dale J. Kempf ,  Clarence J. Maring ,  Vincent S. Stoll ,  Yi-Yin Ku ,  Yu-Ming Pu

    Inventor： Rolf Wagner ,  Pamela L. Donner ,  Dale J. Kempf ,  Clarence J. Maring ,  Vincent S. Stoll ,  Yi-Yin Ku ,  Yu-Ming Pu

    IPC: A61K31/542 ,  C07D285/20 ,  A61P31/12

    CPC classification number: C07D495/04

    Abstract: The present invention provides HCV polymerase inhibiting compounds having the formula (I): where R1 is cyclobutyl—N(Ra)-, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-, In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino])-4-hydroxy -2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.

    Abstract translation: 本发明提供了具有式（I）的HCV聚合酶抑制化合物：其中R 1是环丁基-N（R a）a，n是1,2,3或 4，并且至少一个R 5是R a，R 2，N（R j） - 烷基 - ，In 非限制性实例，本发明的化合物是N - [（3- {1 - [（环丁基）氨基]）-4-羟基-2-氧代-1,2-二氢 - 喹啉-3-基} -1,1-二氧代-1,4-二氢-1-氮杂噻吩并[2,3-e] [1,2,4]噻二嗪-7-基）甲基]甲磺酰胺。 本发明还特征在于包含本发明化合物或其药学上可接受的盐，立体异构体或互变异构体的组合物及其用于治疗或预防HCV感染的方法。

    Retroviral protease inhibiting compounds
    24.
    发明授权
    Retroviral protease inhibiting compounds 失效
    逆转录病毒蛋白酶抑制化合物

    公开(公告)号：US06251906B1

    公开(公告)日：2001-06-26

    申请号：US09309141

    申请日：1999-05-10

    Applicant: Xiaoqi Chen ,  Dale J. Kempf ,  Daniel W. Norbeck

    Inventor： Xiaoqi Chen ,  Dale J. Kempf ,  Daniel W. Norbeck

    IPC: A61K31495

    CPC classification number: C07D417/12 ,  C07D277/24 ,  C07D417/14

    Abstract: The present invention discloses novel compounds, compositions, and methods for inhibiting retroviral proteases and in particular for inhibiting human immunodeficiency virus (HIV) protease. The present invention also relates to compositions and methods for treating a retroviral infection and in particular an HIV infection, and to processes for making such compounds and synthetic intermediates employed in these processes.

    Abstract translation: 本发明公开了用于抑制逆转录病毒蛋白酶，特别是用于抑制人类免疫缺陷病毒（HIV）蛋白酶的新型化合物，组合物和方法。 本发明还涉及用于治疗逆转录病毒感染，特别是HIV感染的组合物和方法，以及用于制备这些化合物和这些方法中使用的合成中间体的方法。

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