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公开(公告)号：US09751946B2
公开(公告)日：2017-09-05
申请号：US14852369
申请日：2015-09-11
Applicant: Genentech, Inc.
Inventor： Bing Zheng , Andrew Polson , Cecilia Chiu , Wei-Ching Liang , Yan Wu
IPC: A61K39/395 , C07K16/28 , A61K31/5517 , A61K31/706 , A61K47/48 , A61K51/10 , C07K16/30 , G01N33/574
CPC classification number: C07K16/2851 , A61K31/5517 , A61K31/706 , A61K47/68 , A61K47/6817 , A61K47/6867 , A61K47/6889 , A61K51/1069 , A61K51/1093 , C07K16/3061 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/57426 , G01N2333/7056
Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：US20160368994A1
公开(公告)日：2016-12-22
申请号：US15182327
申请日：2016-06-14
Applicant: Genentech, Inc.
Inventor： Robert F. Kelley , Steven R. Leong , Wei-Ching Liang , Mary Mathieu , Andrew G. Polson , Bing Zheng , Xiaocheng Chen , Cecilia Pui Chi Chiu , Mark S. Dennis , Allen Ebens , Yan Wu
IPC: C07K16/28 , A61K45/06 , A61K39/395
CPC classification number: C07K16/2851 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/57 , C07K16/2803 , C07K16/2809 , C07K16/2827 , C07K16/3061 , C07K2317/14 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/52 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
Abstract translation: 本发明涉及包含CLL-1结合结构域和CD3结合结构域（例如，抗CLL-1 / CD3T细胞依赖性双特异性（TDB）抗体）的抗CLL-1抗体的抗CLL-1抗体， 使用方法
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公开(公告)号：US09360484B2
公开(公告)日：2016-06-07
申请号：US14078241
申请日：2013-11-12
Applicant: Genentech, Inc.
Inventor： Kristi Elkins , Andrew Polson , Allen Ebens , Camelia Adams , Bing Zheng , Jagath R. Junutula , Jo-Anne Hongo , Yan Wu
IPC: C07K16/00 , G01N33/68 , A61K47/48 , C07K16/28 , G01N33/574 , A61K31/138 , A61K31/4196 , A61K31/454 , A61K31/4745 , A61K31/517 , A61K31/56 , A61K31/568 , A61K31/5685 , A61K31/69 , A61K33/24 , A61K38/19 , A61K39/395 , A61K39/00
CPC classification number: G01N33/6854 , A61K31/138 , A61K31/4196 , A61K31/454 , A61K31/4745 , A61K31/517 , A61K31/56 , A61K31/568 , A61K31/5685 , A61K31/69 , A61K33/24 , A61K38/19 , A61K39/0011 , A61K39/39533 , A61K39/39558 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/283 , C07K2317/24 , C07K2317/522 , C07K2317/73 , G01N33/574 , G01N33/6857 , Y02A50/473
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US11648315B2
公开(公告)日：2023-05-16
申请号：US16827083
申请日：2020-03-23
Applicant: Genentech, Inc.
Inventor： Thomas Pillow , Andrew G. Polson , Bing Zheng
IPC: A61K31/357 , A61K45/06 , C07D407/12 , C07K19/00 , G01N33/567 , A61K47/54 , A61K47/68 , A61K39/00
CPC classification number: A61K47/541 , A61K31/357 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K47/6855 , C07D407/12 , C07K19/00 , G01N33/567 , A61K2039/572 , A61K2039/627
Abstract: The invention relates generally to a silvestrol molecule activated with a leaving group. The invention further relates generally to an antibody-drug conjugate comprising an antibody conjugated by a linker to one or more silvestrol drug moieties and methods of treatment.
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公开(公告)号：US11466087B2
公开(公告)日：2022-10-11
申请号：US16658706
申请日：2019-10-21
Applicant: Genentech, Inc.
Inventor： Robert F. Kelley , Steven R. Leong , Wei-Ching Liang , Mary Mathieu , Andrew G. Polson , Bing Zheng , Xiaocheng Chen , Cecilia Pui Chi Chiu , Mark S. Dennis , Allen Ebens , Yan Wu
IPC: A61K39/395 , C07K16/28 , C07K16/30 , A61K45/06 , A61K39/00
Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US11084877B2
公开(公告)日：2021-08-10
申请号：US16250398
申请日：2019-01-17
Applicant: Genentech, Inc.
Inventor： Bing Zheng , Andrew Polson , Cecilia Chiu , Wei-Ching Liang , Yan Wu
IPC: A61K39/00 , C07K16/28 , A61K47/68 , A61K31/5517 , A61K31/706 , A61K51/10 , C07K16/30 , G01N33/574
Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
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公开(公告)号：USRE48558E1
公开(公告)日：2021-05-18
申请号：US15908703
申请日：2018-02-28
Applicant: GENENTECH, INC.
Inventor： Yvonne Chen , Mark Dennis , David Dornan , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC: A61K51/00 , A61K39/44 , C07K19/00 , C07K16/28 , A61K47/68 , A61K31/537 , A61K38/05 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/30 , G01N33/574 , A61K39/00
Abstract: The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194), (ii) an HVR-L2 sequence of AASNLES (SEQ ID NO: 195), (iii) an HVR-L3 sequence of QQSNEDPLT (SEQ ID NO: 196), (iv) an HVR-H1 sequence of GYTFSSYWIE (SEQ ID NO: 202), (v) an HVR-H2 sequence of GEILPGGGDTNYNEIFKG (SEQ ID NO: 203), and (vi) an HVR-H3 sequence of TRRVPIRLDY (SEQ ID NO: 204) and to methods of using those compositions of matter for the treatment of hematopoietic tumor in mammals.
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公开(公告)号：US10981987B2
公开(公告)日：2021-04-20
申请号：US15803495
申请日：2017-11-03
Applicant: GENENTECH, INC.
Inventor： Yvonne Chen , Mark Dennis , Kristi Elkins , Jagath Reddy Junutula , Andrew Polson , Bing Zheng
IPC: A61K51/00 , A61K39/395 , A61K39/40 , C07K16/28 , C07K16/30 , A61K51/10 , A61K47/68 , C07K16/00 , C12P21/08 , A61K39/00
Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20200148774A1
公开(公告)日：2020-05-14
申请号：US16658706
申请日：2019-10-21
Applicant: Genentech, Inc.
Inventor： Robert F. Kelley , Steven R. Leong , Wei-Ching Liang , Mary Mathieu , Andrew G. Polson , Bing Zheng , Xiaocheng Chen , Cecilia Pui Chi Chiu , Mark S. Dennis , Allen Ebens , Yan Wu
IPC: C07K16/28 , C07K16/30 , A61K39/395 , A61K45/06
Abstract: The present invention relates to anti-CLL-1 antibodies including anti-CLL-1 antibodies comprising a CLL-1 binding domain and a CD3 binding domain (e.g., anti-CLL-1/CD3 T cell dependent bispecific (TDB) antibody) and methods of using the same.
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公开(公告)号：US10239947B2
公开(公告)日：2019-03-26
申请号：US15657471
申请日：2017-07-24
Applicant: Genentech, Inc.
Inventor： Bing Zheng , Andrew Polson , Cecilia Chiu , Wei-Ching Liang , Yan Wu
IPC: A61K39/395 , C07K16/28 , A61K31/5517 , A61K31/706 , A61K51/10 , C07K16/30 , G01N33/574 , A61K47/68
Abstract: The invention provides anti-CLL-1 antibodies and immunoconjugates and methods of using the same.
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