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公开(公告)号:US20120310133A1
公开(公告)日:2012-12-06
申请号:US13555056
申请日:2012-07-20
申请人: Eugene De Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人: Eugene De Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC分类号: A61F9/00
CPC分类号: G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
摘要翻译: 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置,以便至少部分地符合消融的基质表面,以便矫正视力。 适形的内部部分可以具有至少一些刚性,以便平滑上皮,使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量,以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。
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公开(公告)号:US20130066283A1
公开(公告)日:2013-03-14
申请号:US13503841
申请日:2010-10-22
申请人: Yair Alster , Hanson S. Gifford , Cary J. Reich , Eugene de Juan, JR. , John A. Scholl , Jose D. Alejandro , Douglas Sutton , Omer Rafaeli
发明人: Yair Alster , Hanson S. Gifford , Cary J. Reich , Eugene de Juan, JR. , John A. Scholl , Jose D. Alejandro , Douglas Sutton , Omer Rafaeli
IPC分类号: A61F9/01
CPC分类号: A61F9/008 , A61B18/02 , A61F9/0079 , A61F9/00804 , A61F9/009 , A61F2009/00872 , A61F2009/00893 , A61N1/36021 , A61N1/36046 , A61N1/40 , A61N7/02
摘要: Methods and apparatus for the treatment of the eye to reduce pain can treat at least an outer region of the tissue so as to denervate nerves extending into the inner region and reduce the pain. For example, the cornea of the eye may comprise an inner region having an epithelial defect, and an outer portion of the cornea can be treated to reduce pain of the epithelial defect. The outer portion of the cornea can be treated to denervate nerves extending from the outer portion to the inner portion. The outer portion can be treated in many ways to denervate the nerve, for example with one or more of heat, cold or a denervating noxious substance such as capsaicin. The denervation of the nerve can be reversible, such that corneal innervation can return following treatment.
摘要翻译: 用于治疗眼睛以减轻疼痛的方法和装置可以治疗组织的至少外部区域,以便使延伸到内部区域的神经衰老,并减轻疼痛。 例如,眼睛的角膜可以包括具有上皮缺损的内部区域,并且可以治疗角膜的外部部分以减少上皮缺损的疼痛。 角膜的外部可以被处理以将从外部延伸到内部部分的神经去激活。 外部部分可以以许多方式被治疗以使神经变性,例如用一种或多种热,冷或去神经感染的有害物质如辣椒素。 神经的去神经可以是可逆的,使得角膜神经支配可以在治疗后返回。
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公开(公告)号:US20100036488A1
公开(公告)日:2010-02-11
申请号:US12384659
申请日:2009-04-06
申请人: Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfariane , Douglas Sutton , John Anthony
发明人: Eugene de Juan, JR. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfariane , Douglas Sutton , John Anthony
IPC分类号: A61F2/14
CPC分类号: A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要: A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
摘要翻译: 用于治疗上皮缺损的治疗镜片包括设置在基质和/或Bowman膜上的治疗材料层,以抑制从泪液到基质和/或Bowman膜的水流,使得可以恢复角膜deturgescence 减少角膜肿胀和光散射。 该层可以覆盖并保护神经纤维以减轻疼痛。 该层可以包括折射率以抑制从基质和/或Bowman膜的前表面的光散射。 透镜可以包括弯曲的前表面,当上皮再生时,该前表面为患者提供功能视觉。 治疗材料层可以以许多方式定位在眼睛上,例如通过固化以将该层粘附到基质和/或Bowman膜的暴露表面上的喷雾。
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公开(公告)号:US20110226238A1
公开(公告)日:2011-09-22
申请号:US12885199
申请日:2010-09-17
申请人: Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人: Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号: A61M16/20
