公开(公告)号：US20070015143A1

公开(公告)日：2007-01-18

申请号：US11531863

申请日：2006-09-14

Applicant: Egisto Boschetti ,  Pierre Girot

Inventor： Egisto Boschetti ,  Pierre Girot

IPC: C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  C12M3/00

CPC classification number: B01J20/3255 ,  B01D15/1807 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3285 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2219/0074 ,  C07K1/165 ,  C07K1/22 ,  C40B40/10 ,  C40B80/00 ,  G01N33/54353 ,  G01N2001/045 ,  G01N2035/00158 ,  Y10S530/812 ,  Y10T436/25

Abstract: For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.

Abstract translation: 对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。 合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。 这些树脂在其使用条件下具有阴离子特性。 生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

公开(公告)号：US20060205010A1

公开(公告)日：2006-09-14

申请号：US10553923

申请日：2004-04-19

Applicant: Catherine Allioux ,  Egisto Boschetti ,  Virginie Brenac ,  Patrick Santambien ,  James Spencer

Inventor： Catherine Allioux ,  Egisto Boschetti ,  Virginie Brenac ,  Patrick Santambien ,  James Spencer

IPC: G01N33/53

CPC classification number: G01N33/567 ,  C07K1/22 ,  G01N33/543 ,  G01N33/6803 ,  G01N33/6842 ,  G01N33/6851

Abstract: The invention provides methods of determining the presence of host cell proteins in sample. The invention further provides methods of following the purification of target proteins. Kits and articles of manufacture are also provided.

Abstract translation: 本发明提供了确定样品中宿主细胞蛋白质存在的方法。 本发明还提供了追踪靶蛋白纯化的方法。 还提供了工具包和制品。

公开(公告)号：US20050158393A1

公开(公告)日：2005-07-21

申请号：US11030182

申请日：2005-01-07

Applicant: Phillippe Reb ,  Laurent Domas ,  Egisto Boschetti ,  Marie-Paule Leroy-Landercy

Inventor： Phillippe Reb ,  Laurent Domas ,  Egisto Boschetti ,  Marie-Paule Leroy-Landercy

IPC: A61K9/14 ,  A61K33/24 ,  A61K49/18 ,  A61P43/00

CPC classification number: A61K49/18

Abstract: The present invention relates to polymeric materials that are labeled with colloidal metals, preferably colloidal gold, to processes for producing the labeled polymeric material, and to methods of using the materials in prophylactic, therapeutic and cosmetic applications. Specifically, the invention relates to porous injectable and implantable microparticles, preferably microspheres, that are associated with colloidal metals such that the microparticles are visible or detectable under regular light, by radiological and/or magnetic resonance imaging techniques, or both. The microparticles having colloidal metals are particularly useful for embolization, dermal augmentation and tissue bulking, drug delivery, gene therapy, and other prophylactic, therapeutic or cosmetic medical applications.

Abstract translation: 本发明涉及用胶体金属（优选胶体金）标记用于生产标记的聚合物材料的方法的聚合物材料，以及在预防，治疗和美容应用中使用该材料的方法。 具体地，本发明涉及与胶体金属相关的多孔可注射和可植入的微粒，优选微球，使得微粒在常规光下是可见的或可检测的，通过放射和/或磁共振成像技术，或两者兼有。 具有胶体金属的微粒特别可用于栓塞，皮肤增生和组织膨胀，药物递送，基因治疗和其它预防，治疗或美容医学应用。

公开(公告)号：US06613234B2

公开(公告)日：2003-09-02

申请号：US09274013

申请日：1999-03-22

Applicant: Nicolas Voute ,  Egisto Boschetti ,  Pierre Girot ,  Marc Perez ,  Jean-Claude Viguie

Inventor： Nicolas Voute ,  Egisto Boschetti ,  Pierre Girot ,  Marc Perez ,  Jean-Claude Viguie

IPC: B01D1508

CPC classification number: B01J20/3204 ,  B01D15/1807 ,  B01D15/327 ,  B01D15/361 ,  B01D15/3804 ,  B01J20/0211 ,  B01J20/06 ,  B01J20/08 ,  B01J20/28069 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/282 ,  B01J20/3064 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/52

Abstract: The present invention provides porous mineral oxide beads which have large pore volumes and enhanced stability. The beads are based on a tetravalent metal oxide, such as zirconia, titania or hafnia. These highly porous beads are produced from a mixture of tetravalent mineral oxides, mineral pore inducing agents which are oxides or salts of trivalent metals, and optional binders. The porous mineral beads can be filled with a polymer gel and used for adsorption and chromatography applications.

Abstract translation: 本发明提供了具有大孔体积和增强的稳定性的多孔无机氧化物珠粒。 珠粒基于四价金属氧化物，例如氧化锆，二氧化钛或铪。 这些高度多孔的珠子由四价矿物氧化物，矿物孔诱导剂，三价金属的氧化物或盐，和任选的粘合剂的混合物制成。 多孔矿物珠可以用聚合物凝胶填充并用于吸附和色谱应用。

公开(公告)号：US06436424B1

公开(公告)日：2002-08-20

申请号：US09528990

申请日：2000-03-20

Applicant: Jean-Marie Vogel ,  Egisto Boschetti

Inventor： Jean-Marie Vogel ,  Egisto Boschetti

IPC: A61F1300

CPC classification number: A61L27/52 ,  A61L27/26 ,  C08L33/26

Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.

Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。

公开(公告)号：US5906734A

公开(公告)日：1999-05-25

申请号：US858924

申请日：1997-05-19

Applicant: Pierre Girot ,  Egisto Boschetti

Inventor： Pierre Girot ,  Egisto Boschetti

IPC: B01D15/08 ,  B01J20/32

CPC classification number: B01D15/08 ,  B01D15/20 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3282 ,  B01J20/3289 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating agent comprising polyethyleneimine, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

公开(公告)号：US5672276A

公开(公告)日：1997-09-30

申请号：US720799

申请日：1996-10-01

Applicant: Pierre Girot ,  Egisto Boschetti

Inventor： Pierre Girot ,  Egisto Boschetti

IPC: B01D15/08 ,  B01J20/32 ,  B01J39/16

CPC classification number: B01D15/20 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3282 ,  B01J20/3289 ,  B01J39/165 ,  B01D15/3804 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous polymeric supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

公开(公告)号：US5609763A

公开(公告)日：1997-03-11

申请号：US564994

申请日：1995-11-30

Applicant: Egisto Boschetti ,  Pierre Girot ,  Luc P. Guerrier

Inventor： Egisto Boschetti ,  Pierre Girot ,  Luc P. Guerrier

IPC: A61K35/14 ,  B01D15/00 ,  B01J20/28 ,  B01D15/08

CPC classification number: B01J20/3282 ,  B01D15/00 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/28097

Abstract: Novel sorbents and methods for removing small hydrophobic and amphophilic molecules from biological fluids were disclosed. The methods and materials were particularly useful for removing viral inactivating agents from blood and blood fractions. The novel sorbents comprise a porous mineral oxide matrix having its interior porous volume substantially filled with a crosslinked hydrophobic polymer network.

Abstract translation: 公开了从生物液体中去除小疏水和两性分子的新型吸附剂和方法。 所述方法和材料特别可用于从血液和血液部分中除去病毒灭活剂。 新型吸附剂包括多孔矿物氧化物基质，其基本上填充有交联的疏水性聚合物网络的内部多孔体积。

公开(公告)号：US5268097A

公开(公告)日：1993-12-07

申请号：US956404

申请日：1992-10-05

Applicant: Pierre Girot ,  Egisto Boschetti

Inventor： Pierre Girot ,  Egisto Boschetti

IPC: B01D15/08 ,  B01J20/32 ,  B01J39/16

CPC classification number: B01D15/206 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3282 ,  B01J20/3289 ,  B01J39/165 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide supports are disclosed that are stabilized against leaching under harsh environmental conditions by the application of a thin, protective polymeric coating atop their porous surfaces and that are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by the use of a passivation mixture comprising a main monomer, a passivating monomer that is different from the main monomer, and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction between biomolecules and the protective polymeric coating on the surfaces of the mineral oxide matrix.

Abstract translation: 本发明一般涉及改性多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔无机氧化物载体，其在恶劣的环境条件下通过在其多孔表面顶上施加薄的保护性聚合物涂层而稳定化，并且其特征在于基本上不伴随非特异性吸附的可逆的高吸附能力 或与生物分子相互作用。 通过使用包含主单体，不同于主单体的钝化单体和交联剂的钝化混合物来实现钝化，该聚合物上的该混合物导致基本上消除生物分子与生物分子之间不合需要的非特异性相互作用 矿物氧化物基体表面上的保护性聚合物涂层。

公开(公告)号：US09205053B2

公开(公告)日：2015-12-08

申请号：US12534070

申请日：2009-07-31

Applicant: Jean-Marie Vogel ,  Richard Thomas ,  Egisto Boschetti

Inventor： Jean-Marie Vogel ,  Richard Thomas ,  Egisto Boschetti

IPC: A61K9/14 ,  A61K9/00 ,  A61K47/48 ,  A61K49/04 ,  A61L27/38 ,  A61L27/50 ,  A61L31/00 ,  A61L31/14 ,  A61K31/78 ,  A61K31/785 ,  A61K9/16

CPC classification number: A61K9/14 ,  A61K9/0019 ,  A61K9/16 ,  A61K9/1635 ,  A61K9/1641 ,  A61K31/78 ,  A61K31/785 ,  A61K47/6925 ,  A61K47/6927 ,  A61K49/0442 ,  A61K49/048 ,  A61L27/38 ,  A61L27/50 ,  A61L31/005 ,  A61L31/14 ,  A61L2400/06

Abstract: The present invention relates to elastic, hydrophilic and substantially spherical microspheres useful for dermal augmentation and tissue bulking. The invention provides injectable compositions comprising the microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further provides methods of dermal augmentation and tissue bulking, particularly for the treatment of skin contour deficiencies, Gastro-esophageal reflux disease, urinary incontinence, and urinary reflux disease, using the injectable compositions.