-
公开(公告)号：US09801574B2
公开(公告)日：2017-10-31
申请号：US14875539
申请日：2015-10-05
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/05 , A61B5/1486 , C12Q1/00 , A61L31/12 , B01D69/14 , B01D71/54 , B01D71/80 , A61B5/145 , A61B5/1473 , B05D3/00 , B05D5/00
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
-
公开(公告)号：US20170020418A1
公开(公告)日：2017-01-26
申请号：US15264577
申请日：2016-09-13
Applicant: DexCom, Inc.
Inventor： Mark C. Shults , Stuart J. Updike , Rathbun K. Rhodes , Barbara J. Gilligan , Mark A. Tapsak
IPC: A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1486
CPC classification number: A61B5/14532 , A61B5/0031 , A61B5/1455 , A61B5/14558 , A61B5/1459 , A61B5/1486 , A61B5/14865 , A61B2562/17 , C12Q1/006
Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices include unique architectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.
Abstract translation: 描述了用于确定分析物水平的装置和方法。 装置和方法允许植入分析物监测装置，例如葡萄糖监测装置，其导致输送可靠的血液流以将样品输送到植入装置。 这些设备在传感器区域中包括独特的架构布置，可以在长时间内获得准确的数据。
-
公开(公告)号：US20160178558A1
公开(公告)日：2016-06-23
申请号：US15059086
申请日：2016-03-02
Applicant: DexCom, Inc.
Inventor： Rathbun K. Rhodes , Mark A. Tapsak , James H. Brauker , Mark C. Shults
IPC: G01N27/327 , A61B5/145 , A61B5/1486 , G01N33/487
CPC classification number: G01N27/3272 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/006 , G01N33/48707 , G01N33/48785
Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
-
公开(公告)号：US09328371B2
公开(公告)日：2016-05-03
申请号：US13943622
申请日：2013-07-16
Applicant: DexCom, Inc.
Inventor： Rathbun K. Rhodes , Mark A. Tapsak , James H. Brauker , Mark C. Shults
IPC: A61B5/05 , A61B5/00 , C12Q1/00 , A61B5/145 , A61B5/1486
CPC classification number: G01N27/3272 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/006 , G01N33/48707 , G01N33/48785
Abstract: The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
-
公开(公告)号：US20150157248A1
公开(公告)日：2015-06-11
申请号：US14619651
申请日：2015-02-11
Applicant: DexCom, Inc.
Inventor： James H. Brauker , Mark C. Shults , Mark A. Tapsak
IPC: A61B5/1473 , A61B5/145
CPC classification number: A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
Abstract translation: 本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括： 远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。 此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。 还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。
-
Patent Agency Ranking
公开(公告)号：US20150057514A1
公开(公告)日：2015-02-26
申请号：US14529034
申请日：2014-10-30
Applicant: DexCom, Inc.
Inventor： James R. Petisce , Mark A. Tapsak , Peter C. Simpson , Victoria Carr-Brendel , James H. Brauker
IPC: A61B5/1486 , A61B5/1473
CPC classification number: A61B5/1473 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14546 , A61B5/1468 , A61B5/14735 , A61B5/14865
Abstract: The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.
Abstract translation: 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。
-
公开(公告)号：US20140335343A1
公开(公告)日：2014-11-13
申请号：US14341468
申请日：2014-07-25
Applicant: DexCom, Inc.
Inventor： James H. Brauker , Mark C. Shults , Mark A. Tapsak
IPC: A61B5/1486 , A61L31/14 , A61L31/10
CPC classification number: A61B5/14735 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B2562/02 , A61L31/10 , A61L31/14 , Y10T428/249921
Abstract: The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention. Other implantable devices which include the biointerface membrane of the present invention, such as devices for cell transplantation, drug delivery devices, and electrical signal delivery or measuring devices are also provided.
Abstract translation: 本发明提供了一种用于与可植入装置一起使用的生物界面膜，其干扰屏障细胞层的形成，包括： 远离植入装置的第一区域，其中第一结构域支持组织附着并干扰阻挡细胞层形成，以及邻近可植入装置的第二结构域，其中第二结构域对细胞附着有抗性并且对细胞是不可渗透的。 此外，本发明提供了包括生物界面膜，包括这些传感器或生物界面膜的可植入装置的传感器，以及利用本发明的分析物检测可植入装置监测宿主中的葡萄糖水平的方法。 还提供了包括本发明的生物界面膜的其它可植入装置，例如用于细胞移植的装置，药物递送装置和电信号传递或测量装置。
-
28.发明授权公开(公告)号：US08865249B2
公开(公告)日：2014-10-21
申请号：US13631780
申请日：2012-09-28
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
CPC classification number: A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B2562/028 , A61B2562/125 , A61L31/12 , B01D69/141 , B01D71/54 , B01D71/80 , B05D3/007 , B05D5/00 , C12Q1/002 , C12Q1/006 , Y10T428/31551
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
Abstract translation: 本发明提供了一种用于调节分析物通过其的运输的可植入膜，其包括包含第一聚合物的基质; 和分散在整个基质中的第二种聚合物，其中第二种聚合物形成微区网络，当400×放大倍率或更小时，使用光学显微镜不能观察到水合。 在一个方面，本发明的均质膜具有基本上分散在疏水性基质上的亲水性畴，以提供氧和葡萄糖转运到电化学葡萄糖传感器之间的最佳平衡。
-
公开(公告)号：US12226617B2
公开(公告)日：2025-02-18
申请号：US17556761
申请日：2021-12-20
Applicant: DexCom, Inc.
Inventor： James H. Brauker , Mark A. Tapsak , Sean T. Saint , Apurv Ullas Kamath , Paul V. Neale , Peter C. Simpson , Michael Robert Mensinger , Dubravka Markovic
IPC: G16H20/17 , A61B5/00 , A61B5/145 , A61B5/1486 , A61M5/14 , A61M5/172 , A61M5/315 , A61M11/00 , A61M15/00 , A61M37/00 , G16H10/40 , G16H40/63
Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.
-
公开(公告)号：US10154807B2
公开(公告)日：2018-12-18
申请号：US15716998
申请日：2017-09-27
Applicant: DexCom, Inc.
Inventor： Mark A. Tapsak , Rathbun K. Rhodes , Mark C. Shults , Jason D. McClure
IPC: A61B5/05 , A61B5/1486 , C12Q1/00 , A61L31/12 , B01D69/14 , B01D71/54 , B01D71/80 , A61B5/145 , A61B5/1473 , B05D3/00 , B05D5/00
Abstract: The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
-
-
-
-
-
-
-
-
-
Search Results
45
records
(took 0.029 seconds)
