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21.发明申请公开(公告)号：US20090132000A1
公开(公告)日：2009-05-21
申请号：US12319642
申请日：2009-01-08
IPC分类号： A61N1/365
CPC分类号： A61B5/087 , A61B5/02405 , A61B5/053 , A61B5/4878 , A61N1/3627 , A61N1/36521
摘要： A system receives signals indicative of cardiopulmonary conditions sensed by a plurality of sensors and provides for monitoring and automated differential diagnosis of the cardiopulmonary conditions based on the signals. Cardiogenic pulmonary edema is detected based on one or more signals sensed by implantable sensors. If the cardiogenic pulmonary edema is not detected, obstructive pulmonary disease and restrictive pulmonary disease are each detected based on a forced vital capacity (FVC) parameter and a forced expiratory volume (FEV) parameter measured from a respiratory signal sensed by an implantable or non-implantable sensor. In one embodiment, an implantable medical device senses signals indicative of the cardiopulmonary conditions, and an external system detects the cardiopulmonary conditions based on these signals by executing an automatic detection algorithm.
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22.发明授权公开(公告)号：US07572226B2
公开(公告)日：2009-08-11
申请号：US10695430
申请日：2003-10-28
IPC分类号： A61B5/00
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。
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23.发明申请公开(公告)号：US20090299159A1
公开(公告)日：2009-12-03
申请号：US12538553
申请日：2009-08-10
IPC分类号： A61B5/0205
CPC分类号： A61B5/4035 , A61B5/029 , A61B5/0472 , A61N1/36585 , G06F19/00
摘要： An implantable device monitors the balance between sympathetic tone and parasympathetic tone as a function of an activity level. Cardio-neurological healthy users exhibit a generally sympathetic tone in conjunction with heavy activity level and a generally parasympathetic tone in conjunction with periods of low activity level. Deviations from expected results are associated with a health problem. Measured conditions are stored and available for subsequent reporting to a remote programmer. Therapy delivered by an implantable device is determined as a function of the relationship between autonomic balance and activity level.
摘要翻译： 可植入装置监测交感神经张力和副交感神经紧张度之间的平衡，作为活动水平的函数。 心脏神经系统健康用户表现出与大量活动水平和大体上副交感神经紧张以及低活动水平结合的共同心情。 与预期结果的偏差与健康问题有关。 测量条件存储并可用于后续报告给远程程序员。 由植入式装置提供的治疗作为自主平衡与活动水平之间关系的函数确定。
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公开(公告)号：US09254100B2
公开(公告)日：2016-02-09
申请号：US11900596
申请日：2007-09-12
申请人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
发明人： Kenneth Beck , Ramesh Wariar , Chie Kawahara , Gerrard M. Carlson
CPC分类号： A61B5/1118 , A61B5/0002 , A61B5/4866
摘要： An implantable activity detector can detect metabolic stress levels, which can be normalized, such as to identify times of activities such as walking and running or to identify trends such as a decrease in metabolic activity. The data can be derived from different sources such as an accelerometer and pedometer. This data can be compared to independently specifiable thresholds, such as to trigger an alert or responsive therapy, or to display one or more trends. The information can also be combined with other congestive heart failure (CHF) indications. The alert can notify the patient or a caregiver, such as via remote monitoring. Metabolic activity data from one or more of the activity detectors can be used to establish a model of metabolic stress, to which further activity data can be compared for identifying periods of increased or decreased metabolic stress.
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公开(公告)号：US08992436B2
公开(公告)日：2015-03-31
申请号：US11514423
申请日：2006-09-01
申请人： Yachuan Pu , Yi Zhang , Gerrard M. Carlson
发明人： Yachuan Pu , Yi Zhang , Gerrard M. Carlson
IPC分类号： A61B5/08
CPC分类号： A61B5/0816
摘要： Systems and methods provide for detecting respiration disturbances and changes in respiration disturbances, preferably by detecting variability in one or more respiration parameters. Respiration rate variability is determined for a variety of diagnostic and therapeutic purposes, including disease/disorder detection, diagnosis, treatment, and therapy titration. Systems and methods provide for generating a footprint, such as a two- or three-dimensional histogram, representative of a patient's respiration parameter variability, and generating one or more indices representative of quantitative measurements of the footprint.
摘要翻译： 系统和方法优选地通过检测一个或多个呼吸参数中的可变性来检测呼吸紊乱和呼吸干扰的变化。 确定各种诊断和治疗目的的呼吸率变异性，包括疾病/病症检测，诊断，治疗和治疗滴定。 系统和方法提供用于生成代表患者呼吸参数变异性的足迹（例如二维或三维直方图），以及生成代表足迹的定量测量的一个或多个指数。
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26.发明授权Tracking progression of congestive heart failure via a force-frequency relationship 有权通过力 - 频率关系跟踪充血性心力衰竭的进展公开(公告)号：US08755883B2
公开(公告)日：2014-06-17
申请号：US12634277
申请日：2009-12-09
申请人： Ramesh Wariar , Gerrard M. Carlson
发明人： Ramesh Wariar , Gerrard M. Carlson
CPC分类号： A61B7/023 , A61B5/0031 , A61B5/0215 , A61B5/024 , A61B5/0456 , A61B5/11 , A61N1/3627
摘要： A system, method, or device monitor a force-frequency relationship exhibited by a patient's heart. A contractility characteristic, such as a heart sound characteristic of an S1 heart sound, is measured. The contractility characteristic indicates the forcefulness of a contraction of the heart. The frequency at which the heart is contracting is determined. A group of (contractility characteristic, heart rate) pairs is stored in a memory device. The group of pairs defines a force-frequency relationship for the heart. The method may be implemented by an implantable device, or by a system including a implantable device.