CPC分类号: A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要: Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译: 公开了用于调节流入和流出患者肺部区域的流体的方法和装置,例如在呼吸过程中实现期望的流体流动到肺部区域,和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序,确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离,以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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公开(公告)号:US08474460B2
公开(公告)日:2013-07-02
申请号:US12885199
申请日:2010-09-17
申请人: Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人: Michael Barrett , Michael Hendricksen , Alan R. Rapacki , Ronald R. Hundertmark , Jeffrey J. Dolin , Robert M. George , Antony J. Fields , Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号: A62B9/02
CPC分类号: A61B17/12022 , A61B17/12104 , A61B17/12172 , A61F2/2412 , A61F2002/043
摘要: Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
摘要翻译: 公开了用于调节流入和流出患者肺部区域的流体的方法和装置,例如在呼吸过程中实现期望的流体流动到肺部区域,和/或诱导一个或多个肺部区域的塌陷。 根据示例性程序,确定的肺部区域被靶向用于治疗。 然后将目标肺区域支气管分离,以通过一个或多个将空气送入目标肺部区域的支气管通路来调节进入和/或离开目标肺区域的气流。
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公开(公告)号:US20090275899A1
公开(公告)日:2009-11-05
申请号:US12467240
申请日:2009-05-15
CPC分类号: A61N7/00 , A61B2017/00747 , A61B2017/22008 , A61K9/0009 , A61K41/0028 , A61M37/0092 , A61M2037/003 , A61N1/0412 , A61N1/0492 , A61N1/327 , A61N2007/0008 , A61N2007/0039
摘要: An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
摘要翻译: 公开了一种在低声压超声波范围内使用声波处理皮下组织的装置和方法。 该方法包括注射增强剂,其中通过具有在不存在增强剂的情况下不产生组织空泡的能力的超声波产生皮下组织的破坏和皮下空泡生物效应。 该装置和使用方法可用于治疗包括脂肪团,脂肪瘤和肿瘤在内的皮下异常。
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公开(公告)号:US08357139B2
公开(公告)日:2013-01-22
申请号:US12264849
申请日:2008-11-04
CPC分类号: F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
摘要: Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.
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公开(公告)号:US07588547B2
公开(公告)日:2009-09-15
申请号:US11334794
申请日:2006-01-17
IPC分类号: A61H1/00
CPC分类号: A61N7/00 , A61B2017/00747 , A61B2017/22008 , A61K9/0009 , A61K41/0028 , A61M37/0092 , A61M2037/003 , A61N1/0412 , A61N1/0492 , A61N1/327 , A61N2007/0008 , A61N2007/0039
摘要: An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
摘要翻译: 公开了一种在低声压超声波范围内使用声波处理皮下组织的装置和方法。 该方法包括注射增强剂,其中通过具有在不存在增强剂的情况下不产生组织空泡的能力的超声波产生皮下组织的破坏和皮下空泡生物效应。 该装置和使用方法可用于治疗包括脂肪团,脂肪瘤和肿瘤在内的皮下异常。
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公开(公告)号:US20090114226A1
公开(公告)日:2009-05-07
申请号:US12264849
申请日:2008-11-04
CPC分类号: F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
摘要: Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.
摘要翻译: 用于执行肺部手术,特别是治疗肺部疾病的系统,方法和装置。 流量控制元件包括防止气流沿吸入方向但允许呼气方向气流的阀。 流量控制元件被引导到病人气管中并用于在流量控制元件的输送期间观察肺部的支气管镜引导到位置并定位在该位置处。 阀可以包括一个,两个或更多个阀元件,并且其可以是可折叠的以用于更容易的输送。 可以使用真空源或抽吸源来增加从肺组织排出的流体的量。 还公开了一种用于测量诸如细支气管的中空结构的装置和用于去除预先安置的流量控制元件的装置。
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公开(公告)号:US20110130834A1
公开(公告)日:2011-06-02
申请号:US12940787
申请日:2010-11-05
申请人: Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendricksen , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Douglas Sutton
发明人: Peter M. Wilson , Antony J. Fields , Hanson S. Gifford, III , John G. McCutcheon , Michael J. Hendricksen , Alan R. Rapacki , David R. Tholfsen , Michael S. Barrett , Ronald Hundertmark , Douglas Sutton
IPC分类号: A61F2/04
CPC分类号: A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要: Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.
摘要翻译: 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动并且包括至少部分地围绕阀构件的阀保护器。 阀保护器具有足够的刚性以保持阀构件的形状不被压缩。
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