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21.发明申请SYSTEM FOR OPTIMIZING THE INTRODUCTION OF NUCLEIC ACIDS INTO CELLS USING MAGNETIC PARTICLES 审中-公开使用磁性颗粒将核酸引入细胞的优化系统公开(公告)号：US20140093946A1
公开(公告)日：2014-04-03
申请号：US14039323
申请日：2013-09-27
Applicant: General Electric Company
Inventor： Jean-Baptiste Mathieu , Brian Michael Davis , Vasile Bogdan Neculaes , Evelina Roxana Loghin , Kenneth Roger Conway
IPC: C12N15/64
Abstract: An embodiment of a system is provided herein, wherein the system allows for the analysis and selection of numerous experimental conditions to optimize transfection efficiency and cell viability. The system is used for magnetic particle based nucleic acid delivery by optimizing various parameters. The system comprises a control module; an incubation module for incubating magnetic nanoparticle and nucleic acid; a transfection module and an analysis module.
Abstract translation: 本文提供了一种系统的实施例，其中所述系统允许分析和选择许多实验条件以优化转染效率和细胞活力。 该系统通过优化各种参数用于基于磁性粒子的核酸递送。 该系统包括控制模块; 用于孵育磁性纳米颗粒和核酸的孵育模块; 转染模块和分析模块。
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22.发明公开公开(公告)号：US20240062983A1
公开(公告)日：2024-02-22
申请号：US18497508
申请日：2023-10-30
Applicant: General Electric Company
Inventor： John Scott Price , Ye Bai , Antonio Caiafa , Vasile Bogdan Neculaes , Uwe Wiedmann
IPC: H01J29/68 , B29C64/153 , B29C64/273 , H01J37/30 , H01J37/305
CPC classification number: H01J29/68 , B29C64/153 , B29C64/273 , H01J37/3002 , H01J37/305 , B33Y30/00
Abstract: A system for melting, sintering, or heat treating a material is provided. The system includes a cathode, an anode, and a focus coil assembly having a quadrupole magnet. The quadrupole magnet includes four poles and a yoke. The four poles are spaced apart and surround a beam cavity. Each of the four poles includes a pole face proximate the beam cavity and an end opposite the pole face. The first and third poles are aligned along an x-axis and configured to have a first magnetic polarity at their respective pole faces and a second magnetic polarity opposite the first magnetic polarity at their respective ends. The second and fourth poles are aligned along a y-axis and configured to have the second magnetic polarity at their respective pole faces and the first magnetic polarity at their respective ends. The yoke surrounds the poles and is coupled to the poles.
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公开(公告)号：US10968423B2
公开(公告)日：2021-04-06
申请号：US15905463
申请日：2018-02-26
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes
IPC: C12M1/42 , C12M1/00 , C12M1/36 , C12M3/00 , C12N13/00 , A61B5/15 , G01N35/02 , G01N33/487 , A61K35/00 , G01N33/49
Abstract: Disclosed herein are multi-cuvette cartridges, flow cells, and electrical pulse systems for treatment of large volumes of biological samples with pulsed electric fields. The multi-cuvette cartridges systems may include mechanical motors for automatic positioning and alignment between the cuvettes and the electrodes of the electrical pulse systems. The flow cell systems may include fluidic systems, such as pumps, nozzles and valves, which may operate in coordination with the electrical systems for efficient exposition of biological samples. Embodiments having flow cell systems that allow “on-demand” production of activated sample are also disclosed.
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公开(公告)号：US20200068698A1
公开(公告)日：2020-02-27
申请号：US16106688
申请日：2018-08-21
Applicant: General Electric Company
Inventor： Andrew Thomas Cross , Alexander Kagan , Thomas Raber , Vasile Bogdan Neculaes , Nidhishri Tapadia , Ashraf Atalla , Pierre Fernand Habig , Frederic Dahan
Abstract: An apparatus is provided. The apparatus includes a compact vacuum chamber housing defining a vacuum chamber and an ion beam inlet, a rotating target positioned within the vacuum chamber, the ion beam inlet oriented to receive ions such that the ions impinge upon the rotating target, a motor core positioned within the vacuum chamber and coupled to the rotating target, and a motor stator electromagnetically coupled with the motor core.
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公开(公告)号：US10421956B2
公开(公告)日：2019-09-24
申请号：US15955377
申请日：2018-04-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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Patent Agency Ranking
公开(公告)号：US10369200B2
公开(公告)日：2019-08-06
申请号：US15252032
申请日：2016-08-30
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Vasile Bogdan Neculaes , Andrew Soliz Torres , Antonio Caiafa , Brian Dun-Lan Lee , Allen Lawrence Garner
Abstract: Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
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公开(公告)号：US10329551B2
公开(公告)日：2019-06-25
申请号：US15651900
申请日：2017-07-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US20170314009A1
公开(公告)日：2017-11-02
申请号：US15651900
申请日：2017-07-17
Applicant: General Electric Company
Inventor： Antonio Caiafa , Vasile Bogdan Neculaes , Allen Lawrence Garner , Andrew Soliz Torres
CPC classification number: C12N13/00 , A61B5/150755 , C12M35/02 , G01N33/49 , H03K3/53
Abstract: In accordance with the present disclosure, exposure of a sample to one or more electric pulses via capacitive coupling is described. In certain embodiments, the sample may be a biological sample to be treated or modified using the pulsed electric fields. In certain embodiments, the electric pulses may be delivered to a load using capacitive coupling. In other embodiments, the electric pulses may be bipolar pulses.
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公开(公告)号：US20160289664A1
公开(公告)日：2016-10-06
申请号：US14674971
申请日：2015-03-31
Applicant: General Electric Company
Inventor： Vasile Bogdan Neculaes , Juan Jose Becerra , Christine Angela Morton , Andrew Soliz Torres , Antonio Caiafa
CPC classification number: C12N5/0644 , C12M35/02 , C12N2529/00
Abstract: Methods and systems for generating a tunable or customizable activated product composition are related. In certain embodiments, one or more of electric pulse parameters, flow rate, or sample container size are varied so as to generate the activated product composition. The activated product composition may be customized or optimized based for a particular patient or procedure.
Abstract translation: 用于生成可调谐或可定制的活化产品组合物的方法和系统是相关的。 在某些实施例中，电脉冲参数，流速或样本容器尺寸中的一个或多个被改变以便产生活化的产品组合物。 活化的产品组合物可以针对特定的患者或程序进行定制或优化。
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公开(公告)号：US09237872B2
公开(公告)日：2016-01-19
申请号：US13744662
申请日：2013-01-18
Applicant: General Electric Company
Inventor： John Eric Tkaczyk , Remy Andre Klausz , Scott Stephen Zelakiewicz , Vasile Bogdan Neculaes , Xi Zhang
CPC classification number: A61B6/025 , A61B6/4021 , A61B6/502 , A61B6/542 , H01J35/10 , H01J35/26 , H01J35/28
Abstract: An X-ray source comprising a cathode element adapted to generate a stream of electrons. The X-ray source includes an anode element adapted to present a focal spot position for the stream of electrons. A vacuum chamber contains the cathode element and anode element. The anode element and/or the cathode element can be moveable with respect to the other in coordination with the generation of the stream of electrons.
Abstract translation: 一种X射线源，包括适于产生电子流的阴极元件。 X射线源包括适于呈现电子流的焦点位置的阳极元件。 真空室包含阴极元件和阳极元件。 与电子流的产生协调，阳极元件和/或阴极元件可以相对于另一个元件移动。
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