摘要翻译： 系统，方法或设备监测患者心脏展示的力 - 频率关系。 测量S1心音的心音特征的收缩特性。 收缩性特征表明心脏收缩的强度。 确定心脏收缩的频率。 一组（收缩特性，心率）对存储在存储器件中。 一组对定义了心脏的力 - 频率关系。 该方法可以由可植入装置或包括可植入装置的系统来实现。
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公开(公告)号：US08700149B2
公开(公告)日：2014-04-15
申请号：US13479979
申请日：2012-05-24
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/02028 , A61B5/0215 , A61B5/029 , A61B5/0422 , A61B5/0535 , A61B5/0538 , A61B5/1102 , A61B5/7267 , A61B7/00 , A61N1/3684 , A61N1/3704
摘要： Systolic timing intervals are measured in response to delivering pacing energy to a pacing site of a patient's heart. An estimate of a patient's acute response to cardiac resynchronization therapy (CRT) for the pacing site is determined using the measured systolic timing intervals. The estimate is compared to a threshold. The threshold preferably distinguishes between acute responsiveness and non-responsiveness to CRT for a patient population. An indication of acute responsiveness to CRT for the pacing site may be produced in response to the comparison.
摘要翻译： 响应于将起搏能量递送到患者心脏的起搏部位来测量收缩时间间隔。 使用测量的收缩时间间隔来确定对于起搏部位的患者对心脏再同步治疗（CRT）的急性反应的估计。 将估计值与阈值进行比较。 该阈值优选地区分对于患者群体的急性反应性和对CRT的无反应性。 响应于比较可以产生针对起搏部位对CRT的急性反应性的指示。
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公开(公告)号：US20130085407A1
公开(公告)日：2013-04-04
申请号：US13685170
申请日：2012-11-26
IPC分类号： A61B7/04
CPC分类号： A61B7/04
摘要： A cardiac rhythm management system includes a heart sound detector providing for detection of the third heart sounds (S3). An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including the second heart sounds (S2) and S3. The heart sound detector detects occurrences of S2 and starts S3 detection windows each after a predetermined delay after a detected occurrence of S2. The occurrences of S3 are then detected from the acoustic signal within the S3 detection windows.
摘要翻译： 心律管理系统包括提供检测第三心音的心音检测器（S3）。 诸如加速度计或麦克风的可植入传感器感测指示包括第二心音（S2）和S3的心音的声信号。 心音检测器检测到S2的发生，并且在检测到S2发生之后经过预定延迟之后开始S3检测窗口。 然后从S3检测窗口内的声信号检测S3的出现。
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公开(公告)号：US20120271186A1
公开(公告)日：2012-10-25
申请号：US13540092
申请日：2012-07-02
IPC分类号： A61B7/00
CPC分类号： A61B7/006 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/4836 , A61B5/6847 , A61B5/7275 , A61B7/04 , A61B2562/0204 , A61B2562/0219 , A61N1/36514 , A61N1/37 , A61N1/3987
摘要： A cardiac rhythm management system provides for the trending of a third heart sound (S3) index. The S3 index is a ratio, or an estimate of the ratio, of the number of S3 beats to the number of all heart heats, where the S3 beats are each a heart beat during which an occurrence of S3 is detected. An implantable sensor such as an accelerometer or a microphone senses an acoustic signal indicative heart sounds including S3. An S3 detector detects occurrences of S3 from the acoustic signal. A heart sound processing system trends the S3 index on a periodic basis to allow continuous monitoring of the S3 activity level, which is indicative of conditions related to heart failure.
摘要翻译： 心律管理系统提供第三心音（S3）指数的趋势。 S3指数是S3搏动次数与所有心脏热量的比率或比率的估计值，其中S3跳动各自是检测到S3的发生的心跳。 诸如加速度计或麦克风的可植入传感器感测到包括S3的指示心音的声信号。 S3检测器从声信号检测出S3的发生。 心脏声音处理系统周期性地推动S3指数，以允许连续监测S3活动水平，这表明与心力衰竭有关的病症。
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30.发明授权Systems and methods for drug therapy enhancement using expected pharmacodynamic models 有权使用预期药效学模型增强药物治疗的系统和方法公开(公告)号：US08150509B2
公开(公告)日：2012-04-03
申请号：US10970449
申请日：2004-10-21
IPC分类号： A61N1/00
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2205/3561 , A61M2230/04 , A61M2230/08 , A61M2230/30 , A61M2230/50 , A61M2230/63 , G06F19/00 , G06F19/3456 , G16H50/50 , Y10S128/923
摘要： A system or method including a device configured to measure at least one pharmacological effect of a drug on a patient. The measured pharmacological effect is compared to an expected pharmacodynamic model. The system can allow for real-time monitoring of positive and side-effects of drugs as well as drug resistance to optimize individual therapy. The system can also enable patient compliance monitoring.
摘要翻译： 一种包括被配置为测量药物对患者的至少一种药理作用的装置的系统或方法。 将测量的药理作用与预期的药效学模型进行比较。 该系统可以实时监测药物的阳性和副作用以及耐药性，以优化个体治疗。 该系统还可以实现患者依从性监控。
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